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OPENSEQ.org
CARB - Carbamoyl-phosphate synthase large chain
UniProt: P00968 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10135
Length: 1073 (1068)
Sequences: 1519
Seq/Len: 1.42
CARB
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
357_T 394_S 6.045 1.00
467_E 471_R 5.587 1.00
706_K 731_E 4.165 1.00
289_N 292_N 4.025 1.00
563_M 599_V 3.842 1.00
82_R 111_F 3.64 1.00
226_D 273_R 3.636 1.00
9_S 45_I 3.578 1.00
9_S 43_R 3.5 1.00
104_R 124_D 3.434 1.00
623_L 627_L 3.369 1.00
69_I 98_C 3.366 1.00
667_D 677_R 3.318 1.00
684_R 819_E 3.233 1.00
75_R 110_E 3.149 1.00
560_E 636_K 3.142 1.00
867_R 872_K 3.13 1.00
944_R 970_E 3.08 1.00
79_E 111_F 3.066 1.00
192_C 204_L 3.007 1.00
484_L 489_L 2.955 1.00
75_R 111_F 2.954 1.00
811_Q 815_K 2.946 1.00
803_Q 807_D 2.945 1.00
947_L 961_A 2.887 1.00
814_Q 818_F 2.881 1.00
10_I 42_Y 2.804 1.00
264_M 295_L 2.797 1.00
872_K 876_E 2.781 1.00
965_L 987_N 2.77 1.00
155_A 192_C 2.758 1.00
218_M 233_S 2.739 1.00
1064_S 1067_E 2.71 1.00
439_I 452_V 2.702 1.00
138_K 274_E 2.702 1.00
972_D 1010_Y 2.685 1.00
75_R 79_E 2.664 1.00
400_R 625_D 2.658 1.00
980_V 984_A 2.645 1.00
958_V 980_V 2.632 1.00
921_G 926_E 2.611 1.00
443_F 463_L 2.598 1.00
441_D 445_A 2.597 1.00
693_A 704_K 2.553 1.00
486_A 490_R 2.55 1.00
443_F 449_V 2.546 1.00
799_Y 888_Y 2.537 1.00
145_R 208_E 2.507 1.00
703_E 707_E 2.481 1.00
289_N 294_R 2.48 1.00
472_L 495_K 2.48 1.00
156_L 189_E 2.458 1.00
443_F 452_V 2.457 1.00
395_L 436_I 2.434 1.00
693_A 707_E 2.428 1.00
518_D 631_R 2.424 1.00
873_S 877_Q 2.423 1.00
130_R 134_V 2.41 1.00
766_A 813_V 2.41 1.00
160_A 185_R 2.386 1.00
450_D 460_R 2.382 1.00
599_V 629_I 2.363 0.99
712_L 752_L 2.355 0.99
237_F 466_I 2.333 0.99
43_R 63_A 2.32 0.99
439_I 458_I 2.302 0.99
288_V 295_L 2.284 0.99
551_C 632_I 2.283 0.99
691_A 707_E 2.278 0.99
772_M 875_A 2.265 0.99
233_S 253_A 2.261 0.99
702_V 735_R 2.246 0.99
710_Y 731_E 2.226 0.99
125_K 138_K 2.223 0.99
958_V 984_A 2.217 0.99
4_R 114_T 2.208 0.99
873_S 876_E 2.196 0.99
563_M 630_V 2.175 0.99
518_D 523_H 2.173 0.99
808_V 811_Q 2.168 0.99
523_H 631_R 2.153 0.99
963_K 1055_N 2.136 0.99
771_E 873_S 2.123 0.99
652_R 656_A 2.101 0.99
147_G 161_D 2.1 0.99
741_A 745_S 2.095 0.98
509_R 512_E 2.088 0.98
74_V 98_C 2.047 0.98
42_Y 328_V 2.035 0.98
970_E 989_R 2.033 0.98
103_E 120_A 2.011 0.98
149_A 158_V 2.007 0.98
668_A 821_Q 2.007 0.98
47_V 77_I 2.004 0.98
272_L 284_V 2 0.98
392_Q 465_Q 1.994 0.98
185_R 189_E 1.991 0.98
1014_I 1047_G 1.99 0.98
702_V 731_E 1.987 0.98
964_L 1051_A 1.975 0.98
670_D 718_Y 1.971 0.97
448_S 451_G 1.963 0.97
384_V 401_G 1.957 0.97
682_V 839_L 1.942 0.97
39_E 325_K 1.941 0.97
630_V 659_V 1.938 0.97
150_H 203_E 1.934 0.97
991_V 1004_R 1.928 0.97
141_L 270_A 1.923 0.97
390_T 548_E 1.914 0.97
