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HIS2 - HIS4
UniProt: P06989 - P10371
Length: 448
Sequences: 414
Seq/Len: 0.95
I_Prob: 0.00

HIS2 - Histidine biosynthesis bifunctional protein HisIE
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HIS2
HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: HIS4 HIS6
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
160_A 183_N 1.18 0.00
91_N 131_R 1.10 0.00
131_E 101_V 1.06 0.00
22_I 3_I 1.01 0.00
181_L 106_V 0.96 0.00
57_T 4_P 0.95 0.00
103_S 88_V 0.92 0.00
103_S 183_N 0.91 0.00
43_D 237_E 0.90 0.00
180_L 8_L 0.90 0.00
22_I 99_V 0.89 0.00
28_S 67_T 0.87 0.00
188_G 136_G 0.86 0.00
88_V 54_A 0.85 0.00
178_Y 82_V 0.84 0.00
160_A 13_V 0.84 0.00
23_V 197_V 0.83 0.00
196_E 193_R 0.82 0.00
166_R 84_S 0.82 0.00
202_H 132_I 0.82 0.00
86_L 163_V 0.82 0.00
180_L 183_N 0.82 0.00
90_A 196_Q 0.81 0.00
41_A 230_E 0.80 0.00
190_D 118_R 0.80 0.00
112_W 52_T 0.80 0.00
74_V 180_A 0.80 0.00
105_F 116_F 0.79 0.00
168_E 13_V 0.79 0.00
151_G 47_H 0.79 0.00
69_G 190_V 0.78 0.00
49_G 189_E 0.78 0.00
21_V 163_V 0.78 0.00
58_K 130_V 0.78 0.00
129_D 124_L 0.78 0.00
181_L 140_V 0.78 0.00
54_F 32_L 0.77 0.00
135_T 54_A 0.77 0.00
191_L 161_L 0.77 0.00
135_T 227_A 0.77 0.00
22_I 190_V 0.77 0.00
166_R 111_M 0.76 0.00
45_T 63_P 0.76 0.00
51_V 238_A 0.76 0.00
33_M 108_S 0.76 0.00
16_D 36_Q 0.75 0.00
177_M 84_S 0.75 0.00
83_N 17_H 0.75 0.00
155_V 210_D 0.75 0.00
76_S 139_Q 0.75 0.00
147_A 76_V 0.75 0.00
121_L 67_T 0.74 0.00
71_F 103_S 0.74 0.00
48_S 209_D 0.74 0.00
174_S 112_V 0.74 0.00
52_T 34_R 0.74 0.00
105_F 183_N 0.73 0.00
178_Y 54_A 0.73 0.00
168_E 183_N 0.73 0.00
184_L 235_V 0.73 0.00
136_A 227_A 0.72 0.00
19_M 69_V 0.72 0.00
92_P 233_F 0.72 0.00
157_T 227_A 0.72 0.00
184_L 76_V 0.72 0.00
42_L 211_V 0.72 0.00
117_Q 199_F 0.71 0.00
49_G 240_A 0.71 0.00
116_Y 189_E 0.71 0.00
161_A 47_H 0.71 0.00
21_V 39_A 0.71 0.00
92_P 4_P 0.71 0.00
168_E 8_L 0.71 0.00
58_K 143_S 0.70 0.00
189_L 68_L 0.70 0.00
41_A 153_L 0.70 0.00
120_Q 158_E 0.70 0.00
19_M 66_K 0.70 0.00
178_Y 91_L 0.69 0.00
48_S 99_V 0.69 0.00
99_K 217_T 0.69 0.00
108_T 108_S 0.69 0.00
182_V 54_A 0.68 0.00
127_S 150_G 0.68 0.00
133_S 231_G 0.68 0.00
170_T 231_G 0.68 0.00
166_R 118_R 0.68 0.00
41_A 64_L 0.68 0.00
105_F 170_C 0.67 0.00
86_L 67_T 0.67 0.00
12_W 149_S 0.67 0.00
74_V 159_T 0.67 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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