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OPENSEQ.org
CARA - CARB
UniProt: P0A6F1 - P00968
Length: 1455
Sequences: 868
Seq/Len: 0.60
I_Prob: 0.87
CARA - Carbamoyl-phosphate synthase small chain
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CARA 		CARB - Carbamoyl-phosphate synthase large chain
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: CARB
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
1a9xAECG:BFHD:AECGContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
83_R 494_R 2.35 0.87
90_S 459_D 2.12 0.77
57_Y 254_Q 1.97 0.67
124_E 537_A 1.81 0.54
361_H 266_N 1.67 0.42
120_R 550_E 1.66 0.41
87_L 464_V 1.52 0.30
112_D 494_R 1.35 0.18
286_M 342_G 1.34 0.17
83_R 548_E 1.32 0.16
110_I 8_K 1.18 0.10
288_F 537_A 1.17 0.09
228_V 161_D 1.15 0.09
117_K 549_E 1.15 0.09
302_K 423_K 1.14 0.09
276_A 695_V 1.12 0.08
93_R 293_G 1.11 0.07
229_L 121_D 1.10 0.07
281_A 439_I 1.10 0.07
335_G 74_V 1.09 0.07
298_K 333_D 1.08 0.07
315_A 355_V 1.08 0.07
33_N 88_P 1.04 0.06
63_V 257_T 1.04 0.06
87_L 471_R 1.00 0.05
356_A 534_A 0.99 0.05
256_Q 657_A 0.98 0.04
216_L 470_V 0.97 0.04
346_P 903_V 0.96 0.04
302_K 395_L 0.96 0.04
59_H 465_Q 0.96 0.04
14_Q 1012_Y 0.95 0.04
75_V 697_A 0.94 0.04
341_H 112_G 0.94 0.04
256_Q 962_A 0.93 0.04
93_R 260_E 0.93 0.04
256_Q 439_I 0.93 0.04
247_P 662_I 0.93 0.03
346_P 564_V 0.93 0.03
352_G 276_G 0.93 0.03
331_S 581_C 0.92 0.03
37_T 261_Y 0.92 0.03
314_F 692_N 0.91 0.03
374_I 659_V 0.91 0.03
54_T 268_S 0.91 0.03
208_M 172_F 0.90 0.03
10_E 198_L 0.90 0.03
112_D 565_L 0.90 0.03
79_G 1010_Y 0.90 0.03
336_T 681_A 0.89 0.03
146_K 629_I 0.89 0.03
336_T 864_V 0.89 0.03
180_G 355_V 0.89 0.03
163_T 562_I 0.89 0.03
88_I 464_V 0.89 0.03
84_D 390_T 0.88 0.03
295_H 284_V 0.88 0.03
216_L 771_E 0.87 0.03
340_I 202_K 0.87 0.03
199_F 167_I 0.87 0.03
136_D 153_E 0.87 0.03
236_I 11_L 0.87 0.03
130_G 766_A 0.87 0.03
103_K 387_I 0.87 0.03
5_A 213_W 0.86 0.03
333_F 221_V 0.86 0.03
317_D 150_H 0.86 0.03
371_I 174_M 0.86 0.03
127_A 630_V 0.86 0.03
214_C 31_A 0.86 0.02
338_Q 583_V 0.85 0.02
309_A 231_V 0.85 0.02
81_V 484_L 0.85 0.02
130_G 946_L 0.85 0.02
372_E 680_H 0.84 0.02
352_G 704_K 0.84 0.02
295_H 95_A 0.84 0.02
83_R 704_K 0.84 0.02
81_V 873_S 0.84 0.02
113_I 112_G 0.84 0.02
84_D 465_Q 0.83 0.02
218_I 552_E 0.83 0.02
14_Q 815_K 0.83 0.02
315_A 564_V 0.83 0.02
207_R 126_A 0.83 0.02
236_I 121_D 0.82 0.02
18_R 491_Q 0.82 0.02
97_D 3_K 0.82 0.02
287_K 271_V 0.82 0.02
100_S 487_D 0.81 0.02
