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OPENSEQ.org

WZB - Low molecular weight protein-tyrosine-phosphatase wzb
UniProt: P0AAB2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13567
Length: 147 (143)
Sequences: 3592
Seq/Len: 25.12

WZB
Paralog alert: 0.52 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ETP WZB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_Y 136_R 3.192 1.00
20_E 24_Q 2.68 1.00
68_I 90_L 2.616 1.00
53_A 60_L 2.58 1.00
114_P 130_L 2.58 1.00
4_N 31_K 2.494 1.00
132_E 136_R 2.358 1.00
55_E 125_A 2.307 1.00
24_Q 32_V 2.189 1.00
10_V 86_H 2.064 1.00
56_H 128_Y 2.054 1.00
56_H 132_E 2.012 1.00
18_T 53_A 2.004 1.00
81_T 90_L 1.944 1.00
26_Y 132_E 1.935 1.00
7_V 23_L 1.78 1.00
22_L 56_H 1.707 1.00
52_V 128_Y 1.674 1.00
22_L 131_L 1.591 1.00
18_T 49_A 1.583 1.00
6_L 35_A 1.572 1.00
5_I 23_L 1.562 1.00
81_T 87_I 1.551 1.00
33_E 66_R 1.544 1.00
21_R 58_L 1.525 1.00
84_K 112_E 1.517 1.00
119_K 123_T 1.489 1.00
11_G 117_Y 1.396 0.99
48_T 51_S 1.393 0.99
39_A 67_Q 1.392 0.99
23_L 32_V 1.382 0.99
27_H 30_L 1.341 0.99
52_V 125_A 1.34 0.99
45_A 50_I 1.33 0.99
51_S 121_R 1.326 0.99
33_E 76_Y 1.319 0.99
7_V 135_A 1.317 0.99
126_A 130_L 1.308 0.99
104_F 135_A 1.305 0.99
78_L 138_W 1.279 0.99
120_S 123_T 1.27 0.99
56_H 129_T 1.263 0.99
21_R 60_L 1.262 0.99
45_A 63_H 1.253 0.99
113_I 127_V 1.251 0.99
49_A 124_F 1.223 0.98
51_S 55_E 1.201 0.98
52_V 56_H 1.196 0.98
102_M 107_W 1.196 0.98
27_H 139_A 1.183 0.98
105_G 108_D 1.182 0.98
50_I 60_L 1.176 0.98
37_L 89_R 1.155 0.97
22_L 128_Y 1.143 0.97
41_V 65_A 1.133 0.97
22_L 132_E 1.131 0.97
4_N 76_Y 1.126 0.97
46_D 124_F 1.113 0.96
71_R 75_N 1.111 0.96
10_V 38_G 1.102 0.96
60_L 63_H 1.1 0.96
125_A 129_T 1.096 0.96
27_H 32_V 1.091 0.96
52_V 55_E 1.087 0.96
137_Q 140_Q 1.073 0.95
9_C 12_N 1.063 0.95
7_V 19_A 1.053 0.95
31_K 75_N 1.053 0.95
12_N 16_S 1.044 0.94
104_F 131_L 1.037 0.94
58_L 132_E 1.029 0.94
133_R 137_Q 1.025 0.93
50_I 54_A 1.024 0.93
26_Y 135_A 1.021 0.93
41_V 67_Q 1.02 0.93
87_I 91_C 1.014 0.93
121_R 125_A 1.005 0.93
7_V 138_W 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2fekA11100-0.007Contact Map0.705
2wmyA80.97961000.011Contact Map0.835
2wjaA20.97961000.012Contact Map0.83
4etnA10.99321000.053Contact Map0.818
2cwdA40.99321000.063Contact Map0.867
3jviA10.99321000.064Contact Map0.769
4egsA20.9661000.064Contact Map0.835
1p8aA10.95921000.072Contact Map0.523
2gi4A10.97961000.079Contact Map0.423
3n8iA10.9661000.08Contact Map0.844

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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