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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 -0.1 0.7 1.1 1 1 0.1 -0.6 -0.1 -0.6 -0.6 -0.6 -0.6 -0.6 0 -0.6 0.1 0.3 -0.6 -0.6 -0.4
0002 1.2 1.2 0.8 1.9 1.2 -0.3 -0.8 -0.6 -0.5 -0.8 -0.6 -0.8 -0.8 -0.8 -0.8 -0.2 -0.3 0.5 -0.7 0.3
0003 0 -0.2 0.4 0.5 1.2 0.2 -0.9 0 0.2 -0.7 -0.5 -0.9 -0.7 -0.1 -0.1 1.2 1.3 0 -0.9 -0.7
0004 0 -0.1 0.5 0.7 0.8 0 -0.8 -0.8 -0.3 -0.6 -0.6 -0.5 -0.5 -0.6 -0.8 1 2.1 0 0.1 -0.5
0005 -0.1 2.1 1.1 1.6 0.9 0.1 -0.4 -0.3 -0.7 -0.6 -0.7 -0.7 -0.7 -0.3 -0.7 -0.2 0.3 -0.4 0.1 -0.3
0006 0.7 1.4 1.1 1.9 1.3 -0.6 -0.7 -0.5 -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.7 -0.4 0 0.2 -0.7 0.5
0007 0 0.6 1.4 1 1.6 0.5 -0.8 0 -0.9 -0.7 -0.5 -0.9 -0.7 -0.9 -0.4 0 -0.4 1.5 -0.9 -0.7
0008 0.4 -0.6 -0.6 0.2 0.3 -0.4 -0.6 -0.6 0.8 0.3 -0.2 0 0.1 0.2 0.6 0.1 -0.1 0.1 -0.4 -0.4
0009 0.1 1 0 0.8 0.5 -0.3 -0.4 0.3 -0.3 -0.3 -0.3 -0.5 -0.3 -0.5 -0.3 0 0.4 0.1 -0.3 -0.1
0010 0.5 0.1 0.5 0.9 0.9 -0.1 -0.6 -0.6 -0.6 -0.6 -0.6 -0.4 -0.4 -0.4 -0.6 -0.1 0.2 0.6 1 -0.3
0011 -0.2 -0.6 -0.1 0.6 -0.4 -0.1 0.6 0 -0.6 -0.3 0.4 1.7 -0.1 -0.3 -0.1 0.3 -0.2 -0.3 -0.6 -0.3
0012 1.2 0.1 -0.9 -0.5 -0.3 0 -0.3 0.9 -0.2 -0.8 1.4 1.3 -0.6 -0.3 -0.9 0.4 -0.3 0.8 -0.2 -0.9
0013 0 0.7 0.9 2.1 0.6 0.4 -0.6 0.1 -0.9 -0.9 -0.5 0.3 -0.7 -0.1 -0.4 -0.5 -0.7 0.1 -0.4 0.5
0014 -0.1 1.2 1.3 1.5 0.6 0.2 -0.2 -0.6 -0.5 -0.5 -0.1 -0.5 -0.3 -0.1 -0.5 -0.5 -0.3 -0.5 -0.5 0.1
0015 0.8 0.2 -0.1 -0.1 1.2 -0.5 -0.5 0.3 -0.5 0.1 -0.3 -0.3 -0.6 -0.6 -0.3 0.8 0.1 0.3 -0.6 -0.4
0016 -0.1 -0.5 0.1 -0.2 -0.6 -0.4 -0.5 -0.2 0.1 0.4 0.5 0.8 -0.5 -0.1 -0.1 0.5 0.5 0.4 -0.6 0.1
0017 0.1 -0.1 -0.2 0 -0.2 -0.7 -0.1 0.2 -0.8 -0.8 1.1 0.7 0.6 0.1 0 0 0.3 0.3 -0.1 -0.5
0018 -0.3 0.8 0.5 1.2 0.4 0.1 0.1 0.3 -0.8 -0.1 -0.5 -0.4 -0.8 -0.8 -0.3 -0.1 -0.3 -0.3 0.1 0.7
0019 0.1 -0.2 0.1 0.6 -0.1 -0.4 0.2 -0.5 -0.5 -0.3 0.2 -0.3 -0.8 0.4 -0.1 0.8 0 0.3 -0.2 0.3
0020 0 -0.9 -0.3 0 -0.2 -0.5 -0.6 -0.3 -0.2 -0.2 1.4 1 -0.8 -0.2 0.9 0 0.4 0.3 0.1 -0.8
0021 -0.3 0.8 0.2 0.7 0.3 -0.2 0.1 -0.4 -0.6 -0.8 1 0.7 -0.6 -0.1 -0.1 0.6 -0.3 -0.1 -0.5 -0.4
0022 -0.2 0.1 0.7 1.1 0.3 0.1 0.4 -0.5 0.1 -0.4 0.4 0.1 -0.7 -0.4 -0.5 0.1 -0.5 0.1 0.5 -0.2
0023 0 -0.5 -0.8 -0.7 -0.4 -0.3 -0.2 -0.4 -0.4 0.3 0 0.9 -0.1 0.9 0.3 0.9 0.4 1.4 0 -0.5
0024 0.4 -0.7 -0.8 0.5 -0.1 -0.4 -0.9 0.6 -0.7 0.6 1.1 0.8 -0.5 0 0.9 -0.3 0.3 0 0.5 -0.7
0025 0.3 -0.3 -0.4 0.1 0.2 -0.4 -0.6 0 -0.4 0.1 -0.5 0.6 -0.4 -0.3 0.8 0.5 0.1 0 1.6 -0.6
