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OPENSEQ.org
FTSI - Peptidoglycan synthase FtsI
UniProt: P0AD68 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10341
Length: 588 (544)
Sequences: 3584
Seq/Len: 6.59
FTSI
Paralog alert: 0.81 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: FTSI PBP2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
262_A 553_I 3.655 1.00
492_A 521_A 3.572 1.00
493_I 515_T 3.568 1.00
472_E 490_R 3.223 1.00
268_N 523_Q 3.193 1.00
319_Q 463_I 3.138 1.00
244_V 262_A 2.929 1.00
266_D 525_R 2.884 1.00
41_R 44_W 2.843 1.00
271_E 448_K 2.695 1.00
212_D 216_R 2.68 1.00
77_R 271_E 2.652 1.00
343_D 360_S 2.622 1.00
258_E 534_D 2.613 1.00
327_S 370_A 2.592 1.00
355_V 364_V 2.586 1.00
271_E 445_S 2.569 1.00
368_A 416_S 2.541 1.00
324_R 327_S 2.533 1.00
331_T 360_S 2.517 1.00
264_L 528_L 2.499 1.00
196_F 232_L 2.461 1.00
355_V 363_G 2.45 1.00
196_F 392_G 2.447 1.00
350_L 354_G 2.402 1.00
328_V 349_E 2.384 1.00
516_A 529_V 2.333 1.00
319_Q 460_P 2.306 1.00
75_T 231_N 2.283 1.00
245_Y 276_A 2.282 1.00
144_N 147_M 2.253 1.00
468_V 518_V 2.243 1.00
432_Y 471_M 2.212 1.00
91_I 143_V 2.211 1.00
351_T 354_G 2.211 1.00
390_N 396_E 2.197 1.00
461_E 465_R 2.163 1.00
69_T 204_P 2.163 1.00
265_V 429_A 2.136 1.00
111_K 121_L 2.132 1.00
266_D 271_E 2.123 1.00
267_V 527_A 2.122 1.00
264_L 526_F 2.116 1.00
526_F 557_V 2.105 1.00
247_E 552_A 2.085 1.00
347_Y 360_S 2.076 1.00
335_R 340_E 2.068 1.00
378_D 382_R 2.066 1.00
197_D 201_T 2.061 1.00
353_T 473_S 2.053 1.00
320_R 379_T 2.053 1.00
432_Y 516_A 2.044 1.00
490_R 522_S 2.028 1.00
331_T 343_D 2.014 1.00
73_M 231_N 2.007 1.00
500_K 533_N 2.007 1.00
172_G 282_N 1.965 1.00
460_P 463_I 1.948 1.00
243_L 247_E 1.932 1.00
75_T 233_A 1.922 1.00
430_R 441_Y 1.911 1.00
472_E 521_A 1.906 1.00
530_V 550_F 1.904 1.00
434_T 441_Y 1.899 1.00
183_N 189_I 1.888 1.00
389_T 396_E 1.879 1.00
322_V 375_A 1.871 1.00
438_Y 468_V 1.869 1.00
244_V 553_I 1.863 1.00
315_M 383_F 1.862 1.00
192_V 234_L 1.839 1.00
457_R 461_E 1.829 1.00
268_N 525_R 1.822 1.00
320_R 375_A 1.819 1.00
436_G 492_A 1.808 1.00
178_L 236_I 1.807 1.00
265_V 272_V 1.796 1.00
517_G 554_M 1.791 1.00
80_R 239_R 1.783 1.00
433_A 527_A 1.777 1.00
472_E 476_L 1.774 1.00
392_G 445_S 1.771 1.00
357_Q 473_S 1.766 1.00
526_F 561_M 1.762 1.00
354_G 358_K 1.755 1.00
311_P 435_I 1.738 1.00
517_G 550_F 1.738 1.00
