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OPENSEQ.org
IAP - Alkaline phosphatase isozyme conversion protein
UniProt: P10423 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10488
Length: 345 (337)
Sequences: 485
Seq/Len: 1.44
IAP
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: IAP YFBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
115_M 172_T 2.654 1.00
62_R 66_Q 2.536 1.00
106_G 166_G 2.471 1.00
61_I 118_L 2.308 0.99
108_A 164_E 2.208 0.99
150_V 206_L 2.089 0.98
34_N 38_R 2.044 0.98
54_E 173_S 2.034 0.98
53_A 56_L 1.957 0.97
311_N 314_H 1.915 0.97
65_F 171_A 1.868 0.96
109_P 196_N 1.822 0.96
153_E 156_E 1.771 0.95
37_A 149_G 1.766 0.95
111_Q 166_G 1.764 0.94
104_H 169_F 1.743 0.94
148_L 171_A 1.709 0.93
110_Q 165_Y 1.706 0.93
64_Q 67_Q 1.672 0.92
58_A 98_S 1.662 0.92
116_A 171_A 1.661 0.92
117_H 262_D 1.589 0.89
204_D 263_A 1.582 0.89
287_D 291_Q 1.568 0.89
114_I 270_G 1.566 0.88
36_Q 60_Y 1.538 0.87
144_N 204_D 1.531 0.87
20_L 23_H 1.52 0.86
49_T 174_G 1.511 0.86
37_A 145_A 1.49 0.85
45_P 120_T 1.46 0.83
65_F 155_A 1.433 0.82
75_R 184_N 1.424 0.81
130_D 133_L 1.378 0.78
115_M 200_V 1.377 0.78
46_G 120_T 1.359 0.77
10_A 15_G 1.352 0.76
19_I 23_H 1.339 0.75
14_L 19_I 1.336 0.75
111_Q 168_R 1.335 0.75
17_C 25_S 1.322 0.74
14_L 18_F 1.322 0.74
186_L 269_A 1.321 0.74
72_S 120_T 1.304 0.72
151_M 171_A 1.3 0.72
10_A 14_L 1.296 0.72
168_R 185_L 1.293 0.71
103_A 168_R 1.283 0.71
107_K 164_E 1.276 0.70
40_I 57_S 1.269 0.69
103_A 166_G 1.267 0.69
11_A 19_I 1.258 0.68
43_F 139_Q 1.257 0.68
100_V 171_A 1.254 0.68
182_A 265_I 1.244 0.67
51_T 331_M 1.241 0.67
61_I 171_A 1.228 0.66
113_I 197_T 1.225 0.65
16_V 25_S 1.225 0.65
7_H 10_A 1.224 0.65
22_V 25_S 1.212 0.64
60_Y 69_G 1.21 0.64
174_G 177_E 1.209 0.64
312_H 317_K 1.208 0.64
144_N 147_G 1.205 0.64
9_T 14_L 1.203 0.63
19_I 26_S 1.198 0.63
33_A 320_P 1.196 0.63
49_T 177_E 1.194 0.62
150_V 203_L 1.189 0.62
30_G 63_Q 1.188 0.62
227_L 230_D 1.187 0.62
10_A 17_C 1.18 0.61
253_Y 280_N 1.179 0.61
35_T 63_Q 1.178 0.61
320_P 323_I 1.178 0.61
101_I 104_H 1.178 0.61
9_T 20_L 1.176 0.61
18_F 22_V 1.169 0.60
158_L 237_R 1.164 0.60
17_C 28_K 1.163 0.59
12_L 27_P 1.157 0.59
120_T 138_L 1.153 0.58
19_I 27_P 1.152 0.58
38_R 312_H 1.147 0.58
15_G 26_S 1.146 0.58
10_A 13_A 1.144 0.58
34_N 101_I 1.144 0.58
11_A 14_L 1.136 0.57
145_A 255_K 1.131 0.56