0026 -0.3 -0.2 -0.9 -0.5 0.4 -0.7 -0.7 -0.9 1.4 3.4 0.4 0.7 -0.5 -0.7 0.8 -0.5 0.6 -0.4 -0.2 -0.7
0027 -0.3 1.5 -0.3 1 -0.1 0.3 -0.3 -0.1 -0.3 0 -0.3 0.5 -0.1 -0.3 -0.3 0 -0.3 0.2 -0.3 0
0028 0.2 -0.3 -0.7 0.6 0.2 -0.4 -0.7 -0.3 1.5 0.2 -0.1 -0.2 -0.3 1 0.2 0.4 -0.2 0 -0.7 0
0029 -0.2 -0.1 1 1.1 1.4 0.3 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 0.2 0.1 0 -0.4
0030 1 -0.5 0 -0.5 0.1 -0.5 -0.5 -0.5 -0.5 0.2 -0.1 -0.5 0 -0.5 -0.3 1.1 0.7 0.4 1.1 -0.2
- A F I L V M W Y D E K R H N Q S T G P C
0031 0.3 -0.3 -0.7 0.4 -0.4 -0.7 -0.5 -0.1 1.1 0.6 0.4 -0.1 -0.4 0.1 0.6 0.5 0.1 0.1 -0.5 -0.4
0032 0 -0.6 -0.6 -0.1 0.1 -0.2 -0.6 -0.1 -0.2 0.7 0.2 -0.4 0.7 1.4 0 1.2 -0.1 -0.4 -0.6 -0.2
0033 0.3 0 1.2 0.1 1 -0.4 -0.4 0.1 -0.4 -0.4 -0.4 -0.4 -0.3 -0.4 -0.4 0.5 0.9 -0.4 0.1 -0.2
0034 -0.1 0.5 0.8 0 0.6 0.6 -0.3 0 -0.3 0 -0.3 -0.3 0.1 -0.3 -0.3 -0.1 -0.3 -0.3 0 0
0035 0 -0.6 -0.6 -0.6 -0.7 -0.8 -0.6 -0.4 2.1 1.5 -0.6 -0.4 0.4 0.3 0.5 0.4 -0.1 1.4 -0.5 -0.6
0036 0.3 0.1 2.2 2.1 1.2 0.4 -0.6 -0.6 -0.3 -0.6 -0.6 -0.4 -0.6 -0.3 -0.6 -0.6 -0.1 -0.3 -0.3 -0.3
0037 0.2 -0.1 0.8 0.5 0.6 -0.1 -0.4 -0.4 0.1 -0.1 -0.1 -0.4 -0.4 -0.4 -0.4 -0.1 0.5 -0.4 -0.1 0.1
0038 0.1 0.6 -0.4 0.2 -0.1 -0.4 -0.1 0.4 0.3 -0.3 -0.4 -0.4 0.3 0.9 -0.1 -0.2 0 -0.4 -0.1 -0.1
0039 0.6 0 0.4 0.1 -0.2 -0.4 -0.3 -0.4 -0.5 -0.4 -0.6 0.8 -0.6 1 -0.6 0.9 0.6 1 -0.6 -0.4
0040 0 -0.3 0.2 0.5 -0.3 -0.3 -0.3 -0.3 -0.3 0.3 0 0 0 0 1 0 -0.3 0.2 -0.3 -0.3
0041 1.7 -0.8 0.2 -0.3 -0.2 -0.1 -0.8 -0.3 -0.8 -0.8 -0.8 -0.8 -0.8 -0.1 -0.5 0.8 2.6 2.2 -0.3 0
0042 -0.6 -0.3 1.4 2.2 1.8 1.6 -0.3 -0.2 -0.6 -0.6 -0.6 -0.6 -0.4 -0.3 0 -0.3 -0.3 -0.6 -0.3 -0.6
0043 0.2 0.2 0.4 0.9 1.7 -0.4 -0.6 -0.1 -0.6 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 0.6 0.5 -0.1 -0.1 1.2
0044 -0.3 0.3 -0.1 0.3 -0.3 0.2 1 0 -0.3 0 -0.3 0.8 -0.3 -0.3 -0.3 0.2 0.2 -0.3 -0.3 -0.1
0045 -0.1 0.8 1.4 1.8 1.4 0.7 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.5 -0.5 -0.2 0.3 -0.3 -0.5 -0.5
0046 0.5 0.1 0.1 0.1 0.4 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 0.2 0.3 0.7 -0.2 -0.2
0047 0.5 0.6 0.6 0.7 0.4 1.2 -0.5 -0.5 -0.6 -0.4 -0.6 -0.4 -0.2 -0.5 -0.6 1.3 0.6 -0.1 -0.6 0
0048 -0.2 1.3 0.5 1 0.5 0.1 -0.3 1.4 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 0.1 -0.2 -0.5 -0.1 -0.3
0049 0.2 1.2 -0.3 0.3 0.1 0.2 0.1 1.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 0 -0.3 -0.3
0050 2.2 -0.4 -0.6 -0.1 0.8 0.1 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 2.3 -0.1 -0.3 -0.6 2.3
