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OPENSEQ.org
LIVK - Leucine-specific-binding protein
UniProt: P04816 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10540
Length: 369 (346)
Sequences: 7441
Seq/Len: 21.51
LIVK
Paralog alert: 0.68 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: LIVJ LIVK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_K 68_V 3.736 1.00
25_D 68_V 3.642 1.00
54_K 291_D 3.549 1.00
182_Q 195_F 3.262 1.00
163_R 191_N 3.037 1.00
312_T 315_E 3 1.00
25_D 65_D 2.894 1.00
116_G 136_H 2.743 1.00
46_F 50_R 2.738 1.00
95_Y 310_L 2.732 1.00
56_I 311_A 2.717 1.00
185_L 190_A 2.707 1.00
72_Y 87_K 2.706 1.00
286_D 290_A 2.693 1.00
81_A 104_S 2.668 1.00
283_G 287_A 2.642 1.00
54_K 58_A 2.63 1.00
196_D 211_R 2.623 1.00
75_A 80_Q 2.581 1.00
55_D 287_A 2.507 1.00
312_T 316_R 2.392 1.00
282_Q 286_D 2.335 1.00
29_A 88_I 2.331 1.00
96_V 112_Y 2.263 1.00
289_K 295_P 2.228 1.00
333_G 340_P 2.192 1.00
360_H 366_T 2.171 1.00
182_Q 186_K 2.144 1.00
25_D 66_K 2.124 1.00
321_E 324_A 2.116 1.00
50_R 54_K 2.016 1.00
53_I 307_V 1.942 1.00
335_N 340_P 1.933 1.00
31_V 74_D 1.932 1.00
162_Q 218_D 1.916 1.00
311_A 315_E 1.907 1.00
324_A 327_K 1.897 1.00
156_L 188_A 1.887 1.00
76_C 101_C 1.839 1.00
72_Y 84_V 1.838 1.00
31_V 84_V 1.835 1.00
328_D 331_A 1.812 1.00
116_G 323_L 1.795 1.00
307_V 311_A 1.765 1.00
165_A 194_F 1.756 1.00
55_D 304_Y 1.752 1.00
153_K 157_E 1.744 1.00
153_K 188_A 1.736 1.00
53_I 69_G 1.704 1.00
55_D 308_Q 1.682 1.00
330_K 347_G 1.67 1.00
179_R 183_D 1.636 1.00
186_K 191_N 1.621 1.00
333_G 342_N 1.618 1.00
312_T 332_N 1.61 1.00
184_G 187_A 1.609 1.00
305_A 336_T 1.577 1.00
155_I 246_M 1.572 1.00
56_I 308_Q 1.543 1.00
283_G 286_D 1.535 1.00
87_K 91_D 1.529 1.00
183_D 187_A 1.529 1.00
49_A 307_V 1.526 1.00
77_D 80_Q 1.519 1.00
323_L 327_K 1.508 1.00
168_H 197_G 1.506 1.00
255_S 258_N 1.503 1.00
209_I 239_V 1.468 1.00
138_M 330_K 1.463 1.00
326_V 330_K 1.449 1.00
55_D 59_K 1.449 1.00
47_N 288_L 1.448 1.00
148_G 152_A 1.436 1.00
67_L 311_A 1.43 1.00
161_P 219_F 1.425 1.00
316_R 328_D 1.421 1.00
89_V 117_I 1.412 1.00
327_K 331_A 1.407 0.99
260_A 264_A 1.398 0.99
85_A 112_Y 1.397 0.99
163_R 216_N 1.397 0.99
27_K 70_V 1.394 0.99
47_N 50_R 1.392 0.99
284_I 300_V 1.387 0.99
236_A 241_L 1.379 0.99
164_I 219_F 1.37 0.99
235_Q 238_S 1.362 0.99
277_Q 282_Q 1.359 0.99
165_A 196_D 1.359 0.99
48_G 303_T 1.356 0.99
201_G 228_E 1.351 0.99
57_N 61_G 1.351 0.99
99_H 108_A 1.341 0.99
