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OPENSEQ.org
IDH - Isocitrate dehydrogenase [NADP]
UniProt: P08200 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10489
Length: 416 (369)
Sequences: 3158
Seq/Len: 8.56
IDH
Paralog alert: 0.65 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DMLA IDH LEU3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
211_R 252_E 4.442 1.00
86_A 90_D 3.508 1.00
210_V 245_G 3.457 1.00
47_K 410_D 3.223 1.00
218_I 255_G 3.213 1.00
44_A 409_G 3.131 1.00
284_A 288_Q 3.034 1.00
203_E 207_K 2.857 1.00
382_G 415_N 2.848 1.00
218_I 274_E 2.743 1.00
211_R 215_E 2.705 1.00
369_W 372_A 2.655 1.00
50_D 65_W 2.625 1.00
365_R 377_V 2.544 1.00
410_D 414_E 2.525 1.00
28_I 64_S 2.475 1.00
386_A 415_N 2.47 1.00
42_T 356_I 2.445 1.00
411_A 414_E 2.441 1.00
82_V 86_A 2.336 1.00
93_R 122_L 2.314 1.00
44_A 47_K 2.303 1.00
226_T 278_K 2.261 1.00
365_R 374_D 2.242 1.00
357_I 412_I 2.239 1.00
69_Y 77_V 2.201 1.00
31_Y 46_L 2.18 1.00
207_K 247_Q 2.142 1.00
349_D 406_S 2.114 1.00
354_G 412_I 2.113 1.00
46_L 67_E 2.1 1.00
30_P 91_L 2.073 1.00
90_D 94_E 2.07 1.00
57_Y 375_L 2.064 1.00
74_S 85_P 2.051 1.00
383_A 415_N 2.038 1.00
349_D 404_K 2.021 1.00
394_E 402_L 2.019 1.00
374_D 378_K 2.018 1.00
39_V 43_P 2.006 1.00
210_V 300_A 1.988 1.00
207_K 244_W 1.983 1.00
150_V 216_Y 1.956 1.00
227_L 245_G 1.952 1.00
228_V 285_F 1.928 1.00
292_R 295_E 1.91 1.00
413_I 416_M 1.907 1.00
215_E 253_F 1.883 1.00
245_G 277_I 1.882 1.00
404_K 407_E 1.865 1.00
361_E 377_V 1.848 1.00
68_I 91_L 1.832 1.00
370_T 374_D 1.788 1.00
224_S 278_K 1.777 1.00
93_R 121_E 1.765 1.00
47_K 413_I 1.743 1.00
207_K 211_R 1.721 1.00
37_I 351_V 1.711 1.00
378_K 382_G 1.7 1.00
358_L 380_M 1.697 1.00
203_E 247_Q 1.684 1.00
248_L 252_E 1.683 1.00
409_G 413_I 1.675 1.00
92_I 98_A 1.672 1.00
349_D 405_C 1.663 1.00
49_V 63_I 1.654 1.00
128_L 150_V 1.653 1.00
89_L 121_E 1.64 1.00
290_L 312_A 1.616 1.00
240_A 244_W 1.609 1.00
388_T 411_A 1.597 1.00
246_Y 279_D 1.597 1.00
215_E 219_A 1.591 1.00
32_I 70_T 1.581 1.00
30_P 95_Y 1.571 1.00
210_V 248_L 1.568 1.00
225_V 277_I 1.55 1.00
244_W 247_Q 1.544 1.00
365_R 373_A 1.532 1.00
69_Y 78_Y 1.508 1.00
117_A 121_E 1.507 1.00
84_L 89_L 1.5 1.00
222_R 297_D 1.495 1.00
211_R 253_F 1.493 1.00
247_Q 251_E 1.47 1.00
383_A 411_A 1.467 0.99
223_D 297_D 1.46 0.99
45_M 360_A 1.444 0.99
215_E 218_I 1.438 0.99
51_A 413_I 1.43 0.99
30_P 92_I 1.417 0.99
44_A 349_D 1.415 0.99
152_F 216_Y 1.413 0.99
224_S 276_V 1.405 0.99
177_K 181_E 1.404 0.99
70_T 118_L 1.397 0.99
45_M 356_I 1.395 0.99
65_W 360_A 1.384 0.99
345_Y 351_V 1.378 0.99
