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OPENSEQ.org
GPPA - Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
UniProt: P25552 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10413
Length: 494 (489)
Sequences: 1071
Seq/Len: 2.19
GPPA
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GPPA PPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
339_D 352_R 3.58 1.00
214_T 268_G 2.88 1.00
58_E 62_Q 2.725 1.00
377_A 401_L 2.667 1.00
168_L 267_S 2.545 1.00
51_A 91_V 2.529 1.00
137_V 275_I 2.364 1.00
82_V 295_L 2.319 1.00
376_H 379_Y 2.27 1.00
100_A 108_V 2.268 1.00
80_R 109_Q 2.185 1.00
335_A 339_D 2.155 1.00
381_V 401_L 2.099 0.99
12_D 16_N 2.079 0.99
34_T 439_S 2.048 0.99
215_V 272_L 2.036 0.99
484_Q 487_V 2.015 0.99
54_N 99_K 2.014 0.99
68_A 72_Q 1.942 0.99
60_G 96_F 1.914 0.99
348_E 351_S 1.878 0.99
115_E 118_R 1.876 0.99
276_F 284_M 1.852 0.98
71_L 79_I 1.851 0.98
368_V 380_L 1.848 0.98
309_R 389_F 1.847 0.98
52_L 96_F 1.814 0.98
13_L 18_F 1.783 0.98
221_I 265_F 1.77 0.98
146_L 275_I 1.754 0.97
331_A 356_I 1.728 0.97
101_Q 107_P 1.722 0.97
19_H 290_A 1.711 0.97
120_I 212_S 1.698 0.97
83_A 87_L 1.691 0.97
96_F 100_A 1.624 0.96
337_F 430_L 1.618 0.95
118_R 298_G 1.61 0.95
9_A 79_I 1.61 0.95
373_A 404_Q 1.602 0.95
23_V 296_V 1.568 0.94
54_N 58_E 1.567 0.94
335_A 352_R 1.563 0.94
326_Q 329_R 1.562 0.94
165_V 264_V 1.561 0.94
9_A 71_L 1.545 0.94
351_S 423_V 1.544 0.94
84_T 88_R 1.525 0.93
210_G 215_V 1.523 0.93
81_V 106_C 1.513 0.93
61_W 96_F 1.501 0.92
450_T 461_T 1.495 0.92
87_L 96_F 1.494 0.92
113_G 145_E 1.491 0.92
243_A 269_L 1.488 0.92
458_L 484_Q 1.475 0.91
95_D 98_A 1.452 0.91
357_S 389_F 1.452 0.91
190_R 274_A 1.448 0.90
189_A 270_A 1.443 0.90
100_A 104_L 1.44 0.90
16_N 261_R 1.417 0.89
118_R 122_Q 1.407 0.89
47_N 51_A 1.397 0.88
21_L 293_E 1.396 0.88
94_G 98_A 1.378 0.87
57_M 92_N 1.372 0.87
212_S 290_A 1.371 0.87
16_N 145_E 1.368 0.87
65_R 103_I 1.367 0.87
193_L 275_I 1.351 0.86
338_F 352_R 1.349 0.86
341_V 430_L 1.348 0.86
115_E 298_G 1.347 0.86
140_G 143_S 1.341 0.85
98_A 102_E 1.339 0.85
12_D 213_G 1.335 0.85
230_R 283_C 1.335 0.85
60_G 87_L 1.333 0.85
83_A 110_V 1.33 0.85
22_V 34_T 1.322 0.84
13_L 108_V 1.32 0.84
87_L 100_A 1.316 0.84
213_G 261_R 1.312 0.84
113_G 117_A 1.311 0.84
149_G 212_S 1.31 0.83
404_Q 437_F 1.306 0.83
233_L 277_T 1.297 0.83
222_M 235_K 1.296 0.83
263_L 266_P 1.29 0.82
17_S 37_K 1.28 0.82
17_S 145_E 1.278 0.81
11_I 81_V 1.276 0.81
92_N 142_A 1.273 0.81
12_D 17_S 1.273 0.81
127_T 289_G 1.269 0.81
56_A 92_N 1.262 0.80
186_E 274_A 1.261 0.80
19_H 212_S 1.258 0.80
12_D 145_E 1.254 0.80
237_Q 277_T 1.254 0.80
138_D 261_R 1.253 0.80
16_N 37_K 1.248 0.79
18_F 67_F 1.238 0.78
190_R 277_T 1.235 0.78
261_R 292_R 1.231 0.78
16_N 213_G 1.23 0.78
457_L 492_E 1.229 0.78
85_A 166_T 1.226 0.77
12_D 143_S 1.221 0.77
20_M 322_I 1.211 0.76
37_K 145_E 1.211 0.76
474_K 478_A 1.208 0.76
407_P 437_F 1.207 0.76
19_H 296_V 1.206 0.76
231_I 236_L 1.205 0.76
22_V 74_I 1.205 0.76
408_V 484_Q 1.204 0.76
404_Q 435_I 1.203 0.76
454_N 457_L 1.203 0.76
12_D 140_G 1.199 0.75
12_D 261_R 1.198 0.75
192_V 195_P 1.198 0.75
12_D 141_G 1.195 0.75
141_G 292_R 1.191 0.75
453_A 458_L 1.184 0.74
117_A 145_E 1.184 0.74
341_V 345_W 1.183 0.74