47_N 292_K 1.337 0.99
52_A 311_A 1.316 0.99
287_A 290_A 1.313 0.99
33_A 74_D 1.312 0.99
30_V 49_A 1.31 0.99
120_I 310_L 1.308 0.99
99_H 105_T 1.3 0.99
139_R 348_D 1.285 0.99
110_D 114_D 1.284 0.99
310_L 314_L 1.28 0.99
52_A 307_V 1.27 0.99
138_M 326_V 1.269 0.99
125_T 144_D 1.256 0.99
209_I 235_Q 1.253 0.99
102_S 126_N 1.246 0.98
161_P 218_D 1.24 0.98
209_I 236_A 1.235 0.98
317_T 328_D 1.232 0.98
175_E 197_G 1.229 0.98
46_F 71_E 1.214 0.98
170_K 199_T 1.212 0.98
49_A 69_G 1.204 0.98
118_L 322_P 1.202 0.98
309_S 329_L 1.2 0.98
163_R 193_V 1.196 0.98
80_Q 83_A 1.195 0.98
90_N 115_E 1.194 0.98
24_D 65_D 1.191 0.98
198_I 224_G 1.186 0.98
170_K 175_E 1.183 0.98
30_V 53_I 1.182 0.98
157_E 188_A 1.172 0.98
72_Y 91_D 1.172 0.98
210_A 214_K 1.171 0.98
149_P 184_G 1.166 0.97
163_R 218_D 1.163 0.97
80_Q 84_V 1.156 0.97
113_E 135_Q 1.148 0.97
247_G 251_V 1.147 0.97
314_L 325_L 1.141 0.97
50_R 71_E 1.141 0.97
286_D 289_K 1.139 0.97
56_I 307_V 1.131 0.97
86_N 90_N 1.127 0.97
180_S 183_D 1.127 0.97
43_D 47_N 1.123 0.97
202_E 208_L 1.118 0.96
56_I 67_L 1.108 0.96
308_Q 311_A 1.104 0.96
280_A 335_N 1.104 0.96
211_R 215_E 1.098 0.96
156_L 190_A 1.096 0.96
136_H 326_V 1.096 0.96
165_A 193_V 1.082 0.96
48_G 300_V 1.071 0.95
89_V 111_I 1.07 0.95
236_A 245_F 1.069 0.95
85_A 96_V 1.068 0.95
72_Y 88_I 1.067 0.95
35_S 73_D 1.059 0.95
70_V 91_D 1.053 0.95
167_I 208_L 1.052 0.95
213_K 241_L 1.05 0.94
165_A 217_I 1.042 0.94
47_N 294_D 1.034 0.94
178_A 182_Q 1.034 0.94
74_D 104_S 1.033 0.94
156_L 162_Q 1.031 0.94
45_E 303_T 1.031 0.94
316_R 332_N 1.026 0.94
154_Y 268_L 1.024 0.93
31_V 108_A 1.024 0.93
185_L 192_V 1.023 0.93
285_V 289_K 1.022 0.93
99_H 119_M 1.02 0.93
50_R 291_D 1.018 0.93
319_S 324_A 1.016 0.93
34_M 71_E 1.013 0.93
51_Q 55_D 1.013 0.93
127_P 145_S 1.012 0.93
31_V 85_A 1.011 0.93
303_T 307_V 1.01 0.93
63_K 315_E 1.01 0.93
49_A 97_I 1.006 0.93
175_E 179_R 1.005 0.93
112_Y 119_M 1.002 0.92
171_Q 174_G 1.001 0.92
52_A 304_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n0qA40.95121000.221Contact Map0.742
3hutA10.9351000.242Contact Map0.683
4gnrA10.92951000.245Contact Map0.725
1usgA10.93771000.247Contact Map0.734
3h5lA20.96481000.252Contact Map0.67
3ipcA10.9351000.252Contact Map0.687
3lkbA20.94311000.256Contact Map0.663
3td9A10.95661000.264Contact Map0.744
3lopA10.9351000.27Contact Map0.715
4mlcA10.94311000.274Contact Map0.717
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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