63_Q 197_T 1.127 0.56
116_A 152_L 1.126 0.56
19_I 25_S 1.125 0.56
151_M 169_F 1.121 0.55
9_T 19_I 1.12 0.55
45_P 72_S 1.118 0.55
110_Q 198_L 1.115 0.55
116_A 148_L 1.115 0.55
65_F 102_A 1.111 0.54
9_T 12_L 1.11 0.54
36_Q 152_L 1.106 0.54
16_V 24_A 1.103 0.53
64_Q 152_L 1.103 0.53
229_R 274_L 1.101 0.53
287_D 305_H 1.101 0.53
145_A 149_G 1.1 0.53
16_V 27_P 1.098 0.53
34_N 145_A 1.097 0.53
99_T 239_H 1.095 0.53
59_D 62_R 1.091 0.52
9_T 16_V 1.09 0.52
23_H 28_K 1.09 0.52
17_C 22_V 1.084 0.52
11_A 25_S 1.084 0.52
31_D 66_Q 1.079 0.51
8_R 11_A 1.078 0.51
261_N 296_P 1.077 0.51
205_N 323_I 1.075 0.51
58_A 77_F 1.073 0.50
44_F 173_S 1.072 0.50
17_C 26_S 1.072 0.50
145_A 171_A 1.07 0.50
102_A 155_A 1.064 0.49
23_H 26_S 1.064 0.49
11_A 28_K 1.064 0.49
10_A 18_F 1.061 0.49
33_A 331_M 1.057 0.49
288_G 314_H 1.043 0.47
328_R 332_R 1.041 0.47
16_V 23_H 1.04 0.47
62_R 74_I 1.04 0.47
12_L 16_V 1.039 0.47
11_A 26_S 1.039 0.47
147_G 178_G 1.036 0.47
8_R 17_C 1.035 0.46
19_I 24_A 1.035 0.46
107_K 158_L 1.035 0.46
168_R 199_L 1.032 0.46
83_Y 121_Y 1.03 0.46
37_A 40_I 1.029 0.46
55_M 59_D 1.028 0.46
145_A 338_V 1.028 0.46
34_N 317_K 1.028 0.46
183_E 186_L 1.028 0.46
172_T 182_A 1.025 0.45
11_A 18_F 1.024 0.45
263_A 274_L 1.024 0.45
8_R 12_L 1.023 0.45
15_G 24_A 1.023 0.45
143_D 305_H 1.023 0.45
315_I 320_P 1.021 0.45
340_E 343_K 1.019 0.45
205_N 263_A 1.019 0.45
11_A 20_L 1.018 0.45
13_A 19_I 1.016 0.45
158_L 163_T 1.014 0.44
12_L 17_C 1.013 0.44
187_K 192_T 1.013 0.44
41_A 312_H 1.012 0.44
246_N 273_V 1.012 0.44
116_A 151_M 1.011 0.44
60_Y 212_L 1.011 0.44
289_Y 304_W 1.01 0.44
173_S 215_N 1.009 0.44
35_T 66_Q 1.008 0.44
9_T 25_S 1.008 0.44
24_A 28_K 1.007 0.44
100_V 118_L 1.006 0.44
208_V 303_S 1.005 0.43
196_N 245_T 1.005 0.43
337_L 341_L 1.004 0.43
182_A 211_K 1.003 0.43
187_K 269_A 1.001 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ek8A10.76811000.522Contact Map0.709
3iibA10.81451000.535Contact Map0.617
3guxA20.85511000.557Contact Map0.564
2afwA20.84061000.559Contact Map0.602
3k9tA10.77681000.559Contact Map0.555
1tkjA10.78841000.56Contact Map0.62
4fuuA10.8291000.56Contact Map0.586
3tc8A20.85511000.562Contact Map0.609
4f9uA20.77971000.569Contact Map0.589
3pb6X10.83771000.57Contact Map0.6
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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