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OPENSEQ.org

PARC - PARE
UniProt: P0AFI2 - P20083
Length: 1382
Sequences: 989
Seq/Len: 0.74
I_Prob: 0.00

PARC - DNA topoisomerase 4 subunit A
Paralog alert: 0.64 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GYRA PARC
PARE - DNA topoisomerase 4 subunit B
Paralog alert: 0.70 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GYRB PARE
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
60_F 570_N 1.34 0.00
526_K 356_L 1.26 0.00
103_Q 561_Q 1.23 0.00
113_K 468_I 1.18 0.00
18_Y 116_I 1.15 0.00
28_D 39_V 1.15 0.00
264_A 432_R 1.15 0.00
191_A 131_R 1.15 0.00
337_R 624_D 1.13 0.00
85_A 468_I 1.13 0.00
191_A 56_D 1.12 0.00
505_S 622_K 1.11 0.00
569_P 359_N 1.10 0.00
13_F 499_A 1.10 0.00
7_R 588_Q 1.09 0.00
290_D 434_Y 1.08 0.00
139_G 39_V 1.07 0.00
18_Y 37_Q 1.06 0.00
291_H 575_R 1.05 0.00
353_F 604_D 0.98 0.00
326_R 463_D 0.97 0.00
18_Y 500_T 0.97 0.00
337_R 415_F 0.97 0.00
18_Y 39_V 0.96 0.00
118_M 427_K 0.96 0.00
19_L 184_L 0.95 0.00
631_M 609_K 0.95 0.00
500_V 538_A 0.94 0.00
125_L 432_R 0.94 0.00
103_Q 343_A 0.93 0.00
627_N 207_N 0.93 0.00
548_S 211_Q 0.93 0.00
677_A 182_S 0.92 0.00
700_I 165_V 0.92 0.00
570_L 514_V 0.91 0.00
389_V 538_A 0.91 0.00
103_Q 570_N 0.91 0.00
611_L 286_G 0.91 0.00
328_N 359_N 0.90 0.00
15_E 602_M 0.90 0.00
603_G 286_G 0.89 0.00
475_D 77_D 0.89 0.00
352_V 63_Q 0.89 0.00
170_T 356_L 0.89 0.00
81_A 571_P 0.89 0.00
527_A 514_V 0.89 0.00
166_L 613_E 0.89 0.00
145_P 189_K 0.89 0.00
86_M 455_V 0.89 0.00
619_K 296_E 0.89 0.00
358_V 306_K 0.88 0.00
442_K 142_E 0.87 0.00
108_A 458_S 0.87 0.00
63_S 570_N 0.87 0.00
147_F 280_V 0.86 0.00
132_L 381_R 0.86 0.00
151_L 571_P 0.86 0.00
619_K 293_E 0.86 0.00
350_W 303_R 0.86 0.00
472_Y 142_E 0.86 0.00
358_V 345_F 0.86 0.00
447_L 609_K 0.85 0.00
352_V 609_K 0.85 0.00
114_S 407_Q 0.85 0.00
463_K 478_S 0.85 0.00
510_V 7_A 0.85 0.00
433_I 381_R 0.85 0.00
89_M 76_V 0.85 0.00
109_P 432_R 0.85 0.00
727_L 222_Y 0.84 0.00
411_E 410_N 0.84 0.00
328_N 344_A 0.84 0.00
139_G 415_F 0.84 0.00
66_T 84_V 0.83 0.00
47_Y 151_Q 0.83 0.00
478_S 358_L 0.82 0.00
80_S 460_E 0.82 0.00
447_L 415_F 0.82 0.00
22_S 342_C 0.81 0.00
572_G 294_F 0.81 0.00
80_S 485_I 0.81 0.00
583_D 63_Q 0.81 0.00
611_L 445_L 0.81 0.00
644_L 296_E 0.81 0.00
