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OPENSEQ.org
MRAY - Phospho-N-acetylmuramoyl-pentapeptide-transferase
UniProt: P0A6W3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10604
Length: 360 (356)
Sequences: 2632
Seq/Len: 7.39
MRAY
Paralog alert: 0.61 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MRAY WECA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
306_L 318_I 5.696 1.00
320_R 331_K 4.271 1.00
211_G 350_V 3.078 1.00
203_M 343_W 2.788 1.00
213_A 244_T 2.78 1.00
295_G 349_L 2.777 1.00
107_G 140_I 2.754 1.00
243_C 280_I 2.669 1.00
129_I 132_W 2.585 1.00
80_L 109_G 2.495 1.00
37_S 82_A 2.458 1.00
37_S 252_G 2.246 1.00
26_A 244_T 2.217 1.00
310_S 313_L 2.207 1.00
242_V 276_A 2.161 1.00
334_P 337_R 2.135 1.00
193_L 301_T 2.107 1.00
310_S 314_R 2.071 1.00
206_V 247_V 1.92 1.00
84_V 106_V 1.919 1.00
79_I 265_M 1.914 1.00
105_L 272_A 1.91 1.00
138_S 181_Y 1.88 1.00
104_V 275_G 1.871 1.00
311_F 315_G 1.866 1.00
83_I 246_I 1.811 1.00
210_G 247_V 1.806 1.00
202_I 206_V 1.795 1.00
310_S 318_I 1.784 1.00
202_I 250_G 1.776 1.00
60_D 66_F 1.74 1.00
36_I 82_A 1.728 1.00
133_K 137_M 1.703 1.00
208_V 346_S 1.654 1.00
82_A 86_S 1.654 1.00
211_G 293_M 1.654 1.00
111_I 136_W 1.645 1.00
80_L 106_V 1.644 1.00
205_T 209_A 1.638 1.00
204_P 346_S 1.626 1.00
183_V 187_T 1.614 1.00
32_T 90_W 1.595 1.00
18_V 359_V 1.593 1.00
60_D 63_E 1.589 1.00
184_I 279_I 1.566 1.00
113_F 117_Y 1.537 1.00
144_V 279_I 1.537 1.00
36_I 85_I 1.534 1.00
174_L 178_L 1.525 0.99
101_V 239_L 1.517 0.99
104_V 144_V 1.501 0.99
217_W 240_V 1.497 0.99
184_I 278_G 1.495 0.99
142_L 146_F 1.494 0.99
246_I 273_L 1.494 0.99
246_I 276_A 1.488 0.99
141_A 185_V 1.482 0.99
337_R 341_R 1.471 0.99
328_Y 342_F 1.471 0.99
133_K 271_L 1.459 0.99
47_H 50_K 1.457 0.99
208_V 293_M 1.453 0.99
58_R 61_G 1.451 0.99
134_Y 137_M 1.444 0.99
79_I 249_A 1.444 0.99
207_F 350_V 1.435 0.99
114_V 118_R 1.432 0.99
222_M 232_Y 1.421 0.99
302_L 306_L 1.42 0.99
110_V 114_V 1.407 0.99
348_M 352_I 1.405 0.99
204_P 297_F 1.397 0.99
126_K 129_I 1.385 0.99
258_T 340_V 1.383 0.99
186_G 305_I 1.38 0.99
180_A 282_V 1.379 0.99
205_T 273_L 1.378 0.99
45_I 49_Q 1.376 0.99
309_G 313_L 1.374 0.99
197_L 339_I 1.361 0.99
213_A 243_C 1.361 0.99
324_I 328_Y 1.354 0.99
108_Y 275_G 1.352 0.99
320_R 330_L 1.348 0.98
138_S 142_L 1.34 0.98
310_S 316_Q 1.336 0.98
216_A 284_L 1.335 0.98
300_E 325_H 1.332 0.98
191_V 205_T 1.324 0.98
186_G 301_T 1.323 0.98
133_K 188_G 1.323 0.98
