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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0009 -0.2 -0.4 0.1 0.3 0.1 -0.1 0.7 0 -0.9 0.3 0.2 -0.1 -0.1 -0.2 0.8 0.2 -0.2 -1.1 -1.1 -1.1
0010 0.1 -1.2 -0.8 -0.3 -0.9 -0.7 -1.2 -1.2 0.4 0.8 1.4 1 -0.2 1.1 1.3 1.5 0.5 -0.8 -0.1 -1.2
0011 0.5 -0.5 -0.1 0.7 0.5 -0.4 -1 -0.6 0 0.6 0.8 0.5 -0.5 0.6 0.8 0.4 0.4 -0.2 -0.9 -1.1
0012 0.4 -1.2 -0.8 -0.4 -0.6 -0.4 -1.2 -1 0.6 1.1 1.5 0.8 0.1 0.2 1.3 0.9 0.5 -0.3 -0.3 -1
0013 0 -0.7 0.6 0.1 -0.1 0.1 -1.2 -0.8 0.5 0.7 0.6 0.8 -0.1 0.5 0.4 0.9 0.4 -0.7 -0.7 -1
0014 0.5 -0.7 -0.2 -0.5 0 -0.6 -1.3 -0.5 0.2 1 1.2 1 0 0.4 1 0.9 0.2 -0.6 -0.6 -1.3
0015 1.2 -0.9 -0.7 0.1 0.1 -0.5 -1.3 -1.1 0.3 0.8 1 0.7 -0.5 0.4 0.8 0.6 0.3 -0.6 0.7 -1.3
0016 0.8 -0.1 0.1 0.8 -0.3 -0.8 -1.6 -1 0.9 0.7 0.6 0.3 -0.1 0 1 0.6 0.5 0.3 -0.8 -1.4
0017 0.6 -0.6 -0.2 0.3 0.2 -0.8 -1 -0.4 0.4 1 0.4 0.3 -0.6 0.3 0.4 0.8 0.6 0.3 -0.5 -0.9
0018 0.3 -0.6 0.4 0.8 0.8 -0.2 -1.1 -0.8 0.3 0.9 1.1 0.3 -0.8 0.2 0.4 0.5 0.4 -0.1 -0.7 -1.1
0019 0.2 -0.1 -0.5 0.1 0.5 -0.4 -1.4 -0.7 0.3 0.7 0.7 0.9 -0.2 0.5 0.3 1.6 1.1 -0.5 -0.5 -1.1
0020 0.7 -1 -0.1 -0.1 0.5 -0.4 -1.1 -1 -0.2 0.3 1.3 1.2 -0.1 -0.2 0.2 0.7 0.4 -0.1 1.1 -0.8
0021 1 -1 -0.1 -0.1 1.1 -0.6 -1.1 -0.7 0.3 0.5 0.5 0.2 -0.3 -0.3 0.2 0.6 0.6 -0.3 1.5 -0.7
0022 0.2 0.6 -0.1 0.5 0.9 -1.3 -1.7 1.1 -0.6 0.2 0.4 0.8 1.2 0.2 0.7 0.1 0.6 -1.5 0.9 -1.4
0023 -0.3 0.5 -0.1 1 -0.3 0.1 2.4 -0.1 -0.3 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.1 0 -0.3 -0.1 -0.3
0024 0.5 -0.4 0.8 0.2 1 -0.2 -0.7 -0.4 -0.3 0.5 0.8 0.1 -0.7 -0.7 1.2 0 0.3 -0.5 -0.4 -0.7
0025 -0.1 -0.7 -0.6 -0.4 -0.5 -0.5 -0.8 -0.1 1.3 0.8 1 0.3 -0.3 0.2 0.1 0.9 -0.2 -0.5 1.5 -0.9
0026 0 0.6 -0.2 0.2 -0.3 -0.3 -0.4 -0.5 -0.1 0.5 0.1 -0.5 -0.5 0.7 0.1 0.1 -0.2 0 0.8 -0.5
0027 1 -1.4 -1 -0.7 -0.2 -1.1 -1.2 -1 1.2 1.6 1 0.4 0.1 0.8 0.1 1.5 0 0.3 -0.6 -0.7
0028 0.6 -0.7 -0.6 0.3 -0.1 -0.1 -1.1 -0.4 1.2 1.1 0.3 -0.5 0.1 0.4 0 1.1 0.5 -0.1 -0.7 -0.5
0029 1.3 -0.3 1.2 -0.8 1.4 -0.6 -0.9 -0.8 -0.7 -0.6 0.2 0.9 -0.7 -0.2 -0.4 1.6 0.5 0.1 -0.7 0.4
0030 0.6 -1.2 -0.2 0.5 0.1 -1.4 -1.6 -1.1 1.2 0.5 1.4 0.3 -0.2 0.8 0.1 1.7 1.6 -1.1 1.2 -1.4
0031 0.7 -0.6 -0.1 -0.4 0.5 0.1 -1.2 -0.4 -0.1 0.7 1 0.8 0.4 1 0.5 1 0.1 -0.8 -1.5 -0.2
0032 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 4.4