741_A 750_V 1.908 0.97
78_I 111_F 1.904 0.97
892_E 931_A 1.902 0.97
804_E 835_N 1.892 0.97
951_E 954_K 1.89 0.97
171_S 203_E 1.886 0.96
516_L 520_Y 1.875 0.96
377_Q 899_K 1.874 0.96
75_R 105_Q 1.873 0.96
208_E 294_R 1.863 0.96
688_K 812_Q 1.86 0.96
396_Q 497_F 1.844 0.96
159_A 166_C 1.838 0.96
159_A 164_F 1.833 0.96
802_S 805_I 1.832 0.96
388_G 393_E 1.822 0.95
141_L 267_A 1.821 0.95
242_I 431_A 1.811 0.95
591_E 863_K 1.805 0.95
40_E 325_K 1.799 0.95
953_D 1016_T 1.796 0.95
768_C 773_V 1.786 0.95
559_R 595_E 1.782 0.95
944_R 972_D 1.777 0.95
767_I 868_V 1.762 0.94
475_K 491_Q 1.757 0.94
142_E 294_R 1.756 0.94
322_V 338_D 1.754 0.94
768_C 818_F 1.746 0.94
218_M 253_A 1.744 0.94
982_G 990_L 1.729 0.94
103_E 109_E 1.723 0.93
978_A 988_P 1.722 0.93
151_T 154_E 1.712 0.93
1013_I 1033_A 1.708 0.93
100_L 120_A 1.708 0.93
406_A 437_W 1.675 0.92
153_E 157_A 1.671 0.92
182_A 191_I 1.665 0.92
732_A 735_R 1.662 0.92
196_L 202_K 1.657 0.92
164_F 184_N 1.646 0.91
697_A 700_M 1.64 0.91
392_Q 468_E 1.639 0.91
183_Y 187_E 1.634 0.91
253_A 261_Y 1.627 0.91
447_L 451_G 1.626 0.90
515_K 519_Q 1.624 0.90
499_D 517_R 1.619 0.90
164_F 185_R 1.612 0.90
420_A 423_K 1.609 0.90
560_E 594_Y 1.606 0.90
71_W 105_Q 1.606 0.90
488_F 492_L 1.601 0.90
184_N 187_E 1.597 0.89
730_D 733_D 1.596 0.89
489_L 516_L 1.596 0.89
731_E 735_R 1.582 0.89
762_V 801_L 1.581 0.89
490_R 494_R 1.576 0.89
592_D 867_R 1.569 0.88
449_V 463_L 1.569 0.88
617_Y 633_E 1.568 0.88
443_F 467_E 1.566 0.88
135_A 274_E 1.563 0.88
66_I 1065_V 1.563 0.88
975_H 990_L 1.543 0.87
687_L 812_Q 1.534 0.87
71_W 101_E 1.53 0.87
514_R 627_L 1.53 0.87
10_I 328_V 1.52 0.86
168_I 188_F 1.517 0.86
591_E 867_R 1.516 0.86
807_D 810_R 1.512 0.86
623_L 653_A 1.512 0.86
147_G 158_V 1.51 0.86
762_V 832_V 1.505 0.85
766_A 826_M 1.504 0.85
76_K 79_E 1.503 0.85
372_D 433_A 1.503 0.85
75_R 107_V 1.502 0.85
151_T 202_K 1.5 0.85
538_T 541_A 1.498 0.85
149_A 155_A 1.498 0.85
528_R 543_M 1.494 0.85
144_A 296_I 1.486 0.84
440_A 444_R 1.476 0.84
500_A 510_E 1.475 0.84
695_V 704_K 1.474 0.84
764_V 813_V 1.471 0.83
516_L 519_Q 1.471 0.83
421_L 445_A 1.46 0.83
146_S 207_D 1.459 0.83
562_I 662_I 1.457 0.83
681_A 816_L 1.45 0.82
776_G 861_L 1.45 0.82
671_R 819_E 1.447 0.82
287_A 296_I 1.446 0.82
816_L 828_V 1.443 0.82
79_E 110_E 1.441 0.82
237_F 439_I 1.441 0.82
513_I 516_L 1.439 0.82
960_L 1044_L 1.438 0.82
9_S 63_A 1.435 0.81
275_I 300_M 1.433 0.81
978_A 990_L 1.432 0.81
133_D 137_K 1.427 0.81
421_L 451_G 1.427 0.81
592_D 872_K 1.422 0.81
38_R 60_M 1.42 0.80
772_M 814_Q 1.42 0.80
668_A 671_R 1.419 0.80
443_F 466_I 1.419 0.80
476_V 502_L 1.415 0.80
867_R 877_Q 1.413 0.80
805_I 835_N 1.408 0.80
503_A 513_I 1.4 0.79
655_E 667_D 1.397 0.79
556_S 595_E 1.396 0.79
638_V 659_V 1.396 0.79
947_L 971_L 1.389 0.78
271_V 297_V 1.385 0.78
