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OPENSEQ.org
PBPA - Penicillin-binding protein 1A
UniProt: P02918 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10748
Length: 850 (784)
Sequences: 1061
Seq/Len: 1.35
PBPA
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PBPA PBPC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
431_S 780_Y 4.902 1.00
431_S 737_T 4.61 1.00
236_T 239_Q 4.163 1.00
729_S 738_S 3.88 1.00
91_Y 157_D 3.537 1.00
186_K 195_E 3.53 1.00
597_N 601_G 3.466 1.00
237_Q 241_D 3.405 1.00
429_L 737_T 3.347 1.00
76_P 80_K 3.195 1.00
574_A 738_S 3.094 1.00
266_E 269_R 2.969 1.00
194_N 246_E 2.918 1.00
306_N 776_A 2.897 1.00
230_L 240_F 2.86 1.00
473_T 679_L 2.859 1.00
477_D 544_Y 2.747 1.00
71_L 157_D 2.699 1.00
520_G 528_V 2.694 1.00
492_S 503_Q 2.683 1.00
467_I 545_L 2.654 1.00
70_T 73_Q 2.484 1.00
741_I 776_A 2.474 1.00
69_V 188_V 2.439 1.00
737_T 780_Y 2.43 1.00
78_M 196_M 2.415 1.00
230_L 237_Q 2.4 0.99
430_V 571_M 2.376 0.99
507_S 768_G 2.298 0.99
48_M 287_I 2.292 0.99
219_V 223_N 2.288 0.99
527_V 530_V 2.225 0.99
177_G 187_T 2.214 0.99
466_N 573_V 2.199 0.99
242_Q 246_E 2.168 0.99
482_L 682_L 2.151 0.99
74_I 78_M 2.149 0.99
155_T 158_E 2.125 0.98
240_F 244_R 2.105 0.98
266_E 281_Y 2.092 0.98
76_P 79_V 2.086 0.98
168_Y 172_R 2.015 0.98
187_T 190_Q 2.004 0.98
71_L 91_Y 1.976 0.97
226_L 240_F 1.976 0.97
164_L 176_V 1.971 0.97
80_K 234_Y 1.967 0.97
268_V 289_T 1.962 0.97
89_R 97_D 1.951 0.97
85_T 224_V 1.942 0.97
429_L 739_V 1.931 0.97
573_V 729_S 1.876 0.96
305_N 779_A 1.871 0.96
100_G 103_R 1.865 0.96
193_L 235_I 1.858 0.96
726_A 772_S 1.849 0.96
77_E 239_Q 1.845 0.95
84_A 234_Y 1.843 0.95
434_P 736_V 1.84 0.95
198_V 218_A 1.826 0.95
88_S 232_E 1.814 0.95
685_S 688_N 1.804 0.95
511_Y 527_V 1.798 0.95
434_P 735_V 1.786 0.94
77_E 80_K 1.785 0.94
678_P 798_G 1.78 0.94
486_L 517_L 1.751 0.94
193_L 243_T 1.749 0.93
482_L 686_A 1.739 0.93
173_A 182_V 1.735 0.93
522_G 689_T 1.726 0.93
288_Y 594_K 1.714 0.93
684_K 731_Y 1.705 0.92
575_R 586_L 1.701 0.92
52_S 293_R 1.696 0.92
295_V 784_V 1.691 0.92
517_L 532_A 1.69 0.92
230_L 235_I 1.682 0.92
713_I 732_G 1.68 0.92
303_V 427_S 1.679 0.92
463_V 568_F 1.677 0.91
478_K 540_Y 1.674 0.91
438_A 590_W 1.672 0.91
311_D 317_R 1.666 0.91
192_T 246_E 1.665 0.91
440_M 735_V 1.664 0.91
264_L 290_T 1.66 0.91
56_E 293_R 1.645 0.90
297_Q 301_Q 1.639 0.90
689_T 693_G 1.635 0.90
580_M 683_I 1.609 0.89
822_F 828_P 1.607 0.89
691_I 701_G 1.593 0.88
79_V 157_D 1.592 0.88
536_M 540_Y 1.591 0.88
602_V 605_E 1.586 0.88
82_F 176_V 1.562 0.87
473_T 675_I 1.556 0.87
71_L 79_V 1.553 0.87
107_V 116_Q 1.551 0.87
79_V 91_Y 1.534 0.86
777_W 781_M 1.532 0.86
167_I 203_P 1.524 0.85
724_K 746_H 1.521 0.85
103_R 116_Q 1.519 0.85
682_L 799_I 1.514 0.85
168_Y 174_Y 1.511 0.85
