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OPENSEQ.org
ATPA - ATP synthase subunit alpha
UniProt: P0ABB0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10098
Length: 513 (501)
Sequences: 3832
Seq/Len: 7.65
ATPA
Paralog alert: 0.61 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: ATPA ATPB FLII
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_N 113_A 7.747 1.00
41_I 73_A 4.086 1.00
356_E 369_N 3.79 1.00
161_R 255_D 3.75 1.00
196_V 242_G 3.676 1.00
53_I 73_A 3.112 1.00
443_Q 476_D 3.051 1.00
47_C 63_A 2.985 1.00
152_A 368_V 2.885 1.00
458_D 508_K 2.717 1.00
106_R 116_D 2.687 1.00
246_G 324_L 2.667 1.00
194_I 246_G 2.511 1.00
210_R 213_E 2.499 1.00
494_D 497_E 2.43 1.00
61_A 73_A 2.404 1.00
393_I 427_V 2.375 1.00
146_V 191_I 2.263 1.00
243_C 328_P 2.197 1.00
264_S 268_V 2.194 1.00
101_R 254_E 2.192 1.00
151_K 468_E 2.188 1.00
31_I 82_L 2.16 1.00
222_I 245_M 2.156 1.00
177_A 435_Q 2.125 1.00
463_K 466_S 2.085 1.00
159_I 327_L 2.078 1.00
442_A 487_N 2.07 1.00
209_V 223_V 2.051 1.00
54_S 89_K 2.033 1.00
466_S 470_A 2.02 1.00
423_H 457_A 1.958 1.00
144_Q 161_R 1.954 1.00
243_C 324_L 1.93 1.00
364_I 428_T 1.928 1.00
102_G 124_D 1.926 1.00
93_R 96_E 1.904 1.00
210_R 214_E 1.902 1.00
108_V 245_M 1.852 1.00
118_K 213_E 1.817 1.00
96_E 126_F 1.814 1.00
150_Y 153_V 1.804 1.00
101_R 252_R 1.802 1.00
485_E 496_I 1.799 1.00
484_Q 488_Q 1.797 1.00
382_Q 387_K 1.797 1.00
383_T 441_V 1.787 1.00
256_A 324_L 1.783 1.00
440_S 443_Q 1.772 1.00
192_K 222_I 1.768 1.00
446_L 475_V 1.767 1.00
155_S 444_Q 1.753 1.00
55_L 61_A 1.751 1.00
140_Q 143_D 1.749 1.00
454_G 457_A 1.749 1.00
147_Q 154_D 1.745 1.00
470_A 507_F 1.734 1.00
422_D 425_Q 1.729 1.00
40_R 70_S 1.72 1.00
485_E 499_K 1.715 1.00
156_M 393_I 1.713 1.00
144_Q 303_R 1.711 1.00
216_G 219_A 1.709 1.00
110_T 115_I 1.698 1.00
359_L 364_I 1.697 1.00
108_V 224_V 1.691 1.00
147_Q 441_V 1.638 1.00
404_A 408_Q 1.631 1.00
467_F 508_K 1.627 1.00
151_K 439_M 1.617 1.00
192_K 254_E 1.615 1.00
427_V 451_A 1.61 1.00
144_Q 255_D 1.596 1.00
243_C 301_A 1.592 1.00
194_I 245_M 1.587 1.00
56_P 86_M 1.574 1.00
158_P 378_G 1.572 1.00
224_V 245_M 1.565 1.00
177_A 436_Y 1.559 1.00
443_Q 472_L 1.557 1.00
53_I 88_V 1.556 1.00
47_C 53_I 1.543 1.00
95_L 129_V 1.536 1.00
206_S 210_R 1.513 1.00
33_S 40_R 1.512 0.99
170_D 173_T 1.506 0.99
401_R 404_A 1.495 0.99
97_V 245_M 1.49 0.99
247_E 300_R 1.487 0.99
41_I 88_V 1.483 0.99
166_L 349_T 1.483 0.99
298_L 348_I 1.48 0.99
47_C 71_V 1.474 0.99
330_I 345_V 1.445 0.99
14_Q 17_A 1.44 0.99
101_R 248_Y 1.438 0.99
109_N 230_E 1.435 0.99
489_T 496_I 1.424 0.99
379_G 394_R 1.423 0.99
150_Y 178_L 1.416 0.99
51_E 92_G 1.407 0.99
485_E 489_T 1.403 0.99
250_R 304_V 1.4 0.99
480_A 484_Q 1.4 0.99
102_G 122_D 1.396 0.99
481_P 499_K 1.392 0.99
443_Q 483_M 1.381 0.99
140_Q 306_A 1.38 0.99
27_N 90_C 1.379 0.99
453_R 497_E 1.369 0.99
250_R 256_A 1.368 0.99
472_L 476_D 1.366 0.99
493_N 496_I 1.364 0.99
48_M 51_E 1.364 0.99
