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OPENSEQ.org
REP - ATP-dependent DNA helicase rep
UniProt: P09980 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10837
Length: 673 (638)
Sequences: 5053
Seq/Len: 7.92
REP
Paralog alert: 0.89 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: REP UVRD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
557_L 599_G 4.945 1.00
49_H 209_R 4.282 1.00
327_V 571_V 4.263 1.00
367_I 552_V 4.227 1.00
573_M 609_F 3.95 1.00
330_E 333_A 3.63 1.00
8_Q 12_E 3.488 1.00
575_E 628_R 3.395 1.00
195_Q 225_E 3.354 1.00
344_D 566_P 3.351 1.00
566_P 605_K 3.292 1.00
4_N 277_Y 3.28 1.00
570_M 599_G 3.246 1.00
9_Q 269_K 3.209 1.00
566_P 604_Q 3.126 1.00
330_E 569_Y 2.953 1.00
3_L 11_V 2.902 1.00
343_K 550_D 2.712 1.00
335_H 342_Y 2.695 1.00
224_Y 264_D 2.689 1.00
569_Y 608_T 2.647 1.00
341_Q 550_D 2.587 1.00
306_L 605_K 2.576 1.00
192_L 196_R 2.572 1.00
567_Y 606_E 2.522 1.00
281_G 285_K 2.454 1.00
555_M 565_F 2.453 1.00
13_F 18_C 2.443 1.00
402_F 406_V 2.433 1.00
189_L 192_L 2.367 1.00
198_E 201_R 2.358 1.00
88_G 190_P 2.356 1.00
349_Y 554_L 2.325 1.00
347_I 362_L 2.31 1.00
331_L 345_Y 2.308 1.00
6_G 9_Q 2.236 1.00
330_E 608_T 2.232 1.00
170_L 173_A 2.213 1.00
567_Y 608_T 2.178 1.00
462_E 481_G 2.174 1.00
194_L 201_R 2.171 1.00
350_R 592_E 2.152 1.00
342_Y 368_P 2.151 1.00
382_E 504_N 2.146 1.00
228_K 264_D 2.145 1.00
82_S 87_L 2.126 1.00
173_A 177_A 2.114 1.00
46_Q 49_H 2.112 1.00
341_Q 344_D 2.11 1.00
340_T 567_Y 2.076 1.00
256_Q 260_L 2.032 1.00
36_I 52_A 2.029 1.00
18_C 271_I 2.011 1.00
187_I 222_S 2.001 1.00
80_M 208_I 1.974 1.00
334_H 569_Y 1.967 1.00
244_D 297_V 1.949 1.00
174_H 177_A 1.947 1.00
140_S 184_D 1.944 1.00
323_E 610_T 1.942 1.00
123_G 170_L 1.932 1.00
201_R 205_Q 1.922 1.00
175_L 185_D 1.915 1.00
335_H 345_Y 1.902 1.00
557_L 578_L 1.898 1.00
398_D 401_A 1.89 1.00
194_L 229_L 1.876 1.00
91_I 194_L 1.874 1.00
30_R 34_N 1.872 1.00
51_A 211_L 1.866 1.00
286_A 312_L 1.837 1.00
349_Y 355_S 1.821 1.00
332_I 365_N 1.813 1.00
358_F 571_V 1.811 1.00
475_V 512_M 1.8 1.00
120_L 174_H 1.794 1.00
570_M 609_F 1.785 1.00
347_I 358_F 1.773 1.00
62_E 66_R 1.768 1.00
334_H 567_Y 1.755 1.00
328_T 365_N 1.75 1.00
512_M 530_V 1.74 1.00
392_V 405_I 1.737 1.00
515_M 529_Q 1.736 1.00
20_V 238_T 1.736 1.00
211_L 231_V 1.733 1.00
564_E 604_Q 1.732 1.00
24_A 288_N 1.732 1.00
153_A 169_G 1.72 1.00
329_G 365_N 1.72 1.00
181_L 189_L 1.715 1.00
340_T 605_K 1.698 1.00
421_L 432_M 1.679 1.00
477_D 481_G 1.673 1.00
96_Y 181_L 1.666 1.00
225_E 228_K 1.65 1.00
483_D 486_S 1.647 1.00
40_I 71_L 1.645 1.00
116_L 174_H 1.644 1.00