681_F 821_Y 1.507 0.84
518_R 685_S 1.507 0.84
177_G 188_V 1.504 0.84
565_S 721_N 1.498 0.84
78_M 176_V 1.498 0.84
522_G 693_G 1.487 0.83
320_A 409_W 1.485 0.83
308_L 446_F 1.479 0.83
433_N 436_N 1.477 0.83
424_E 748_R 1.467 0.82
101_I 123_Q 1.464 0.82
594_K 605_E 1.464 0.82
515_I 525_K 1.458 0.82
239_Q 242_Q 1.446 0.81
227_S 240_F 1.441 0.81
471_L 529_M 1.438 0.80
556_V 566_A 1.437 0.80
77_E 196_M 1.431 0.80
191_L 196_M 1.431 0.80
49_Q 60_Q 1.429 0.80
81_A 229_M 1.425 0.80
3_F 6_Y 1.419 0.79
466_N 729_S 1.416 0.79
116_Q 135_R 1.415 0.79
741_I 773_A 1.415 0.79
469_P 580_M 1.407 0.78
675_I 680_A 1.405 0.78
238_Q 241_D 1.405 0.78
194_N 243_T 1.404 0.78
690_N 699_G 1.402 0.78
272_M 287_I 1.393 0.77
593_S 605_E 1.387 0.77
430_V 570_P 1.386 0.77
52_S 56_E 1.386 0.77
522_G 528_V 1.379 0.76
295_V 440_M 1.377 0.76
228_R 231_D 1.374 0.76
726_A 741_I 1.374 0.76
433_N 440_M 1.373 0.76
737_T 781_M 1.372 0.76
14_C 18_G 1.368 0.76
533_M 541_A 1.364 0.75
71_L 161_E 1.362 0.75
129_F 150_I 1.358 0.75
167_I 206_P 1.357 0.75
673_H 677_T 1.357 0.75
71_L 74_I 1.353 0.74
570_P 738_S 1.35 0.74
128_N 204_K 1.349 0.74
684_K 793_L 1.339 0.73
73_Q 189_D 1.336 0.73
121_I 167_I 1.333 0.73
54_D 293_R 1.332 0.73
313_R 767_E 1.33 0.73
480_L 535_A 1.33 0.73
726_A 770_A 1.328 0.72
176_V 199_I 1.322 0.72
193_L 226_L 1.322 0.72
442_L 454_N 1.317 0.72
307_V 427_S 1.317 0.72
268_V 272_M 1.309 0.71
432_I 574_A 1.307 0.71
529_M 532_A 1.307 0.71
687_L 714_G 1.3 0.70
241_D 245_T 1.3 0.70
811_L 828_P 1.292 0.69
688_N 692_F 1.291 0.69
100_G 118_A 1.282 0.69
432_I 573_V 1.279 0.68
379_V 398_V 1.275 0.68
356_S 363_T 1.274 0.68
377_E 380_R 1.273 0.68
82_F 164_L 1.27 0.68
515_I 520_G 1.269 0.67
485_M 514_P 1.269 0.67
10_L 14_C 1.268 0.67
812_A 815_G 1.266 0.67
574_A 729_S 1.264 0.67
480_L 532_A 1.264 0.67
579_V 674_V 1.263 0.67
129_F 162_L 1.257 0.66
49_Q 286_R 1.255 0.66
481_T 826_T 1.254 0.66
779_A 783_A 1.253 0.66
512_A 525_K 1.253 0.66
543_E 547_R 1.252 0.66
825_G 828_P 1.252 0.66
488_D 512_A 1.251 0.66
78_M 193_L 1.248 0.66
798_G 824_E 1.247 0.65
539_D 557_H 1.243 0.65
484_S 532_A 1.242 0.65
301_Q 783_A 1.238 0.65
12_V 16_L 1.238 0.65
310_Y 314_H 1.234 0.64
314_H 767_E 1.23 0.64
230_L 244_R 1.23 0.64
512_A 515_I 1.229 0.64
24_G 28_Y 1.227 0.64
227_S 244_R 1.226 0.64
53_A 292_T 1.225 0.63
713_I 737_T 1.223 0.63
374_L 402_L 1.223 0.63
137_L 141_I 1.219 0.63
455_R 744_D 1.217 0.63
804_I 822_F 1.217 0.63
352_A 410_V 1.216 0.63
349_L 365_M 1.204 0.61
486_L 528_V 1.202 0.61
805_D 808_T 1.2 0.61
51_Y 286_R 1.199 0.61
225_V 676_N 1.195 0.61
298_A 783_A 1.194 0.61
576_G 733_P 1.194 0.61
214_S 217_R 1.19 0.60
690_N 700_T 1.187 0.60
193_L 196_M 1.187 0.60
267_M 591_F 1.185 0.60
596_E 602_V 1.18 0.59
49_Q 57_L 1.179 0.59
680_A 683_I 1.179 0.59
301_Q 305_N 1.175 0.59