347_L 609_K 0.80 0.00
136_L 541_E 0.80 0.00
358_V 268_V 0.80 0.00
13_F 585_R 0.80 0.00
641_D 165_V 0.80 0.00
394_R 441_K 0.80 0.00
302_R 470_I 0.80 0.00
8_L 431_D 0.80 0.00
267_L 391_L 0.79 0.00
125_L 251_W 0.79 0.00
18_Y 480_L 0.79 0.00
243_A 342_C 0.79 0.00
421_K 552_K 0.79 0.00
100_V 152_V 0.79 0.00
85_A 464_I 0.79 0.00
85_A 395_P 0.79 0.00
659_D 228_N 0.79 0.00
22_S 505_L 0.79 0.00
440_L 475_D 0.79 0.00
72_G 267_Y 0.79 0.00
112_P 427_K 0.79 0.00
86_M 37_Q 0.79 0.00
313_N 616_R 0.78 0.00
290_D 571_P 0.78 0.00
557_P 160_N 0.78 0.00
70_V 326_D 0.78 0.00
24_Y 493_S 0.78 0.00
24_Y 629_E 0.78 0.00
71_L 405_T 0.78 0.00
103_Q 39_V 0.78 0.00
640_S 519_V 0.78 0.00
298_V 596_D 0.78 0.00
475_D 485_I 0.77 0.00
230_K 350_V 0.77 0.00
208_D 592_D 0.77 0.00
254_I 267_Y 0.77 0.00
191_A 54_R 0.77 0.00
89_M 351_K 0.77 0.00
571_T 310_E 0.77 0.00
290_D 428_Q 0.77 0.00
324_S 559_N 0.77 0.00
401_P 153_V 0.77 0.00
347_L 376_A 0.76 0.00
549_T 216_Q 0.76 0.00
345_E 199_E 0.76 0.00
292_E 432_R 0.76 0.00
480_L 365_A 0.76 0.00
65_R 563_F 0.76 0.00
386_I 585_R 0.76 0.00
566_Q 486_C 0.76 0.00
321_L 361_N 0.76 0.00
65_R 141_F 0.76 0.00
379_L 388_R 0.76 0.00
322_E 196_P 0.76 0.00
126_S 221_D 0.76 0.00
499_P 305_V 0.76 0.00
566_Q 580_D 0.76 0.00
653_L 8_D 0.76 0.00
47_Y 514_V 0.75 0.00
641_D 354_F 0.75 0.00
149_G 459_Q 0.75 0.00
605_V 267_Y 0.75 0.00
269_Q 188_L 0.75 0.00
28_D 440_L 0.75 0.00
118_M 573_Q 0.75 0.00
92_P 428_Q 0.75 0.00
31_L 229_G 0.75 0.00
701_H 431_D 0.75 0.00
264_A 399_G 0.75 0.00
574_L 63_Q 0.75 0.00
252_V 189_K 0.75 0.00
568_E 359_N 0.74 0.00
106_W 629_E 0.74 0.00
652_M 213_W 0.74 0.00
82_C 571_P 0.74 0.00
414_A 582_N 0.74 0.00
161_L 193_V 0.74 0.00
467_A 523_L 0.74 0.00
276_N 307_L 0.74 0.00
560_L 546_G 0.74 0.00
489_M 373_I 0.74 0.00
192_A 415_F 0.74 0.00
147_F 496_L 0.74 0.00
308_M 363_Q 0.74 0.00
85_A 416_L 0.74 0.00
174_V 404_C 0.74 0.00
510_V 129_N 0.74 0.00
570_L 520_Y 0.74 0.00
85_A 486_C 0.73 0.00
161_L 39_V 0.73 0.00
118_M 402_A 0.73 0.00
194_A 51_H 0.73 0.00
125_L 256_L 0.73 0.00
582_V 507_V 0.73 0.00
289_S 428_Q 0.73 0.00
596_M 37_Q 0.73 0.00
453_S 366_E 0.73 0.00
659_D 453_D 0.73 0.00
141_A 37_Q 0.73 0.00
724_R 141_F 0.73 0.00
275_R 394_G 0.73 0.00
659_D 205_E 0.73 0.00
433_I 429_A 0.73 0.00
230_K 166_H 0.73 0.00
200_K 160_N 0.73 0.00
