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OPENSEQ.org
CODB - Cytosine permease
UniProt: P0AA82 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11327
Length: 419 (401)
Sequences: 2073
Seq/Len: 5.17
CODB
Paralog alert: 0.62 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ALLP CODB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
341_A 392_A 4.311 1.00
341_A 396_L 3.496 1.00
74_G 212_A 3.476 1.00
371_L 394_S 2.805 1.00
345_M 392_A 2.794 1.00
53_F 241_I 2.708 1.00
372_G 394_S 2.523 1.00
372_G 391_G 2.419 1.00
62_L 201_V 2.301 1.00
363_W 367_L 2.259 1.00
368_A 394_S 2.253 1.00
368_A 398_L 2.194 1.00
337_G 341_A 2.126 1.00
193_F 197_L 2.082 1.00
345_M 396_L 1.969 1.00
366_I 370_A 1.957 1.00
17_R 78_G 1.94 1.00
48_S 51_D 1.925 1.00
109_F 310_G 1.923 1.00
298_S 301_T 1.91 1.00
58_I 197_L 1.887 1.00
113_V 139_M 1.865 1.00
76_K 221_A 1.853 1.00
368_A 372_G 1.805 1.00
389_L 392_A 1.803 1.00
372_G 390_G 1.796 1.00
389_L 393_L 1.779 1.00
352_H 355_T 1.756 1.00
376_G 387_A 1.744 1.00
88_S 342_D 1.729 1.00
375_A 390_G 1.72 1.00
342_D 347_R 1.703 1.00
108_W 111_V 1.698 1.00
170_W 174_N 1.68 1.00
30_L 282_N 1.676 0.99
365_A 395_Y 1.673 0.99
337_G 388_V 1.669 0.99
109_F 280_N 1.668 0.99
226_L 230_V 1.633 0.99
222_K 226_L 1.623 0.99
338_V 368_A 1.6 0.99
71_G 215_V 1.6 0.99
220_N 223_L 1.59 0.99
340_I 344_L 1.583 0.99
139_M 280_N 1.561 0.99
137_L 141_V 1.544 0.99
264_L 267_P 1.519 0.99
13_P 16_A 1.515 0.99
145_F 149_A 1.504 0.99
280_N 283_A 1.483 0.98
73_I 84_L 1.468 0.98
54_L 193_F 1.468 0.98
140_T 307_G 1.467 0.98
219_R 223_L 1.455 0.98
217_F 289_L 1.44 0.98
86_R 94_S 1.43 0.98
390_G 394_S 1.42 0.98
169_V 238_L 1.41 0.98
197_L 201_V 1.407 0.98
112_G 283_A 1.4 0.98
5_N 8_S 1.384 0.97
304_V 308_I 1.383 0.97
338_V 365_A 1.377 0.97
13_P 17_R 1.37 0.97
86_R 342_D 1.367 0.97
136_G 311_T 1.358 0.97
166_G 170_W 1.357 0.97
371_L 390_G 1.354 0.97
367_L 398_L 1.334 0.96
385_V 389_L 1.326 0.96
64_G 68_S 1.32 0.96
55_A 193_F 1.312 0.96
365_A 368_A 1.303 0.96
143_V 303_S 1.302 0.96
232_F 236_N 1.298 0.96
394_S 398_L 1.295 0.96
107_G 325_L 1.29 0.95
178_G 181_A 1.289 0.95
393_L 396_L 1.277 0.95
68_S 229_M 1.269 0.95
94_S 293_N 1.264 0.95
118_I 254_D 1.256 0.95
163_C 167_Y 1.253 0.94
396_L 400_P 1.248 0.94
84_L 212_A 1.246 0.94
114_A 117_A 1.242 0.94
216_R 342_D 1.24 0.94
47_L 55_A 1.238 0.94
296_G 301_T 1.235 0.94
338_V 369_V 1.233 0.94
364_V 399_N 1.232 0.94
41_G 74_G 1.232 0.94
159_P 162_A 1.208 0.93
117_A 131_L 1.202 0.93
373_I 376_G 1.2 0.93
367_L 371_L 1.198 0.93