0033 0.4 0.4 -0.7 0.2 -0.2 0.2 -1 0.3 -0.4 -0.3 0.2 0 0.3 0.3 0.6 0.8 0.6 -0.3 -0.3 -0.5
0034 0.2 -0.3 0.5 1.1 0.2 -0.7 -1.5 -0.2 0.1 0.1 -0.1 0.4 0.4 0.6 0.5 0.8 0.7 0.5 -1.5 -0.3
0035 0.5 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 0.2 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 2
0036 1.1 -0.6 -1.3 -0.2 -1.8 -1.2 -1.8 -1.2 0.9 0.9 1.5 0.7 0.7 1.1 1.6 1.4 0.6 1.6 -1.8 -0.7
0037 1 -1.2 -0.1 -0.4 1.1 -0.4 -1.2 -1.2 0 -0.2 1.6 1.2 -0.6 0.3 0.5 1.1 1.6 -0.5 -1.2 0
0038 0.7 -1.1 -0.3 0 -0.5 -0.8 -0.8 -0.9 0.6 1.1 1.3 0.8 -0.8 0.1 0.6 1 0.6 0 1 -1.3
- A F I L V M W Y D E K R H N Q S T G P C
0039 -0.3 1.6 -0.3 1.4 0 0.1 -0.3 0.6 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 0.2 -0.3 -0.3 -0.3 -0.3
0040 0 -0.6 -0.1 -0.5 -0.6 -0.8 -0.1 -0.5 0.8 -0.3 0.1 -0.2 0.6 1.1 0.1 0.8 1 0.8 -0.1 -0.7
0041 0.9 0.8 0.9 1.1 0.7 0.4 -0.3 -0.3 -0.4 -1 0 -0.2 -1.1 -0.4 -0.2 0.6 0.5 0.1 0 -0.8
0042 0.8 1.2 0.4 1.2 0.3 0.1 -0.5 -0.2 -0.7 -0.9 0 0.4 -0.9 0.2 -0.8 0.8 1.5 0.3 -0.8 -1
0043 -0.9 0.2 0.1 0.8 0.8 -0.6 -0.7 -0.6 -0.2 0.2 1 2.2 0 1.5 -0.2 -0.2 0.3 -0.8 -1.2 -0.6
0044 -0.1 -0.3 -0.2 0 -0.1 -0.5 -0.1 -0.3 0.2 0.4 0.8 -0.2 -0.1 -0.3 0.5 0.6 0.1 0.7 0 -0.5
0045 0.2 -0.1 0.2 0.4 -0.2 -0.1 -0.5 -0.5 -0.5 -0.2 1.4 0.7 0 -0.1 1.1 0.2 -0.5 -0.5 -0.1 -0.5
0046 -0.2 0 0.5 0.3 0.4 0 -0.4 0.3 -0.4 -0.2 -0.2 0.1 0.3 0.1 0.3 0 0.3 -0.4 -0.2 -0.4
0047 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 0.3 0.1 1.6 -0.2 0.1 -0.2 -0.2 0.1 -0.2
0048 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 6.8
0049 0 -0.4 -0.4 0.3 -0.4 -0.4 0.4 0.2 -0.4 -0.4 0.8 1.8 0.2 0.1 -0.1 0.1 -0.1 -0.4 -0.4 -0.4
0050 0.5 -0.5 0.5 1.6 0.6 0.2 -1.1 -0.6 -0.8 -0.6 1.1 0.8 0.5 0.3 -0.5 0.4 -0.1 -0.3 -1.1 0.3
0051 -0.1 -0.1 -0.1 0 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 1.3
0052 0 -0.3 -0.3 0.2 -0.3 -0.3 -0.3 -0.3 0.4 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.1 -0.3 4.2 -0.3 0
0053 0.2 -0.2 -0.7 0.6 -0.6 -0.7 -0.6 -0.1 0.1 0.7 1.2 1.4 0.4 0.4 0.7 0.4 -0.5 0.1 -1.2 -0.2
0054 0.3 -0.6 1.6 1.6 1.4 0.1 -0.6 -0.6 -0.6 -0.2 -0.6 -0.6 -0.6 -0.3 -0.6 0.1 0 0.3 -0.6 0.7
0055 0.1 0.9 1.6 0.3 2 0.7 -0.6 1 -0.6 -0.6 -0.6 -0.4 -0.1 -0.6 -0.5 -0.6 -0.2 -0.5 -0.6 -0.1
0056 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.4 -0.2 -0.2 -0.2 1.9
0057 1.2 -0.5 -0.3 -0.6 -0.9 -1 0 -0.1 0.6 -0.2 0.3 0.9 0 0.7 0.2 1.6 -0.1 1.1 -0.4 -1.2