485_E 502_M 1.643 1.00
85_H 186_L 1.637 1.00
593_R 632_E 1.634 1.00
326_R 610_T 1.632 1.00
290_L 600_I 1.631 1.00
169_G 173_A 1.629 1.00
108_F 180_V 1.629 1.00
354_Q 572_G 1.618 1.00
18_C 238_T 1.615 1.00
102_K 179_N 1.587 1.00
314_V 611_L 1.587 1.00
317_A 326_R 1.576 1.00
334_H 345_Y 1.569 1.00
91_I 190_P 1.566 1.00
276_N 279_S 1.563 1.00
626_P 630_L 1.563 1.00
34_N 70_T 1.561 1.00
260_L 264_D 1.555 1.00
95_E 203_R 1.555 1.00
403_L 422_G 1.554 1.00
437_F 461_A 1.55 1.00
325_E 361_F 1.547 1.00
213_V 227_V 1.546 1.00
486_S 489_Y 1.545 1.00
221_T 254_R 1.53 1.00
362_L 554_L 1.526 1.00
596_A 600_I 1.522 1.00
38_H 42_G 1.521 1.00
195_Q 229_L 1.521 1.00
327_V 569_Y 1.518 1.00
191_T 226_L 1.514 1.00
210_Y 236_R 1.509 1.00
275_Q 303_F 1.509 1.00
216_Y 224_Y 1.507 1.00
174_H 178_C 1.496 0.99
284_L 302_L 1.491 0.99
327_V 358_F 1.489 0.99
330_E 334_H 1.487 0.99
386_L 505_V 1.481 0.99
361_F 365_N 1.479 0.99
6_G 275_Q 1.472 0.99
342_Y 345_Y 1.466 0.99
98_A 200_V 1.463 0.99
146_L 222_S 1.459 0.99
567_Y 605_K 1.456 0.99
485_E 506_N 1.452 0.99
328_T 361_F 1.45 0.99
12_E 38_H 1.45 0.99
95_E 204_W 1.447 0.99
275_Q 305_E 1.446 0.99
261_L 268_L 1.445 0.99
198_E 202_K 1.442 0.99
325_E 365_N 1.442 0.99
65_E 69_Q 1.44 0.99
390_L 475_V 1.433 0.99
117_L 136_I 1.426 0.99
286_A 600_I 1.422 0.99
96_Y 99_L 1.418 0.99
466_L 477_D 1.412 0.99
148_T 151_Q 1.411 0.99
334_H 606_E 1.405 0.99
204_W 208_I 1.399 0.99
191_T 225_E 1.399 0.99
382_E 501_R 1.394 0.99
202_K 206_N 1.39 0.99
600_I 607_L 1.386 0.99
484_Y 488_L 1.381 0.99
235_A 267_A 1.38 0.99
123_G 174_H 1.376 0.99
392_V 402_F 1.375 0.99
315_L 326_R 1.371 0.99
202_K 205_Q 1.37 0.99
334_H 340_T 1.37 0.99
316_S 611_L 1.37 0.99
172_D 175_L 1.368 0.99
39_L 45_Y 1.364 0.99
99_L 193_L 1.362 0.99
470_E 473_A 1.356 0.99
313_K 606_E 1.354 0.99
260_L 263_Q 1.354 0.99
36_I 67_V 1.353 0.99
170_L 174_H 1.351 0.99
119_E 174_H 1.348 0.99
37_A 70_T 1.346 0.99
16_G 236_R 1.34 0.99
557_L 570_M 1.334 0.99
101_M 181_L 1.334 0.99
349_Y 571_V 1.333 0.99
36_I 50_I 1.324 0.98
448_R 452_A 1.321 0.98
92_I 190_P 1.32 0.98
419_K 423_E 1.314 0.98
291_I 294_N 1.313 0.98
334_H 608_T 1.31 0.98
407_N 411_R 1.306 0.98
39_L 210_Y 1.303 0.98
5_P 8_Q 1.302 0.98
171_Y 182_D 1.302 0.98
573_M 596_A 1.3 0.98
313_K 330_E 1.298 0.98
293_N 632_E 1.295 0.98
310_A 606_E 1.289 0.98
281_G 307_G 1.288 0.98
289_I 634_P 1.28 0.98
91_I 204_W 1.268 0.98
340_T 345_Y 1.266 0.98
328_T 552_V 1.261 0.98
87_L 204_W 1.26 0.98
9_Q 12_E 1.259 0.98
67_V 81_I 1.256 0.98
361_F 364_Q 1.244 0.97
87_L 91_I 1.241 0.97
114_L 132_L 1.24 0.97
476_R 509_F 1.234 0.97
54_T 59_A 1.233 0.97
51_A 208_I 1.229 0.97