127_S 131_A 1.353 0.99
214_E 217_A 1.352 0.99
363_G 391_G 1.35 0.99
502_G 506_S 1.349 0.99
474_Y 507_F 1.347 0.99
274_S 282_G 1.345 0.99
474_Y 503_I 1.334 0.98
497_E 501_K 1.318 0.98
51_E 90_C 1.31 0.98
53_I 61_A 1.308 0.98
131_A 251_D 1.305 0.98
434_K 437_A 1.302 0.98
56_P 87_K 1.291 0.98
148_T 159_I 1.286 0.98
248_Y 252_R 1.282 0.98
256_A 272_Q 1.281 0.98
192_K 249_F 1.277 0.98
103_L 245_M 1.276 0.98
354_F 357_T 1.27 0.98
392_G 419_K 1.264 0.98
202_A 227_T 1.263 0.98
104_L 218_L 1.261 0.98
496_I 499_K 1.256 0.97
332_T 339_A 1.253 0.97
455_Y 501_K 1.251 0.97
102_G 123_H 1.247 0.97
142_V 160_G 1.245 0.97
219_A 222_I 1.244 0.97
294_H 344_N 1.241 0.97
106_R 119_G 1.238 0.97
106_R 114_P 1.237 0.97
198_I 238_A 1.236 0.97
501_K 505_D 1.231 0.97
388_K 491_G 1.228 0.97
424_G 428_T 1.222 0.97
483_M 487_N 1.219 0.97
378_G 390_S 1.219 0.97
423_H 454_G 1.217 0.97
100_G 103_L 1.213 0.97
399_Q 417_T 1.208 0.97
127_S 248_Y 1.199 0.96
378_G 386_M 1.196 0.96
255_D 303_R 1.193 0.96
429_E 432_K 1.189 0.96
143_D 321_T 1.18 0.96
241_A 245_M 1.18 0.96
351_G 376_R 1.172 0.96
34_V 82_L 1.165 0.96
110_T 241_A 1.163 0.96
485_E 493_N 1.155 0.95
114_P 119_G 1.15 0.95
415_D 419_K 1.141 0.95
455_Y 505_D 1.139 0.95
475_V 483_M 1.139 0.95
213_E 216_G 1.13 0.95
392_G 395_T 1.126 0.94
337_V 354_F 1.122 0.94
263_L 345_V 1.122 0.94
467_F 504_L 1.121 0.94
298_L 345_V 1.12 0.94
222_I 249_F 1.118 0.94
157_I 368_V 1.112 0.94
197_A 205_I 1.112 0.94
399_Q 402_E 1.111 0.94
467_F 471_L 1.108 0.94
498_G 502_G 1.107 0.94
239_P 297_L 1.1 0.93
475_V 503_I 1.097 0.93
489_T 493_N 1.093 0.93
248_Y 251_D 1.09 0.93
190_G 254_E 1.083 0.93
167_I 179_A 1.083 0.93
235_Q 272_Q 1.083 0.93
364_I 431_L 1.08 0.93
238_A 242_G 1.08 0.93
125_G 248_Y 1.079 0.93
10_E 14_Q 1.076 0.92
484_Q 487_N 1.07 0.92
32_V 42_H 1.07 0.92
481_P 484_Q 1.067 0.92
101_R 249_F 1.066 0.92
403_L 417_T 1.065 0.92
450_A 471_L 1.062 0.92
498_G 501_K 1.06 0.92
337_V 372_I 1.059 0.92
252_R 256_A 1.055 0.91
138_E 305_N 1.049 0.91
19_F 23_S 1.046 0.91
145_P 381_A 1.04 0.91
332_T 342_P 1.039 0.91
388_K 489_T 1.032 0.90
392_G 396_A 1.028 0.90
60_Y 113_A 1.028 0.90
5_S 9_S 1.023 0.90
31_I 86_M 1.022 0.90
458_D 467_F 1.018 0.89
476_D 483_M 1.016 0.89
109_N 115_I 1.014 0.89
474_Y 479_H 1.014 0.89
470_A 511_Q 1.013 0.89
378_G 382_Q 1.013 0.89
339_A 342_P 1.007 0.89
148_T 327_L 1.006 0.89
443_Q 447_V 1.006 0.89
196_V 260_Y 1.004 0.89
179_A 329_I 1 0.88
170_D 357_T 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3oaaA1211000.077Contact Map0.692
2qe7A30.97471000.085Contact Map0.754
2ck3A30.97861000.098Contact Map0.76
1fx0A10.97861000.098Contact Map0.666
2r9vA10.97861000.105Contact Map0.765
3gqbB20.85381000.225Contact Map0.629
3vr4D30.86941000.225Contact Map0.673
2c61A20.87721000.226Contact Map0.604
3mfyA10.91621000.234Contact Map0.577
1fx0B10.90061000.246Contact Map0.617
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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