207_D 210_L 1.378 0.78
168_I 204_L 1.377 0.78
133_D 207_D 1.376 0.77
982_G 988_P 1.372 0.77
808_V 837_V 1.371 0.77
691_A 754_H 1.367 0.77
1031_R 1035_Q 1.366 0.77
623_L 657_A 1.364 0.77
670_D 677_R 1.364 0.77
992_N 1000_H 1.36 0.76
945_A 1014_I 1.355 0.76
502_L 506_A 1.351 0.76
679_Q 689_Q 1.351 0.76
407_T 504_K 1.349 0.75
802_S 835_N 1.345 0.75
391_Q 461_W 1.345 0.75
425_R 451_G 1.344 0.75
741_A 744_V 1.343 0.75
961_A 971_L 1.339 0.75
805_I 832_V 1.336 0.74
73_V 77_I 1.336 0.74
150_H 154_E 1.336 0.74
395_L 409_F 1.335 0.74
508_V 512_E 1.335 0.74
440_A 470_V 1.333 0.74
762_V 837_V 1.333 0.74
453_F 457_N 1.332 0.74
832_V 837_V 1.331 0.74
71_W 74_V 1.327 0.74
681_A 819_E 1.326 0.74
164_F 188_F 1.326 0.74
189_E 193_A 1.326 0.74
813_V 830_F 1.325 0.74
872_K 877_Q 1.321 0.73
742_V 750_V 1.318 0.73
407_T 500_A 1.315 0.73
511_A 656_A 1.31 0.72
66_I 918_M 1.31 0.72
188_F 206_I 1.306 0.72
453_F 463_L 1.305 0.72
703_E 706_K 1.304 0.72
428_L 442_A 1.3 0.72
69_I 74_V 1.3 0.72
762_V 809_M 1.293 0.71
121_D 131_R 1.289 0.71
962_A 966_K 1.287 0.71
562_I 870_A 1.286 0.70
864_V 877_Q 1.283 0.70
738_F 741_A 1.277 0.70
449_V 464_V 1.275 0.69
194_R 198_L 1.275 0.69
816_L 839_L 1.275 0.69
124_D 131_R 1.272 0.69
71_W 98_C 1.27 0.69
680_H 684_R 1.266 0.69
70_H 73_V 1.264 0.69
469_L 497_F 1.262 0.68
808_V 812_Q 1.261 0.68
452_V 466_I 1.26 0.68
677_R 718_Y 1.259 0.68
154_E 157_A 1.253 0.68
474_E 477_A 1.25 0.67
218_M 228_C 1.247 0.67
86_V 108_L 1.247 0.67
392_Q 495_K 1.245 0.67
125_K 274_E 1.244 0.67
679_Q 692_N 1.243 0.67
806_Q 810_R 1.241 0.66
485_N 488_F 1.241 0.66
168_I 206_I 1.24 0.66
811_Q 814_Q 1.239 0.66
923_T 926_E 1.238 0.66
979_I 983_E 1.237 0.66
808_V 836_E 1.236 0.66
152_M 188_F 1.233 0.66
144_A 210_L 1.233 0.66
322_V 335_L 1.23 0.65
523_H 628_E 1.223 0.65
688_K 836_E 1.222 0.65
518_D 628_E 1.221 0.65
704_K 707_E 1.221 0.65
449_V 467_E 1.22 0.65
510_E 514_R 1.22 0.65
724_A 741_A 1.218 0.64
1027_R 1031_R 1.218 0.64
973_A 988_P 1.216 0.64
149_A 154_E 1.216 0.64
266_N 270_A 1.216 0.64
468_E 472_L 1.214 0.64
35_K 611_D 1.212 0.64
924_F 1049_A 1.212 0.64
687_L 808_V 1.204 0.63
947_L 1014_I 1.201 0.63
476_V 492_L 1.2 0.63
736_R 740_T 1.199 0.63
267_A 295_L 1.198 0.62
124_D 172_F 1.194 0.62
330_Y 335_L 1.192 0.62
404_V 437_W 1.187 0.61
563_M 629_I 1.182 0.61
101_E 105_Q 1.182 0.61
399_L 436_I 1.179 0.61
809_M 813_V 1.178 0.61
944_R 1011_T 1.178 0.61
395_L 466_I 1.177 0.60
767_I 861_L 1.176 0.60
237_F 248_I 1.175 0.60
589_L 596_T 1.171 0.60
225_N 331_T 1.17 0.60
1041_D 1050_T 1.169 0.60
253_A 352_I 1.169 0.60
468_E 495_K 1.168 0.60
508_V 513_I 1.168 0.60
812_Q 837_V 1.167 0.59
444_R 473_E 1.166 0.59
147_G 157_A 1.164 0.59
134_V 138_K 1.162 0.59
639_I 866_A 1.161 0.59
963_K 1051_A 1.161 0.59
813_V 828_V 1.16 0.59
170_P 179_G 1.16 0.59
174_M 934_G 1.157 0.58
