May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

HOLA - KTHY
UniProt: P28630 - P0A720
Length: 556
Sequences: 675
Seq/Len: 1.30
I_Prob: 0.01

HOLA - DNA polymerase III subunit delta
Paralog alert: 0.85 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: HOLA
KTHY - Thymidylate kinase
Paralog alert: 0.03 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: KTHY
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4huqB:AContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
15_E 139_L 1.29 0.01
221_L 162_E 1.19 0.00
57_P 12_E 1.15 0.00
126_W 47_A 1.14 0.00
110_L 120_L 1.12 0.00
258_V 12_E 1.05 0.00
21_Y 98_G 1.03 0.00
176_G 105_T 1.03 0.00
75_A 137_L 0.99 0.00
178_L 95_W 0.99 0.00
319_S 106_Q 0.98 0.00
225_K 139_L 0.98 0.00
16_G 142_T 0.97 0.00
82_L 118_H 0.96 0.00
310_L 7_V 0.96 0.00
241_S 69_A 0.94 0.00
257_L 97_I 0.93 0.00
172_Y 97_I 0.93 0.00
106_D 47_A 0.92 0.00
164_D 25_E 0.92 0.00
22_L 171_R 0.92 0.00
21_Y 75_Y 0.91 0.00
95_E 78_R 0.91 0.00
101_T 7_V 0.89 0.00
79_T 143_P 0.89 0.00
143_E 18_T 0.89 0.00
305_L 45_Q 0.88 0.00
292_R 92_N 0.87 0.00
8_Q 186_T 0.87 0.00
46_G 87_K 0.86 0.00
186_E 165_D 0.85 0.00
147_L 208_V 0.85 0.00
79_T 110_G 0.85 0.00
83_L 185_H 0.85 0.00
84_L 104_S 0.84 0.00
325_E 184_I 0.84 0.00
114_G 118_H 0.84 0.00
179_L 167_F 0.84 0.00
111_I 49_K 0.84 0.00
278_V 86_I 0.84 0.00
114_G 36_V 0.83 0.00
328_S 11_L 0.83 0.00
317_G 71_V 0.83 0.00
23_L 45_Q 0.83 0.00
45_Q 69_A 0.83 0.00
246_L 92_N 0.83 0.00
96_Q 105_T 0.82 0.00
111_I 14_A 0.82 0.00
294_S 193_L 0.82 0.00
258_V 14_A 0.82 0.00
18_R 75_Y 0.82 0.00
247_L 143_P 0.81 0.00
250_L 86_I 0.81 0.00
126_W 194_E 0.81 0.00
230_L 141_V 0.81 0.00
82_L 4_K 0.81 0.00
82_L 153_R 0.81 0.00
241_S 105_T 0.80 0.00
263_Q 204_V 0.79 0.00
73_L 47_A 0.79 0.00
111_I 142_T 0.79 0.00
71_M 12_E 0.79 0.00
174_Y 166_F 0.79 0.00
46_G 53_L 0.79 0.00
56_D 160_E 0.79 0.00
238_L 190_T 0.78 0.00
315_D 75_Y 0.78 0.00
73_L 74_F 0.78 0.00
139_C 139_L 0.78 0.00
92_A 160_E 0.78 0.00
52_T 204_V 0.78 0.00
74_F 167_F 0.78 0.00
79_T 69_A 0.77 0.00
325_E 177_L 0.77 0.00
130_L 115_I 0.77 0.00
190_L 6_I 0.77 0.00
247_L 85_V 0.77 0.00
105_H 114_G 0.77 0.00
35_Q 54_V 0.77 0.00
135_V 126_A 0.76 0.00
50_H 77_A 0.76 0.00
111_I 170_T 0.76 0.00
93_I 204_V 0.76 0.00
145_A 25_E 0.76 0.00
134_S 101_H 0.76 0.00
283_R 18_T 0.76 0.00
328_S 17_T 0.76 0.00
15_E 107_A 0.75 0.00
145_A 28_E 0.75 0.00
146_Q 191_Q 0.75 0.00
332_C 97_I 0.75 0.00
143_E 194_E 0.75 0.00
37_A 31_G 0.74 0.00
170_L 28_E 0.74 0.00
170_L 7_V 0.74 0.00
172_Y 20_R 0.74 0.00
258_V 3_S 0.74 0.00
325_E 131_F 0.74 0.00
101_T 43_G 0.74 0.00
46_G 47_A 0.74 0.00
60_D 188_D 0.74 0.00
221_L 81_L 0.74 0.00
263_Q 106_Q 0.74 0.00
24_L 92_N 0.74 0.00
327_L 112_G 0.74 0.00
61_W 187_I 0.74 0.00
90_N 104_S 0.74 0.00
255_L 19_A 0.73 0.00
42_A 91_A 0.73 0.00
84_L 177_L 0.73 0.00
277_R 191_Q 0.73 0.00
80_L 116_D 0.73 0.00
136_Q 204_V 0.73 0.00
16_G 161_Q 0.73 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

Page generated in 0.0697 seconds.