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OPENSEQ.org
YBHO - Putative cardiolipin synthase YbhO
UniProt: P0AA84 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13671
Length: 413 (362)
Sequences: 2799
Seq/Len: 7.73
YBHO
Paralog alert: 0.56 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CLS YBHO YMDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_A 61_R 5.732 1.00
29_G 57_A 4.867 1.00
27_A 125_F 4.854 1.00
280_Q 346_Q 4.478 1.00
28_I 54_A 3.985 1.00
249_R 280_Q 3.503 1.00
24_V 117_V 3.498 1.00
124_A 159_I 3.313 1.00
27_A 150_R 2.919 1.00
29_G 54_A 2.878 1.00
298_D 333_R 2.719 1.00
302_T 320_N 2.613 1.00
10_K 152_E 2.513 1.00
25_F 54_A 2.484 1.00
224_I 251_K 2.474 1.00
57_A 61_R 2.468 1.00
301_A 332_L 2.305 1.00
36_I 66_E 2.27 1.00
223_V 296_M 2.241 1.00
12_Q 23_A 2.219 1.00
35_I 119_I 2.213 1.00
25_F 51_L 2.192 1.00
253_I 344_C 2.158 1.00
301_A 329_N 2.133 1.00
151_L 321_V 2.084 1.00
251_K 280_Q 2.067 1.00
355_R 363_S 2.012 1.00
8_G 154_P 2.001 1.00
295_L 329_N 1.994 1.00
20_Y 24_V 1.988 1.00
20_Y 39_T 1.987 1.00
323_I 328_F 1.968 1.00
28_I 35_I 1.957 1.00
121_A 160_L 1.938 1.00
338_G 341_A 1.93 1.00
224_I 249_R 1.929 1.00
345_Q 351_M 1.927 1.00
56_L 60_Q 1.922 1.00
64_K 91_V 1.894 1.00
14_L 23_A 1.864 1.00
282_F 346_Q 1.864 1.00
56_L 88_A 1.826 1.00
286_R 343_D 1.82 1.00
222_E 298_D 1.809 1.00
45_D 48_G 1.801 1.00
44_E 49_K 1.78 1.00
69_L 94_Y 1.778 1.00
145_Q 339_I 1.773 1.00
216_L 223_V 1.754 1.00
124_A 156_V 1.735 1.00
42_W 67_V 1.734 1.00
54_A 58_A 1.707 1.00
125_F 150_R 1.696 1.00
122_R 152_E 1.695 1.00
23_A 27_A 1.693 1.00
258_P 264_R 1.691 1.00
244_A 279_V 1.683 1.00
333_R 337_N 1.673 1.00
27_A 123_I 1.663 1.00
222_E 333_R 1.653 1.00
196_L 321_V 1.653 1.00
6_R 158_D 1.645 1.00
123_I 150_R 1.639 1.00
116_I 159_I 1.621 1.00
151_L 155_I 1.618 1.00
26_K 30_E 1.606 1.00
23_A 150_R 1.604 1.00
34_R 121_A 1.588 1.00
349_E 353_P 1.563 1.00
241_R 273_Y 1.558 1.00
251_K 337_N 1.543 1.00
85_L 90_V 1.543 1.00
253_I 340_I 1.53 1.00
215_M 296_M 1.526 1.00
52_H 84_E 1.503 0.99
83_N 87_A 1.5 0.99
12_Q 150_R 1.497 0.99
352_L 355_R 1.496 0.99
208_I 306_S 1.491 0.99
226_A 289_L 1.488 0.99
23_A 125_F 1.453 0.99
155_I 196_L 1.453 0.99
47_V 133_A 1.448 0.99
54_A 57_A 1.443 0.99
27_A 30_E 1.433 0.99
222_E 249_R 1.422 0.99
23_A 26_K 1.407 0.99
43_F 134_E 1.401 0.99
32_Q 122_R 1.399 0.99
36_I 160_L 1.389 0.99
37_L 117_V 1.385 0.99
224_I 333_R 1.385 0.99
251_K 340_I 1.377 0.99
52_H 81_F 1.371 0.99
215_M 300_W 1.362 0.99
14_L 125_F 1.345 0.99
66_E 91_V 1.327 0.98
224_I 337_N 1.32 0.98
52_H 56_L 1.317 0.98
309_D 316_N 1.299 0.98
46_D 133_A 1.29 0.98
340_I 344_C 1.288 0.98
116_I 319_A 1.283 0.98
27_A 119_I 1.273 0.98
283_E 347_V 1.261 0.98
16_N 19_Q 1.256 0.98
32_Q 61_R 1.247 0.97
24_V 51_L 1.242 0.97
285_R 345_Q 1.236 0.97
276_K 349_E 1.228 0.97
271_Y 281_V 1.226 0.97
20_Y 148_A 1.224 0.97
60_Q 87_A 1.222 0.97
40_F 316_N 1.221 0.97
52_H 90_V 1.205 0.97
221_R 298_D 1.201 0.97
118_V 159_I 1.201 0.97
34_R 160_L 1.199 0.96
226_A 253_I 1.193 0.96
126_I 159_I 1.179 0.96
9_N 154_P 1.177 0.96
41_I 134_E 1.162 0.96
219_A 296_M 1.158 0.95
45_D 49_K 1.151 0.95
275_V 281_V 1.151 0.95
19_Q 22_P 1.148 0.95
130_N 135_H 1.145 0.95
271_Y 283_E 1.136 0.95
118_V 124_A 1.127 0.95
275_V 349_E 1.124 0.94
222_E 295_L 1.119 0.94
11_I 194_V 1.118 0.94
326_R 330_Q 1.111 0.94
68_L 169_G 1.105 0.94
334_D 338_G 1.103 0.94
239_A 243_A 1.103 0.94
254_I 271_Y 1.096 0.93
53_A 56_L 1.095 0.93
306_S 320_N 1.092 0.93
355_R 359_N 1.083 0.93
29_G 50_Q 1.071 0.92
149_V 323_I 1.069 0.92
256_G 285_R 1.061 0.92
223_V 240_L 1.059 0.92
226_A 293_V 1.059 0.92
11_I 323_I 1.058 0.92
24_V 119_I 1.057 0.92
272_N 276_K 1.053 0.91
159_I 319_A 1.051 0.91
26_K 29_G 1.046 0.91
57_A 60_Q 1.044 0.91
54_A 61_R 1.041 0.91
301_A 328_F 1.038 0.91
217_T 239_A 1.034 0.90
298_D 330_Q 1.033 0.90
15_E 335_N 1.028 0.90
251_K 282_F 1.025 0.90
126_I 319_A 1.024 0.90
221_R 299_H 1.02 0.90
358_W 362_K 1.015 0.89
236_F 313_L 1.012 0.89
118_V 156_V 1.012 0.89
338_G 343_D 1.01 0.89
211_H 322_I 1.006 0.89
65_A 90_V 1.005 0.89
300_W 322_I 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v0wA10.84751000.397Contact Map0.563
3hsiA30.89591000.408Contact Map0.481
2o8rA20.8161000.537Contact Map0.484
1xdpA20.78451000.54Contact Map0.438
4ggjA10.452899.90.762Contact Map0.595
1byrA10.370599.90.767Contact Map0.673
4gelA20.464999.90.772Contact Map0.689
2c1lA20.510999.90.792Contact Map0.5
3qphA10.714397.80.922Contact Map0.235
2f5tX10.447996.40.936Contact Map0.396
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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