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OPENSEQ.org

KTHY - Thymidylate kinase
UniProt: P0A720 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12302
Length: 213 (207)
Sequences: 2194
Seq/Len: 10.60

KTHY
Paralog alert: 0.03 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
191_Q 199_A 3.244 1.00
26_T 201_R 3.236 1.00
139_L 189_A 3.072 1.00
111_G 173_R 2.615 1.00
140_D 171_R 2.613 1.00
22_V 197_M 2.519 1.00
171_R 175_L 2.514 1.00
191_Q 195_A 2.464 1.00
24_V 28_E 2.367 1.00
187_I 196_V 2.275 1.00
38_T 81_L 2.243 1.00
157_D 160_E 2.242 1.00
36_V 94_T 2.217 1.00
192_P 195_A 2.128 1.00
145_V 148_K 2.119 1.00
103_L 183_S 2.063 1.00
80_Q 84_T 2.03 1.00
140_D 175_L 1.93 1.00
20_R 97_I 1.877 1.00
34_D 94_T 1.845 1.00
137_L 187_I 1.819 1.00
175_L 186_T 1.817 1.00
20_R 37_F 1.806 1.00
19_A 197_M 1.755 1.00
48_E 77_A 1.753 1.00
24_V 97_I 1.746 1.00
4_K 95_W 1.737 1.00
113_R 162_E 1.729 1.00
12_E 146_G 1.725 1.00
142_T 190_T 1.721 1.00
19_A 22_V 1.718 1.00
19_A 200_I 1.702 1.00
5_Y 98_G 1.68 1.00
87_K 91_A 1.634 1.00
14_A 141_V 1.628 1.00
50_L 73_M 1.621 1.00
141_V 145_V 1.616 1.00
138_Y 184_I 1.559 1.00
197_M 201_R 1.548 1.00
137_L 203_T 1.536 1.00
138_Y 186_T 1.53 1.00
176_E 180_Q 1.508 1.00
32_I 95_W 1.508 1.00
22_V 194_E 1.492 1.00
187_I 203_T 1.472 1.00
83_E 87_K 1.452 1.00
185_H 203_T 1.442 1.00
26_T 30_L 1.419 1.00
24_V 37_F 1.415 1.00
23_V 204_V 1.408 1.00
36_V 89_A 1.408 1.00
146_G 150_A 1.382 0.99
7_V 103_L 1.363 0.99
66_T 83_E 1.357 0.99
139_L 200_I 1.35 0.99
138_Y 178_A 1.335 0.99
75_Y 124_R 1.332 0.99
103_L 136_T 1.313 0.99
8_I 23_V 1.305 0.99
32_I 35_M 1.29 0.99
71_V 75_Y 1.29 0.99
178_A 186_T 1.283 0.99
11_L 167_F 1.274 0.99
107_A 111_G 1.27 0.99
197_M 200_I 1.249 0.99
198_D 202_T 1.244 0.98
165_D 168_N 1.24 0.98
116_D 120_L 1.227 0.98
47_A 77_A 1.225 0.98
7_V 183_S 1.224 0.98
25_E 29_Q 1.222 0.98
143_P 164_F 1.22 0.98
46_L 65_I 1.202 0.98
38_T 98_G 1.198 0.98
145_V 190_T 1.161 0.97
7_V 98_G 1.141 0.97
138_Y 175_L 1.132 0.97
137_L 200_I 1.13 0.97
22_V 193_L 1.126 0.97
79_V 83_E 1.125 0.97
128_L 131_F 1.124 0.97
124_R 127_V 1.124 0.97
21_N 25_E 1.119 0.96
172_A 176_E 1.118 0.96
176_E 179_A 1.117 0.96
86_I 96_V 1.116 0.96
199_A 202_T 1.108 0.96
89_A 94_T 1.103 0.96
30_L 205_T 1.096 0.96
18_T 193_L 1.085 0.96
28_E 35_M 1.084 0.96
75_Y 105_T 1.082 0.96
141_V 189_A 1.081 0.95
135_L 185_H 1.078 0.95
12_E 167_F 1.077 0.95
138_Y 171_R 1.074 0.95
185_H 207_W 1.073 0.95
44_T 47_A 1.068 0.95
33_R 94_T 1.048 0.94
75_Y 102_D 1.044 0.94
168_N 172_A 1.039 0.94
177_L 184_I 1.034 0.94
5_Y 90_L 1.031 0.94
26_T 198_D 1.015 0.93
122_T 125_D 1.015 0.93
103_L 184_I 1.009 0.93
77_A 81_L 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4edhA20.98121000.35Contact Map0.762
3czpA20.84511000.37Contact Map0.444
4tmkA111000.393Contact Map0.745
2plrA20.93431000.42Contact Map0.781
1p6xA20.96241000.424Contact Map0.421
2yogA20.92021000.426Contact Map0.797
4hlcA20.95311000.437Contact Map0.81
1nn5A10.93431000.437Contact Map0.724
1gtvA20.93431000.44Contact Map0.511
2z0hA20.92021000.453Contact Map0.82

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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