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OPENSEQ.org
GLPX2 - Fructose-1,6-bisphosphatase 2 class 2
UniProt: P21437 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11245
Length: 321 (306)
Sequences: 565
Seq/Len: 1.85
GLPX2
Paralog alert: 0.30 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GLPX2 GLPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
160_T 173_A 5.522 1.00
139_T 172_E 3.144 1.00
27_D 30_K 2.813 1.00
49_R 78_E 2.739 1.00
142_L 156_L 2.707 1.00
49_R 70_E 2.669 1.00
191_S 216_S 2.586 1.00
145_V 203_V 2.571 1.00
170_I 182_A 2.532 1.00
20_W 295_Q 2.519 1.00
33_G 37_T 2.47 1.00
135_S 230_E 2.459 1.00
114_A 117_M 2.449 1.00
303_Q 318_D 2.398 1.00
138_L 205_Y 2.367 1.00
123_V 220_V 2.293 1.00
221_K 269_D 2.287 1.00
253_K 257_A 2.211 1.00
9_F 304_T 2.199 0.99
227_M 268_L 2.188 0.99
158_M 203_V 2.173 0.99
122_L 132_I 2.141 0.99
207_I 232_I 2.139 0.99
171_E 175_Q 2.054 0.99
51_R 108_R 2.041 0.99
234_F 251_E 2.011 0.99
168_A 172_E 1.971 0.99
134_L 265_V 1.961 0.99
135_S 265_V 1.936 0.98
120_K 230_E 1.932 0.98
173_A 178_V 1.926 0.98
142_L 203_V 1.922 0.98
78_E 108_R 1.92 0.98
51_R 70_E 1.862 0.98
142_L 153_L 1.731 0.96
221_K 272_V 1.723 0.96
134_L 230_E 1.7 0.96
136_L 140_D 1.697 0.95
86_I 284_V 1.695 0.95
234_F 248_A 1.686 0.95
169_A 205_Y 1.643 0.94
133_D 265_V 1.623 0.94
132_I 145_V 1.62 0.94
130_G 226_D 1.609 0.93
195_C 220_V 1.601 0.93
153_L 178_V 1.569 0.92
127_L 149_L 1.565 0.92
107_P 276_D 1.561 0.92
81_I 105_F 1.506 0.90
90_R 94_M 1.482 0.89
19_A 101_A 1.431 0.87
266_Y 270_E 1.426 0.87
308_G 313_T 1.425 0.87
158_M 205_Y 1.419 0.86
17_L 300_V 1.393 0.85
91_M 184_P 1.369 0.83
296_T 299_G 1.367 0.83
210_A 213_G 1.366 0.83
124_V 203_V 1.36 0.83
164_P 167_S 1.341 0.82
114_A 254_R 1.317 0.80
115_P 214_V 1.315 0.80
283_G 287_G 1.314 0.80
260_V 264_R 1.291 0.78
160_T 170_I 1.289 0.78
10_R 308_G 1.28 0.77
31_I 92_V 1.274 0.77
116_D 210_A 1.272 0.77
120_K 207_I 1.267 0.76
218_C 277_I 1.263 0.76
116_D 254_R 1.261 0.76
159_V 190_A 1.26 0.76
67_I 210_A 1.258 0.76
120_K 134_L 1.254 0.75
112_L 210_A 1.238 0.74
60_D 89_T 1.234 0.74
142_L 176_L 1.227 0.73
133_D 228_Q 1.212 0.72
67_I 114_A 1.197 0.70
303_Q 316_I 1.191 0.70
107_P 274_G 1.185 0.69
151_K 202_D 1.174 0.68
100_L 159_V 1.17 0.68
98_N 190_A 1.165 0.67
301_R 318_D 1.165 0.67
140_D 144_N 1.163 0.67
122_L 319_S 1.157 0.67
60_D 64_M 1.152 0.66
253_K 256_K 1.149 0.66
8_L 189_A 1.133 0.64
249_E 252_R 1.126 0.63
181_F 288_E 1.122 0.63
58_E 64_M 1.122 0.63
213_G 229_A 1.117 0.63
226_D 268_L 1.112 0.62
160_T 206_T 1.112 0.62
31_I 86_I 1.104 0.61
85_P 89_T 1.086 0.59
250_Q 253_K 1.085 0.59
168_A 171_E 1.085 0.59
136_L 144_N 1.085 0.59
106_A 111_L 1.084 0.59
71_V 192_V 1.082 0.59
112_L 116_D 1.069 0.57
171_E 252_R 1.069 0.57
172_E 205_Y 1.067 0.57
132_I 141_N 1.066 0.57
89_T 211_P 1.064 0.57
51_R 113_H 1.059 0.56
47_A 73_K 1.059 0.56
50_G 71_V 1.057 0.56
67_I 116_D 1.047 0.55
92_V 122_L 1.044 0.55
159_V 183_L 1.043 0.55
64_M 89_T 1.041 0.54
7_P 107_P 1.039 0.54
228_Q 265_V 1.035 0.54
123_V 227_M 1.034 0.54
62_A 89_T 1.034 0.54
59_I 234_F 1.033 0.54
261_D 264_R 1.033 0.54
160_T 180_V 1.031 0.53
167_S 172_E 1.03 0.53
54_I 60_D 1.027 0.53
70_E 108_R 1.022 0.52
254_R 258_M 1.021 0.52
124_V 226_D 1.021 0.52
167_S 171_E 1.02 0.52
100_L 155_K 1.017 0.52
21_P 155_K 1.016 0.52
200_P 293_I 1.014 0.52
71_V 277_I 1.012 0.51
28_K 59_I 1.012 0.51
67_I 113_H 1.011 0.51
7_P 311_D 1.011 0.51
248_A 251_E 1.009 0.51
264_R 270_E 1.009 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bigA111000.002Contact Map0.665
3rojA40.99691000.016Contact Map0.689
3b8bA10.725996.50.951Contact Map0.387
1g0hA20.688595.80.954Contact Map0.446
4g62A20.741494.90.956Contact Map0.386
3t0jA40.781994.50.957Contact Map0.422
2pcrA40.716594.50.957Contact Map0.433
2bjiA20.75793.50.959Contact Map0.333
1xi6A10.691693.40.959Contact Map0.414
1vdwA20.694793.40.959Contact Map0.477
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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