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OPENSEQ.org
KBL - 2-amino-3-ketobutyrate coenzyme A ligase
UniProt: P0AB77 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10512
Length: 398 (392)
Sequences: 3204
Seq/Len: 8.17
KBL
Paralog alert: 0.62 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: BIOF KBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
162_E 202_K 4.596 1.00
66_K 70_D 4.349 1.00
95_K 290_E 4.12 1.00
308_Q 381_T 4.031 1.00
348_E 389_R 3.65 1.00
154_A 160_E 3.644 1.00
160_E 164_R 3.592 1.00
201_D 234_R 3.542 1.00
192_N 195_G 3.375 1.00
287_K 290_E 3.278 1.00
162_E 203_Y 3.179 1.00
178_I 200_A 3.019 1.00
180_T 184_F 2.974 1.00
63_A 67_A 2.866 1.00
308_Q 377_P 2.828 1.00
256_A 260_V 2.756 1.00
312_Q 384_V 2.639 1.00
95_K 286_I 2.547 1.00
108_Y 268_S 2.541 1.00
158_M 199_L 2.466 1.00
160_E 163_A 2.439 1.00
221_N 227_E 2.407 1.00
162_E 166_K 2.396 1.00
95_K 293_E 2.392 1.00
60_D 287_K 2.301 1.00
301_R 305_N 2.228 1.00
194_K 229_C 2.216 1.00
256_A 261_V 2.209 1.00
130_I 164_R 2.155 1.00
211_D 214_A 2.095 1.00
180_T 209_V 2.085 1.00
220_E 227_E 2.084 1.00
103_E 258_K 2.03 1.00
240_G 253_Y 2.003 1.00
47_F 375_H 2.001 1.00
295_G 298_L 1.985 1.00
304_A 377_P 1.951 1.00
62_I 69_M 1.935 1.00
98_A 293_E 1.933 1.00
195_G 198_D 1.923 1.00
131_S 135_N 1.912 1.00
58_H 291_M 1.849 1.00
376_T 379_Q 1.836 1.00
133_A 154_A 1.832 1.00
119_F 179_A 1.821 1.00
311_E 315_A 1.818 1.00
316_A 388_T 1.811 1.00
60_D 294_A 1.809 1.00
344_E 347_K 1.799 1.00
312_Q 315_A 1.798 1.00
296_S 300_D 1.794 1.00
332_L 341_F 1.782 1.00
141_D 269_R 1.771 1.00
344_E 393_Q 1.755 1.00
312_Q 381_T 1.745 1.00
17_R 22_F 1.743 1.00
63_A 70_D 1.728 1.00
308_Q 380_I 1.701 1.00
99_F 223_R 1.669 1.00
97_A 105_A 1.662 1.00
178_I 199_L 1.652 1.00
200_A 207_V 1.646 1.00
35_D 43_H 1.643 1.00
105_A 255_A 1.636 1.00
309_F 371_M 1.636 1.00
35_D 379_Q 1.613 1.00
44_V 346_Q 1.604 1.00
129_I 143_V 1.601 1.00
123_L 129_I 1.6 1.00
211_D 225_S 1.599 1.00
88_S 286_I 1.593 1.00
80_R 85_T 1.573 1.00
130_I 176_V 1.569 1.00
178_I 205_A 1.561 1.00
198_D 234_R 1.556 1.00
85_T 90_K 1.548 1.00
14_E 18_A 1.543 1.00
300_D 304_A 1.539 1.00
258_K 262_E 1.53 1.00
62_I 66_K 1.527 1.00
47_F 383_A 1.526 1.00
153_Y 180_T 1.52 1.00
67_A 71_S 1.512 1.00
96_L 289_L 1.505 1.00
336_V 340_K 1.504 1.00
177_L 208_M 1.501 1.00
154_A 157_D 1.495 1.00
68_G 283_A 1.483 0.99
352_V 367_I 1.466 0.99
117_G 270_P 1.457 0.99
139_I 179_A 1.455 0.99
166_K 203_Y 1.434 0.99
137_A 269_R 1.427 0.99
60_D 291_M 1.424 0.99
143_V 150_R 1.414 0.99
199_L 203_Y 1.406 0.99
308_Q 312_Q 1.401 0.99
197_C 201_D 1.393 0.99
87_D 91_E 1.365 0.99