0051 0.7 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.4 3.4 -0.3
0052 -0.2 0.9 0.7 2.8 0.5 0.9 -0.7 -0.5 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 0 -0.7 1.8 0 0.3
0053 0.1 0.1 1.2 1.9 0.6 0.7 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.4 -0.2 -0.2 -0.4 -0.4
0054 0.9 -0.5 0.6 0.2 1 -0.1 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.9 0.6 -0.2 1.1 -0.1
0055 0.8 0.8 0.6 1.2 1.1 -0.1 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.3 0.1 0.8 -0.3 0.1
0056 0.2 0.3 2.2 1.7 1.4 1.1 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.3 -0.1 -0.3 -0.6 -0.6 -0.6
0057 1.2 -0.5 0.5 0.1 0.8 -0.2 -0.7 -0.6 -0.7 -0.5 -0.7 -0.7 -0.3 1.2 0.9 0.5 0.1 1.1 -0.7 -0.2
0058 1.1 0.3 1.1 1.2 1.8 0.6 -0.8 -0.8 -0.5 -0.8 -0.8 -0.8 -0.8 -0.1 -0.8 0.3 1.4 -0.3 -0.5 -0.1
0059 0.3 1.1 1.8 1.8 1.9 0.1 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.4 -0.6 -0.3 0 -0.4 -0.2
0060 -0.2 0 0.4 0.2 -0.2 0.4 -0.4 -0.2 -0.4 -0.2 0.1 -0.2 -0.1 -0.4 -0.2 1 0.4 0 -0.4 0
- A F I L V M W Y D E K R H N Q S T G P C
0061 -0.4 0.3 0.5 0.3 0.2 0.2 -0.4 -0.1 -0.4 -0.4 -0.2 -0.4 -0.2 0.8 -0.2 0.2 0.2 -0.2 -0.4 0.2
0062 -0.1 2 1.6 1.6 1.2 0 -0.8 -0.3 -0.8 -0.8 -0.8 -0.8 0.1 -0.8 -0.8 -0.2 0.4 -0.1 -0.8 0
0063 0.4 0.5 2.5 1.7 1.7 -0.1 -0.7 -0.7 -0.7 -0.5 -0.7 -0.5 -0.7 -0.7 -0.7 -0.4 1 -0.1 -0.7 -0.5
0064 -0.8 0.1 1 2.2 1.1 0.9 -0.8 -0.5 -0.5 -0.8 -0.4 -0.3 -0.8 -0.5 -0.6 0.9 1.1 -0.4 -0.8 -0.8
0065 -0.3 2.7 -0.2 0.5 0.1 1.4 0.4 0.4 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 0 -0.5 -0.5 -0.5 -0.5 -0.5
0066 -0.1 0.5 -0.1 0.2 0.1 -0.4 0 1 -0.2 -0.4 -0.1 -0.4 0.4 0.1 -0.3 -0.1 -0.4 -0.1 -0.1 -0.1
0067 -0.3 0.4 1.5 1.3 1.3 0.3 -0.6 -0.1 -0.6 -0.6 -0.6 -0.6 -0.3 -0.6 -0.6 0 0.3 -0.4 -0.5 0.2
0068 -0.2 -0.4 -0.5 0.5 0.2 -0.3 -0.5 -0.3 -0.5 -0.5 1.3 1.2 0 0.5 0.5 -0.1 0 -0.5 -0.5 -0.5
0069 -0.1 -0.2 -0.2 0.1 -0.4 -0.2 -0.5 0.7 -0.5 0.2 0.3 0.5 -0.5 -0.3 0.3 0.4 -0.2 -0.2 -0.1 0.4
Select residue pair below:
i_j Score Prob
0030_0037 2.715 1.00
0011_0023 1.751 1.00
0043_0057 1.742 1.00
0040_0044 1.693 1.00
0065_0068 1.667 1.00
0047_0062 1.639 1.00
0034_0044 1.456 0.99
0059_0062 1.411 0.98
0029_0061 1.401 0.98
0034_0040 1.380 0.98
0034_0037 1.379 0.98
0016_0019 1.340 0.97
0001_0005 1.329 0.97
0045_0050 1.306 0.97
0007_0010 1.289 0.96
0033_0054 1.283 0.96
0028_0031 1.220 0.95
0046_0051 1.213 0.95
0031_0035 1.201 0.94
0027_0044 1.198 0.94
0008_0032 1.186 0.94
0060_0064 1.184 0.94
0009_0012 1.173 0.93
