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YEHT - Transcriptional regulatory protein YehT
UniProt: P0AFT5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12006
Length: 239 (237)
Sequences: 3064
Seq/Len: 12.93

YEHT
Paralog alert: 0.61 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: YEHT YPDB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
191_C 223_V 3.89 1.00
14_R 32_E 3.635 1.00
3_K 28_E 3.191 1.00
183_E 190_R 3.181 1.00
92_E 107_R 2.916 1.00
18_R 32_E 2.889 1.00
33_C 42_A 2.88 1.00
7_V 39_G 2.743 1.00
8_D 57_M 2.485 1.00
61_S 64_E 2.471 1.00
14_R 34_S 2.458 1.00
67_G 89_K 2.275 1.00
50_V 115_L 2.194 1.00
5_L 33_C 2.185 1.00
79_F 95_A 2.17 1.00
139_C 165_V 2.067 1.00
66_V 79_F 2.055 1.00
35_N 38_E 1.982 1.00
6_I 18_R 1.964 1.00
18_R 22_Q 1.936 1.00
36_A 65_M 1.931 1.00
6_I 14_R 1.929 1.00
226_S 229_Y 1.907 1.00
80_L 103_I 1.855 1.00
144_R 204_E 1.82 1.00
189_L 233_L 1.814 1.00
230_L 234_K 1.812 1.00
156_V 163_V 1.797 1.00
183_E 196_L 1.79 1.00
78_V 111_T 1.764 1.00
8_D 14_R 1.742 1.00
36_A 60_I 1.719 1.00
164_Y 171_K 1.641 1.00
43_V 48_P 1.636 1.00
149_Q 152_D 1.628 1.00
16_N 20_F 1.624 1.00
192_H 195_Y 1.601 1.00
23_E 105_E 1.6 1.00
66_V 77_I 1.578 1.00
167_S 172_E 1.543 1.00
56_Q 83_F 1.514 1.00
94_H 114_R 1.507 1.00
192_H 224_P 1.505 1.00
214_E 222_T 1.497 1.00
97_D 107_R 1.493 1.00
10_E 13_A 1.477 1.00
31_G 42_A 1.463 1.00
197_V 215_L 1.453 1.00
4_V 27_I 1.45 1.00
42_A 46_L 1.443 1.00
78_V 115_L 1.423 1.00
51_L 75_P 1.419 1.00
155_F 223_V 1.411 1.00
34_S 38_E 1.393 0.99
155_F 195_Y 1.389 0.99
177_L 181_T 1.386 0.99
97_D 114_R 1.386 0.99
168_H 201_H 1.376 0.99
154_A 201_H 1.366 0.99
138_P 147_L 1.351 0.99
206_R 222_T 1.347 0.99
162_G 174_F 1.334 0.99
26_D 116_R 1.33 0.99
189_L 199_L 1.329 0.99
40_I 65_M 1.328 0.99
232_S 236_A 1.297 0.99
83_F 86_Y 1.287 0.99
63_L 66_V 1.285 0.99
5_L 48_P 1.282 0.99
195_Y 223_V 1.276 0.99
43_V 65_M 1.27 0.99
152_D 168_H 1.269 0.99
40_I 68_M 1.266 0.99
231_K 235_E 1.26 0.99
205_I 233_L 1.25 0.99
105_E 109_E 1.246 0.98
97_D 111_T 1.236 0.98
156_V 182_L 1.234 0.98
153_V 165_V 1.231 0.98
197_V 202_L 1.21 0.98
191_C 215_L 1.201 0.98
204_E 216_I 1.188 0.98
108_L 112_L 1.18 0.98
52_F 78_V 1.176 0.98
4_V 50_V 1.176 0.98
139_C 148_L 1.17 0.97
9_D 54_D 1.167 0.97
57_M 60_I 1.166 0.97
159_R 164_Y 1.153 0.97
31_G 48_P 1.153 0.97
60_I 68_M 1.149 0.97
189_L 229_Y 1.145 0.97
155_F 166_T 1.14 0.97
42_A 48_P 1.14 0.97
178_T 181_T 1.138 0.97
76_Y 115_L 1.137 0.97
195_Y 224_P 1.132 0.97
201_H 218_R 1.13 0.97
157_S 166_T 1.13 0.97
11_P 15_E 1.118 0.96
52_F 80_L 1.116 0.96
154_A 219_N 1.113 0.96
79_F 93_E 1.103 0.96
80_L 99_L 1.098 0.96
96_F 111_T 1.094 0.96
198_N 201_H 1.092 0.96
136_F 147_L 1.091 0.96
89_K 92_E 1.09 0.96
186_T 196_L 1.08 0.95
203_Q 218_R 1.08 0.95
158_S 193_R 1.079 0.95
64_E 67_G 1.078 0.95
20_F 105_E 1.071 0.95
66_V 93_E 1.071 0.95
99_L 108_L 1.07 0.95
16_N 19_V 1.069 0.95
9_D 101_K 1.063 0.95
92_E 110_K 1.057 0.95
63_L 93_E 1.054 0.95
158_S 161_S 1.053 0.95
232_S 235_E 1.052 0.95
216_I 222_T 1.05 0.94
152_D 169_E 1.047 0.94
155_F 221_L 1.045 0.94
103_I 108_L 1.041 0.94
163_V 177_L 1.035 0.94
144_R 206_R 1.028 0.94
53_L 66_V 1.019 0.93
109_E 113_A 1.011 0.93
56_Q 61_S 1.007 0.93
157_S 195_Y 1.005 0.93
39_G 65_M 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kgsA10.907999.90.574Contact Map0.693
3d6wA20.443599.90.58Contact Map0.843
3n0rA10.527299.80.596Contact Map0.594
4g4kA20.418499.80.612Contact Map0.819
4hyeA20.799299.80.616Contact Map0.797
4l4uA10.962399.80.617Contact Map0.675
1ny5A20.95499.80.618Contact Map0.688
2a9oA10.493799.80.626Contact Map0.761
3dzdA20.945699.80.626Contact Map0.734
1dz3A10.52399.80.628Contact Map0.592

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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