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OPENSEQ.org
PABB - Para-aminobenzoate synthase component 1
UniProt: P05041 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10683
Length: 453 (442)
Sequences: 2759
Seq/Len: 6.24
PABB
Paralog alert: 0.54 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PABB TRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
318_A 346_A 4.475 1.00
319_V 347_Q 4.284 1.00
367_I 391_C 4.212 1.00
84_Q 353_H 4.095 1.00
319_V 350_E 3.289 1.00
277_L 292_K 3.242 1.00
190_R 194_G 3.102 1.00
203_Y 208_D 2.929 1.00
326_P 345_T 2.895 1.00
203_Y 381_E 2.827 1.00
193_Y 425_G 2.68 1.00
267_E 345_T 2.661 1.00
78_D 359_R 2.629 1.00
333_P 338_H 2.51 1.00
32_M 50_V 2.504 1.00
112_Y 376_M 2.494 1.00
374_R 377_E 2.481 1.00
432_Q 435_A 2.476 1.00
395_G 405_T 2.45 1.00
202_E 206_S 2.421 1.00
327_E 330_V 2.392 1.00
349_P 352_L 2.327 1.00
252_I 389_A 2.289 1.00
219_H 418_Q 2.287 1.00
276_T 337_V 2.282 1.00
78_D 81_Q 2.215 1.00
291_V 295_N 2.211 1.00
194_G 434_E 2.209 1.00
219_H 420_F 2.199 1.00
314_I 318_A 2.185 1.00
290_A 333_P 2.164 1.00
364_G 407_I 2.154 1.00
287_S 290_A 2.142 1.00
195_E 198_R 2.136 1.00
190_R 434_E 2.135 1.00
200_V 212_V 2.12 1.00
324_K 345_T 2.109 1.00
22_F 31_A 2.102 1.00
317_V 360_A 2.054 1.00
243_A 254_S 2.002 1.00
287_S 291_V 1.984 1.00
188_M 196_K 1.982 1.00
266_S 347_Q 1.94 1.00
296_S 299_D 1.936 1.00
243_A 394_I 1.929 1.00
211_Q 426_G 1.928 1.00
259_R 404_D 1.915 1.00
214_L 425_G 1.908 1.00
378_I 382_L 1.886 1.00
221_T 418_Q 1.883 1.00
189_T 192_Q 1.876 1.00
279_R 286_D 1.864 1.00
273_I 341_V 1.859 1.00
374_R 381_E 1.842 1.00
45_R 146_D 1.828 1.00
200_V 214_L 1.799 1.00
209_C 375_A 1.795 1.00
127_Q 130_V 1.783 1.00
288_K 292_K 1.768 1.00
271_R 332_E 1.767 1.00
332_E 341_V 1.765 1.00
352_L 356_D 1.756 1.00
270_T 310_M 1.754 1.00
331_V 340_L 1.753 1.00
48_I 144_I 1.749 1.00
226_E 251_A 1.743 1.00
285_E 288_K 1.734 1.00
203_Y 378_I 1.714 1.00
209_C 212_V 1.704 1.00
216_Q 440_T 1.699 1.00
294_A 340_L 1.687 1.00
315_G 321_G 1.665 1.00
203_Y 374_R 1.635 1.00
267_E 347_Q 1.611 1.00
414_A 419_I 1.606 1.00
389_A 408_T 1.606 1.00
113_D 380_D 1.598 1.00
192_Q 384_P 1.592 0.99
198_R 201_Q 1.589 0.99
197_F 433_E 1.579 0.99
214_L 427_I 1.577 0.99
246_R 251_A 1.576 0.99
225_D 228_Q 1.562 0.99
280_L 285_E 1.532 0.99
110_F 114_L 1.515 0.99
106_A 138_I 1.506 0.99
35_H 234_N 1.504 0.99
32_M 107_L 1.494 0.99
190_R 437_Y 1.484 0.99
187_N 385_Q 1.481 0.99
113_D 386_R 1.47 0.99
437_Y 441_F 1.461 0.99
268_I 314_I 1.458 0.99
215_A 422_S 1.454 0.99
202_E 205_H 1.44 0.99
307_V 328_L 1.432 0.99
438_Q 442_D 1.43 0.99
199_Q 202_E 1.425 0.99
319_V 322_S 1.421 0.99
254_S 406_S 1.405 0.98
35_H 230_F 1.383 0.98
280_L 289_Q 1.38 0.98
253_L 414_A 1.378 0.98
230_F 234_N 1.373 0.98
283_P 287_S 1.363 0.98
435_A 438_Q 1.36 0.98
213_N 424_G 1.353 0.98
113_D 116_R 1.345 0.98
389_A 413_T 1.345 0.98
212_V 379_I 1.342 0.98
244_F 251_A 1.339 0.98
274_K 366_S 1.321 0.97