0058 0.6 -0.8 -0.6 0.1 -0.3 -0.9 -1.2 -0.9 1.4 0.1 1.4 1 -0.5 1 -0.3 1.5 0.7 -0.1 0 -1.2
0059 0 -0.6 -0.4 -0.1 0 -0.6 -0.6 -0.6 -0.3 -0.1 -0.1 0.1 1.4 -0.3 0.1 0.2 0 0.3 -0.1 2.1
0060 0 -0.3 0.5 1.2 0.7 -0.1 -0.5 0.3 -0.5 -0.3 0 0.2 -0.5 -0.1 -0.5 -0.9 0.6 -0.1 -0.5 0.8
0061 0.4 -1.1 -0.7 -0.1 -0.3 -0.4 -1.3 -0.8 0.3 0.7 0.6 0.3 -0.1 1.1 0.3 1.6 0.8 0.1 0.5 -1.2
0062 -0.1 0.8 -0.8 0 -0.4 -0.6 -0.8 0.3 -0.1 0.1 0.9 0.3 0.6 0.8 0.3 0.1 0.2 -0.3 -0.5 -0.8
0063 -0.5 -0.2 0.2 0.7 0.4 -0.2 -0.3 -0.8 -0.1 0.7 1.5 1.2 -0.8 -0.5 0.2 0.7 0.7 -1 -1.3 -1
0064 1.1 -0.3 1.4 1.1 1.5 0.3 -0.9 -0.4 -0.9 -0.2 0.3 -0.2 -1 -0.9 -0.6 1 0.4 -0.3 -0.3 -0.7
0065 0 0.2 0 0.9 0.3 -0.6 -1.3 0 0.1 0.2 0.3 0 -0.3 0.2 0 0.7 0.2 -0.9 1.1 -0.9
0066 0.6 -0.2 1.2 1.4 1.3 -0.1 -1.1 -0.5 -0.4 0 -0.1 -0.5 -0.7 -0.7 -0.7 0.6 0.4 0.3 -0.2 -0.6
0067 0.7 -0.3 -0.7 -0.2 -0.1 -1 -1.3 -0.5 0.5 0.7 0.8 0.1 -0.6 0.2 0.1 1.1 0.3 0.3 1.6 -1.3
0068 0.9 -0.9 -0.6 0.1 -0.1 -0.9 -1.6 0 0.1 0.4 0.6 0.9 0.4 0.5 0.4 1.1 0.2 0.2 0 -1.5
- A F I L V M W Y D E K R H N Q S T G P C
0069 0.4 0 0.1 0.9 -0.3 -0.1 -1.5 -0.3 0.6 0.6 0.1 0.3 -0.3 0.3 0.7 0.3 -0.2 0.8 -1.1 -1.2
0070 1.1 -0.8 -0.6 -0.4 -0.5 -0.2 -1.2 -0.8 0.7 0.4 1.6 -0.2 -0.4 0.6 0.3 -0.3 0.3 0.9 0.1 -0.6
0071 -0.1 0 0.3 0.1 0.3 -0.1 -1 -0.1 0 0.3 0.6 -0.2 -0.2 0.2 0 0.7 -0.2 -0.2 -0.1 -0.7
0072 0.5 0.2 -0.6 0.6 0.3 -1 -1.6 -0.2 0.8 0.5 0.3 0 -0.3 0.7 0.2 0.8 0.5 0.1 -0.2 -1.2
0073 0.3 -0.8 -0.8 -0.2 -0.1 -0.9 -1.3 -0.6 0.8 1.1 1.5 1.1 -0.1 0.1 0.5 0.6 0.7 0.6 -0.8 -1.3
0074 0.1 -1.2 -0.6 0.6 -0.6 -0.1 -1 -0.8 0.7 0.8 1.1 0.2 -0.4 -0.1 0.5 0.5 0.6 -0.2 2.2 -1.2
0075 0.5 0.2 0.9 0.8 1.6 0.3 -1 0 -0.6 0.2 -0.4 -0.9 -0.1 0.1 0.9 0.2 0 -0.6 -1 0
0076 -0.1 -0.3 -0.1 0.4 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 1.1 1 0.4 0.2 0.2 -0.1 -0.1 -0.3 0.3 -0.3
0077 1.1 -0.2 2 1.6 3.5 0.4 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.7 -0.8 -0.6 0 0.6 -0.8 -0.8 0.7
0078 -0.1 -0.1 0.2 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 2.3
0079 -0.2 -0.9 -0.2 0.2 0.5 -0.9 -1.5 -0.5 1.4 0.3 1.4 1.4 0.1 1.1 0.4 0.6 0.4 -0.3 -0.7 -0.9
0080 0.7 -0.6 -0.1 0 0.4 -0.7 -1.2 -0.7 0.4 0.6 0.7 0.3 0.5 0.7 -0.1 0.8 0.8 -0.2 0.1 -1.2
0081 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 6.8
0082 0.5 1.2 0.1 0.7 0.4 -0.1 -0.6 1.3 -0.7 -0.4 1.2 0.9 0.4 0.3 0.1 -0.1 -0.7 -1.1 -1.1 -0.6