137_V 208_C 1.174 0.73
54_N 61_W 1.174 0.73
89_L 166_T 1.171 0.73
322_I 364_I 1.168 0.73
16_N 159_S 1.167 0.72
288_G 337_F 1.165 0.72
114_E 192_V 1.165 0.72
243_A 252_L 1.165 0.72
19_H 293_E 1.164 0.72
141_G 261_R 1.155 0.71
143_S 261_R 1.155 0.71
82_V 291_L 1.155 0.71
12_D 117_A 1.153 0.71
117_A 261_R 1.152 0.71
138_D 141_G 1.151 0.71
459_T 492_E 1.149 0.71
390_T 393_Q 1.147 0.71
259_L 262_A 1.146 0.70
41_R 264_V 1.145 0.70
485_S 490_P 1.145 0.70
218_L 269_L 1.144 0.70
116_E 213_G 1.143 0.70
316_I 364_I 1.141 0.70
117_A 143_S 1.134 0.69
139_I 144_T 1.13 0.69
53_S 56_A 1.13 0.69
57_M 99_K 1.128 0.69
287_A 364_I 1.127 0.69
144_T 379_Y 1.126 0.69
138_D 143_S 1.124 0.68
335_A 356_I 1.124 0.68
237_Q 241_Q 1.121 0.68
19_H 35_R 1.117 0.68
66_L 370_F 1.116 0.68
10_A 115_E 1.115 0.67
16_N 19_H 1.111 0.67
354_L 396_L 1.111 0.67
16_N 141_G 1.11 0.67
13_L 83_A 1.109 0.67
83_A 408_V 1.106 0.67
162_M 193_L 1.104 0.66
117_A 138_D 1.103 0.66
142_A 166_T 1.101 0.66
365_G 368_V 1.098 0.66
265_F 393_Q 1.098 0.66
218_L 265_F 1.096 0.65
33_L 383_N 1.095 0.65
43_A 166_T 1.094 0.65
141_G 145_E 1.092 0.65
380_L 386_L 1.092 0.65
210_G 272_L 1.09 0.65
9_A 24_R 1.088 0.65
124_V 136_V 1.088 0.65
333_V 438_A 1.082 0.64
454_N 459_T 1.08 0.64
82_V 111_I 1.08 0.64
140_G 261_R 1.079 0.64
320_F 384_L 1.074 0.63
55_E 193_L 1.071 0.63
145_E 213_G 1.071 0.63
164_C 264_V 1.068 0.63
188_A 446_V 1.064 0.62
141_G 213_G 1.064 0.62
16_N 116_E 1.063 0.62
221_I 257_L 1.061 0.62
171_Y 188_A 1.061 0.62
212_S 309_R 1.06 0.62
126_H 152_A 1.057 0.61
99_K 193_L 1.057 0.61
9_A 14_G 1.057 0.61
12_D 138_D 1.054 0.61
116_E 261_R 1.053 0.61
16_N 140_G 1.052 0.61
237_Q 273_I 1.049 0.60
202_Y 282_Q 1.048 0.60
375_Q 404_Q 1.048 0.60
113_G 141_G 1.046 0.60
240_K 269_L 1.046 0.60
117_A 139_I 1.046 0.60
61_W 100_A 1.046 0.60
23_V 212_S 1.044 0.60
108_V 147_V 1.043 0.60
17_S 113_G 1.043 0.60
12_D 15_S 1.042 0.60
93_A 110_V 1.041 0.60
57_M 96_F 1.039 0.59
121_Y 301_H 1.039 0.59
213_G 292_R 1.038 0.59
117_A 213_G 1.035 0.59
200_L 204_G 1.035 0.59
128_T 209_V 1.03 0.58
56_A 59_R 1.029 0.58
470_H 473_G 1.029 0.58
14_G 138_D 1.027 0.58
392_A 420_P 1.024 0.58
37_K 41_R 1.023 0.58
16_N 117_A 1.023 0.58
145_E 159_S 1.023 0.58
331_A 360_Q 1.021 0.57
12_D 88_R 1.019 0.57
132_D 150_T 1.017 0.57
37_K 113_G 1.016 0.57
24_R 31_Q 1.016 0.57
398_A 458_L 1.015 0.57
12_D 84_T 1.014 0.57
12_D 19_H 1.014 0.57
59_R 268_G 1.011 0.56
19_H 41_R 1.011 0.56
377_A 404_Q 1.01 0.56
186_E 277_T 1.007 0.56
340_Q 451_L 1.006 0.56
337_F 460_L 1.006 0.56
53_S 101_Q 1.004 0.55
88_R 138_D 1.003 0.55
452_Q 461_T 1.003 0.55
113_G 140_G 1.002 0.55
319_R 384_L 1.002 0.55
109_Q 119_L 1.002 0.55
374_P 405_T 1 0.55
149_G 309_R 1 0.55
479_Q 490_P 1 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u6zA211000.086Contact Map0.516
3hi0A20.96961000.187Contact Map0.474
3cerA50.61941000.467Contact Map0.515
1t6cA10.60931000.484Contact Map0.485
3mdqA10.61541000.489Contact Map0.485
4brcA20.61131000.65Contact Map0.267
3rf0A20.38661000.678Contact Map0.63
3cj1A10.64781000.749Contact Map0.267
3zx3A40.64981000.754Contact Map0.333
4a2aA20.58199.70.868Contact Map0.162
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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