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OPENSEQ.org
DHSB - Succinate dehydrogenase iron-sulfur subunit
UniProt: P07014 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10932
Length: 238 (234)
Sequences: 1382
Seq/Len: 5.91
DHSB
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DHSB FRDB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
4_E 24_T 3.849 1.00
41_Q 45_K 3.514 1.00
40_I 51_F 3.476 1.00
2_R 26_E 3.303 1.00
5_F 38_A 3.205 1.00
21_Q 46_D 2.918 1.00
6_S 90_V 2.811 1.00
118_K 122_L 2.774 1.00
6_S 22_D 2.731 1.00
50_S 104_V 2.583 1.00
11_N 14_V 2.488 1.00
182_L 229_I 2.401 1.00
110_F 153_A 2.153 1.00
228_H 231_S 2.082 1.00
182_L 232_M 2.081 1.00
122_L 189_E 2.061 1.00
65_L 74_A 2 1.00
38_A 79_I 1.955 1.00
71_N 158_S 1.945 1.00
175_L 229_I 1.898 1.00
6_S 87_K 1.892 1.00
118_K 192_S 1.873 1.00
25_L 42_L 1.867 1.00
5_F 42_L 1.851 1.00
146_L 225_A 1.76 1.00
123_N 188_T 1.73 1.00
2_R 24_T 1.702 1.00
210_M 222_P 1.602 0.99
4_E 22_D 1.574 0.99
39_L 65_L 1.569 0.99
124_N 188_T 1.565 0.99
35_L 67_M 1.555 0.99
160_P 209_I 1.545 0.99
72_G 77_T 1.515 0.99
137_P 141_E 1.512 0.99
175_L 197_L 1.506 0.99
125_G 188_T 1.488 0.99
31_R 41_Q 1.44 0.99
176_L 220_L 1.433 0.98
11_N 19_R 1.424 0.98
123_N 133_H 1.423 0.98
171_G 225_A 1.4 0.98
1_M 29_E 1.383 0.98
179_Y 183_I 1.376 0.98
191_D 195_D 1.364 0.98
16_D 19_R 1.356 0.98
26_E 41_Q 1.348 0.98
139_Q 185_S 1.313 0.97
40_I 44_E 1.272 0.96
6_S 20_M 1.265 0.96
83_N 86_G 1.263 0.96
110_F 156_S 1.263 0.96
64_G 116_K 1.261 0.96
129_P 132_E 1.26 0.96
142_K 228_H 1.257 0.96
197_L 200_A 1.255 0.96
7_I 49_L 1.246 0.96
211_N 215_V 1.239 0.95
113_Q 197_L 1.233 0.95
170_I 174_G 1.22 0.95
3_L 79_I 1.217 0.95
135_Q 185_S 1.21 0.95
213_V 223_T 1.201 0.94
23_Y 47_P 1.196 0.94
169_F 183_I 1.183 0.94
176_L 225_A 1.164 0.93
59_V 76_I 1.152 0.92
5_F 89_I 1.141 0.92
213_V 221_N 1.141 0.92
52_R 62_S 1.136 0.92
113_Q 201_F 1.135 0.92
49_L 103_L 1.117 0.91
8_Y 18_P 1.112 0.91
4_E 87_K 1.108 0.90
196_G 202_S 1.102 0.90
190_T 232_M 1.098 0.90
110_F 174_G 1.095 0.90
10_Y 14_V 1.09 0.89
97_L 107_M 1.087 0.89
5_F 35_L 1.079 0.89
14_V 101_R 1.077 0.89
8_Y 20_M 1.077 0.89
25_L 38_A 1.072 0.88
3_L 38_A 1.071 0.88
92_R 215_V 1.07 0.88
67_M 72_G 1.069 0.88
82_L 89_I 1.068 0.88
27_A 38_A 1.067 0.88
67_M 74_A 1.062 0.88
11_N 16_D 1.059 0.87
112_A 115_E 1.059 0.87
147_Y 153_A 1.043 0.86
71_N 211_N 1.041 0.86
32_D 129_P 1.04 0.86
63_D 96_G 1.04 0.86
23_Y 97_L 1.037 0.86
195_D 198_S 1.021 0.85
8_Y 92_R 1.02 0.85
25_L 41_Q 1.016 0.84
206_C 212_C 1.011 0.84
145_G 148_E 1.008 0.84
7_I 65_L 1.006 0.84
66_N 209_I 1.004 0.83
124_N 192_S 1.004 0.83
20_M 92_R 1 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwlA10.82351000.355Contact Map0.597
3vr8B20.98321000.406Contact Map0.688
2h88B20.98321000.416Contact Map0.717
2wdqB30.98741000.417Contact Map0.694
1kf6B20.97481000.422Contact Map0.641
2bs2B20.9791000.448Contact Map0.678
3i9v320.844599.90.748Contact Map0.351
3c8yA10.857199.80.757Contact Map0.328
1ffvA20.672399.80.759Contact Map0.536
1t3qA20.668199.80.774Contact Map0.452
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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