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OPENSEQ.org
HFLC - Modulator of FtsH protease HflC
UniProt: P0ABC3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10435
Length: 334 (279)
Sequences: 1576
Seq/Len: 5.65
HFLC
Paralog alert: 0.58 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: HFLC QMCA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_R 60_E 6.898 1.00
37_V 40_D 4.587 1.00
278_E 281_K 4.529 1.00
252_T 256_E 3.536 1.00
99_D 102_R 3.485 1.00
274_E 278_E 3.179 1.00
281_K 285_D 3.091 1.00
245_E 248_K 2.989 1.00
39_R 60_E 2.917 1.00
23_V 29_G 2.716 1.00
266_R 270_I 2.594 1.00
285_D 289_K 2.233 1.00
96_R 204_E 2.186 1.00
263_E 267_Q 2.155 1.00
20_V 54_F 2.077 1.00
305_N 308_S 1.995 1.00
217_T 221_E 1.945 1.00
131_I 139_I 1.855 1.00
232_E 236_R 1.812 1.00
230_E 233_A 1.8 1.00
265_E 269_R 1.798 1.00
93_I 123_F 1.796 1.00
261_L 265_E 1.783 1.00
298_R 301_R 1.767 1.00
267_Q 270_I 1.695 1.00
254_D 261_L 1.656 1.00
237_R 241_Q 1.607 0.99
146_R 150_E 1.601 0.99
268_G 272_R 1.592 0.99
15_V 58_F 1.578 0.99
28_R 100_F 1.574 0.99
29_G 62_V 1.521 0.99
301_R 304_E 1.511 0.99
22_V 52_L 1.506 0.99
28_R 67_A 1.505 0.99
149_L 153_D 1.501 0.99
98_S 204_E 1.49 0.99
128_R 132_G 1.482 0.99
246_A 250_R 1.479 0.99
38_L 60_E 1.479 0.99
89_V 131_I 1.477 0.99
133_R 150_E 1.466 0.99
125_D 129_S 1.458 0.99
37_V 101_S 1.436 0.98
247_E 250_R 1.436 0.98
239_R 243_Q 1.426 0.98
228_R 232_E 1.402 0.98
270_I 274_E 1.399 0.98
24_K 27_E 1.398 0.98
250_R 254_D 1.396 0.98
233_A 237_R 1.396 0.98
56_I 60_E 1.391 0.98
82_K 135_D 1.386 0.98
272_R 276_D 1.386 0.98
270_I 313_V 1.355 0.97
262_A 271_M 1.345 0.97
287_F 290_D 1.333 0.97
221_E 225_N 1.331 0.97
73_D 90_D 1.319 0.97
132_G 216_P 1.317 0.97
303_Y 306_S 1.313 0.97
225_N 228_R 1.305 0.97
130_E 150_E 1.304 0.96
252_T 255_Y 1.303 0.96
115_A 118_L 1.272 0.96
271_M 274_E 1.262 0.96
278_E 282_L 1.262 0.96
33_R 38_L 1.253 0.95
31_T 62_V 1.22 0.94
267_Q 271_M 1.22 0.94
257_V 261_L 1.204 0.94
81_T 131_I 1.195 0.94
254_D 258_T 1.194 0.93
7_A 13_L 1.171 0.93
15_V 19_S 1.166 0.92
65_L 104_Y 1.165 0.92
32_L 105_L 1.162 0.92
148_T 209_R 1.149 0.92
122_K 155_L 1.146 0.92
243_Q 247_E 1.145 0.91
18_M 21_F 1.134 0.91
91_S 127_L 1.125 0.91
227_M 230_E 1.125 0.91
321_D 324_R 1.124 0.90
19_S 54_F 1.123 0.90
135_D 138_D 1.122 0.90
271_M 275_G 1.12 0.90
21_F 53_H 1.117 0.90
269_R 313_V 1.112 0.90
21_F 55_K 1.112 0.90
240_S 249_L 1.111 0.90
29_G 64_M 1.108 0.90
130_E 133_R 1.106 0.90
119_L 123_F 1.105 0.89
251_A 255_Y 1.097 0.89
102_R 106_A 1.097 0.89
276_D 287_F 1.079 0.88
81_T 213_I 1.073 0.88
214_N 220_S 1.066 0.87
69_I 206_V 1.061 0.87
255_Y 259_R 1.061 0.87
12_V 16_L 1.053 0.86
34_F 38_L 1.053 0.86
30_I 104_Y 1.048 0.86
119_L 203_I 1.045 0.86
119_L 198_M 1.044 0.86
138_D 142_D 1.043 0.85
153_D 157_S 1.042 0.85
236_R 243_Q 1.032 0.85
215_L 219_V 1.028 0.84
87_L 136_V 1.025 0.84
123_F 155_L 1.023 0.84
15_V 18_M 1.022 0.84
98_S 199_A 1.013 0.83
90_D 211_K 1.012 0.83
264_A 269_R 1.006 0.83
241_Q 245_E 1.003 0.82
277_A 286_A 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bk6A30.56291000.651Contact Map0.688
4fvgA10.398299.90.718Contact Map0.658
1winA10.416299.90.722Contact Map0.476
2rpbA10.338399.80.769Contact Map0.459
2zuoA130.859368.20.955Contact Map0.589
2dm9A20.3144340.963Contact Map0.871
3v6iB20.290413.50.97Contact Map0.558
2kk7A10.155712.50.97Contact Map0.489
3v6iA20.335312.20.97Contact Map0.528
1w7dA10.16778.20.973Contact Map0.444
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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