May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
GLNA - Glutamine synthetase
UniProt: P0A9C5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10383
Length: 469 (467)
Sequences: 2669
Seq/Len: 5.72
GLNA
Paralog alert: 0.38 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: GLNA PUUA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
300_G 387_I 5.308 1.00
423_D 448_R 5.055 1.00
273_M 298_Y 4.601 1.00
122_A 275_L 3.996 1.00
298_Y 379_G 3.725 1.00
115_Y 384_K 3.569 1.00
91_D 110_K 3.55 1.00
195_E 250_F 3.477 1.00
8_T 12_E 3.308 1.00
381_D 385_N 3.235 1.00
308_A 428_F 3.229 1.00
420_N 448_R 3.153 1.00
114_D 118_S 3.002 1.00
119_T 384_K 2.987 1.00
134_F 215_A 2.978 1.00
297_Y 386_K 2.911 1.00
293_E 386_K 2.909 1.00
273_M 375_L 2.889 1.00
460_P 464_E 2.824 1.00
108_I 439_A 2.798 1.00
282_L 294_Q 2.751 1.00
305_H 425_D 2.716 1.00
94_E 99_Q 2.707 1.00
112_A 377_M 2.633 1.00
304_K 385_N 2.626 1.00
308_A 425_D 2.607 1.00
44_F 72_A 2.538 1.00
195_E 249_R 2.462 1.00
227_N 231_K 2.44 1.00
135_L 192_I 2.43 1.00
9_M 13_H 2.332 1.00
114_D 117_R 2.269 1.00
437_D 441_D 2.269 1.00
296_L 388_H 2.263 1.00
429_L 437_D 2.263 1.00
243_V 254_A 2.259 1.00
297_Y 300_G 2.251 1.00
419_L 444_I 2.214 1.00
313_A 371_C 2.182 1.00
113_E 230_T 2.128 1.00
16_K 198_L 2.101 1.00
127_F 372_F 2.096 1.00
192_I 196_M 2.089 1.00
227_N 235_E 2.077 1.00
311_A 422_L 2.07 1.00
297_Y 387_I 2.032 1.00
384_K 431_A 2.015 1.00
113_E 229_M 2.011 1.00
231_K 235_E 1.996 1.00
421_E 424_L 1.986 1.00
416_E 455_R 1.978 1.00
228_T 231_K 1.977 1.00
136_F 261_M 1.921 1.00
203_M 242_V 1.918 1.00
414_S 417_E 1.91 1.00
452_D 455_R 1.895 1.00
305_H 381_D 1.869 1.00
312_L 374_A 1.856 1.00
413_G 417_E 1.856 1.00
366_A 371_C 1.817 1.00
293_E 297_Y 1.812 1.00
4_E 8_T 1.808 1.00
239_Y 243_V 1.795 1.00
293_E 388_H 1.781 1.00
300_G 389_P 1.766 1.00
15_V 77_I 1.765 1.00
232_K 235_E 1.76 1.00
94_E 97_T 1.734 1.00
422_L 440_I 1.728 1.00
305_H 378_A 1.703 1.00
430_K 437_D 1.686 1.00
37_H 201_E 1.661 1.00
453_R 465_L 1.652 1.00
294_Q 383_I 1.646 1.00
307_K 421_E 1.64 1.00
307_K 409_P 1.639 1.00
309_I 313_A 1.624 0.99
116_L 125_V 1.62 0.99
189_A 220_N 1.619 0.99
10_L 36_A 1.618 0.99
200_M 242_V 1.618 0.99
426_R 437_D 1.612 0.99
20_L 90_C 1.604 0.99
23_T 237_Q 1.586 0.99
233_A 372_F 1.577 0.99
304_K 387_I 1.568 0.99
140_R 164_Q 1.562 0.99
427_E 434_V 1.553 0.99
416_E 420_N 1.537 0.99
196_M 243_V 1.531 0.99
291_L 295_A 1.53 0.99
298_Y 375_L 1.526 0.99
74_T 89_R 1.525 0.99
423_D 426_R 1.52 0.99
112_A 373_A 1.503 0.99
423_D 441_D 1.496 0.99
13_H 84_S 1.493 0.99
6_V 72_A 1.492 0.99
117_R 124_T 1.492 0.99
21_R 87_I 1.472 0.99
116_L 119_T 1.471 0.99
224_T 232_K 1.446 0.98
113_E 228_T 1.444 0.98
417_E 420_N 1.444 0.98
29_E 89_R 1.439 0.98
396_N 399_D 1.437 0.98
426_R 430_K 1.433 0.98
102_D 438_E 1.427 0.98
209_A 223_A 1.426 0.98