0083 0.4 -0.8 -0.3 -0.3 0.3 -0.6 -1.1 -0.5 0.8 1.1 0.8 0.5 -0.1 0.8 0.6 0.9 0.7 0.1 -0.5 -1.3
0084 0.5 -0.2 0.8 0.5 0.4 -0.3 -1.3 -0.4 0 0.6 0.8 0.2 -0.2 0.3 0.5 0.8 0.9 -0.7 -1.2 -1.4
0085 0.7 0.2 1.8 3.1 1.4 0.2 -0.3 0.1 -0.9 -0.8 -1 0.1 -0.6 -0.9 -1 -0.3 0.1 -1.2 -1.1 -0.4
0086 -0.2 0.7 -0.8 1.1 0.3 -0.4 -1.6 -0.9 0.5 1.1 0.7 0.3 -0.6 0.3 0.9 1 0.8 -1.4 -1.6 -1.2
0087 0.8 -0.8 -0.6 -0.3 -0.2 -0.1 -1.3 -1.1 0 0.6 1.2 1.3 -0.4 0.7 0.6 0.9 0.7 -0.2 -0.5 -0.9
0088 0.4 -1 -0.2 -0.7 -0.2 -0.7 -0.6 0.2 -0.2 1.1 0.9 2 0.3 -0.2 1.3 0.3 0.3 -0.8 -1.1 -1
0089 0.4 -1 -0.6 -0.7 -0.8 -0.3 -1 -0.8 0.7 1.6 1.2 1 -0.4 0.6 1.9 0.3 0 -1 -1 -1
0090 0.4 -0.9 -0.9 -0.8 -0.7 -0.7 -0.9 -0.1 0.9 0.9 1.2 -0.1 -0.2 0.1 1.3 0.6 -0.2 -0.8 -0.9 -0.9
Select residue pair below:
i_j Score Prob
0060_0076 3.566 1.00
0034_0055 2.987 1.00
0029_0054 2.886 1.00
0055_0060 2.060 1.00
0062_0079 2.054 1.00
0026_0045 2.007 1.00
0026_0047 1.992 1.00
0024_0033 1.987 1.00
0045_0054 1.871 1.00
0050_0077 1.783 1.00
0044_0047 1.697 1.00
0026_0044 1.653 1.00
0046_0076 1.519 1.00
0046_0049 1.465 1.00
0039_0044 1.447 1.00
0034_0080 1.307 0.99
0044_0049 1.270 0.99
0037_0043 1.246 0.98
0033_0053 1.240 0.98
0041_0044 1.216 0.98
0026_0046 1.212 0.98
0075_0083 1.171 0.98
0067_0070 1.156 0.97
0049_0076 1.144 0.97
0057_0076 1.132 0.97
0039_0046 1.113 0.96
0011_0014 1.095 0.96
0018_0025 1.089 0.96
0017_0021 1.081 0.95
0014_0018 1.064 0.95
0029_0033 1.056 0.95
0037_0058 1.049 0.94
0071_0074 1.041 0.94
0063_0067 1.026 0.94
0013_0021 1.017 0.93
0033_0080 0.977 0.91
0080_0083 0.971 0.91
0035_0056 0.954 0.90
0031_0038 0.940 0.89
0024_0054 0.935 0.89
0054_0066 0.924 0.88
0024_0053 0.921 0.88
0069_0073 0.900 0.86
0060_0066 0.900 0.86
0009_0012 0.896 0.86
0017_0050 0.890 0.85
0050_0075 0.880 0.84
0039_0059 0.879 0.84
0040_0044 0.878 0.84
0019_0024 0.877 0.84
0053_0080 0.870 0.83
0064_0085 0.869 0.83
0077_0082 0.866 0.83
0058_0077 0.865 0.83
0026_0029 0.861 0.82
0017_0020 0.859 0.82
0024_0029 0.853 0.81
0023_0047 0.851 0.81
0037_0057 0.846 0.81
0046_0060 0.845 0.81
0021_0033 0.839 0.80
0028_0084 0.838 0.80
0025_0080 0.834 0.79
0018_0042 0.834 0.79
0062_0065 0.824 0.78
0050_0084 0.814 0.77
0087_0090 0.811 0.77
0055_0059 0.804 0.76
0015_0080 0.804 0.76
0051_0078 0.803 0.76
0058_0086 0.796 0.75
0061_0079 0.794 0.75
