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OPENSEQ.org
PPIA - Peptidyl-prolyl cis-trans isomerase A
UniProt: P0AFL3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10757
Length: 190 (163)
Sequences: 4224
Seq/Len: 25.91
PPIA
Paralog alert: 0.66 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: PPIA PPIB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_R 160_D 3.212 1.00
41_E 154_K 3.179 1.00
110_G 156_M 3.095 1.00
131_V 163_S 3.005 1.00
66_N 185_S 3.003 1.00
34_T 39_N 2.933 1.00
68_T 81_G 2.258 1.00
107_N 113_A 2.251 1.00
40_I 159_A 2.249 1.00
43_E 151_K 2.113 1.00
51_V 98_K 2.094 1.00
54_Q 58_D 2.053 1.00
33_L 42_L 2.001 1.00
33_L 186_A 1.944 1.00
113_A 128_F 1.935 1.00
40_I 152_V 1.932 1.00
32_L 39_N 1.915 1.00
58_D 62_S 1.872 1.00
32_L 189_L 1.848 1.00
69_T 180_P 1.786 1.00
34_T 187_K 1.774 1.00
165_V 181_V 1.754 1.00
42_L 112_I 1.754 1.00
108_T 151_K 1.749 1.00
33_L 40_I 1.722 1.00
75_P 163_S 1.694 1.00
73_V 162_I 1.674 1.00
60_V 186_A 1.649 1.00
34_T 184_L 1.599 1.00
37_A 161_K 1.583 1.00
97_I 123_A 1.579 1.00
29_P 46_K 1.543 1.00
46_K 53_V 1.529 1.00
111_T 130_N 1.517 1.00
75_P 167_T 1.51 1.00
34_T 185_S 1.509 1.00
166_P 178_S 1.509 1.00
32_L 187_K 1.445 1.00
106_R 138_D 1.444 1.00
28_D 46_K 1.442 1.00
43_E 153_V 1.419 1.00
98_K 121_D 1.388 0.99
30_H 153_V 1.383 0.99
49_A 53_V 1.368 0.99
61_N 188_V 1.356 0.99
30_H 41_E 1.319 0.99
152_V 159_A 1.308 0.99
79_I 131_V 1.304 0.99
45_D 151_K 1.303 0.99
48_K 105_L 1.29 0.99
79_I 162_I 1.288 0.99
183_I 186_A 1.28 0.99
110_G 160_D 1.278 0.99
129_I 159_A 1.273 0.99
58_D 94_N 1.266 0.99
44_L 53_V 1.264 0.99
108_T 111_T 1.26 0.99
32_L 41_E 1.249 0.99
75_P 164_Q 1.248 0.99
36_S 184_L 1.245 0.98
111_T 151_K 1.243 0.98
74_I 78_M 1.236 0.98
62_S 94_N 1.208 0.98
68_T 83_G 1.195 0.98
162_I 181_V 1.185 0.98
107_N 138_D 1.166 0.97
48_K 104_G 1.156 0.97
166_P 175_N 1.149 0.97
156_M 159_A 1.148 0.97
57_V 61_N 1.141 0.97
152_V 156_M 1.139 0.97
160_D 163_S 1.115 0.96
76_G 132_A 1.11 0.96
43_E 46_K 1.082 0.96
51_V 54_Q 1.067 0.95
69_T 182_V 1.065 0.95
167_T 175_N 1.061 0.95
52_S 114_M 1.06 0.95
168_H 178_S 1.06 0.95
41_E 189_L 1.053 0.95
116_R 122_S 1.043 0.94
31_V 57_V 1.033 0.94
131_V 159_A 1.017 0.93
33_L 183_I 1.016 0.93
169_D 174_Q 1.011 0.93
58_D 61_N 1.004 0.93
99_N 123_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2k7nA10.85791000.19Contact Map0.628
2x7kA10.85791000.192Contact Map0.811
2fu0A10.82631000.2Contact Map0.862
1v9tA20.85791000.202Contact Map0.832
3s6mA10.84741000.208Contact Map0.824
1zkcA20.87371000.211Contact Map0.825
2ok3A10.81000.212Contact Map0.785
3bo7A40.83161000.213Contact Map0.821
1lopA10.83161000.214Contact Map0.844
2poeA10.87891000.222Contact Map0.786
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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