May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
CYSN - Sulfate adenylyltransferase subunit 1
UniProt: P23845 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10194
Length: 475 (421)
Sequences: 2704
Seq/Len: 6.42
CYSN
Paralog alert: 0.34 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CYSN EFTU1 EFTU2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
177_E 181_T 5.596 1.00
277_R 286_E 5.08 1.00
338_S 436_E 4.762 1.00
325_L 331_L 3.97 1.00
408_R 436_E 3.967 1.00
336_S 399_T 3.813 1.00
179_T 182_R 3.721 1.00
336_S 439_S 3.465 1.00
338_S 395_L 3.06 1.00
77_D 80_L 3.028 1.00
267_L 302_A 2.856 1.00
273_E 301_E 2.745 1.00
167_I 187_Y 2.695 1.00
388_L 394_G 2.664 1.00
170_M 204_P 2.656 1.00
269_S 407_D 2.56 1.00
267_L 308_I 2.56 1.00
336_S 397_D 2.527 1.00
181_T 184_R 2.485 1.00
271_R 301_E 2.442 1.00
341_V 396_V 2.39 1.00
288_N 313_T 2.304 1.00
338_S 397_D 2.288 1.00
246_M 272_V 2.28 1.00
76_L 84_G 2.27 1.00
84_G 98_A 2.25 1.00
272_V 302_A 2.22 1.00
181_T 204_P 2.199 1.00
209_E 212_N 2.175 1.00
64_N 68_R 2.162 1.00
152_S 187_Y 2.132 1.00
279_K 327_A 2.109 1.00
351_P 371_I 2.079 1.00
291_R 298_D 2.071 1.00
272_V 292_I 2.058 1.00
184_R 188_L 2.056 1.00
70_G 73_G 2.051 1.00
227_T 230_E 2.035 1.00
133_L 235_V 2.035 1.00
175_Y 220_M 2.025 1.00
285_V 317_D 1.903 1.00
266_T 307_A 1.887 1.00
408_R 411_Q 1.867 1.00
43_L 207_A 1.867 1.00
276_Q 326_A 1.82 1.00
274_V 298_D 1.811 1.00
134_A 163_L 1.809 1.00
167_I 180_F 1.797 1.00
340_D 395_L 1.791 1.00
357_I 366_A 1.786 1.00
294_T 297_G 1.768 1.00
68_R 223_Y 1.765 1.00
241_V 244_Q 1.746 1.00
142_K 145_L 1.703 1.00
372_R 397_D 1.701 1.00
335_Q 439_S 1.684 1.00
216_Q 230_E 1.672 1.00
228_L 231_V 1.67 1.00
135_I 166_A 1.664 1.00
370_G 397_D 1.642 1.00
287_S 314_D 1.631 1.00
125_A 154_I 1.613 1.00
369_D 399_T 1.611 1.00
222_W 227_T 1.611 1.00
166_A 205_L 1.596 1.00
278_V 289_V 1.596 1.00
187_Y 202_F 1.593 1.00
84_G 96_D 1.591 1.00
339_V 418_L 1.585 1.00
232_L 235_V 1.578 0.99
246_M 267_L 1.569 0.99
165_V 202_F 1.559 0.99
373_Y 382_Q 1.554 0.99
224_S 227_T 1.546 0.99
369_D 397_D 1.538 0.99
230_E 234_T 1.537 0.99
341_V 430_G 1.534 0.99
337_A 400_F 1.53 0.99
76_L 80_L 1.529 0.99
337_A 398_L 1.519 0.99
407_D 415_T 1.516 0.99
275_G 292_I 1.508 0.99
46_R 50_D 1.507 0.99
89_R 96_D 1.505 0.99
359_I 404_L 1.502 0.99
79_A 89_R 1.501 0.99
274_V 292_I 1.495 0.99
272_V 310_L 1.49 0.99
273_E 276_Q 1.484 0.99
88_E 92_G 1.48 0.99
310_L 324_L 1.477 0.99
367_R 399_T 1.472 0.99
351_P 369_D 1.451 0.99
222_W 225_G 1.45 0.99
63_H 100_R 1.447 0.99
303_F 306_E 1.445 0.99
83_D 88_E 1.444 0.99
