| UniProt: | P00811 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10040 | ||
| Length: | 377 (325) | ||
| Sequences: | 4501 | ||
| Seq/Len: | 13.85 |
| AMPC
Paralog alert: 0.65 [within 20: 0.07] - ratio of genomes with paralogs Cluster includes: AMPC AMPH YFEW |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 184_L | 192_T | 4.279 | 1.00 | |
| 96_R | 193_R | 3.709 | 1.00 | |
| 191_Q | 196_Q | 3.623 | 1.00 | |
| 203_T | 241_S | 3.612 | 1.00 | |
| 102_S | 123_L | 3.598 | 1.00 | |
| 51_Q | 349_E | 3.521 | 1.00 | |
| 100_K | 103_D | 3.496 | 1.00 | |
| 89_L | 189_A | 3.476 | 1.00 | |
| 103_D | 107_K | 3.466 | 1.00 | |
| 92_D | 189_A | 3.09 | 1.00 | |
| 92_D | 193_R | 3.028 | 1.00 | |
| 178_A | 189_A | 2.893 | 1.00 | |
| 74_T | 216_A | 2.878 | 1.00 | |
| 182_S | 189_A | 2.805 | 1.00 | |
| 70_V | 76_F | 2.788 | 1.00 | |
| 103_D | 108_Y | 2.736 | 1.00 | |
| 189_A | 193_R | 2.622 | 1.00 | |
| 78_L | 241_S | 2.535 | 1.00 | |
| 185_S | 188_Q | 2.464 | 1.00 | |
| 47_A | 247_A | 2.447 | 1.00 | |
| 58_T | 72_Q | 2.434 | 1.00 | |
| 62_A | 68_Q | 2.378 | 1.00 | |
| 95_A | 260_N | 2.372 | 1.00 | |
| 111_E | 180_K | 2.262 | 1.00 | |
| 200_L | 203_T | 2.169 | 1.00 | |
| 56_Y | 59_W | 2.143 | 1.00 | |
| 143_S | 146_D | 2.122 | 1.00 | |
| 84_T | 249_W | 2.121 | 1.00 | |
| 88_V | 249_W | 2.101 | 1.00 | |
| 90_G | 174_F | 2.09 | 1.00 | |
| 61_Y | 67_K | 2.084 | 1.00 | |
| 29_H | 59_W | 2.049 | 1.00 | |
| 176_A | 179_V | 2.029 | 1.00 | |
| 104_P | 107_K | 2.026 | 1.00 | |
| 63_D | 66_K | 2.018 | 1.00 | |
| 176_A | 180_K | 1.987 | 1.00 | |
| 250_V | 351_G | 1.957 | 1.00 | |
| 130_A | 133_L | 1.924 | 1.00 | |
| 184_L | 189_A | 1.918 | 1.00 | |
| 95_A | 263_T | 1.893 | 1.00 | |
| 121_T | 124_H | 1.857 | 1.00 | |
| 130_A | 170_S | 1.85 | 1.00 | |
| 93_A | 178_A | 1.846 | 1.00 | |
| 90_G | 99_I | 1.833 | 1.00 | |
| 92_D | 96_R | 1.794 | 1.00 | |
| 175_G | 235_E | 1.788 | 1.00 | |
| 190_M | 195_F | 1.787 | 1.00 | |
| 61_Y | 66_K | 1.767 | 1.00 | |
| 122_L | 177_L | 1.762 | 1.00 | |
| 260_N | 263_T | 1.736 | 1.00 | |
| 90_G | 178_A | 1.735 | 1.00 | |
| 202_H | 214_N | 1.725 | 1.00 | |
| 43_G | 76_F | 1.72 | 1.00 | |
| 195_F | 200_L | 1.717 | 1.00 | |
| 45_A | 243_I | 1.717 | 1.00 | |
| 192_T | 196_Q | 1.697 | 1.00 | |
| 250_V | 342_V | 1.679 | 1.00 | |
| 33_T | 37_E | 1.677 | 1.00 | |
| 218_G | 338_F | 1.659 | 1.00 | |
| 186_F | 190_M | 1.659 | 1.00 | |
| 47_A | 353_V | 1.648 | 1.00 | |
| 45_A | 76_F | 1.647 | 1.00 | |
| 89_L | 190_M | 1.625 | 1.00 | |
| 124_H | 161_G | 1.596 | 1.00 | |
| 184_L | 193_R | 1.589 | 1.00 | |
| 81_V | 342_V | 1.568 | 1.00 | |
| 45_A | 58_T | 1.567 | 1.00 | |
| 73_Q | 244_E | 1.567 | 1.00 | |
| 45_A | 70_V | 1.564 | 1.00 | |
| 195_F | 239_V | 1.545 | 1.00 | |
| 49_I | 351_G | 1.544 | 1.00 | |
| 90_G | 126_A | 1.535 | 1.00 | |
| 124_H | 129_T | 1.518 | 1.00 | |
| 49_I | 247_A | 1.515 | 1.00 | |
| 89_L | 178_A | 1.504 | 1.00 | |
| 327_S | 347_E | 1.502 | 1.00 | |
| 72_Q | 244_E | 1.496 | 1.00 | |
| 93_A | 182_S | 1.474 | 1.00 | |
| 87_G | 126_A | 1.463 | 1.00 | |
| 80_S | 83_K | 1.448 | 1.00 | |
| 188_Q | 192_T | 1.424 | 1.00 | |
| 284_G | 289_M | 1.414 | 1.00 | |
| 43_G | 70_V | 1.409 | 1.00 | |
| 168_N | 236_A | 1.394 | 0.99 | |
