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OPENSEQ.org
PT1 - Phosphoenolpyruvate-protein phosphotransferase
UniProt: P08839 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10789
Length: 575 (569)
Sequences: 2215
Seq/Len: 3.89
PT1
Paralog alert: 0.54 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PT1 PT1P PTFX1 PTFX2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
486_K 490_D 5.236 1.00
400_R 445_E 4.848 1.00
178_G 220_L 4.837 1.00
314_F 383_F 3.497 1.00
105_H 109_E 3.383 1.00
324_C 329_V 3.025 1.00
436_A 484_L 2.887 1.00
377_I 386_L 2.868 1.00
155_E 177_L 2.853 1.00
492_S 499_T 2.775 1.00
414_R 420_F 2.77 1.00
357_W 365_D 2.714 1.00
493_H 521_D 2.687 1.00
42_R 101_D 2.627 1.00
232_T 235_V 2.616 1.00
409_Y 412_E 2.501 1.00
447_D 494_A 2.497 1.00
44_L 90_I 2.495 1.00
403_R 445_E 2.491 1.00
501_M 515_L 2.475 1.00
282_E 286_R 2.462 1.00
321_A 386_L 2.457 1.00
501_M 520_L 2.444 1.00
284_A 289_A 2.355 1.00
371_R 408_I 2.346 1.00
117_E 120_D 2.292 1.00
318_K 322_E 2.272 1.00
43_F 89_I 2.259 1.00
314_F 379_R 2.23 1.00
212_V 229_V 2.221 1.00
371_R 409_Y 2.207 1.00
488_V 499_T 2.193 1.00
304_R 312_E 2.168 1.00
541_N 544_D 2.165 1.00
360_I 393_I 2.135 1.00
483_N 491_A 2.127 1.00
390_F 406_I 2.103 1.00
264_L 541_N 2.099 1.00
374_L 406_I 2.092 1.00
16_A 218_L 2.076 1.00
269_V 516_L 2.069 1.00
439_A 491_A 2.06 1.00
512_T 533_I 2.053 1.00
40_V 94_K 2.047 1.00
437_T 484_L 2.043 1.00
432_T 459_Y 2.039 1.00
430_V 435_A 2.033 1.00
390_F 402_L 2.029 1.00
219_I 239_M 1.997 1.00
285_E 327_Q 1.976 1.00
363_A 370_L 1.974 1.00
328_A 387_R 1.935 1.00
403_R 407_E 1.931 1.00
273_A 284_A 1.927 1.00
159_V 218_L 1.925 1.00
50_A 140_N 1.923 1.00
112_A 252_E 1.918 1.00
216_D 230_N 1.914 1.00
273_A 289_A 1.912 1.00
475_Q 562_M 1.902 1.00
314_F 318_K 1.895 1.00
208_V 212_V 1.893 1.00
267_H 542_F 1.851 1.00
552_A 564_L 1.833 1.00
320_V 329_V 1.829 1.00
360_I 402_L 1.823 1.00
399_V 446_V 1.817 1.00
202_I 222_A 1.812 1.00
157_I 218_L 1.803 0.99
460_T 484_L 1.793 0.99
485_I 518_M 1.791 0.99
440_R 483_N 1.786 0.99
261_A 534_K 1.77 0.99
371_R 405_E 1.758 0.99
394_I 432_T 1.748 0.99
387_R 425_E 1.744 0.99
520_L 523_F 1.742 0.99
259_L 538_R 1.742 0.99
333_T 363_A 1.731 0.99
144_L 154_D 1.731 0.99
180_I 220_L 1.728 0.99
330_I 500_G 1.719 0.99
16_A 212_V 1.709 0.99
37_D 94_K 1.705 0.99
507_G 525_M 1.703 0.99
338_G 354_F 1.701 0.99