121_I 282_L 1.424 0.98
262_F 458_P 1.423 0.98
73_S 231_K 1.418 0.98
311_A 419_L 1.415 0.98
300_G 390_G 1.414 0.98
137_D 252_K 1.414 0.98
5_H 8_T 1.404 0.98
293_E 296_L 1.398 0.98
199_V 242_V 1.39 0.98
227_N 232_K 1.39 0.98
215_A 265_N 1.39 0.98
307_K 310_N 1.384 0.98
299_I 357_I 1.378 0.98
303_I 344_I 1.371 0.98
110_K 230_T 1.359 0.98
273_M 379_G 1.348 0.97
206_V 225_R 1.345 0.97
134_F 267_S 1.34 0.97
401_P 404_E 1.335 0.97
69_M 93_L 1.332 0.97
320_Y 415_L 1.33 0.97
87_I 238_I 1.33 0.97
62_N 396_N 1.327 0.97
447_R 450_E 1.326 0.97
373_A 435_F 1.325 0.97
294_Q 297_Y 1.32 0.97
377_M 434_V 1.318 0.97
131_P 236_I 1.315 0.97
126_L 226_F 1.313 0.97
271_C 375_L 1.307 0.97
199_V 246_V 1.304 0.97
200_M 205_L 1.304 0.97
10_L 39_V 1.304 0.97
147_G 151_A 1.303 0.97
112_A 115_Y 1.283 0.96
125_V 376_L 1.281 0.96
15_V 86_L 1.277 0.96
136_F 255_T 1.277 0.96
75_A 86_L 1.27 0.96
423_D 437_D 1.267 0.96
300_G 388_H 1.253 0.95
420_N 424_L 1.242 0.95
395_K 404_E 1.241 0.95
312_L 422_L 1.229 0.95
134_F 265_N 1.226 0.95
135_L 247_A 1.224 0.95
419_L 451_D 1.22 0.94
428_F 435_F 1.217 0.94
258_P 365_A 1.213 0.94
423_D 444_I 1.205 0.94
344_I 357_I 1.198 0.94
16_K 201_E 1.198 0.94
68_L 92_I 1.193 0.94
310_N 361_F 1.186 0.93
309_I 374_A 1.178 0.93
153_D 160_N 1.176 0.93
71_D 91_D 1.165 0.93
308_A 421_E 1.151 0.92
208_E 225_R 1.148 0.92
312_L 440_I 1.143 0.92
76_V 87_I 1.135 0.91
258_P 363_D 1.132 0.91
277_K 280_V 1.124 0.91
236_I 269_M 1.123 0.91
305_H 385_N 1.121 0.91
199_V 202_Q 1.113 0.90
359_V 375_L 1.113 0.90
452_D 456_M 1.112 0.90
8_T 11_N 1.11 0.90
135_L 254_A 1.108 0.90
121_I 294_Q 1.1 0.89
296_L 389_P 1.094 0.89
116_L 380_L 1.091 0.89
139_I 152_I 1.082 0.88
108_I 373_A 1.077 0.88
297_Y 388_H 1.075 0.88
257_M 318_N 1.074 0.88
213_E 270_H 1.071 0.88
135_L 189_A 1.069 0.88
454_V 461_V 1.066 0.87
102_D 436_T 1.066 0.87
297_Y 383_I 1.061 0.87
335_Y 346_I 1.061 0.87
104_D 107_S 1.06 0.87
109_A 229_M 1.058 0.87
425_D 429_L 1.056 0.87
6_V 75_A 1.055 0.87
213_E 221_E 1.053 0.86
214_V 265_N 1.044 0.86
115_Y 377_M 1.044 0.86
18_V 39_V 1.042 0.86
195_E 199_V 1.041 0.86
246_V 250_F 1.034 0.85
149_H 162_S 1.033 0.85
110_K 114_D 1.025 0.84
127_F 298_Y 1.023 0.84
321_K 462_E 1.023 0.84
429_L 440_I 1.02 0.84
319_S 363_D 1.011 0.83
365_A 469_V 1.009 0.83
429_L 441_D 1.008 0.83
299_I 344_I 1.002 0.83
400_L 404_E 1.002 0.83
126_L 276_S 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4acfA60.98931000.075Contact Map0.796
1f52A120.98721000.077Contact Map0.81
3ng0A10.98931000.082Contact Map0.722
4lniA120.92541000.092Contact Map0.84
3qajA120.92541000.094Contact Map0.894
4hppA10.89341000.128Contact Map0.711
2j9iA120.87851000.177Contact Map0.317
3o6xA60.93391000.345Contact Map0.436
3fkyA200.75051000.361Contact Map0.548
2ojwA50.73351000.366Contact Map0.617
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0497 seconds.