577_P 67_V 0.73 0.00
677_A 131_R 0.73 0.00
626_E 149_D 0.73 0.00
86_M 563_F 0.73 0.00
94_S 512_A 0.73 0.00
705_R 238_F 0.73 0.00
125_L 356_L 0.73 0.00
255_S 59_L 0.73 0.00
124_R 251_W 0.72 0.00
505_S 445_L 0.72 0.00
136_L 527_Y 0.72 0.00
95_Y 142_E 0.72 0.00
11_H 39_V 0.72 0.00
208_D 588_Q 0.72 0.00
689_L 189_K 0.72 0.00
114_S 550_Q 0.72 0.00
653_L 85_P 0.72 0.00
648_Q 59_L 0.72 0.00
332_I 361_N 0.72 0.00
94_S 267_Y 0.72 0.00
101_D 12_V 0.72 0.00
81_A 80_P 0.72 0.00
479_P 580_D 0.72 0.00
205_Q 252_A 0.72 0.00
496_P 131_R 0.72 0.00
22_S 84_V 0.72 0.00
687_A 202_F 0.72 0.00
20_N 55_V 0.72 0.00
539_S 198_V 0.72 0.00
423_R 441_K 0.72 0.00
273_Q 169_P 0.72 0.00
268_E 499_A 0.72 0.00
715_Q 165_V 0.72 0.00
103_Q 573_Q 0.72 0.00
71_L 540_T 0.71 0.00
650_G 563_F 0.71 0.00
595_L 133_D 0.71 0.00
299_I 182_S 0.71 0.00
653_L 523_L 0.71 0.00
509_W 360_Q 0.71 0.00
279_L 433_E 0.71 0.00
174_V 327_P 0.71 0.00
576_L 264_T 0.71 0.00
640_S 582_N 0.71 0.00
200_K 303_R 0.71 0.00
141_A 381_R 0.71 0.00
380_L 255_W 0.71 0.00
301_P 585_R 0.71 0.00
243_A 58_I 0.71 0.00
73_K 496_L 0.71 0.00
715_Q 53_K 0.71 0.00
223_T 238_F 0.71 0.00
555_I 264_T 0.71 0.00
373_L 464_I 0.71 0.00
103_Q 539_L 0.71 0.00
543_V 308_S 0.71 0.00
160_R 415_F 0.71 0.00
454_E 267_Y 0.71 0.00
541_Q 470_I 0.71 0.00
61_K 103_K 0.71 0.00
637_E 541_E 0.71 0.00
548_S 172_T 0.71 0.00
579_G 431_D 0.70 0.00
270_I 182_S 0.70 0.00
326_R 219_L 0.70 0.00
700_I 246_T 0.70 0.00
364_Y 252_A 0.70 0.00
150_T 559_N 0.70 0.00
581_T 626_A 0.70 0.00
412_T 507_V 0.70 0.00
358_V 429_A 0.70 0.00
132_L 484_K 0.70 0.00
208_D 300_I 0.70 0.00
372_R 130_V 0.70 0.00
243_A 387_V 0.70 0.00
555_I 407_Q 0.70 0.00
108_A 460_E 0.70 0.00
57_S 549_E 0.70 0.00
191_A 179_F 0.70 0.00
478_S 17_E 0.70 0.00
452_A 149_D 0.70 0.00
470_Q 300_I 0.70 0.00
143_W 461_V 0.70 0.00
103_Q 396_A 0.70 0.00
477_R 70_D 0.70 0.00
14_T 602_M 0.69 0.00
19_L 24_G 0.69 0.00
654_M 256_L 0.69 0.00
297_L 601_A 0.69 0.00
89_M 284_R 0.69 0.00
688_Q 85_P 0.69 0.00
199_P 132_R 0.69 0.00
328_N 52_A 0.69 0.00
283_D 185_T 0.69 0.00
344_L 521_V 0.69 0.00
350_W 402_A 0.69 0.00
525_Y 505_L 0.69 0.00
57_S 509_H 0.69 0.00
390_I 326_D 0.69 0.00
565_G 236_K 0.69 0.00
367_E 147_V 0.69 0.00
513_A 627_E 0.69 0.00
210_V 284_R 0.69 0.00
477_R 65_L 0.69 0.00
568_E 52_A 0.69 0.00