586_L 672_P 1.174 0.59
714_G 731_Y 1.172 0.58
470_F 576_G 1.171 0.58
588_D 609_K 1.167 0.58
741_I 772_S 1.164 0.58
688_N 712_D 1.162 0.57
200_A 203_P 1.148 0.56
352_A 364_A 1.148 0.56
91_Y 118_A 1.146 0.56
459_A 569_T 1.146 0.56
435_Q 734_G 1.145 0.56
217_R 220_A 1.144 0.56
115_S 135_R 1.142 0.55
114_A 118_A 1.141 0.55
675_I 679_L 1.139 0.55
783_A 786_E 1.138 0.55
128_N 167_I 1.137 0.55
580_M 680_A 1.137 0.55
168_Y 173_A 1.136 0.55
612_C 615_C 1.134 0.55
804_I 820_E 1.13 0.54
809_G 820_E 1.127 0.54
541_A 545_L 1.127 0.54
228_R 232_E 1.124 0.54
273_Y 280_A 1.114 0.53
317_R 421_Q 1.111 0.52
736_V 739_V 1.108 0.52
303_V 443_V 1.106 0.52
169_L 176_V 1.1 0.51
555_I 561_L 1.1 0.51
279_S 283_D 1.099 0.51
480_L 484_S 1.098 0.51
431_S 739_V 1.096 0.51
460_L 572_Q 1.094 0.51
730_G 777_W 1.093 0.51
185_G 251_N 1.091 0.50
44_L 68_P 1.091 0.50
78_M 164_L 1.089 0.50
241_D 244_R 1.088 0.50
118_A 127_R 1.083 0.50
84_A 232_E 1.08 0.49
310_Y 750_L 1.079 0.49
285_Y 603_I 1.078 0.49
542_A 555_I 1.078 0.49
131_L 139_R 1.078 0.49
540_Y 544_Y 1.077 0.49
305_N 309_D 1.075 0.49
568_F 572_Q 1.073 0.49
51_Y 288_Y 1.07 0.48
428_A 455_R 1.068 0.48
238_Q 242_Q 1.063 0.48
476_M 682_L 1.061 0.47
53_A 440_M 1.061 0.47
205_A 208_T 1.06 0.47
570_P 574_A 1.057 0.47
180_A 191_L 1.054 0.47
121_I 281_Y 1.054 0.47
545_L 550_F 1.053 0.46
811_L 829_T 1.052 0.46
362_A 402_L 1.052 0.46
678_P 799_I 1.051 0.46
103_R 228_R 1.051 0.46
712_D 792_P 1.05 0.46
362_A 374_L 1.048 0.46
230_L 241_D 1.047 0.46
429_L 780_Y 1.047 0.46
461_R 725_D 1.043 0.46
533_M 538_V 1.042 0.45
466_N 738_S 1.039 0.45
809_G 822_F 1.038 0.45
51_Y 55_G 1.037 0.45
114_A 135_R 1.036 0.45
151_E 156_K 1.036 0.45
104_A 118_A 1.035 0.45
428_A 740_W 1.033 0.45
428_A 570_P 1.032 0.44
474_A 478_K 1.031 0.44
74_I 591_F 1.029 0.44
198_V 248_I 1.027 0.44
82_F 167_I 1.027 0.44
271_E 592_I 1.026 0.44
810_Q 830_Q 1.024 0.44
463_V 467_I 1.023 0.44
488_D 511_Y 1.023 0.44
266_E 448_F 1.023 0.44
77_E 193_L 1.019 0.43
714_G 793_L 1.017 0.43
805_D 816_N 1.017 0.43
184_F 248_I 1.016 0.43
128_N 452_K 1.016 0.43
425_V 750_L 1.015 0.43
299_A 780_Y 1.013 0.43
723_S 726_A 1.011 0.42
804_I 809_G 1.01 0.42
126_A 130_F 1.009 0.42
303_V 429_L 1.008 0.42
12_V 17_L 1.005 0.42
467_I 559_E 1 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3udfA20.85531000.285Contact Map0.814
3fwmA10.75061000.348Contact Map0.703
2jchA10.75061000.36Contact Map0.698
2olvA20.72351000.42Contact Map0.741
3zg7B10.59651000.541Contact Map0.758
2y2mA10.52591000.659Contact Map0.655
2v2fF10.42241000.718Contact Map0.764
3un7A20.44471000.721Contact Map0.639
2oqoA10.23531000.722Contact Map0.787
3vmtA20.26241000.731Contact Map0.797
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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