May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
TNAB - Low affinity tryptophan permease
UniProt: P23173 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11006
Length: 415 (405)
Sequences: 424
Seq/Len: 1.05
TNAB
Paralog alert: 0.83 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: MTR TNAB TYRP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
43_A 242_L 2.408 0.99
13_W 149_S 2.278 0.99
387_L 391_I 1.981 0.96
311_A 326_T 1.92 0.95
39_F 179_L 1.839 0.93
158_L 231_V 1.824 0.92
328_L 332_L 1.723 0.89
57_G 234_S 1.722 0.89
102_Y 344_G 1.719 0.89
149_S 153_S 1.691 0.88
207_G 302_V 1.68 0.87
125_N 128_I 1.665 0.87
101_T 303_T 1.646 0.86
210_G 305_G 1.638 0.86
21_T 29_A 1.626 0.85
183_T 415_G 1.623 0.85
90_G 309_Y 1.619 0.85
109_G 129_V 1.611 0.84
67_Y 79_D 1.6 0.84
372_R 384_G 1.592 0.83
100_L 207_G 1.576 0.83
96_V 237_A 1.57 0.82
149_S 218_C 1.566 0.82
210_G 360_A 1.476 0.76
62_E 372_R 1.469 0.76
372_R 385_G 1.46 0.75
29_A 201_V 1.457 0.75
58_L 227_I 1.455 0.75
211_N 360_A 1.449 0.75
77_T 85_W 1.441 0.74
112_I 246_Y 1.413 0.72
13_W 218_C 1.412 0.72
302_V 331_F 1.408 0.71
382_V 385_G 1.408 0.71
19_A 236_L 1.402 0.71
145_S 218_C 1.392 0.70
36_G 305_G 1.384 0.70
107_A 295_V 1.38 0.69
344_G 350_G 1.355 0.67
207_G 352_A 1.353 0.67
214_S 308_D 1.349 0.67
44_F 47_I 1.348 0.67
308_D 311_A 1.345 0.66
80_L 367_L 1.344 0.66
22_V 159_K 1.344 0.66
95_F 342_P 1.341 0.66
405_G 408_F 1.331 0.65
92_T 339_L 1.322 0.64
237_A 349_I 1.32 0.64
29_A 306_L 1.302 0.63
100_L 208_F 1.302 0.63
57_G 213_P 1.296 0.62
170_F 361_V 1.294 0.62
106_S 130_G 1.293 0.62
102_Y 350_G 1.288 0.62
17_V 145_S 1.264 0.59
370_K 374_K 1.262 0.59
161_I 220_G 1.26 0.59
100_L 305_G 1.257 0.59
246_Y 256_S 1.24 0.57
47_I 373_K 1.24 0.57
184_S 187_A 1.239 0.57
302_V 360_A 1.23 0.56
13_W 153_S 1.23 0.56
145_S 304_L 1.226 0.56
117_S 122_Y 1.225 0.56
132_C 328_L 1.224 0.56
54_L 230_V 1.224 0.56
95_F 355_C 1.221 0.55
21_T 70_G 1.22 0.55
95_F 305_G 1.214 0.55
239_V 386_N 1.205 0.54
211_N 305_G 1.203 0.54
56_S 356_A 1.202 0.54
23_I 208_F 1.201 0.54
311_A 322_G 1.192 0.53
44_F 132_C 1.191 0.53
13_W 17_V 1.191 0.53
53_M 95_F 1.19 0.52
61_L 75_T 1.189 0.52
18_I 329_L 1.182 0.52
132_C 224_D 1.178 0.51
356_A 360_A 1.176 0.51
75_T 312_D 1.175 0.51
17_V 211_N 1.172 0.51
298_S 345_F 1.17 0.51
106_S 348_G 1.169 0.51
20_G 50_W 1.167 0.50
358_I 401_L 1.163 0.50
76_I 291_S 1.161 0.50
19_A 25_G 1.158 0.49
86_N 357_T 1.151 0.49
336_L 405_G 1.141 0.48
12_F 131_I 1.139 0.48
243_F 252_I 1.138 0.48
29_A 108_N 1.136 0.47
25_G 385_G 1.134 0.47
47_I 112_I 1.131 0.47
354_L 362_I 1.131 0.47
239_V 401_L 1.13 0.47
332_L 336_L 1.128 0.47
34_L 108_N 1.128 0.47
257_F 260_I 1.127 0.47
310_L 361_V 1.127 0.47
30_L 80_L 1.126 0.46
154_L 293_L 1.125 0.46
228_K 382_V 1.122 0.46
56_S 349_I 1.122 0.46
13_W 145_S 1.122 0.46