243_L 556_G 1.734 1.00
265_V 433_A 1.734 1.00
265_V 444_L 1.733 1.00
43_A 47_V 1.716 1.00
77_R 237_D 1.712 1.00
366_K 370_A 1.699 1.00
40_G 44_W 1.682 1.00
249_N 278_S 1.681 1.00
314_V 364_V 1.672 1.00
429_A 529_V 1.671 1.00
309_V 380_Y 1.661 1.00
500_K 534_D 1.651 1.00
244_V 274_A 1.645 1.00
242_A 246_R 1.645 1.00
315_M 463_I 1.634 1.00
77_R 273_L 1.61 1.00
49_S 52_M 1.608 1.00
312_M 431_V 1.607 1.00
352_L 363_G 1.594 1.00
316_T 379_T 1.59 1.00
519_A 558_L 1.584 1.00
171_S 238_E 1.577 1.00
263_V 429_A 1.569 0.99
465_R 468_V 1.563 0.99
419_Y 499_K 1.562 0.99
542_G 548_P 1.56 0.99
343_D 347_Y 1.545 0.99
205_G 226_S 1.545 0.99
520_P 524_P 1.544 0.99
266_D 269_T 1.541 0.99
323_V 352_L 1.54 0.99
176_A 280_S 1.536 0.99
354_G 357_Q 1.534 0.99
273_L 526_F 1.53 0.99
357_Q 478_G 1.528 0.99
143_V 147_M 1.527 0.99
550_F 554_M 1.527 0.99
335_R 338_G 1.524 0.99
386_G 399_G 1.517 0.99
175_T 245_Y 1.512 0.99
350_L 358_K 1.511 0.99
330_N 349_E 1.51 0.99
252_V 260_G 1.498 0.99
295_R 301_D 1.487 0.99
551_G 555_G 1.475 0.99
81_P 84_V 1.463 0.99
320_R 371_M 1.462 0.99
385_L 431_V 1.456 0.99
233_A 448_K 1.455 0.99
261_S 298_T 1.424 0.99
52_M 56_E 1.424 0.99
429_A 527_A 1.4 0.99
41_R 45_L 1.398 0.99
250_N 254_F 1.398 0.99
317_A 367_L 1.395 0.99
328_V 351_T 1.392 0.98
381_S 387_K 1.389 0.98
192_V 232_L 1.382 0.98
375_A 378_D 1.377 0.98
440_I 457_R 1.372 0.98
481_G 495_T 1.372 0.98
353_T 469_H 1.368 0.98
248_L 260_G 1.367 0.98
78_S 237_D 1.363 0.98
240_L 273_L 1.359 0.98
235_S 271_E 1.356 0.98
83_A 170_P 1.353 0.98
493_I 547_A 1.347 0.98
100_D 108_D 1.339 0.98
120_P 123_Q 1.337 0.98
175_T 236_I 1.331 0.98
235_S 445_S 1.329 0.98
61_S 210_R 1.329 0.98
311_P 471_M 1.317 0.98
90_A 164_E 1.314 0.98
203_Q 227_Q 1.312 0.98
240_L 264_L 1.311 0.98
121_L 125_S 1.311 0.98
94_D 135_R 1.305 0.97
552_A 555_G 1.305 0.97
486_I 551_G 1.3 0.97
475_A 493_I 1.292 0.97
315_M 467_V 1.286 0.97
532_I 549_V 1.285 0.97
91_I 151_I 1.281 0.97
267_V 433_A 1.276 0.97
73_M 84_V 1.273 0.97
519_A 554_M 1.272 0.97
514_Y 531_V 1.271 0.97
244_V 260_G 1.268 0.97
240_L 557_V 1.259 0.97
140_A 147_M 1.255 0.97
199_W 230_H 1.255 0.97
408_S 411_E 1.25 0.96
272_V 391_L 1.244 0.96
91_I 159_I 1.237 0.96
112_A 115_N 1.234 0.96
484_A 547_A 1.233 0.96
350_L 360_S 1.225 0.96
108_D 112_A 1.218 0.96
245_Y 280_S 1.218 0.96
356_L 470_M 1.216 0.96
383_F 459_F 1.215 0.96
323_V 327_S 1.209 0.95