199_Q 203_Y 1.32 0.97
289_Q 292_K 1.319 0.97
154_L 167_L 1.315 0.97
192_Q 195_E 1.313 0.97
268_I 318_A 1.291 0.97
348_L 357_L 1.29 0.97
282_D 285_E 1.288 0.97
190_R 438_Q 1.288 0.97
229_A 414_A 1.288 0.97
434_E 438_Q 1.284 0.97
227_W 244_F 1.279 0.97
396_Y 404_D 1.278 0.97
131_L 413_T 1.264 0.96
198_R 433_E 1.258 0.96
281_P 285_E 1.252 0.96
53_P 139_Y 1.245 0.96
200_V 209_C 1.245 0.96
423_A 444_V 1.24 0.96
300_R 329_F 1.24 0.96
290_A 338_H 1.239 0.96
304_L 329_F 1.233 0.96
306_I 366_S 1.229 0.96
194_G 198_R 1.227 0.95
274_K 303_N 1.218 0.95
116_R 380_D 1.218 0.95
213_N 391_C 1.217 0.95
319_V 349_P 1.215 0.95
412_L 419_I 1.214 0.95
274_K 306_I 1.197 0.95
154_L 164_R 1.195 0.95
222_Y 414_A 1.193 0.95
124_I 380_D 1.193 0.95
58_T 65_V 1.191 0.94
243_A 252_I 1.181 0.94
220_A 419_I 1.168 0.94
241_F 259_R 1.168 0.94
264_D 402_N 1.163 0.93
278_P 281_P 1.163 0.93
213_N 367_I 1.158 0.93
212_V 378_I 1.153 0.93
271_R 327_E 1.153 0.93
216_Q 437_Y 1.151 0.93
198_R 205_H 1.147 0.93
144_I 155_L 1.147 0.93
154_L 166_W 1.145 0.93
303_N 306_I 1.143 0.93
79_P 134_M 1.142 0.93
358_L 405_T 1.142 0.93
314_I 346_A 1.141 0.93
412_L 447_I 1.14 0.93
265_N 402_N 1.138 0.93
208_D 374_R 1.137 0.92
221_T 417_G 1.136 0.92
243_A 406_S 1.131 0.92
239_A 336_A 1.13 0.92
263_C 357_L 1.126 0.92
193_Y 214_L 1.125 0.92
393_S 405_T 1.123 0.92
194_G 433_E 1.123 0.92
310_M 364_G 1.122 0.92
110_F 134_M 1.113 0.91
226_E 414_A 1.106 0.91
252_I 394_I 1.105 0.91
254_S 394_I 1.105 0.91
309_L 365_G 1.101 0.91
326_P 343_T 1.099 0.91
205_H 429_A 1.098 0.91
191_E 195_E 1.095 0.91
271_R 343_T 1.094 0.90
131_L 389_A 1.094 0.90
118_F 362_F 1.09 0.90
268_I 346_A 1.09 0.90
285_E 289_Q 1.078 0.90
217_R 420_F 1.072 0.89
269_Q 343_T 1.071 0.89
425_G 440_T 1.069 0.89
421_C 444_V 1.069 0.89
398_S 402_N 1.068 0.89
242_S 255_L 1.068 0.89
378_I 381_E 1.066 0.89
304_L 328_L 1.064 0.89
260_F 270_T 1.062 0.89
200_V 427_I 1.056 0.88
222_Y 229_A 1.055 0.88
209_C 378_I 1.053 0.88
119_E 373_V 1.053 0.88
47_D 147_H 1.047 0.88
358_L 397_L 1.046 0.88
303_N 310_M 1.045 0.88
79_P 117_R 1.043 0.87
249_Q 415_I 1.04 0.87
299_D 435_A 1.039 0.87
438_Q 441_F 1.033 0.87
125_A 380_D 1.033 0.87
290_A 331_V 1.033 0.87
293_L 331_V 1.032 0.87
327_E 343_T 1.026 0.86
218_F 448_L 1.025 0.86
201_Q 205_H 1.015 0.85
284_Q 288_K 1.012 0.85
199_Q 381_E 1.011 0.85
277_L 289_Q 1.01 0.85
110_F 397_L 1.009 0.85
303_N 366_S 1.004 0.85
213_N 368_T 1.004 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k0eA20.99781000.125Contact Map0.864
4grhA10.9891000.157Contact Map0.652
1i1qA10.98231000.162Contact Map0.749
1qdlA10.92721000.178Contact Map0.804
3logA40.94921000.227Contact Map0.736
3h9mA10.91831000.229Contact Map0.734
2fn0A20.94481000.277Contact Map0.727
3gseA10.92051000.342Contact Map0.668
3bzmA10.8831000.369Contact Map0.664
3hwoA20.85211000.375Contact Map0.714
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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