29_A 50_W 1.12 0.46
255_E 378_Q 1.119 0.46
184_S 411_L 1.117 0.46
90_G 101_T 1.117 0.46
406_N 415_G 1.114 0.45
387_L 390_A 1.114 0.45
91_I 404_F 1.113 0.45
329_L 405_G 1.112 0.45
239_V 390_A 1.112 0.45
88_I 332_L 1.11 0.45
14_G 32_V 1.109 0.45
69_V 398_T 1.108 0.45
98_Y 333_P 1.107 0.45
141_L 235_L 1.106 0.45
131_I 158_L 1.106 0.45
160_I 394_L 1.105 0.45
405_G 410_V 1.104 0.44
131_I 174_V 1.104 0.44
152_T 359_W 1.101 0.44
271_V 295_V 1.098 0.44
405_G 412_P 1.097 0.44
281_G 390_A 1.097 0.44
329_L 332_L 1.096 0.44
25_G 91_I 1.096 0.44
116_I 125_N 1.091 0.43
184_S 415_G 1.091 0.43
200_P 294_A 1.09 0.43
270_L 273_S 1.089 0.43
73_F 144_S 1.087 0.43
295_V 338_Y 1.083 0.42
57_G 163_F 1.081 0.42
334_P 372_R 1.081 0.42
209_H 294_A 1.081 0.42
164_V 175_D 1.081 0.42
43_A 362_I 1.081 0.42
74_N 230_V 1.079 0.42
23_I 195_I 1.078 0.42
107_A 155_F 1.078 0.42
25_G 103_A 1.077 0.42
219_Y 297_S 1.075 0.42
38_W 102_Y 1.074 0.42
13_W 25_G 1.074 0.42
138_A 327_V 1.074 0.42
159_K 237_A 1.074 0.42
370_K 373_K 1.071 0.41
106_S 410_V 1.07 0.41
222_R 358_I 1.07 0.41
141_L 148_A 1.07 0.41
93_V 267_V 1.069 0.41
96_V 356_A 1.069 0.41
269_S 273_S 1.068 0.41
406_N 413_K 1.068 0.41
385_G 389_P 1.068 0.41
410_V 413_K 1.067 0.41
218_C 331_F 1.066 0.41
20_G 24_G 1.065 0.41
358_I 386_N 1.064 0.41
81_I 366_V 1.062 0.41
59_L 389_P 1.061 0.40
108_N 149_S 1.061 0.40
54_L 235_L 1.06 0.40
380_F 396_G 1.057 0.40
14_G 99_I 1.055 0.40
184_S 409_N 1.053 0.40
324_F 387_L 1.053 0.40
299_F 334_P 1.05 0.39
241_Y 302_V 1.049 0.39
38_W 96_V 1.048 0.39
372_R 382_V 1.046 0.39
132_C 135_I 1.044 0.39
103_A 334_P 1.042 0.39
400_I 403_W 1.042 0.39
59_L 368_A 1.04 0.39
224_D 228_K 1.039 0.39
64_N 72_S 1.039 0.39
129_V 397_I 1.039 0.39
64_N 70_G 1.039 0.39
215_L 283_I 1.038 0.38
405_G 411_L 1.035 0.38
74_N 152_T 1.035 0.38
50_W 94_A 1.034 0.38
166_V 293_L 1.032 0.38
130_G 248_T 1.031 0.38
368_A 372_R 1.031 0.38
27_M 207_G 1.022 0.37
85_W 144_S 1.022 0.37
78_K 394_L 1.021 0.37
154_L 175_D 1.021 0.37
379_M 404_F 1.02 0.37
17_V 25_G 1.018 0.37
176_Y 332_L 1.016 0.36
30_L 64_N 1.016 0.36
158_L 236_L 1.015 0.36
120_L 379_M 1.015 0.36
383_W 400_I 1.014 0.36
113_S 157_G 1.013 0.36
134_A 335_A 1.01 0.36
30_L 72_S 1.007 0.36
201_V 346_I 1.006 0.36
39_F 348_G 1.006 0.36
20_G 26_G 1.006 0.36
404_F 408_F 1.003 0.35
406_N 411_L 1.002 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.96871000.77Contact Map0.21
4djkA20.971199.90.803Contact Map0.153
3giaA10.942299.90.811Contact Map0.184
2jlnA10.89498.20.922Contact Map0.17
2a65A10.961497.40.935Contact Map0.198
3dh4A40.951897.20.936Contact Map0.159
2xq2A10.949497.20.937Contact Map0.19
4m48A10.9614960.945Contact Map0.128
2gfpA20.614514.10.977Contact Map0.13
3qrxB10.062711.70.978Contact Map0.645
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0594 seconds.