0046_0066 1.163 0.93
0056_0064 1.130 0.91
0027_0040 1.125 0.91
0015_0018 1.122 0.91
0016_0024 1.110 0.90
0037_0044 1.101 0.90
0008_0050 1.076 0.88
0047_0061 1.072 0.88
0015_0019 1.063 0.88
0049_0060 1.021 0.85
0001_0006 1.020 0.85
0025_0030 1.017 0.84
0063_0067 1.016 0.84
0014_0018 1.014 0.84
0033_0052 1.003 0.83
0001_0067 0.996 0.83
0036_0061 0.987 0.82
0049_0069 0.968 0.80
0039_0060 0.966 0.80
0053_0060 0.953 0.79
0014_0063 0.941 0.77
0010_0014 0.939 0.77
0039_0043 0.930 0.76
0046_0053 0.924 0.76
0019_0059 0.921 0.75
0035_0039 0.911 0.74
0038_0044 0.906 0.74
0001_0059 0.901 0.73
0001_0018 0.896 0.72
0037_0040 0.895 0.72
0034_0054 0.893 0.72
0039_0061 0.892 0.72
0047_0067 0.886 0.71
0003_0025 0.883 0.71
0027_0034 0.880 0.70
0011_0022 0.873 0.70
0055_0060 0.859 0.68
0008_0025 0.857 0.67
0020_0055 0.851 0.67
0061_0066 0.850 0.67
0005_0008 0.841 0.65
0031_0042 0.841 0.65
0060_0066 0.832 0.64
0029_0036 0.831 0.64
0024_0028 0.828 0.64
0029_0057 0.824 0.63
0004_0009 0.824 0.63
0065_0069 0.822 0.63
0002_0021 0.812 0.61
0023_0030 0.810 0.61
0016_0055 0.806 0.60
0029_0038 0.802 0.60
0013_0021 0.801 0.60
0056_0067 0.798 0.59
0038_0042 0.795 0.59
0012_0020 0.795 0.59
0006_0010 0.793 0.59
0008_0015 0.793 0.59
0033_0043 0.780 0.57
0028_0049 0.780 0.57
0006_0058 0.772 0.56
0038_0049 0.767 0.55
0045_0048 0.766 0.55
0049_0066 0.759 0.54
0027_0037 0.753 0.53
0002_0005 0.752 0.53
0002_0055 0.746 0.52
0017_0020 0.745 0.52
0021_0069 0.744 0.51
0004_0011 0.743 0.51
0029_0032 0.735 0.50
0041_0069 0.731 0.49
0045_0061 0.731 0.49
0010_0067 0.730 0.49
0025_0033 0.727 0.49
0009_0047 0.727 0.49
0058_0061 0.726 0.49
0003_0006 0.725 0.49
0047_0059 0.723 0.48
0022_0025 0.722 0.48
Local Interactions:
i_j Score Prob
0017_0018 2.000 1.00
0016_0017 1.911 1.00
0054_0055 1.800 1.00
0015_0016 1.596 0.99
0048_0049 1.536 0.99
0013_0014 1.497 0.99
0017_0019 1.491 0.99
0038_0040 1.326 0.97
0018_0019 1.323 0.97
0053_0054 1.182 0.93
0030_0031 1.160 0.93
0022_0024 1.072 0.88
0015_0017 1.059 0.87
0019_0021 1.053 0.87
0066_0068 1.033 0.86
0009_0010 1.029 0.85
0008_0009 1.012 0.84
0060_0061 0.900 0.73
0046_0048 0.889 0.72
0032_0034 0.884 0.71
0028_0030 0.852 0.67
0016_0018 0.827 0.63
0043_0045 0.822 0.63
0068_0069 0.811 0.61
0033_0034 0.798 0.59
0021_0022 0.784 0.57
0055_0056 0.776 0.56
0056_0057 0.756 0.53
0009_0011 0.741 0.51
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: S P V L E ...
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