150_S 169_G 1.228 0.97
416_A 420_K 1.22 0.97
120_L 124_L 1.218 0.97
181_L 186_L 1.21 0.97
287_A 600_I 1.206 0.97
120_L 170_L 1.203 0.97
101_M 189_L 1.197 0.97
393_L 478_L 1.185 0.96
197_N 200_V 1.18 0.96
117_L 167_C 1.18 0.96
10_A 20_V 1.179 0.96
91_I 193_L 1.179 0.96
318_N 322_H 1.179 0.96
485_E 489_Y 1.168 0.96
530_V 534_F 1.167 0.96
13_F 16_G 1.157 0.96
35_K 238_T 1.154 0.96
139_I 143_K 1.154 0.96
262_S 270_V 1.152 0.96
98_A 199_E 1.152 0.96
85_H 187_I 1.15 0.95
282_R 312_L 1.149 0.95
124_L 170_L 1.146 0.95
317_A 610_T 1.143 0.95
405_I 456_F 1.143 0.95
335_H 341_Q 1.141 0.95
215_E 561_K 1.141 0.95
166_H 169_G 1.139 0.95
323_E 572_G 1.138 0.95
5_P 9_Q 1.13 0.95
385_D 404_R 1.125 0.95
95_E 98_A 1.123 0.95
94_R 207_K 1.121 0.95
144_N 184_D 1.118 0.94
346_A 565_F 1.114 0.94
333_A 338_N 1.113 0.94
262_S 298_F 1.109 0.94
331_L 569_Y 1.109 0.94
158_G 161_D 1.105 0.94
331_L 552_V 1.102 0.94
246_S 249_S 1.102 0.94
386_L 508_L 1.1 0.94
424_W 438_D 1.096 0.94
388_A 404_R 1.096 0.94
187_I 226_L 1.094 0.94
423_E 427_T 1.094 0.94
386_L 475_V 1.092 0.94
597_Y 601_T 1.091 0.93
402_F 436_S 1.088 0.93
609_F 630_L 1.088 0.93
21_L 243_D 1.088 0.93
633_L 637_D 1.088 0.93
2_R 34_N 1.086 0.93
98_A 197_N 1.084 0.93
191_T 195_Q 1.083 0.93
219_T 257_N 1.076 0.93
191_T 229_L 1.075 0.93
461_A 464_Q 1.069 0.93
297_V 300_K 1.069 0.93
13_F 269_K 1.068 0.93
345_Y 569_Y 1.066 0.92
190_P 226_L 1.061 0.92
211_L 230_L 1.058 0.92
15_T 210_Y 1.048 0.92
555_M 560_S 1.048 0.92
454_T 458_H 1.045 0.91
458_H 462_E 1.041 0.91
282_R 637_D 1.038 0.91
246_S 253_A 1.035 0.91
428_R 438_D 1.032 0.91
106_S 112_D 1.031 0.91
290_L 596_A 1.03 0.91
396_P 464_Q 1.027 0.90
33_T 67_V 1.027 0.90
598_V 602_R 1.027 0.90
58_K 62_E 1.026 0.90
61_R 64_K 1.023 0.90
243_D 300_K 1.022 0.90
370_K 551_Q 1.022 0.90
143_K 172_D 1.022 0.90
212_L 238_T 1.02 0.90
143_K 185_D 1.02 0.90
455_R 458_H 1.017 0.90
345_Y 567_Y 1.017 0.90
391_R 398_D 1.016 0.90
24_A 597_Y 1.012 0.90
536_L 540_M 1.012 0.90
172_D 176_K 1.009 0.89
205_Q 233_S 1.007 0.89
462_E 466_L 1.003 0.89
117_L 139_I 1.002 0.89
80_M 90_D 1.001 0.89
255_P 258_L 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4c2tA40.98511000.143Contact Map0.852
1pjrA10.98811000.151Contact Map0.857
1uaaA211000.156Contact Map0.802
4c2uA20.9511000.222Contact Map0.833
3lfuA10.94651000.224Contact Map0.795
3u4qA10.98221000.231Contact Map0.76
1w36B20.93911000.301Contact Map0.732
3u4qB10.93461000.347Contact Map0.675
4b3fX10.62411000.65Contact Map0.532
2wjyA10.61961000.678Contact Map0.612
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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