4_W 7_E 1.31 0.98
34_L 255_W 1.304 0.98
196_G 325_H 1.3 0.98
41_G 78_M 1.299 0.98
57_V 125_T 1.298 0.98
175_F 178_L 1.297 0.98
38_L 255_W 1.297 0.98
346_S 350_V 1.283 0.98
105_L 276_A 1.281 0.98
133_K 136_W 1.28 0.98
44_M 78_M 1.28 0.98
259_Y 336_P 1.278 0.98
255_W 341_R 1.266 0.97
42_P 46_A 1.257 0.97
299_V 324_I 1.255 0.97
137_M 188_G 1.246 0.97
209_A 246_I 1.241 0.97
202_I 265_M 1.236 0.97
106_V 110_V 1.236 0.97
117_Y 121_V 1.224 0.97
12_Y 15_G 1.216 0.97
293_M 353_G 1.213 0.96
326_H 329_E 1.204 0.96
46_A 49_Q 1.203 0.96
209_A 277_L 1.203 0.96
86_S 245_A 1.198 0.96
250_G 273_L 1.197 0.96
47_H 51_L 1.196 0.96
306_L 309_G 1.195 0.96
207_F 346_S 1.185 0.96
36_I 86_S 1.179 0.96
201_A 273_L 1.177 0.96
144_V 184_I 1.175 0.96
333_W 338_V 1.167 0.95
191_V 201_A 1.165 0.95
288_F 291_V 1.16 0.95
245_A 248_G 1.158 0.95
46_A 50_K 1.148 0.95
202_I 254_L 1.147 0.95
209_A 243_C 1.145 0.95
312_K 318_I 1.144 0.95
66_F 125_T 1.137 0.94
64_S 67_S 1.135 0.94
333_W 341_R 1.134 0.94
4_W 12_Y 1.132 0.94
84_V 102_L 1.125 0.94
345_I 349_L 1.123 0.94
208_V 277_L 1.121 0.94
53_F 120_V 1.116 0.94
194_T 204_P 1.114 0.94
133_K 193_L 1.113 0.94
207_F 343_W 1.113 0.94
187_T 298_V 1.111 0.93
191_V 294_G 1.111 0.93
104_V 279_I 1.11 0.93
22_L 237_G 1.106 0.93
134_Y 138_S 1.103 0.93
87_V 98_V 1.101 0.93
298_V 301_T 1.1 0.93
54_G 65_H 1.09 0.93
121_V 125_T 1.087 0.92
103_V 143_G 1.087 0.92
103_V 107_G 1.085 0.92
80_L 105_L 1.083 0.92
41_G 252_G 1.08 0.92
41_G 263_V 1.075 0.92
216_A 240_V 1.074 0.92
71_T 264_F 1.07 0.92
80_L 272_A 1.069 0.92
213_A 217_W 1.057 0.91
223_N 226_S 1.046 0.90
79_I 250_G 1.041 0.90
160_L 163_P 1.041 0.90
7_E 12_Y 1.034 0.90
304_V 307_Q 1.033 0.90
105_L 242_V 1.033 0.90
54_G 57_V 1.027 0.89
145_A 181_Y 1.026 0.89
292_I 353_G 1.024 0.89
212_F 281_A 1.024 0.89
54_G 58_R 1.021 0.89
218_A 230_I 1.016 0.89
145_A 177_I 1.016 0.89
191_V 208_V 1.008 0.88
301_T 305_I 1.006 0.88
138_S 185_V 1.003 0.88
209_A 247_V 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j72A20.98891000.142Contact Map0.722
4dx5A30.215.50.969Contact Map0.67
3aqpA20.169415.30.969Contact Map0.077
2ls4A10.06676.60.974Contact Map0.728
3w9iA60.18065.70.975Contact Map0.745
4k0jA60.183350.976Contact Map0.543
1ldfA10.19173.60.977Contact Map0.293
3ux4A30.25833.20.978Contact Map0.113
1tlqA10.18062.10.98Contact Map0.202
4bwzA10.17781.70.981Contact Map0.485
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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