414_R 422_E 1.686 0.99
407_E 410_K 1.665 0.99
51_S 81_E 1.652 0.99
407_E 411_Q 1.622 0.99
93_I 100_A 1.619 0.99
217_Y 236_I 1.616 0.99
267_H 521_D 1.615 0.99
489_I 499_T 1.613 0.99
108_I 134_G 1.609 0.99
435_A 442_L 1.609 0.99
549_A 552_A 1.569 0.98
390_F 403_R 1.551 0.98
115_L 118_L 1.537 0.98
300_L 316_A 1.531 0.98
243_Q 247_A 1.53 0.98
364_M 401_A 1.508 0.98
461_L 481_V 1.497 0.97
555_Q 564_L 1.493 0.97
440_R 491_A 1.488 0.97
321_A 377_I 1.485 0.97
370_L 402_L 1.483 0.97
53_Q 140_N 1.481 0.97
241_A 245_Q 1.479 0.97
15_K 154_D 1.477 0.97
331_V 377_I 1.466 0.97
213_K 216_D 1.462 0.97
330_I 498_W 1.455 0.97
322_E 383_F 1.448 0.97
318_K 383_F 1.437 0.96
112_A 116_E 1.436 0.96
310_E 379_R 1.431 0.96
548_L 564_L 1.42 0.96
244_E 248_S 1.419 0.96
295_Y 320_V 1.417 0.96
41_E 45_S 1.413 0.96
408_I 412_E 1.408 0.96
315_A 319_A 1.407 0.96
406_I 426_I 1.406 0.96
309_T 312_E 1.406 0.96
104_A 137_L 1.402 0.96
513_L 540_T 1.401 0.96
396_V 445_E 1.397 0.96
39_E 100_A 1.397 0.96
281_V 284_A 1.397 0.96
202_I 227_V 1.381 0.95
443_A 449_F 1.374 0.95
432_T 462_A 1.374 0.95
500_G 522_E 1.37 0.95
451_I 488_V 1.37 0.95
514_L 518_M 1.37 0.95
438_I 442_L 1.37 0.95
401_A 404_K 1.364 0.95
405_E 408_I 1.358 0.95
489_I 520_L 1.353 0.95
546_K 550_E 1.351 0.94
33_A 38_Q 1.348 0.94
379_R 413_L 1.346 0.94
441_H 479_P 1.346 0.94
281_V 285_E 1.345 0.94
251_A 254_A 1.345 0.94
40_V 90_I 1.343 0.94
92_L 96_K 1.342 0.94
116_E 131_R 1.34 0.94
451_I 485_I 1.331 0.94
440_R 494_A 1.324 0.94
411_Q 415_D 1.321 0.94
256_L 538_R 1.318 0.93
271_V 530_I 1.318 0.93
428_V 442_L 1.315 0.93
557_T 560_E 1.311 0.93
54_L 77_I 1.308 0.93
236_I 240_R 1.303 0.93
311_E 315_A 1.302 0.93
289_A 530_I 1.299 0.93
278_V 316_A 1.297 0.93
252_E 255_K 1.296 0.93
505_L 511_A 1.296 0.93
555_Q 561_L 1.293 0.93
42_R 141_I 1.289 0.92
272_C 291_G 1.282 0.92
512_T 537_I 1.276 0.92
425_E 498_W 1.27 0.92
451_I 520_L 1.266 0.92
262_I 268_Q 1.264 0.91
378_L 406_I 1.263 0.91
310_E 375_R 1.26 0.91
486_K 517_G 1.255 0.91
126_R 129_D 1.251 0.91
439_A 443_A 1.249 0.91
542_F 546_K 1.248 0.91
489_I 523_F 1.247 0.91
485_I 515_L 1.242 0.90
371_R 412_E 1.241 0.90
400_R 403_R 1.238 0.90
540_T 545_A 1.238 0.90
375_R 416_E 1.237 0.90
396_V 400_R 1.234 0.90
52_A 55_E 1.233 0.90
404_K 408_I 1.233 0.90
125_E 253_L 1.232 0.90
308_P 340_K 1.227 0.90
234_E 238_K 1.222 0.90
161_A 183_A 1.22 0.89
485_I 488_V 1.214 0.89
