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OPENSEQ.org

FOLB - Dihydroneopterin aldolase
UniProt: P0AC16 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11673
Length: 122 (117)
Sequences: 1411
Seq/Len: 12.06

FOLB
Paralog alert: 0.20 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FOLB FOLX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_S 55_D 3.961 1.00
22_Q 70_A 2.855 1.00
44_S 49_D 2.839 1.00
97_S 107_N 2.668 1.00
10_S 27_K 2.381 1.00
32_I 60_V 2.295 1.00
5_F 109_G 2.282 1.00
95_K 111_I 2.229 1.00
93_R 113_E 2.189 1.00
33_E 93_R 2.135 1.00
8_Q 31_D 2.102 1.00
59_T 86_R 2.072 1.00
91_W 113_E 2.04 1.00
22_Q 68_R 1.976 1.00
34_M 56_I 1.9 1.00
8_Q 106_A 1.885 1.00
83_L 89_S 1.861 1.00
35_A 91_W 1.789 1.00
77_E 81_E 1.708 1.00
69_F 78_E 1.624 1.00
17_V 47_V 1.572 1.00
74_R 78_E 1.549 1.00
32_I 94_I 1.54 1.00
59_T 82_L 1.501 1.00
62_S 66_G 1.497 1.00
11_V 57_A 1.493 1.00
40_K 49_D 1.492 1.00
12_I 27_K 1.435 1.00
80_A 92_V 1.376 0.99
64_V 75_V 1.359 0.99
14_T 25_E 1.358 0.99
20_W 24_I 1.341 0.99
63_H 82_L 1.34 0.99
36_W 51_L 1.329 0.99
93_R 111_I 1.301 0.99
20_W 23_T 1.285 0.99
46_D 49_D 1.285 0.99
15_I 28_L 1.248 0.99
69_F 74_R 1.231 0.98
52_S 58_E 1.226 0.98
31_D 97_S 1.221 0.98
7_E 106_A 1.216 0.98
7_E 95_K 1.212 0.98
80_A 112_I 1.209 0.98
69_F 75_V 1.197 0.98
2_D 114_R 1.195 0.98
84_L 116_N 1.192 0.98
27_K 100_G 1.172 0.98
34_M 89_S 1.168 0.97
95_K 109_G 1.162 0.97
42_A 77_E 1.155 0.97
56_I 83_L 1.14 0.97
3_I 33_E 1.133 0.97
3_I 111_I 1.126 0.97
12_I 25_E 1.093 0.96
58_E 62_S 1.076 0.95
7_E 107_N 1.07 0.95
84_L 92_V 1.066 0.95
77_E 112_I 1.056 0.95
51_L 89_S 1.055 0.95
61_V 65_E 1.032 0.94
76_A 112_I 1.023 0.93
42_A 74_R 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o90A111000.07Contact Map0.743
1sqlA1611000.098Contact Map0.932
3r2eA10.97541000.111Contact Map0.715
1dhnA10.9591000.114Contact Map0.71
3o1kA40.9591000.116Contact Map0.92
4aeyA10.95081000.124Contact Map0.499
1z9wA111000.126Contact Map0.592
1b9lA80.95081000.128Contact Map0.766
3v9oA10.99181000.131Contact Map0.605
1nbuA50.95081000.132Contact Map0.863

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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