165_L 199_L 1.364 0.99
250_S 278_A 1.353 0.99
66_K 69_M 1.348 0.99
350_I 382_R 1.347 0.99
158_M 192_N 1.338 0.99
15_T 19_E 1.328 0.99
197_C 207_V 1.327 0.99
91_E 286_I 1.318 0.99
306_A 328_I 1.317 0.99
307_R 311_E 1.316 0.99
96_L 242_L 1.298 0.98
153_Y 184_F 1.291 0.98
118_L 254_T 1.283 0.98
113_D 274_S 1.279 0.98
67_A 70_D 1.277 0.98
316_A 384_V 1.276 0.98
155_N 189_V 1.259 0.98
278_A 281_I 1.256 0.98
76_M 276_S 1.25 0.98
309_F 313_M 1.249 0.98
338_A 365_A 1.246 0.98
115_N 138_S 1.243 0.98
341_F 390_I 1.24 0.98
169_R 176_V 1.234 0.97
161_L 178_I 1.232 0.97
64_A 68_G 1.231 0.97
242_L 285_S 1.23 0.97
59_P 63_A 1.228 0.97
187_D 366_R 1.227 0.97
94_Q 98_A 1.22 0.97
215_V 246_L 1.219 0.97
312_Q 316_A 1.213 0.97
377_P 381_T 1.212 0.97
88_S 282_V 1.209 0.97
97_A 255_A 1.208 0.97
151_Y 164_R 1.202 0.97
164_R 167_E 1.2 0.97
17_R 24_E 1.199 0.97
10_T 14_E 1.198 0.97
159_Q 163_A 1.187 0.97
257_R 260_V 1.181 0.96
10_T 259_E 1.174 0.96
123_L 177_L 1.172 0.96
287_K 291_M 1.151 0.96
162_E 199_L 1.15 0.96
334_D 337_V 1.149 0.96
340_K 344_E 1.149 0.96
104_D 258_K 1.149 0.96
226_H 231_V 1.148 0.96
165_L 205_A 1.145 0.96
100_L 255_A 1.139 0.95
100_L 215_V 1.133 0.95
72_H 87_D 1.128 0.95
382_R 386_A 1.124 0.95
335_A 365_A 1.123 0.95
190_I 218_V 1.119 0.95
63_A 66_K 1.118 0.95
130_I 168_A 1.109 0.94
8_Q 175_H 1.104 0.94
159_Q 195_G 1.1 0.94
197_C 234_R 1.094 0.94
318_F 391_G 1.08 0.93
357_Y 362_K 1.077 0.93
372_S 375_H 1.077 0.93
134_L 366_R 1.076 0.93
344_E 348_E 1.068 0.93
78_S 82_I 1.067 0.93
339_Q 356_F 1.061 0.93
350_I 386_A 1.055 0.92
197_C 235_V 1.053 0.92
156_N 192_N 1.052 0.92
135_N 139_I 1.052 0.92
119_F 177_L 1.052 0.92
186_M 355_F 1.05 0.92
305_N 308_Q 1.048 0.92
90_K 104_D 1.045 0.92
119_F 123_L 1.043 0.92
348_E 393_Q 1.038 0.92
286_I 290_E 1.036 0.91
339_Q 354_G 1.035 0.91
182_G 214_A 1.032 0.91
110_S 113_D 1.029 0.91
182_G 225_S 1.024 0.91
297_E 301_R 1.023 0.91
102_M 255_A 1.019 0.91
153_Y 156_N 1.016 0.90
182_G 211_D 1.011 0.90
343_R 347_K 1.011 0.90
47_F 380_I 1.005 0.90
90_K 94_Q 1.003 0.90
283_A 287_K 1.003 0.90
131_S 152_R 1.002 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2w8tA10.98991000.456Contact Map0.658
1fc4A211000.502Contact Map0.815
3kkiA20.96731000.505Contact Map0.742
2bwnA40.97991000.507Contact Map0.796
3tqxA20.99251000.526Contact Map0.816
1bs0A10.95981000.529Contact Map0.647
3a2bA10.98991000.544Contact Map0.769
4iw7A10.94721000.551Contact Map0.679
2epjA10.92961000.653Contact Map0.498
4e77A10.91711000.654Contact Map0.578
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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