157_I 220_L 1.209 0.89
267_H 290_E 1.2 0.88
182_D 209_T 1.195 0.88
261_A 531_P 1.184 0.87
180_I 205_T 1.184 0.87
513_L 545_A 1.181 0.87
43_F 47_R 1.175 0.87
179_F 194_A 1.171 0.87
378_L 410_K 1.17 0.87
268_Q 516_L 1.168 0.87
272_C 522_E 1.166 0.86
544_D 547_V 1.159 0.86
319_A 323_A 1.158 0.86
365_D 469_M 1.155 0.86
6_L 222_A 1.155 0.86
501_M 523_F 1.149 0.85
517_G 549_A 1.149 0.85
548_L 551_Q 1.149 0.85
270_E 290_E 1.145 0.85
88_E 107_V 1.144 0.85
394_I 434_A 1.143 0.85
405_E 409_Y 1.142 0.85
563_T 567_K 1.139 0.85
441_H 483_N 1.138 0.85
180_I 227_V 1.13 0.84
162_D 190_T 1.122 0.83
291_G 328_A 1.12 0.83
403_R 447_D 1.113 0.83
117_E 123_L 1.109 0.82
92_L 106_E 1.109 0.82
14_G 177_L 1.107 0.82
161_A 182_D 1.105 0.82
16_A 159_V 1.093 0.81
439_A 449_F 1.089 0.81
118_L 266_G 1.088 0.81
507_G 529_S 1.088 0.81
551_Q 564_L 1.087 0.81
330_I 448_F 1.079 0.80
304_R 308_P 1.077 0.80
58_K 74_E 1.077 0.80
292_V 324_C 1.077 0.80
79_L 130_V 1.075 0.80
200_P 308_P 1.075 0.80
159_V 180_I 1.075 0.80
163_L 179_F 1.072 0.79
525_M 530_I 1.067 0.79
168_T 197_L 1.066 0.79
268_Q 290_E 1.066 0.79
260_P 268_Q 1.065 0.79
272_C 387_R 1.058 0.78
13_F 236_I 1.057 0.78
281_V 324_C 1.057 0.78
460_T 481_V 1.054 0.78
132_D 166_S 1.054 0.78
330_I 387_R 1.051 0.77
410_K 420_F 1.049 0.77
301_F 313_Q 1.049 0.77
312_E 340_K 1.048 0.77
461_L 478_S 1.047 0.77
15_K 155_E 1.046 0.77
326_S 385_K 1.042 0.77
428_V 446_V 1.039 0.76
516_L 537_I 1.037 0.76
13_F 219_I 1.037 0.76
485_I 520_L 1.035 0.76
350_E 467_N 1.035 0.76
518_M 549_A 1.033 0.76
367_R 401_A 1.033 0.76
2_I 205_T 1.027 0.75
444_K 495_E 1.026 0.75
516_L 523_F 1.023 0.75
168_T 201_A 1.022 0.75
390_F 426_I 1.021 0.75
547_V 551_Q 1.02 0.74
307_L 345_M 1.016 0.74
438_I 483_N 1.009 0.73
430_V 492_S 1.009 0.73
272_C 498_W 1.009 0.73
288_G 534_K 1.007 0.73
370_L 405_E 1.006 0.73
543_E 546_K 1.003 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hwgA211000.198Contact Map0.814
2wqdA10.98781000.207Contact Map0.722
1kblA10.89741000.38Contact Map0.638
1vbgA10.89221000.382Contact Map0.65
1h6zA10.921000.389Contact Map0.583
2olsA10.84521000.486Contact Map0.632
2xz9A20.56351000.565Contact Map0.827
1zymA20.44871000.679Contact Map0.828
3qqwA60.50781000.791Contact Map0.427
1izcA10.50961000.812Contact Map0.457
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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