662_Q 432_R 0.69 0.00
448_Q 213_W 0.69 0.00
401_P 326_D 0.69 0.00
603_G 161_T 0.69 0.00
564_R 342_C 0.69 0.00
56_A 90_I 0.69 0.00
65_R 496_L 0.69 0.00
526_K 268_V 0.69 0.00
129_S 415_F 0.69 0.00
546_V 523_L 0.69 0.00
269_Q 325_Q 0.69 0.00
18_Y 280_V 0.69 0.00
42_Q 458_S 0.69 0.00
687_A 370_E 0.69 0.00
599_D 124_K 0.69 0.00
129_S 560_V 0.68 0.00
18_Y 414_L 0.68 0.00
675_P 141_F 0.68 0.00
528_G 541_E 0.68 0.00
570_L 52_A 0.68 0.00
533_A 456_L 0.68 0.00
149_G 308_S 0.68 0.00
580_A 471_D 0.68 0.00
356_D 153_V 0.68 0.00
71_L 44_V 0.68 0.00
613_A 221_D 0.68 0.00
31_L 81_E 0.68 0.00
114_S 312_I 0.68 0.00
441_E 137_Y 0.68 0.00
86_M 560_V 0.68 0.00
575_T 324_M 0.68 0.00
606_C 467_A 0.68 0.00
348_S 253_L 0.68 0.00
219_A 146_K 0.68 0.00
667_K 485_I 0.68 0.00
63_S 360_Q 0.68 0.00
505_S 118_V 0.68 0.00
473_G 142_E 0.68 0.00
323_K 570_N 0.68 0.00
461_L 455_V 0.68 0.00
28_D 116_I 0.68 0.00
199_P 480_L 0.68 0.00
543_V 415_F 0.68 0.00
335_D 588_Q 0.67 0.00
277_K 189_K 0.67 0.00
13_F 342_C 0.67 0.00
404_M 263_L 0.67 0.00
653_L 587_V 0.67 0.00
18_Y 343_A 0.67 0.00
89_M 457_A 0.67 0.00
93_F 384_K 0.67 0.00
240_R 130_V 0.67 0.00
616_R 407_Q 0.67 0.00
208_D 235_E 0.67 0.00
495_L 464_I 0.67 0.00
241_M 143_N 0.67 0.00
86_M 406_A 0.67 0.00
642_M 4_T 0.67 0.00
65_R 444_I 0.67 0.00
84_E 605_M 0.67 0.00
206_L 88_E 0.67 0.00
129_S 298_R 0.67 0.00
128_Y 486_C 0.67 0.00
392_I 542_E 0.67 0.00
409_L 310_E 0.67 0.00
472_Y 58_I 0.67 0.00
31_L 17_E 0.67 0.00
232_Y 174_F 0.67 0.00
570_L 216_Q 0.67 0.00
278_K 130_V 0.67 0.00
74_Y 369_A 0.67 0.00
579_G 44_V 0.67 0.00
264_A 289_D 0.67 0.00
545_F 126_V 0.67 0.00
356_D 589_L 0.67 0.00
289_S 339_S 0.67 0.00
18_Y 468_I 0.67 0.00
288_E 267_Y 0.67 0.00
219_A 83_G 0.67 0.00
240_R 76_V 0.67 0.00
352_V 165_V 0.67 0.00
169_T 320_L 0.66 0.00
19_L 359_N 0.66 0.00
400_K 329_F 0.66 0.00
477_R 431_D 0.66 0.00
285_L 518_H 0.66 0.00
371_K 135_Q 0.66 0.00
160_R 208_N 0.66 0.00
332_I 222_Y 0.66 0.00
54_L 381_R 0.66 0.00
301_P 620_Q 0.66 0.00
317_A 441_K 0.66 0.00
208_D 61_A 0.66 0.00
364_Y 140_A 0.66 0.00
332_I 159_R 0.66 0.00
210_V 231_P 0.66 0.00
204_D 264_T 0.66 0.00
645_A 299_N 0.66 0.00
295_T 85_P 0.66 0.00
174_V 493_S 0.66 0.00
210_V 56_D 0.66 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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