| 177_L | 181_P | 1.394 | 0.99 | |
| 57_F | 244_E | 1.386 | 0.99 | |
| 186_F | 235_E | 1.385 | 0.99 | |
| 251_Q | 254_L | 1.378 | 0.99 | |
| 79_G | 335_T | 1.376 | 0.99 | |
| 89_L | 182_S | 1.375 | 0.99 | |
| 200_L | 245_D | 1.369 | 0.99 | |
| 94_I | 99_I | 1.365 | 0.99 | |
| 70_V | 74_T | 1.36 | 0.99 | |
| 205_I | 239_V | 1.358 | 0.99 | |
| 47_A | 243_I | 1.351 | 0.99 | |
| 123_L | 285_L | 1.343 | 0.99 | |
| 50_Y | 350_L | 1.341 | 0.99 | |
| 103_D | 122_L | 1.34 | 0.99 | |
| 98_E | 181_P | 1.338 | 0.99 | |
| 252_S | 257_L | 1.322 | 0.99 | |
| 145_S | 149_R | 1.315 | 0.99 | |
| 49_I | 54_P | 1.314 | 0.99 | |
| 243_I | 355_L | 1.314 | 0.99 | |
| 87_G | 171_I | 1.302 | 0.99 | |
| 184_L | 188_Q | 1.301 | 0.99 | |
| 195_F | 203_T | 1.3 | 0.99 | |
| 71_T | 74_T | 1.292 | 0.99 | |
| 91_G | 101_L | 1.292 | 0.99 | |
| 85_F | 239_V | 1.286 | 0.99 | |
| 47_A | 54_P | 1.276 | 0.99 | |
| 94_I | 101_L | 1.266 | 0.99 | |
| 32_I | 46_V | 1.263 | 0.99 | |
| 254_L | 344_F | 1.242 | 0.98 | |
| 46_V | 354_M | 1.242 | 0.98 | |
| 99_I | 181_P | 1.241 | 0.98 | |
| 83_K | 166_Y | 1.233 | 0.98 | |
| 246_M | 355_L | 1.221 | 0.98 | |
| 345_I | 348_K | 1.205 | 0.98 | |
| 246_M | 353_V | 1.202 | 0.98 | |
| 203_T | 245_D | 1.198 | 0.98 | |
| 124_H | 127_T | 1.192 | 0.98 | |
| 344_F | 351_G | 1.191 | 0.98 | |
| 119_G | 159_A | 1.185 | 0.98 | |
| 58_T | 70_V | 1.181 | 0.98 | |
| 158_W | 163_Q | 1.18 | 0.98 | |
| 100_K | 108_Y | 1.167 | 0.97 | |
| 261_E | 265_Q | 1.165 | 0.97 | |
| 62_A | 74_T | 1.16 | 0.97 | |
| 91_G | 94_I | 1.143 | 0.97 | |
| 85_F | 200_L | 1.127 | 0.97 | |
| 29_H | 56_Y | 1.125 | 0.97 | |
| 167_A | 170_S | 1.124 | 0.97 | |
| 75_L | 214_N | 1.123 | 0.97 | |
| 334_A | 339_G | 1.109 | 0.96 | |
| 85_F | 249_W | 1.101 | 0.96 | |
| 129_T | 161_G | 1.1 | 0.96 | |
| 86_T | 186_F | 1.09 | 0.96 | |
| 87_G | 286_G | 1.086 | 0.96 | |
| 148_L | 176_A | 1.083 | 0.96 | |
| 93_A | 96_R | 1.081 | 0.95 | |
| 36_I | 59_W | 1.079 | 0.95 | |
| 63_D | 217_W | 1.078 | 0.95 | |
| 159_A | 162_T | 1.072 | 0.95 | |
| 171_I | 174_F | 1.071 | 0.95 | |
| 182_S | 185_S | 1.067 | 0.95 | |
| 199_K | 248_R | 1.064 | 0.95 | |
| 64_I | 219_Y | 1.059 | 0.95 | |
| 81_V | 246_M | 1.047 | 0.94 | |
| 86_T | 175_G | 1.046 | 0.94 | |
| 29_H | 33_T | 1.046 | 0.94 | |
| 82_S | 239_V | 1.043 | 0.94 | |
| 77_E | 335_T | 1.043 | 0.94 | |
| 75_L | 240_K | 1.04 | 0.94 | |
| 104_P | 119_G | 1.028 | 0.94 | |
| 92_D | 194_V | 1.026 | 0.94 | |
| 266_Q | 269_Q | 1.017 | 0.93 | |
| 175_G | 186_F | 1.011 | 0.93 | |
| 43_G | 357_N | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2ffyA | 2 | 0.9496 | 100 | 0.17 | Contact Map | 0.798 |
| 2qz6A | 1 | 0.9416 | 100 | 0.192 | Contact Map | 0.758 |
| 2wzxA | 1 | 0.9523 | 100 | 0.202 | Contact Map | 0.745 |
| 1zkjA | 1 | 0.9443 | 100 | 0.206 | Contact Map | 0.723 |
| 2qmiA | 8 | 0.8541 | 100 | 0.247 | Contact Map | 0.885 |
| 1ei5A | 1 | 0.8382 | 100 | 0.251 | Contact Map | 0.684 |
| 4gdnA | 4 | 0.87 | 100 | 0.251 | Contact Map | 0.887 |
| 4e6wA | 3 | 0.8355 | 100 | 0.254 | Contact Map | 0.798 |
| 4ivkA | 1 | 0.9231 | 100 | 0.267 | Contact Map | 0.835 |
| 2drwA | 6 | 0.8488 | 100 | 0.268 | Contact Map | 0.849 |
Sequence Conservation (Image Generated using WebLogo v3)