254_D 257_D 1.19 0.92
56_V 60_N 1.188 0.92
287_S 306_N 1.183 0.92
85_A 335_V 1.168 0.91
19_G 22_A 1.167 0.91
370_A 394_S 1.158 0.91
361_V 366_I 1.157 0.91
83_L 86_R 1.153 0.91
107_G 324_W 1.146 0.90
96_L 366_I 1.141 0.90
142_T 277_W 1.138 0.90
32_F 161_I 1.138 0.90
371_L 374_A 1.137 0.90
193_F 196_A 1.136 0.90
390_G 393_L 1.136 0.90
24_T 230_V 1.131 0.89
367_L 370_A 1.13 0.89
31_T 235_G 1.13 0.89
288_G 302_L 1.129 0.89
109_F 307_G 1.127 0.89
74_G 215_V 1.12 0.89
20_V 223_L 1.119 0.89
92_K 95_W 1.117 0.89
101_L 210_L 1.113 0.88
297_M 305_I 1.112 0.88
62_L 197_L 1.107 0.88
112_G 280_N 1.105 0.88
54_L 58_I 1.099 0.88
295_T 301_T 1.097 0.87
341_A 345_M 1.097 0.87
264_L 268_A 1.096 0.87
214_F 286_A 1.094 0.87
137_L 166_G 1.093 0.87
89_F 365_A 1.09 0.87
142_T 153_L 1.09 0.87
77_T 350_Y 1.086 0.87
9_Q 86_R 1.086 0.87
69_F 344_L 1.084 0.87
130_L 134_V 1.081 0.86
112_G 276_I 1.078 0.86
34_S 112_G 1.078 0.86
267_P 270_V 1.074 0.86
27_M 34_S 1.074 0.86
298_S 302_L 1.071 0.86
342_D 346_N 1.071 0.86
109_F 112_G 1.069 0.86
134_V 223_L 1.068 0.85
397_I 401_I 1.068 0.85
60_N 240_F 1.067 0.85
49_Y 53_F 1.066 0.85
238_L 242_F 1.066 0.85
364_V 368_A 1.062 0.85
52_F 244_A 1.062 0.85
297_M 302_L 1.062 0.85
110_G 310_G 1.062 0.85
230_V 367_L 1.061 0.85
393_L 397_I 1.06 0.85
75_A 218_G 1.06 0.85
182_L 185_V 1.06 0.85
309_I 313_C 1.057 0.85
102_G 291_F 1.056 0.85
368_A 391_G 1.052 0.84
346_N 396_L 1.052 0.84
239_M 243_G 1.051 0.84
109_F 283_A 1.047 0.84
72_Y 76_K 1.046 0.84
204_F 207_A 1.045 0.84
308_I 312_V 1.042 0.84
81_T 101_L 1.041 0.83
392_A 395_Y 1.041 0.83
164_L 271_V 1.04 0.83
87_F 350_Y 1.032 0.83
223_L 227_V 1.031 0.83
132_I 136_G 1.031 0.83
152_V 156_I 1.031 0.83
348_R 400_P 1.029 0.82
250_L 261_A 1.028 0.82
34_S 276_I 1.027 0.82
87_F 353_F 1.024 0.82
109_F 284_L 1.023 0.82
7_F 16_A 1.021 0.82
389_L 398_L 1.019 0.82
63_L 209_T 1.016 0.81
148_S 152_V 1.015 0.81
72_Y 344_L 1.014 0.81
305_I 309_I 1.014 0.81
30_L 275_N 1.012 0.81
126_L 134_V 1.004 0.80
105_Q 210_L 1.002 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jlnA10.99521000.165Contact Map0.644
3l1lA10.954799.40.85Contact Map0.465
3dh4A40.949999.20.861Contact Map0.548
2xq2A10.949999.10.864Contact Map0.582
3giaA10.937998.80.879Contact Map0.407
4djkA20.964298.70.886Contact Map0.444
2a65A10.952392.80.941Contact Map0.506
4m48A10.961887.80.947Contact Map0.353
4ainA30.859284.40.95Contact Map0.377
2wswA10.830574.30.954Contact Map0.298
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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