134_V 137_K 1.156 0.58
101_E 104_R 1.156 0.58
47_V 78_I 1.15 0.58
957_V 981_L 1.15 0.58
1005_I 1038_V 1.149 0.58
489_L 522_L 1.147 0.57
47_V 74_V 1.146 0.57
993_K 1025_D 1.14 0.57
563_M 659_V 1.14 0.57
218_M 268_S 1.137 0.56
11_L 86_V 1.135 0.56
79_E 107_V 1.134 0.56
78_I 113_V 1.131 0.56
224_K 331_T 1.13 0.56
688_K 808_V 1.129 0.56
972_D 989_R 1.127 0.55
137_K 143_T 1.126 0.55
234_I 249_T 1.126 0.55
627_L 659_V 1.124 0.55
141_L 297_V 1.123 0.55
456_T 470_V 1.119 0.55
384_V 398_A 1.118 0.55
156_L 160_A 1.117 0.54
337_N 340_T 1.117 0.54
321_K 338_D 1.113 0.54
561_K 595_E 1.109 0.54
227_N 347_S 1.107 0.53
13_L 95_A 1.107 0.53
221_V 272_L 1.105 0.53
774_L 879_V 1.104 0.53
793_A 892_E 1.104 0.53
771_E 818_F 1.103 0.53
513_I 520_Y 1.103 0.53
778_I 806_Q 1.1 0.53
728_V 750_V 1.1 0.53
636_K 660_P 1.098 0.53
1005_I 1032_S 1.098 0.53
152_M 156_L 1.098 0.53
38_R 730_D 1.097 0.52
556_S 561_K 1.096 0.52
724_A 742_V 1.095 0.52
156_L 164_F 1.093 0.52
866_A 870_A 1.093 0.52
447_L 455_L 1.089 0.52
687_L 837_V 1.088 0.52
260_E 293_G 1.087 0.51
718_Y 748_A 1.086 0.51
428_L 456_T 1.085 0.51
812_Q 830_F 1.082 0.51
262_Q 265_R 1.077 0.50
954_K 976_G 1.076 0.50
971_L 988_P 1.076 0.50
440_A 466_I 1.075 0.50
19_V 177_S 1.075 0.50
164_F 635_P 1.071 0.50
728_V 741_A 1.061 0.49
621_V 650_L 1.053 0.48
258_D 262_Q 1.053 0.48
8_K 43_R 1.052 0.48
160_A 164_F 1.049 0.48
157_A 160_A 1.046 0.47
86_V 986_I 1.045 0.47
36_A 335_L 1.045 0.47
63_A 1064_S 1.044 0.47
589_L 870_A 1.042 0.47
454_N 457_N 1.042 0.47
156_L 159_A 1.041 0.47
766_A 773_V 1.04 0.47
107_V 111_F 1.04 0.47
76_K 1059_T 1.04 0.47
798_A 806_Q 1.037 0.46
221_V 322_V 1.037 0.46
447_L 452_V 1.035 0.46
472_L 488_F 1.033 0.46
34_C 60_M 1.032 0.46
142_E 208_E 1.028 0.45
221_V 229_I 1.025 0.45
852_F 918_M 1.025 0.45
729_Y 1019_G 1.024 0.45
472_L 492_L 1.023 0.45
451_G 454_N 1.023 0.45
971_L 986_I 1.023 0.45
945_A 961_A 1.022 0.45
484_L 513_I 1.022 0.45
587_L 612_T 1.02 0.45
805_I 837_V 1.017 0.44
742_V 745_S 1.016 0.44
424_I 445_A 1.012 0.44
453_F 458_I 1.012 0.44
699_E 703_E 1.009 0.43
441_D 444_R 1.008 0.43
465_Q 468_E 1.007 0.43
186_E 475_K 1.007 0.43
556_S 559_R 1.007 0.43
133_D 205_L 1.005 0.43
355_V 394_S 1.004 0.43
745_S 750_V 1.002 0.43
342_G 539_D 1.001 0.43
955_E 984_A 1.001 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a9xA40.99911000.396Contact Map0.817
3glkA10.41011000.896Contact Map0.638
3orqA20.33641000.899Contact Map0.587
2vpqA20.39051000.9Contact Map0.571
1ulzA10.39241000.901Contact Map0.55
3jrxA10.45671000.902Contact Map0.592
1w96A30.38581000.904Contact Map0.593
3q2oA20.34761000.905Contact Map0.551
2dzdA20.38771000.905Contact Map0.599
3ouzA20.37931000.907Contact Map0.566
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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