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OPENSEQ.org
FDOH - Formate dehydrogenase-O iron-sulfur subunit
UniProt: P0AAJ5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11857
Length: 300 (287)
Sequences: 362
Seq/Len: 1.26
FDOH
Paralog alert: 0.65 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FDNH FDOH HYBA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
235_N 242_E 3.222 1.00
193_K 213_L 2.434 0.99
185_H 195_L 2.395 0.99
150_L 157_V 2.357 0.99
176_V 184_I 2.304 0.99
107_G 142_G 2.029 0.97
46_Q 69_P 1.997 0.97
78_T 97_K 1.972 0.97
6_Q 9_I 1.946 0.96
40_I 181_T 1.85 0.95
145_F 222_T 1.824 0.94
189_K 193_K 1.676 0.90
3_Y 6_Q 1.656 0.90
6_Q 27_Q 1.634 0.89
30_V 188_T 1.632 0.89
34_I 224_V 1.613 0.88
202_E 205_T 1.604 0.88
23_A 26_F 1.524 0.84
208_Y 286_E 1.51 0.83
197_S 215_D 1.498 0.82
193_K 200_V 1.496 0.82
19_P 22_Q 1.49 0.82
193_K 215_D 1.451 0.79
57_D 76_S 1.428 0.78
74_A 198_E 1.417 0.77
57_D 60_G 1.413 0.77
18_T 22_Q 1.403 0.76
38_T 182_G 1.389 0.75
9_I 122_A 1.385 0.75
38_T 185_H 1.385 0.75
20_A 25_D 1.363 0.73
235_N 243_N 1.352 0.72
164_V 168_V 1.351 0.72
88_N 153_E 1.348 0.72
6_Q 122_A 1.308 0.69
260_L 266_A 1.3 0.68
32_K 224_V 1.299 0.68
6_Q 50_S 1.295 0.68
193_K 197_S 1.288 0.67
189_K 225_M 1.269 0.65
197_S 201_A 1.265 0.65
285_D 289_N 1.252 0.64
191_S 256_I 1.246 0.63
140_I 191_S 1.24 0.63
40_I 44_A 1.24 0.63
21_P 26_F 1.234 0.62
172_E 176_V 1.23 0.62
34_I 184_I 1.222 0.61
194_T 197_S 1.218 0.61
211_A 228_L 1.215 0.60
188_T 191_S 1.207 0.60
129_Q 278_G 1.206 0.60
77_W 158_Y 1.203 0.59
10_R 287_E 1.201 0.59
190_E 201_A 1.195 0.58
6_Q 129_Q 1.189 0.58
52_W 165_D 1.18 0.57
268_T 272_S 1.179 0.57
3_Y 268_T 1.178 0.57
80_M 95_I 1.177 0.57
219_V 222_T 1.175 0.57
15_N 269_F 1.17 0.56
155_N 200_V 1.168 0.56
73_S 257_W 1.167 0.56
44_A 51_E 1.161 0.55
88_N 263_V 1.159 0.55
10_R 284_A 1.156 0.55
11_R 25_D 1.156 0.55
83_S 238_H 1.148 0.54
285_D 288_E 1.142 0.53
6_Q 25_D 1.141 0.53
203_L 211_A 1.139 0.53
78_T 99_G 1.137 0.53
71_D 149_R 1.136 0.53
5_S 8_I 1.135 0.53
34_I 99_G 1.135 0.53
20_A 24_R 1.132 0.52
52_W 174_A 1.131 0.52
8_I 18_T 1.13 0.52
267_A 271_A 1.13 0.52
4_Q 129_Q 1.13 0.52
271_A 277_V 1.128 0.52
22_Q 25_D 1.127 0.52
18_T 23_A 1.124 0.52
19_P 25_D 1.121 0.51
3_Y 18_T 1.121 0.51
18_T 24_R 1.12 0.51
68_N 111_A 1.118 0.51
46_Q 68_N 1.11 0.50
14_T 18_T 1.109 0.50
128_F 148_P 1.105 0.50
213_L 225_M 1.092 0.48
10_R 20_A 1.086 0.48
265_F 268_T 1.078 0.47
117_A 150_L 1.077 0.47
162_L 224_V 1.075 0.47
8_I 24_R 1.075 0.47
2_A 6_Q 1.075 0.47
18_T 26_F 1.071 0.46
117_A 132_Q 1.069 0.46
11_R 26_F 1.068 0.46
9_I 27_Q 1.067 0.46
172_E 186_F 1.064 0.46
10_R 247_S 1.059 0.45
36_V 92_E 1.059 0.45
284_A 287_E 1.056 0.45
2_A 5_S 1.056 0.45
46_Q 64_G 1.056 0.45
3_Y 270_A 1.055 0.45
118_I 215_D 1.055 0.45
3_Y 15_N 1.054 0.45
248_E 272_S 1.054 0.45
15_N 272_S 1.05 0.44
34_I 226_Y 1.047 0.44
9_I 15_N 1.045 0.44
182_G 225_M 1.045 0.44
2_A 27_Q 1.044 0.44
47_V 77_W 1.039 0.43
119_I 228_L 1.036 0.43
6_Q 130_S 1.034 0.43
286_E 289_N 1.032 0.43
263_V 273_I 1.029 0.42
117_A 142_G 1.028 0.42
41_G 180_P 1.022 0.42
3_Y 27_Q 1.02 0.41
9_I 25_D 1.02 0.41
8_I 14_T 1.019 0.41
3_Y 132_Q 1.019 0.41
281_P 284_A 1.019 0.41
10_R 272_S 1.018 0.41
52_W 166_R 1.018 0.41
284_A 289_N 1.018 0.41
43_K 51_E 1.016 0.41
92_E 223_H 1.016 0.41
283_R 286_E 1.016 0.41
107_G 247_S 1.014 0.41
20_A 23_A 1.014 0.41
279_V 286_E 1.013 0.41
191_S 213_L 1.013 0.41
260_L 263_V 1.01 0.40
2_A 25_D 1.008 0.40
6_Q 257_W 1.006 0.40
147_I 210_N 1.006 0.40
205_T 209_D 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kqfB10.981000.419Contact Map0.411
1h0hB20.69331000.592Contact Map0.524
2ivfB10.911000.664Contact Map0.501
1ti6B60.83671000.677Contact Map0.54
2vpzB20.64331000.695Contact Map0.52
1q16B10.871000.757Contact Map0.6
3mm5B20.833399.80.836Contact Map0.193
2fgoA10.2599.40.878Contact Map0.25
1rgvA10.256799.30.88Contact Map0.258
3eunA10.263399.30.882Contact Map0.277
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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