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YGFZ - tRNA-modifying protein YgfZ
UniProt: P0ADE8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12685
Length: 326 (310)
Sequences: 3565
Seq/Len: 11.50
YGFZ
Paralog alert: 0.62 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: GCST YGFZ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_Q 127_A 4.123 1.00
19_L 128_A 3.683 1.00
252_A 289_Q 3.475 1.00
264_D 275_R 3.465 1.00
210_I 238_A 3.249 1.00
265_L 294_V 3.188 1.00
31_T 81_G 2.999 1.00
251_L 292_V 2.88 1.00
262_G 278_T 2.627 1.00
116_V 170_A 2.567 1.00
18_P 124_Q 2.548 1.00
203_A 261_A 2.513 1.00
237_R 241_R 2.473 1.00
20_T 184_N 2.466 1.00
36_D 39_K 2.35 1.00
305_I 314_T 2.348 1.00
306_F 315_L 2.216 1.00
305_I 316_H 2.151 1.00
42_Q 48_D 2.131 1.00
33_T 81_G 2.129 1.00
30_A 95_L 2.122 1.00
44_Q 98_L 2.11 1.00
38_E 82_F 2.109 1.00
307_R 312_A 2.101 1.00
266_E 312_A 2.068 1.00
254_S 316_H 1.992 1.00
54_E 77_R 1.983 1.00
57_H 74_R 1.977 1.00
116_V 167_E 1.969 1.00
97_E 101_Y 1.962 1.00
252_A 316_H 1.944 1.00
232_Q 236_A 1.935 1.00
171_N 175_D 1.867 1.00
31_T 110_A 1.808 1.00
36_D 106_K 1.792 1.00
251_L 294_V 1.77 1.00
249_W 296_M 1.77 1.00
21_L 118_L 1.759 1.00
169_T 172_M 1.755 1.00
166_D 169_T 1.752 1.00
279_V 292_V 1.752 1.00
33_T 110_A 1.729 1.00
97_E 230_T 1.728 1.00
174_T 183_L 1.724 1.00
35_A 106_K 1.713 1.00
228_C 232_Q 1.708 1.00
128_A 181_A 1.708 1.00
49_V 75_L 1.707 1.00
165_T 173_L 1.701 1.00
46_T 63_C 1.684 1.00
296_M 306_F 1.683 1.00
233_E 236_A 1.676 1.00
61_A 69_M 1.641 1.00
218_A 221_G 1.615 1.00
33_T 108_T 1.612 1.00
92_E 96_T 1.6 1.00
265_L 308_V 1.574 1.00
93_P 207_G 1.564 1.00
32_I 84_W 1.555 1.00
61_A 221_G 1.542 1.00
209_F 295_V 1.534 1.00
61_A 216_L 1.527 1.00
212_Q 224_F 1.509 1.00
120_V 129_L 1.479 1.00
84_W 98_L 1.473 1.00
228_C 233_E 1.468 1.00
274_R 297_N 1.463 1.00
176_K 179_G 1.455 1.00
38_E 50_S 1.447 1.00
31_T 112_D 1.438 1.00
44_Q 101_Y 1.4 0.99
206_S 209_F 1.395 0.99
37_S 82_F 1.391 0.99
18_P 182_E 1.382 0.99
135_E 138_S 1.372 0.99
307_R 314_T 1.366 0.99
32_I 98_L 1.354 0.99
53_A 56_Q 1.337 0.99
32_I 37_S 1.334 0.99
30_A 86_E 1.321 0.99
233_E 237_R 1.316 0.99
145_K 148_A 1.311 0.99
147_G 176_K 1.308 0.99
266_E 275_R 1.307 0.99
266_E 307_R 1.3 0.99
21_L 178_R 1.299 0.99
95_L 99_K 1.299 0.99
40_Y 107_V 1.289 0.99
19_L 181_A 1.282 0.99
96_T 100_K 1.27 0.99
42_Q 50_S 1.27 0.99
251_L 315_L 1.264 0.99
45_V 60_A 1.252 0.99
293_Q 320_L 1.25 0.99
172_M 176_K 1.244 0.98
45_V 75_L 1.241 0.98
276_T 300_M 1.234 0.98
214_T 295_V 1.229 0.98
38_E 77_R 1.228 0.98
212_Q 235_V 1.227 0.98
95_L 109_I 1.222 0.98
301_E 304_S 1.212 0.98
77_R 82_F 1.212 0.98
15_A 20_T 1.201 0.98
146_E 149_T 1.194 0.98
75_L 84_W 1.192 0.98
213_A 246_R 1.189 0.98
210_I 213_A 1.185 0.98
194_I 281_A 1.184 0.98
239_K 242_G 1.175 0.98
227_G 232_Q 1.173 0.98
32_I 40_Y 1.172 0.98
234_M 238_A 1.172 0.98
284_K 288_G 1.172 0.98
18_P 180_E 1.166 0.97
276_T 306_F 1.162 0.97
69_M 205_N 1.158 0.97
126_R 159_E 1.156 0.97
102_A 109_I 1.136 0.97
21_L 174_T 1.133 0.97
300_M 304_S 1.13 0.97
127_A 130_A 1.124 0.97
193_N 281_A 1.116 0.96
43_G 230_T 1.11 0.96
36_D 103_V 1.1 0.96
194_I 283_V 1.095 0.96
28_A 91_R 1.093 0.96
48_D 51_Q 1.091 0.96
78_D 81_G 1.081 0.95
24_L 119_G 1.081 0.95
70_W 93_P 1.08 0.95
224_F 236_A 1.08 0.95
273_W 312_A 1.076 0.95
91_R 111_P 1.071 0.95
14_S 18_P 1.07 0.95
251_L 308_V 1.057 0.95
270_G 274_R 1.057 0.95
236_A 240_F 1.053 0.95
304_S 317_I 1.052 0.95
165_T 170_A 1.052 0.95
31_T 83_A 1.049 0.94
75_L 82_F 1.047 0.94
47_A 223_S 1.042 0.94
238_A 244_N 1.041 0.94
43_G 105_S 1.041 0.94
199_P 205_N 1.041 0.94
62_H 98_L 1.041 0.94
13_A 17_L 1.04 0.94
251_L 306_F 1.039 0.94
266_E 273_W 1.038 0.94
151_L 161_F 1.029 0.94
224_F 232_Q 1.026 0.94
21_L 120_V 1.02 0.93
185_N 188_Q 1.016 0.93
296_M 317_I 1.016 0.93
99_K 102_A 1.011 0.93
54_E 79_G 1.01 0.93
254_S 305_I 1.008 0.93
191_A 283_V 1.004 0.93
253_G 315_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vlyA111000.052Contact Map0.669
3ttgA10.98161000.119Contact Map0.689
3girA10.97551000.121Contact Map0.747
2gagA10.97551000.126Contact Map0.778
1yx2A20.97241000.126Contact Map0.868
1wosA10.97241000.132Contact Map0.834
1vloA10.97851000.137Contact Map0.782
1v5vA20.97551000.137Contact Map0.852
1pj5A10.96631000.138Contact Map0.825
1wsrA20.97551000.149Contact Map0.806
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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