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OPENSEQ.org
DHAS - Aspartate-semialdehyde dehydrogenase
UniProt: P0A9Q9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10088
Length: 367 (333)
Sequences: 3287
Seq/Len: 9.87
DHAS
Paralog alert: 0.71 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ARGC DHAS USG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
291_V 342_L 4.384 1.00
3_N 31_R 4.261 1.00
145_G 149_A 3.892 1.00
136_T 162_Q 3.609 1.00
154_D 283_K 3.435 1.00
5_G 66_L 2.894 1.00
303_K 326_T 2.811 1.00
43_A 51_T 2.788 1.00
164_A 222_L 2.746 1.00
167_G 218_F 2.715 1.00
293_E 297_A 2.703 1.00
303_K 328_P 2.609 1.00
155_W 281_K 2.5 1.00
316_L 330_G 2.325 1.00
159_A 277_A 2.246 1.00
79_N 100_S 2.237 1.00
80_E 84_K 2.234 1.00
43_A 53_T 2.192 1.00
116_Q 299_N 2.163 1.00
136_T 160_T 2.119 1.00
139_L 276_Q 2.106 1.00
226_L 268_V 2.091 1.00
154_D 281_K 2.089 1.00
17_L 70_V 2.087 1.00
93_Y 130_F 2.066 1.00
150_N 294_L 2.047 1.00
139_L 348_G 2.038 1.00
45_P 51_T 1.941 1.00
290_T 293_E 1.908 1.00
287_S 290_T 1.895 1.00
144_L 156_V 1.867 1.00
38_S 56_D 1.863 1.00
236_N 243_W 1.833 1.00
143_S 344_A 1.82 1.00
58_F 61_E 1.786 1.00
118_V 254_N 1.761 1.00
57_A 81_I 1.745 1.00
39_Q 42_Q 1.741 1.00
150_N 290_T 1.728 1.00
16_V 272_R 1.721 1.00
9_W 35_F 1.71 1.00
143_S 278_F 1.685 1.00
301_W 325_L 1.677 1.00
114_V 145_G 1.667 1.00
149_A 298_H 1.66 1.00
147_L 282_L 1.659 1.00
4_V 68_I 1.656 1.00
288_I 332_L 1.649 1.00
293_E 296_A 1.627 1.00
307_N 312_T 1.623 1.00
13_V 356_A 1.62 1.00
292_E 296_A 1.618 1.00
304_V 332_L 1.609 1.00
296_A 306_P 1.606 1.00
108_I 122_G 1.582 1.00
117_D 254_N 1.579 1.00
144_L 280_I 1.572 1.00
157_S 279_T 1.571 1.00
141_L 248_E 1.559 1.00
231_D 240_R 1.559 1.00
160_T 276_Q 1.556 1.00
158_V 278_F 1.554 1.00
140_M 278_F 1.548 1.00
143_S 295_L 1.548 1.00
140_M 158_V 1.547 1.00
86_R 129_T 1.544 1.00
232_K 240_R 1.536 1.00
140_M 276_Q 1.534 1.00
270_A 318_P 1.523 1.00
3_N 67_D 1.508 1.00
7_I 57_A 1.476 1.00
83_P 87_E 1.47 1.00
145_G 252_I 1.456 1.00
3_N 33_V 1.452 1.00
280_I 344_A 1.435 1.00
292_E 306_P 1.435 1.00
143_S 346_T 1.409 0.99
7_I 71_T 1.395 0.99
327_T 346_T 1.389 0.99
151_D 286_V 1.388 0.99
84_K 87_E 1.373 0.99
82_Y 129_T 1.364 0.99
167_G 171_H 1.354 0.99
156_V 280_I 1.353 0.99
10_R 54_L 1.35 0.99
118_V 121_D 1.35 0.99
33_V 55_Q 1.336 0.99
111_L 141_L 1.328 0.99
278_F 344_A 1.327 0.99
147_L 295_L 1.318 0.99
327_T 348_G 1.312 0.99
177_T 180_G 1.309 0.99
273_C 350_Q 1.307 0.99
29_A 32_P 1.296 0.99
63_L 85_L 1.294 0.99
295_L 304_V 1.293 0.99
117_D 120_T 1.291 0.99
81_I 84_K 1.278 0.99
18_M 32_P 1.267 0.99
147_L 342_L 1.266 0.99
289_P 293_E 1.265 0.99
169_A 173_R 1.264 0.99
76_D 100_S 1.263 0.99
147_L 291_V 1.255 0.99
288_I 292_E 1.246 0.98
176_L 180_G 1.232 0.98
325_L 352_L 1.23 0.98
280_I 342_L 1.207 0.98
139_L 160_T 1.199 0.98
229_W 313_M 1.195 0.98
173_R 176_L 1.184 0.98
285_D 340_E 1.183 0.98
275_S 318_P 1.182 0.98
177_T 181_H 1.173 0.97
295_L 344_A 1.17 0.97
139_L 347_V 1.167 0.97
115_N 118_V 1.163 0.97
285_D 334_K 1.163 0.97
71_T 82_Y 1.163 0.97
22_V 30_I 1.162 0.97
292_E 307_N 1.161 0.97
43_A 46_S 1.159 0.97
275_S 347_V 1.154 0.97
69_I 92_G 1.153 0.97
288_I 334_K 1.152 0.97
248_E 251_K 1.152 0.97
3_N 30_I 1.149 0.97
33_V 66_L 1.148 0.97
275_S 345_F 1.145 0.97
352_L 357_E 1.145 0.97
139_L 346_T 1.142 0.97
281_K 341_F 1.139 0.97
262_D 279_T 1.137 0.97
83_P 94_W 1.134 0.97
278_F 346_T 1.127 0.97
150_N 284_K 1.126 0.97
113_P 353_W 1.124 0.97
241_E 244_K 1.118 0.96
68_I 95_I 1.117 0.96
161_Y 268_V 1.115 0.96
78_T 101_L 1.102 0.96
13_V 355_A 1.101 0.96
307_N 314_R 1.099 0.96
5_G 69_I 1.098 0.96
140_M 245_G 1.088 0.96
93_Y 128_R 1.082 0.95
268_V 318_P 1.066 0.95
226_L 318_P 1.058 0.95
136_T 245_G 1.052 0.94
152_L 283_K 1.046 0.94
4_V 30_I 1.04 0.94
42_Q 46_S 1.039 0.94
167_G 227_I 1.035 0.94
82_Y 94_W 1.031 0.94
282_L 342_L 1.026 0.93
305_V 328_P 1.021 0.93
58_F 80_E 1.019 0.93
115_N 248_E 1.018 0.93
83_P 89_G 1.016 0.93
135_C 166_G 1.014 0.93
220_V 317_T 1.013 0.93
18_M 44_A 1.012 0.93
159_A 279_T 1.007 0.93
55_Q 62_A 1.002 0.92
260_P 339_P 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1t4bA20.99731000.199Contact Map0.682
3uw3A20.99731000.202Contact Map0.681
3pzrA20.99731000.211Contact Map0.675
2yv3A20.88831000.25Contact Map0.752
2r00A20.89371000.264Contact Map0.707
3tz6A10.90461000.27Contact Map0.73
2hjsA10.8911000.295Contact Map0.662
3pwkA20.90461000.297Contact Map0.785
1vknA40.80651000.31Contact Map0.788
2nqtA20.81741000.339Contact Map0.688
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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