406_L 434_V 1.436 0.99
175_Y 209_E 1.424 0.99
374_Q 392_G 1.424 0.99
359_I 406_L 1.416 0.99
272_V 289_V 1.411 0.99
203_V 231_V 1.392 0.98
278_V 324_L 1.391 0.98
109_F 232_L 1.388 0.98
140_A 167_I 1.38 0.98
220_M 224_S 1.37 0.98
146_D 347_Q 1.345 0.98
220_M 223_Y 1.345 0.98
290_A 313_T 1.344 0.98
271_R 303_F 1.327 0.98
166_A 227_T 1.324 0.98
292_I 302_A 1.322 0.98
141_R 172_L 1.317 0.97
420_F 430_G 1.3 0.97
211_D 219_S 1.3 0.97
77_D 96_D 1.299 0.97
83_D 92_G 1.292 0.97
74_E 80_L 1.291 0.97
366_A 398_L 1.282 0.97
250_V 318_I 1.276 0.97
185_E 189_T 1.262 0.97
362_K 402_E 1.249 0.96
340_D 435_H 1.246 0.96
335_Q 399_T 1.224 0.96
223_Y 229_L 1.224 0.96
173_V 179_T 1.22 0.96
56_E 60_S 1.219 0.96
279_K 286_E 1.214 0.95
136_L 187_Y 1.207 0.95
292_I 310_L 1.204 0.95
25_K 103_S 1.198 0.95
211_D 217_S 1.191 0.95
51_T 100_R 1.187 0.95
170_M 220_M 1.176 0.94
63_H 67_K 1.175 0.94
336_S 369_D 1.16 0.94
166_A 225_G 1.16 0.94
106_K 233_E 1.159 0.94
229_L 232_L 1.157 0.94
39_G 42_T 1.154 0.93
287_S 313_T 1.152 0.93
226_P 230_E 1.15 0.93
177_E 222_W 1.149 0.93
73_G 76_L 1.13 0.93
180_F 204_P 1.128 0.92
83_D 87_A 1.119 0.92
162_H 199_D 1.119 0.92
357_I 420_F 1.117 0.92
41_S 45_G 1.108 0.92
164_V 235_V 1.107 0.92
302_A 308_I 1.107 0.92
371_I 388_L 1.104 0.91
352_G 367_R 1.094 0.91
83_D 91_Q 1.088 0.91
80_L 89_R 1.088 0.91
371_I 394_G 1.082 0.90
397_D 438_V 1.082 0.90
218_E 223_Y 1.078 0.90
184_R 202_F 1.076 0.90
357_I 404_L 1.068 0.89
105_E 233_E 1.065 0.89
362_K 404_L 1.064 0.89
357_I 398_L 1.059 0.89
359_I 362_K 1.054 0.89
170_M 222_W 1.053 0.89
259_D 314_D 1.047 0.88
137_L 166_A 1.043 0.88
267_L 310_L 1.042 0.88
88_E 91_Q 1.041 0.88
338_S 372_R 1.041 0.88
145_L 347_Q 1.041 0.88
69_H 229_L 1.04 0.88
260_F 263_Y 1.034 0.87
172_L 208_L 1.03 0.87
280_V 324_L 1.029 0.87
277_R 288_N 1.027 0.87
83_D 89_R 1.027 0.87
34_G 37_D 1.025 0.87
228_L 233_E 1.024 0.87
43_L 166_A 1.02 0.86
30_F 232_L 1.019 0.86
275_G 288_N 1.018 0.86
248_F 267_L 1.008 0.85
87_A 91_Q 1.006 0.85
55_Y 58_Q 1.005 0.85
124_M 128_A 1.005 0.85
175_Y 219_S 1.003 0.85
192_G 200_I 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3j2k710.89051000.389Contact Map0.031
1zunB10.91161000.396Contact Map0.745
1f60A10.90951000.396Contact Map0.665
1r5bA10.90951000.398Contact Map0.735
1jnyA20.88421000.41Contact Map0.771
3izq110.91161000.414Contact Map0.584
3mcaA10.89471000.417Contact Map0.689
3p26A20.92211000.419Contact Map0.758
3avxA10.91161000.512Contact Map0.702
2c78A10.81261000.516Contact Map0.679
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0172 seconds.