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TRMJ - tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
UniProt: P0AE01 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13452
Length: 246 (240)
Sequences: 904
Seq/Len: 3.77
TRMJ
Paralog alert: 0.36 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: LAST TRMJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
65_T 68_E 4.32 1.00
26_K 55_D 3.649 1.00
67_D 127_K 3.526 1.00
32_N 61_H 3.19 1.00
73_C 110_A 3.022 1.00
20_S 49_L 3.002 1.00
132_V 152_I 2.86 1.00
9_L 145_L 2.829 1.00
11_E 37_N 2.612 1.00
34_W 63_V 2.568 1.00
94_R 158_M 2.564 1.00
11_E 115_R 2.507 1.00
66_L 112_V 2.426 1.00
64_D 68_E 2.337 1.00
78_G 128_C 2.309 1.00
46_A 57_I 2.291 1.00
7_I 153_A 2.272 1.00
115_R 124_E 2.247 1.00
78_G 125_L 2.242 1.00
47_I 58_G 2.233 1.00
189_H 230_R 2.212 1.00
145_L 149_V 2.206 1.00
37_N 64_D 2.088 1.00
6_R 34_W 2.072 1.00
113_F 149_V 2.034 1.00
8_V 110_A 2.013 1.00
184_E 213_R 1.964 1.00
7_I 25_M 1.897 1.00
34_W 61_H 1.824 0.99
111_L 152_I 1.811 0.99
76_V 112_V 1.767 0.99
186_F 216_F 1.762 0.99
24_A 150_Q 1.756 0.99
25_M 30_L 1.657 0.99
121_T 124_E 1.652 0.99
77_V 96_C 1.651 0.99
182_D 223_S 1.613 0.98
70_L 76_V 1.59 0.98
9_L 149_V 1.575 0.98
193_T 237_E 1.55 0.98
66_L 70_L 1.523 0.98
194_L 232_I 1.521 0.98
113_F 145_L 1.514 0.97
32_N 108_P 1.513 0.97
182_D 185_R 1.502 0.97
94_R 155_E 1.435 0.96
115_R 121_T 1.418 0.96
81_A 141_S 1.393 0.95
185_R 230_R 1.385 0.95
49_L 147_M 1.37 0.95
10_V 120_L 1.37 0.95
37_N 65_T 1.35 0.94
76_V 180_V 1.346 0.94
28_M 150_Q 1.315 0.93
179_L 182_D 1.311 0.93
178_P 226_L 1.311 0.93
112_V 128_C 1.308 0.93
6_R 32_N 1.303 0.93
192_Q 237_E 1.295 0.92
36_V 69_A 1.279 0.92
80_S 131_H 1.276 0.92
226_L 230_R 1.264 0.91
197_T 235_S 1.259 0.91
75_L 130_Y 1.25 0.90
81_A 84_R 1.242 0.90
72_G 108_P 1.218 0.89
197_T 236_I 1.204 0.88
35_L 38_P 1.191 0.87
187_Y 217_T 1.189 0.87
72_G 181_D 1.188 0.87
6_R 63_V 1.184 0.87
16_G 49_L 1.174 0.86
193_T 236_I 1.174 0.86
57_I 60_A 1.171 0.86
16_G 45_Q 1.167 0.86
186_F 190_L 1.141 0.84
21_V 223_S 1.14 0.84
26_K 53_A 1.127 0.83
34_W 72_G 1.12 0.83
196_A 237_E 1.12 0.83
18_M 21_V 1.12 0.83
74_S 107_T 1.115 0.82
157_R 161_L 1.114 0.82
10_V 115_R 1.097 0.81
7_I 111_L 1.094 0.80
30_L 153_A 1.092 0.80
215_L 229_L 1.08 0.79
81_A 122_N 1.08 0.79
22_A 122_N 1.074 0.79
12_T 35_L 1.071 0.78
99_K 130_Y 1.068 0.78
193_T 233_L 1.068 0.78
70_L 73_C 1.062 0.78
129_H 183_L 1.058 0.77
118_V 121_T 1.057 0.77
186_F 229_L 1.054 0.77
136_A 140_Y 1.05 0.77
22_A 46_A 1.025 0.74
94_R 159_A 1.023 0.74
8_V 73_C 1.013 0.73
2_L 101_V 1.011 0.73
47_I 54_S 1.008 0.72
40_V 43_D 1.002 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3onpA10.99191000.304Contact Map0.776
3ilkA20.97561000.311Contact Map0.796
3ic6A10.76831000.517Contact Map0.743
3ktyA30.65451000.557Contact Map0.761
3dcmX10.64631000.607Contact Map0.611
1zjrA10.75611000.634Contact Map0.536
1v2xA10.69921000.637Contact Map0.602
1x7oA20.63011000.649Contact Map0.586
3l8uA20.65851000.656Contact Map0.589
3n4jA10.61791000.658Contact Map0.671
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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