227_L 279_D 1.374 0.99
151_I 310_S 1.348 0.99
128_L 152_F 1.335 0.99
48_V 416_M 1.335 0.99
152_F 212_A 1.334 0.99
73_K 77_V 1.313 0.99
350_K 391_Y 1.306 0.99
206_T 210_V 1.3 0.99
30_P 68_I 1.29 0.98
199_K 302_M 1.282 0.98
280_V 284_A 1.281 0.98
280_V 288_Q 1.276 0.98
364_L 372_A 1.267 0.98
349_D 407_E 1.267 0.98
243_D 247_Q 1.266 0.98
214_I 275_I 1.259 0.98
231_G 242_K 1.259 0.98
132_R 148_D 1.253 0.98
408_F 412_I 1.25 0.98
78_Y 82_V 1.25 0.98
66_M 94_E 1.249 0.98
46_L 50_D 1.247 0.98
288_Q 295_E 1.246 0.98
74_S 78_Y 1.245 0.98
211_R 248_L 1.244 0.98
136_G 385_N 1.241 0.98
90_D 93_R 1.23 0.98
214_I 225_V 1.224 0.98
365_R 370_T 1.223 0.98
203_E 244_W 1.216 0.97
201_C 302_M 1.213 0.97
354_G 408_F 1.212 0.97
47_K 409_G 1.204 0.97
214_I 249_A 1.199 0.97
135_Q 385_N 1.198 0.97
280_V 296_Y 1.189 0.97
155_N 327_N 1.185 0.97
151_I 313_L 1.184 0.97
69_Y 74_S 1.179 0.97
66_M 95_Y 1.178 0.97
45_M 99_I 1.177 0.97
159_I 302_M 1.174 0.97
132_R 381_E 1.173 0.97
407_E 410_D 1.167 0.96
388_T 403_L 1.164 0.96
345_Y 391_Y 1.162 0.96
146_L 294_A 1.159 0.96
286_L 309_I 1.159 0.96
85_P 88_T 1.153 0.96
217_A 225_V 1.15 0.96
52_A 376_I 1.144 0.96
361_E 365_R 1.139 0.96
33_E 67_E 1.133 0.96
218_I 275_I 1.13 0.96
216_Y 220_N 1.123 0.95
66_M 91_L 1.122 0.95
149_M 289_I 1.121 0.95
87_E 90_D 1.114 0.95
48_V 376_I 1.112 0.95
27_P 369_W 1.104 0.95
278_K 295_E 1.103 0.95
228_V 282_A 1.093 0.94
72_E 76_Q 1.092 0.94
49_V 360_A 1.088 0.94
123_D 208_R 1.083 0.94
394_E 400_A 1.083 0.94
207_K 248_L 1.08 0.94
204_E 207_K 1.071 0.94
74_S 88_T 1.065 0.93
61_R 369_W 1.061 0.93
364_L 376_I 1.059 0.93
286_L 312_A 1.048 0.93
47_K 406_S 1.047 0.93
126_I 209_L 1.046 0.93
344_K 391_Y 1.045 0.92
375_L 416_M 1.045 0.92
403_L 411_A 1.038 0.92
231_G 281_I 1.038 0.92
360_A 363_M 1.035 0.92
225_V 275_I 1.034 0.92
102_P 339_H 1.034 0.92
350_K 402_L 1.033 0.92
41_V 356_I 1.032 0.92
99_I 360_A 1.029 0.92
45_M 49_V 1.027 0.92
363_M 367_M 1.019 0.91
225_V 298_V 1.018 0.91
48_V 357_I 1.018 0.91
345_Y 350_K 1.009 0.91
63_I 360_A 1.008 0.91
213_A 300_A 1.006 0.90
214_I 253_F 1.005 0.90
282_A 302_M 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dmsA10.99521000.096Contact Map0.767
2d4vA40.99521000.097Contact Map0.792
2iv0A20.97841000.109Contact Map0.818
2e0cA20.9761000.113Contact Map0.819
1tyoA20.98561000.113Contact Map0.783
1hqsA20.97841000.117Contact Map0.769
3flkA40.82691000.184Contact Map0.767
2d1cA20.84861000.187Contact Map0.807
1a05A20.82451000.19Contact Map0.784
3u1hA20.86781000.192Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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