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PMBA - Protein PmbA
UniProt: P0AFK0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10741
Length: 450 (432)
Sequences: 2167
Seq/Len: 5.02
PMBA
Paralog alert: 0.96 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: PMBA TLDD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
371_L 406_V 4.34 1.00
320_K 325_T 4.014 1.00
368_G 399_N 3.808 1.00
283_Q 287_D 3.701 1.00
367_M 397_V 3.621 1.00
369_T 398_E 3.468 1.00
317_D 320_K 3.455 1.00
364_L 397_V 3.295 1.00
423_V 443_P 3.198 1.00
294_H 315_R 3.092 1.00
243_K 444_E 2.926 1.00
237_R 404_Y 2.923 1.00
423_V 441_L 2.842 1.00
279_S 282_K 2.828 1.00
398_E 404_Y 2.639 1.00
133_S 136_E 2.622 1.00
369_T 396_W 2.585 1.00
143_R 220_E 2.532 1.00
398_E 403_Q 2.526 1.00
359_S 362_Q 2.503 1.00
359_S 427_N 2.454 1.00
196_E 199_G 2.408 1.00
154_R 197_E 2.396 1.00
396_W 403_Q 2.376 1.00
225_D 228_R 2.359 1.00
139_E 143_R 2.33 1.00
155_I 195_A 2.287 1.00
396_W 404_Y 2.26 1.00
77_G 96_A 2.245 1.00
288_W 425_V 2.196 1.00
358_L 362_Q 2.195 1.00
42_K 169_V 2.181 1.00
283_Q 420_R 2.145 1.00
182_Y 305_P 2.072 1.00
428_D 439_S 2.055 1.00
363_M 439_S 2.052 1.00
288_W 321_D 2.034 1.00
397_V 403_Q 2.019 1.00
25_A 36_A 2.012 1.00
244_A 447_I 1.994 1.00
285_L 419_W 1.944 1.00
365_K 401_E 1.942 1.00
19_E 23_S 1.866 1.00
315_R 352_R 1.853 1.00
287_D 321_D 1.846 1.00
283_Q 323_I 1.819 1.00
91_R 94_Q 1.818 1.00
363_M 424_T 1.817 1.00
418_M 442_L 1.774 1.00
195_A 231_L 1.742 1.00
414_N 417_D 1.723 1.00
224_A 228_R 1.698 1.00
148_A 223_G 1.682 0.99
290_T 317_D 1.672 0.99
42_K 64_G 1.664 0.99
197_E 235_S 1.652 0.99
247_I 363_M 1.643 0.99
360_F 363_M 1.634 0.99
361_E 401_E 1.629 0.99
360_F 439_S 1.606 0.99
260_L 419_W 1.6 0.99
264_I 318_I 1.589 0.99
151_A 224_A 1.581 0.99
355_G 429_I 1.579 0.99
218_T 221_W 1.539 0.99
329_L 339_L 1.532 0.99
395_F 402_I 1.531 0.99
334_A 340_K 1.526 0.99
36_A 175_S 1.525 0.99
367_M 441_L 1.524 0.99
90_A 94_Q 1.512 0.99
147_A 223_G 1.492 0.98
387_D 414_N 1.484 0.98
321_D 325_T 1.484 0.98
139_E 142_A 1.482 0.98
304_T 313_T 1.457 0.98
147_A 224_A 1.453 0.98
247_I 367_M 1.452 0.98
142_A 146_Q 1.451 0.98
370_G 397_V 1.442 0.98
151_A 227_A 1.44 0.98
195_A 230_T 1.439 0.98
290_T 321_D 1.433 0.98
137_A 163_F 1.433 0.98
366_E 424_T 1.43 0.98
382_S 387_D 1.429 0.98
329_L 337_L 1.409 0.98
75_R 105_P 1.408 0.98
73_Q 105_P 1.397 0.97
296_H 313_T 1.376 0.97
292_E 315_R 1.375 0.97
317_D 321_D 1.374 0.97
70_V 96_A 1.361 0.97
329_L 333_S 1.356 0.97
20_E 86_P 1.351 0.97
382_S 385_T 1.346 0.96
315_R 354_A 1.345 0.96
289_L 425_V 1.344 0.96
171_V 179_L 1.339 0.96
136_E 139_E 1.335 0.96
37_E 69_T 1.325 0.96
311_V 341_S 1.31 0.96
316_R 344_H 1.309 0.96
314_E 340_K 1.308 0.96
94_Q 98_D 1.306 0.96
180_Q 306_F 1.304 0.96
372_V 439_S 1.303 0.96
204_D 226_C 1.293 0.95
155_I 231_L 1.288 0.95
421_N 443_P 1.279 0.95
425_V 440_V 1.277 0.95
304_T 349_H 1.275 0.95
292_E 354_A 1.273 0.95