493_I 517_G 1.209 0.95
192_V 446_I 1.208 0.95
438_Y 464_V 1.204 0.95
314_V 352_L 1.198 0.95
365_S 417_F 1.196 0.95
36_A 40_G 1.192 0.95
543_G 547_A 1.189 0.95
264_L 557_V 1.184 0.95
250_N 552_A 1.169 0.94
332_I 366_K 1.168 0.94
374_S 378_D 1.161 0.94
44_W 49_S 1.16 0.94
90_A 138_Y 1.159 0.94
474_V 481_G 1.158 0.94
347_Y 358_K 1.152 0.94
192_V 196_F 1.144 0.93
73_M 81_P 1.144 0.93
93_A 159_I 1.143 0.93
463_I 466_T 1.142 0.93
414_T 420_G 1.138 0.93
438_Y 465_R 1.138 0.93
249_N 253_A 1.138 0.93
545_V 548_P 1.138 0.93
481_G 484_A 1.133 0.93
438_Y 461_E 1.133 0.93
244_V 247_E 1.132 0.93
176_A 281_Y 1.132 0.93
275_M 298_T 1.13 0.93
252_V 278_S 1.13 0.93
372_P 375_A 1.128 0.93
436_G 518_V 1.128 0.93
304_E 512_I 1.126 0.93
260_G 532_I 1.126 0.93
356_L 471_M 1.124 0.93
173_E 245_Y 1.118 0.92
69_T 205_G 1.118 0.92
423_V 428_L 1.114 0.92
262_A 530_V 1.114 0.92
43_A 48_I 1.111 0.92
232_L 447_T 1.109 0.92
202_G 205_G 1.102 0.92
322_V 371_M 1.101 0.92
495_T 517_G 1.1 0.92
149_D 153_K 1.096 0.91
372_P 412_R 1.095 0.91
385_L 423_V 1.09 0.91
397_R 424_T 1.088 0.91
391_L 446_I 1.088 0.91
265_V 430_R 1.087 0.91
247_E 553_I 1.082 0.91
532_I 545_V 1.073 0.90
75_T 81_P 1.07 0.90
248_L 276_A 1.066 0.90
386_G 427_Q 1.065 0.90
492_A 518_V 1.059 0.89
249_N 257_A 1.055 0.89
243_L 246_R 1.055 0.89
196_F 447_T 1.052 0.89
542_G 547_A 1.049 0.89
428_L 514_Y 1.046 0.89
80_R 238_E 1.045 0.89
233_A 449_V 1.043 0.88
239_R 560_T 1.042 0.88
205_G 229_A 1.037 0.88
312_M 385_L 1.035 0.88
110_W 125_S 1.033 0.88
519_A 526_F 1.033 0.88
353_T 470_M 1.032 0.88
476_L 485_A 1.03 0.88
542_G 545_V 1.03 0.88
334_Y 365_S 1.027 0.87
267_V 526_F 1.025 0.87
459_F 464_V 1.022 0.87
462_S 466_T 1.022 0.87
377_V 381_S 1.014 0.86
522_S 566_D 1.012 0.86
240_L 274_A 1.011 0.86
380_Y 401_Y 1.008 0.86
148_A 161_L 1.004 0.86
436_G 527_A 1.003 0.86
94_D 97_E 1 0.85
417_F 499_K 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3equA20.9151000.217Contact Map0.798
3pbtA10.90311000.25Contact Map0.769
3ue3A10.89461000.252Contact Map0.747
2wadA30.91161000.273Contact Map0.743
1qmeA10.91671000.288Contact Map0.724
3vskA20.8691000.304Contact Map0.733
1vqqA20.92861000.322Contact Map0.732
4jbfA20.76871000.338Contact Map0.759
4mnrA10.71261000.394Contact Map0.753
3un7A20.72281000.443Contact Map0.695
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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