20_I 271_V 0.81 0.02
128_Q 362_F 0.81 0.02
141_A 502_L 0.81 0.02
68_A 450_D 0.81 0.02
113_I 1009_E 0.81 0.02
328_T 534_A 0.81 0.02
57_Y 218_M 0.81 0.02
136_D 513_I 0.81 0.02
301_E 486_A 0.81 0.02
18_R 38_R 0.80 0.02
40_Q 903_V 0.80 0.02
305_V 670_D 0.80 0.02
81_V 518_D 0.80 0.02
310_Q 583_V 0.80 0.02
316_V 1044_L 0.80 0.02
57_Y 437_W 0.79 0.02
167_A 840_I 0.79 0.02
319_A 454_N 0.79 0.02
226_E 450_D 0.79 0.02
236_I 109_E 0.79 0.02
122_L 494_R 0.79 0.02
336_T 1013_I 0.79 0.02
109_A 642_Y 0.79 0.02
286_M 143_T 0.79 0.02
212_R 231_V 0.78 0.02
100_S 699_E 0.78 0.02
91_N 293_G 0.78 0.02
145_E 875_A 0.78 0.02
120_R 534_A 0.78 0.02
72_S 387_I 0.78 0.02
31_V 854_S 0.78 0.02
315_A 149_A 0.78 0.02
365_P 405_G 0.78 0.02
286_M 131_R 0.78 0.02
100_S 969_F 0.78 0.02
143_A 71_W 0.78 0.02
163_T 1059_T 0.78 0.02
270_L 953_D 0.77 0.02
110_I 82_R 0.77 0.02
106_N 639_I 0.77 0.02
113_I 184_N 0.77 0.02
59_H 9_S 0.77 0.02
133_I 122_A 0.77 0.02
26_A 498_A 0.77 0.02
358_P 254_Q 0.77 0.02
320_T 436_I 0.77 0.02
99_S 138_K 0.77 0.01
286_M 550_E 0.77 0.01
67_D 688_K 0.76 0.01
295_H 1027_R 0.76 0.01
153_L 167_I 0.76 0.01
108_V 840_I 0.76 0.01
100_S 804_E 0.76 0.01
293_G 695_V 0.76 0.01
5_A 576_I 0.76 0.01
145_E 452_V 0.76 0.01
282_K 629_I 0.76 0.01
82_I 565_L 0.76 0.01
106_N 979_I 0.76 0.01
232_N 970_E 0.75 0.01
253_T 1033_A 0.75 0.01
203_R 490_R 0.75 0.01
107_I 699_E 0.75 0.01
21_G 594_Y 0.75 0.01
256_Q 291_K 0.75 0.01
65_T 960_L 0.75 0.01
224_S 519_Q 0.75 0.01
5_A 228_C 0.75 0.01
236_I 151_T 0.75 0.01
113_I 989_R 0.75 0.01
282_K 971_L 0.75 0.01
132_I 634_K 0.74 0.01
167_A 242_I 0.74 0.01
106_N 686_K 0.74 0.01
197_Y 991_V 0.74 0.01
286_M 357_T 0.74 0.01
274_L 522_L 0.74 0.01
288_F 271_V 0.74 0.01
216_L 546_T 0.74 0.01
214_C 630_V 0.74 0.01
371_I 351_S 0.74 0.01
119_T 921_G 0.74 0.01
274_L 988_P 0.74 0.01
226_E 970_E 0.74 0.01
57_Y 233_S 0.74 0.01
130_G 1027_R 0.74 0.01
122_L 139_I 0.74 0.01
65_T 744_V 0.74 0.01
94_N 730_D 0.74 0.01
317_D 7_I 0.74 0.01
163_T 456_T 0.74 0.01
60_I 825_L 0.74 0.01
187_E 182_A 0.74 0.01
201_A 992_N 0.73 0.01
65_T 10_I 0.73 0.01
330_K 210_L 0.73 0.01
43_L 674_D 0.73 0.01
84_D 494_R 0.73 0.01
89_A 453_F 0.73 0.01
363_A 166_C 0.73 0.01
276_A 958_V 0.73 0.01
346_P 1014_I 0.73 0.01
227_D 686_K 0.73 0.01
113_I 390_T 0.73 0.01
257_K 1009_E 0.73 0.01
129_N 934_G 0.73 0.01
318_E 342_G 0.73 0.01
130_G 813_V 0.73 0.01
357_S 259_K 0.73 0.01
201_A 471_R 0.73 0.01
237_F 867_R 0.73 0.01
53_V 403_E 0.73 0.01
