May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

IDH - ILVN
UniProt: P08200 - P0ADF8
Length: 512
Sequences: 369
Seq/Len: 0.82
I_Prob: 0.02

IDH - Isocitrate dehydrogenase [NADP]
Paralog alert: 0.65 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DMLA IDH LEU3
ILVN - Acetolactate synthase isozyme 1 small subunit
Paralog alert: 0.28 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ILVH ILVN
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
248_L 60_Q 1.59 0.02
134_Y 25_V 1.28 0.01
320_I 75_V 1.17 0.01
349_D 40_L 1.15 0.01
41_V 11_L 1.07 0.01
39_V 33_A 1.07 0.01
282_A 73_E 1.04 0.01
360_A 45_Q 1.03 0.01
251_E 87_M 1.02 0.00
33_E 65_M 1.02 0.00
355_S 64_Q 1.01 0.00
41_V 62_L 1.01 0.00
215_E 52_I 1.00 0.00
30_P 29_F 0.99 0.00
356_I 91_I 0.98 0.00
385_N 26_C 0.96 0.00
249_A 71_K 0.95 0.00
344_K 44_I 0.94 0.00
412_I 67_S 0.94 0.00
373_A 24_H 0.94 0.00
365_R 37_E 0.94 0.00
93_R 49_K 0.93 0.00
50_D 87_M 0.89 0.00
314_A 49_K 0.89 0.00
284_A 29_F 0.89 0.00
358_L 48_D 0.89 0.00
381_E 73_E 0.88 0.00
409_G 42_L 0.88 0.00
151_I 72_L 0.88 0.00
150_V 73_E 0.87 0.00
222_R 87_M 0.86 0.00
382_G 76_V 0.86 0.00
103_L 92_A 0.85 0.00
364_L 56_V 0.85 0.00
214_I 29_F 0.85 0.00
222_R 47_S 0.85 0.00
328_I 28_L 0.85 0.00
301_C 45_Q 0.84 0.00
242_K 17_N 0.83 0.00
314_A 28_L 0.83 0.00
314_A 41_C 0.83 0.00
121_E 52_I 0.83 0.00
371_E 82_Q 0.82 0.00
91_L 74_D 0.82 0.00
28_I 77_K 0.81 0.00
52_A 47_S 0.81 0.00
359_S 56_V 0.81 0.00
215_E 60_Q 0.81 0.00
39_V 74_D 0.80 0.00
133_Y 23_T 0.80 0.00
211_R 33_A 0.80 0.00
132_R 73_E 0.80 0.00
74_S 41_C 0.80 0.00
348_Q 62_L 0.80 0.00
30_P 12_E 0.80 0.00
316_Q 18_H 0.80 0.00
76_Q 90_K 0.79 0.00
374_D 60_Q 0.79 0.00
329_G 13_L 0.79 0.00
358_L 92_A 0.79 0.00
37_I 69_I 0.79 0.00
363_M 25_V 0.78 0.00
345_Y 89_N 0.78 0.00
328_I 51_H 0.78 0.00
45_M 46_D 0.77 0.00
222_R 73_E 0.77 0.00
149_M 34_F 0.77 0.00
102_P 24_H 0.77 0.00
409_G 54_L 0.77 0.00
164_E 9_V 0.77 0.00
324_P 10_I 0.76 0.00
300_A 15_V 0.76 0.00
365_R 52_I 0.76 0.00
39_V 47_S 0.76 0.00
85_P 41_C 0.76 0.00
292_R 76_V 0.76 0.00
416_M 17_N 0.76 0.00
203_E 76_V 0.76 0.00
407_E 60_Q 0.76 0.00
210_V 30_A 0.75 0.00
295_E 44_I 0.75 0.00
412_I 17_N 0.75 0.00
349_D 16_R 0.75 0.00
355_S 67_S 0.75 0.00
150_V 55_L 0.75 0.00
342_A 89_N 0.75 0.00
320_I 81_N 0.75 0.00
29_I 57_N 0.74 0.00
63_I 74_D 0.74 0.00
94_E 58_D 0.74 0.00
98_A 63_E 0.74 0.00
304_L 53_W 0.74 0.00
233_I 34_F 0.73 0.00
122_L 52_I 0.73 0.00
365_R 43_P 0.73 0.00
339_H 91_I 0.73 0.00
30_P 67_S 0.73 0.00
249_A 84_D 0.72 0.00
284_A 65_M 0.72 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

Page generated in 0.0217 seconds.