0038_0041 0.789 0.74
0026_0076 0.782 0.73
0040_0076 0.776 0.72
0028_0083 0.773 0.72
0082_0089 0.771 0.71
0028_0031 0.770 0.71
0039_0045 0.768 0.71
0019_0067 0.767 0.71
0025_0028 0.765 0.71
0039_0047 0.759 0.70
0033_0054 0.759 0.70
0051_0056 0.758 0.70
0024_0059 0.746 0.68
0035_0051 0.741 0.67
0013_0043 0.741 0.67
0047_0076 0.739 0.67
0020_0073 0.738 0.67
0065_0089 0.735 0.66
0038_0077 0.735 0.66
0034_0053 0.728 0.65
0012_0028 0.726 0.65
0031_0043 0.726 0.65
0040_0045 0.725 0.65
0020_0033 0.721 0.64
0067_0088 0.720 0.64
0059_0070 0.719 0.64
0032_0051 0.717 0.63
0014_0017 0.716 0.63
0062_0082 0.716 0.63
0068_0071 0.715 0.63
0023_0052 0.715 0.63
0038_0062 0.714 0.63
0027_0058 0.714 0.63
0083_0087 0.701 0.61
0025_0033 0.700 0.61
0042_0057 0.697 0.60
0024_0055 0.696 0.60
0037_0087 0.695 0.60
0024_0028 0.693 0.59
0061_0064 0.693 0.59
0015_0058 0.693 0.59
0016_0037 0.691 0.59
0013_0016 0.690 0.59
0015_0043 0.683 0.58
0049_0060 0.682 0.58
0065_0075 0.682 0.58
0056_0078 0.681 0.57
0020_0050 0.680 0.57
0035_0078 0.679 0.57
0026_0040 0.676 0.57
Local Interactions:
i_j Score Prob
0044_0046 2.296 1.00
0013_0014 1.850 1.00
0070_0071 1.828 1.00
0010_0011 1.783 1.00
0059_0060 1.700 1.00
0073_0074 1.603 1.00
0054_0055 1.593 1.00
0061_0062 1.550 1.00
0025_0027 1.480 1.00
0045_0047 1.480 1.00
0009_0010 1.459 1.00
0016_0017 1.437 1.00
0062_0063 1.411 1.00
0064_0066 1.395 0.99
0046_0047 1.395 0.99
0089_0090 1.386 0.99
0027_0028 1.362 0.99
0041_0042 1.294 0.99
0065_0066 1.270 0.99
0011_0013 1.265 0.99
0068_0069 1.240 0.98
0071_0073 1.191 0.98
0014_0015 1.182 0.98
0020_0021 1.164 0.97
0040_0042 1.143 0.97
0017_0018 1.140 0.97
0009_0011 1.133 0.97
0072_0073 1.130 0.97
0030_0031 1.091 0.96
0069_0070 1.069 0.95
0060_0062 1.029 0.94
0088_0089 1.007 0.93
0087_0088 1.007 0.93
0070_0072 1.002 0.92
0011_0012 1.002 0.92
0064_0065 1.000 0.92
0072_0074 0.998 0.92
0088_0090 0.997 0.92
0075_0076 0.963 0.90
0071_0072 0.939 0.89
0021_0022 0.904 0.86
0066_0067 0.890 0.85
0012_0013 0.883 0.84
0084_0085 0.878 0.84
0069_0071 0.797 0.75
0047_0049 0.788 0.74
0024_0025 0.783 0.73
0025_0026 0.781 0.73
0028_0030 0.777 0.72
0074_0075 0.764 0.71
0053_0055 0.728 0.65
0061_0063 0.723 0.64
0018_0019 0.692 0.59
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: D S R G R ...
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