194_V 565_L 0.73 0.01
5_A 88_P 0.73 0.01
141_A 86_V 0.73 0.01
326_R 733_D 0.73 0.01
236_I 104_R 0.73 0.01
248_C 254_Q 0.72 0.01
165_A 474_E 0.72 0.01
309_A 864_V 0.72 0.01
236_I 417_D 0.72 0.01
236_I 478_E 0.72 0.01
5_A 581_C 0.72 0.01
335_G 509_R 0.72 0.01
331_S 43_R 0.72 0.01
344_D 697_A 0.72 0.01
132_I 686_K 0.72 0.01
106_N 941_K 0.72 0.01
109_A 79_E 0.72 0.01
291_H 714_V 0.72 0.01
15_F 198_L 0.72 0.01
313_G 552_E 0.72 0.01
281_A 155_A 0.72 0.01
80_L 254_Q 0.72 0.01
298_K 513_I 0.72 0.01
295_H 651_A 0.72 0.01
66_N 257_T 0.71 0.01
221_A 77_I 0.71 0.01
113_I 971_L 0.71 0.01
109_A 60_M 0.71 0.01
16_H 488_F 0.71 0.01
291_H 583_V 0.71 0.01
196_A 763_D 0.71 0.01
371_I 424_I 0.71 0.01
56_T 661_V 0.71 0.01
235_G 594_Y 0.71 0.01
373_L 470_V 0.71 0.01
232_N 987_N 0.71 0.01
235_G 89_T 0.71 0.01
208_M 204_L 0.71 0.01
133_I 1013_I 0.71 0.01
349_S 729_Y 0.71 0.01
235_G 565_L 0.71 0.01
194_V 741_A 0.71 0.01
237_F 585_A 0.71 0.01
333_F 272_L 0.71 0.01
90_S 610_Y 0.71 0.01
110_I 88_P 0.71 0.01
330_K 859_V 0.71 0.01
167_A 1012_Y 0.71 0.01
310_Q 888_Y 0.71 0.01
309_A 115_M 0.70 0.01
93_R 595_E 0.70 0.01
94_N 803_Q 0.70 0.01
44_T 1039_H 0.70 0.01
286_M 752_L 0.70 0.01
128_Q 456_T 0.70 0.01
275_L 182_A 0.70 0.01
130_G 149_A 0.70 0.01
105_H 75_R 0.70 0.01
293_G 561_K 0.70 0.01
128_Q 172_F 0.70 0.01
91_N 321_K 0.70 0.01
110_I 266_N 0.70 0.01
216_L 452_V 0.70 0.01
113_I 386_A 0.70 0.01
291_H 282_S 0.70 0.01
216_L 192_C 0.70 0.01
46_P 250_V 0.70 0.01
52_I 537_A 0.70 0.01
156_M 610_Y 0.70 0.01
266_F 442_A 0.70 0.01
229_L 727_I 0.70 0.01
125_K 736_R 0.70 0.01
81_V 336_M 0.70 0.01
99_S 70_H 0.70 0.01
30_V 167_I 0.70 0.01
52_I 155_A 0.70 0.01
226_E 653_A 0.69 0.01
333_F 492_L 0.69 0.01
141_A 494_R 0.69 0.01
276_A 449_V 0.69 0.01
346_P 386_A 0.69 0.01
104_R 1059_T 0.69 0.01
338_Q 392_Q 0.69 0.01
92_F 940_K 0.69 0.01
210_V 211_I 0.69 0.01
81_V 1048_F 0.69 0.01
36_M 351_S 0.69 0.01
42_I 188_F 0.69 0.01
6_L 526_Y 0.69 0.01
104_R 452_V 0.69 0.01
217_T 181_I 0.69 0.01
124_E 157_A 0.69 0.01
344_D 924_F 0.69 0.01
304_V 500_A 0.69 0.01
112_D 1051_A 0.69 0.01
308_T 583_V 0.69 0.01
232_N 121_D 0.69 0.01
90_S 453_F 0.69 0.01
356_A 38_R 0.69 0.01
304_V 225_N 0.69 0.01
277_L 384_V 0.69 0.01
86_P 469_L 0.69 0.01
251_A 526_Y 0.69 0.01
78_Q 861_L 0.69 0.01
40_Q 842_V 0.69 0.01
10_E 1028_V 0.69 0.01
35_S 632_I 0.69 0.01
106_N 839_L 0.69 0.01
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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