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OPENSEQ.org
GUTQ - Arabinose 5-phosphate isomerase GutQ
UniProt: P17115 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10973
Length: 321 (318)
Sequences: 1068
Seq/Len: 3.36
GUTQ
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GUTQ KDSD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_I 161_L 4.331 1.00
101_G 129_P 3.543 1.00
121_A 134_A 3.324 1.00
11_Q 173_Q 3.14 1.00
45_V 69_T 2.994 1.00
221_A 265_V 2.913 1.00
246_F 265_V 2.752 1.00
96_I 160_T 2.666 1.00
50_I 77_A 2.653 1.00
60_I 64_L 2.629 1.00
274_T 292_R 2.616 1.00
215_T 266_N 2.59 1.00
47_V 57_G 2.553 1.00
13_L 162_M 2.527 1.00
214_L 243_Q 2.443 1.00
140_I 163_M 2.42 1.00
42_E 90_R 2.357 1.00
6_L 27_L 2.352 1.00
26_R 139_D 2.331 1.00
234_A 298_P 2.319 1.00
63_T 168_A 2.297 1.00
17_L 20_A 2.253 1.00
140_I 160_T 2.246 1.00
298_P 306_L 2.217 1.00
224_E 228_T 2.215 1.00
45_V 94_L 2.169 1.00
264_P 267_E 2.152 1.00
50_I 76_P 2.145 1.00
17_L 24_P 2.064 1.00
242_V 306_L 2.027 1.00
37_I 136_A 2.011 1.00
295_T 311_N 1.986 1.00
93_M 112_L 1.983 1.00
41_C 92_V 1.943 1.00
200_H 279_Q 1.925 1.00
14_M 24_P 1.922 1.00
48_S 95_F 1.868 0.99
242_V 298_P 1.824 0.99
44_K 88_E 1.81 0.99
237_D 241_Q 1.769 0.99
57_G 96_I 1.768 0.99
34_A 120_L 1.767 0.99
18_Q 21_S 1.725 0.99
276_L 280_S 1.685 0.99
17_L 21_S 1.677 0.99
17_L 162_M 1.664 0.98
199_V 285_A 1.643 0.98
124_G 139_D 1.611 0.98
34_A 136_A 1.6 0.98
48_S 93_M 1.598 0.98
60_I 94_L 1.597 0.98
38_I 45_V 1.574 0.98
75_H 78_E 1.562 0.97
37_I 118_A 1.549 0.97
61_A 71_A 1.527 0.97
74_V 87_I 1.525 0.97
15_L 155_S 1.524 0.97
14_M 18_Q 1.497 0.96
123_T 137_V 1.469 0.96
6_L 10_R 1.46 0.96
19_E 155_S 1.457 0.96
9_G 31_F 1.434 0.95
287_E 291_K 1.434 0.95
8_A 11_Q 1.413 0.95
65_A 86_M 1.406 0.94
5_L 174_A 1.402 0.94
45_V 64_L 1.398 0.94
47_V 94_L 1.392 0.94
118_A 135_K 1.388 0.94
36_N 40_H 1.383 0.94
39_L 174_A 1.38 0.94
26_R 141_S 1.378 0.94
246_F 251_L 1.358 0.93
38_I 41_C 1.351 0.93
276_L 299_V 1.345 0.93
248_D 252_R 1.343 0.93
206_D 228_T 1.334 0.92
6_L 32_V 1.326 0.92
14_M 21_S 1.325 0.92
60_I 96_I 1.322 0.92
230_L 309_A 1.314 0.91
114_D 281_R 1.306 0.91
211_Q 234_A 1.303 0.91
38_I 69_T 1.3 0.91
202_L 282_A 1.288 0.90
96_I 122_M 1.283 0.90
202_L 310_I 1.278 0.90
214_L 271_V 1.278 0.90
214_L 266_N 1.275 0.90
38_I 92_V 1.273 0.90
8_A 12_T 1.272 0.90
212_V 233_V 1.27 0.89
102_A 105_L 1.26 0.89
113_E 135_K 1.247 0.88
280_S 284_D 1.247 0.88
122_M 163_M 1.241 0.88
5_L 32_V 1.238 0.88
87_I 93_M 1.232 0.88
44_K 86_M 1.226 0.87
199_V 276_L 1.208 0.86
61_A 65_A 1.203 0.86
30_D 33_R 1.189 0.85
67_T 171_V 1.189 0.85
221_A 233_V 1.186 0.85
22_R 143_E 1.186 0.85
122_M 140_I 1.182 0.84
154_T 169_M 1.179 0.84
286_K 319_G 1.175 0.84
55_H 74_V 1.172 0.84
183_A 193_A 1.171 0.84
212_V 235_V 1.16 0.83
80_L 188_A 1.152 0.82
103_K 107_L 1.142 0.82
240_Q 243_Q 1.133 0.81
204_R 314_D 1.132 0.81
276_L 297_A 1.116 0.79
11_Q 15_L 1.108 0.79
131_G 137_V 1.102 0.78
213_A 238_A 1.101 0.78
35_A 167_L 1.095 0.78
246_F 268_A 1.094 0.78
36_N 271_V 1.091 0.77
12_T 170_A 1.091 0.77
124_G 140_I 1.086 0.77
240_Q 306_L 1.08 0.76
72_F 86_M 1.072 0.76
121_A 137_V 1.068 0.75
19_E 143_E 1.067 0.75
218_V 221_A 1.055 0.74
218_V 265_V 1.052 0.74
105_L 130_L 1.052 0.74
249_G 253_R 1.044 0.73
254_W 268_A 1.04 0.72
124_G 142_V 1.04 0.72
37_I 92_V 1.039 0.72
232_L 309_A 1.038 0.72
214_L 238_A 1.035 0.72
12_T 150_H 1.034 0.72
55_H 79_A 1.033 0.72
20_A 23_L 1.032 0.72
224_E 233_V 1.03 0.71
232_L 245_V 1.025 0.71
296_A 311_N 1.023 0.71
115_K 185_S 1.022 0.70
241_Q 303_N 1.021 0.70
23_L 159_N 1.017 0.70
5_L 35_A 1.014 0.70
212_V 216_A 1.013 0.69
138_L 163_M 1.011 0.69
139_D 142_V 1.011 0.69
33_R 36_N 1.006 0.69
46_V 87_I 1.003 0.68
110_P 183_A 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fxaA40.61681000.705Contact Map0.796
3etnA40.62311000.723Contact Map0.754
3fj1A40.93461000.735Contact Map0.567
3c3jA60.9191000.736Contact Map0.47
3euaA80.85981000.737Contact Map0.482
1moqA10.93461000.745Contact Map0.579
3hbaA20.93461000.746Contact Map0.61
2bplA30.94081000.746Contact Map0.588
3fkjA20.90031000.746Contact Map0.474
2pocA40.9191000.747Contact Map0.573
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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