316_R 326_Q 1.26 0.94
363_M 426_G 1.258 0.94
18_L 173_G 1.243 0.94
247_I 397_V 1.238 0.94
261_V 351_W 1.227 0.93
269_V 327_W 1.226 0.93
146_Q 150_Q 1.224 0.93
165_S 213_M 1.219 0.93
352_R 429_I 1.214 0.93
270_Y 337_L 1.213 0.93
50_T 55_V 1.212 0.93
360_F 364_L 1.208 0.93
286_P 425_V 1.207 0.93
24_T 90_A 1.205 0.92
85_S 88_A 1.198 0.92
48_V 55_V 1.198 0.92
272_K 277_L 1.195 0.92
66_L 81_S 1.192 0.92
206_A 225_D 1.189 0.92
372_V 397_V 1.188 0.92
417_D 420_R 1.185 0.92
226_C 230_T 1.182 0.92
361_E 365_K 1.18 0.91
195_A 227_A 1.172 0.91
83_D 88_A 1.171 0.91
50_T 142_A 1.17 0.91
25_A 32_K 1.169 0.91
275_F 416_K 1.169 0.91
279_S 416_K 1.168 0.91
366_E 441_L 1.167 0.91
371_L 409_I 1.162 0.91
266_G 329_L 1.159 0.90
169_V 183_C 1.157 0.90
358_L 424_T 1.155 0.90
127_F 167_Y 1.152 0.90
24_T 28_L 1.148 0.90
245_P 444_E 1.145 0.90
79_A 92_T 1.143 0.90
318_I 328_L 1.142 0.90
195_A 234_L 1.142 0.90
245_P 441_L 1.136 0.89
22_V 175_S 1.134 0.89
25_A 33_S 1.13 0.89
291_I 319_I 1.124 0.89
65_A 78_S 1.122 0.88
173_G 179_L 1.12 0.88
285_L 289_L 1.118 0.88
220_E 224_A 1.112 0.88
270_Y 329_L 1.111 0.88
20_E 23_S 1.108 0.88
202_E 407_S 1.108 0.88
247_I 441_L 1.107 0.88
376_L 380_G 1.104 0.87
155_I 227_A 1.101 0.87
317_D 325_T 1.1 0.87
257_F 353_I 1.099 0.87
316_R 342_T 1.096 0.87
326_Q 342_T 1.095 0.87
417_D 421_N 1.092 0.87
291_I 351_W 1.092 0.87
212_A 299_K 1.092 0.87
147_A 220_E 1.089 0.86
295_P 304_T 1.088 0.86
227_A 231_L 1.087 0.86
426_G 439_S 1.083 0.86
248_F 373_V 1.083 0.86
38_V 66_L 1.081 0.86
303_S 350_N 1.081 0.86
53_G 145_E 1.078 0.86
249_A 372_V 1.078 0.86
137_A 165_S 1.076 0.85
223_G 227_A 1.076 0.85
360_F 427_N 1.068 0.85
237_R 396_W 1.063 0.85
152_D 197_E 1.062 0.84
290_T 354_A 1.061 0.84
208_T 222_V 1.057 0.84
290_T 320_K 1.057 0.84
46_I 165_S 1.054 0.84
376_L 379_Q 1.053 0.84
244_A 406_V 1.051 0.84
148_A 226_C 1.048 0.83
362_Q 365_K 1.048 0.83
334_A 341_S 1.042 0.83
292_E 317_D 1.037 0.82
363_M 367_M 1.037 0.82
52_Y 157_N 1.036 0.82
245_P 443_P 1.034 0.82
72_H 97_L 1.033 0.82
24_T 27_E 1.032 0.82
174_N 178_M 1.03 0.82
21_A 89_I 1.021 0.81
367_M 370_G 1.02 0.81
266_G 337_L 1.017 0.81
259_H 381_V 1.017 0.81
247_I 360_F 1.016 0.81
258_G 262_G 1.015 0.81
422_I 440_V 1.012 0.80
253_A 440_V 1.011 0.80
364_L 367_M 1.011 0.80
148_A 193_V 1.01 0.80
421_N 444_E 1.008 0.80
388_Y 418_M 1.006 0.80
144_A 219_P 1.005 0.80
352_R 436_Q 1.004 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qtdA40.99111000.11Contact Map0.769
3tv9A10.98221000.128Contact Map0.757
1vpbA10.981000.143Contact Map0.674
1vl4A20.96891000.152Contact Map0.775
3arcO20.267.40.978Contact Map0.011
2vxaA120.11786.20.979Contact Map0.221
1q5nA10.20675.20.979Contact Map0.313
1s3cA10.27565.20.98Contact Map0.164
1jg8A40.21784.50.98Contact Map0.379
3e9kA10.23334.40.98Contact Map0.393
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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