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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0007 0.5 -2.1 -0.7 -1.8 1.4 -1.8 -2.1 -0.6 -0.1 1.4 1.4 0.9 -0.7 0.3 0.8 1.4 0.1 -0.1 -0.2 -2.1
0008 0.3 -1.8 -0.4 -0.9 -0.5 -1.8 -1.8 -1.8 -0.2 2.5 1.8 0.5 -0.9 0.8 1.4 2.2 2.1 1 0.2 -1.8
0009 -0.1 -1.8 -1.1 0.9 0.4 -0.6 -1.5 -0.7 0.1 0.8 0.5 0.8 -0.4 0.4 0.9 0.7 0.2 1.4 0.8 -1.6
0010 0.8 -1.1 -0.6 -1.4 -0.5 -1.7 -1.9 -0.3 0.4 1.6 0.5 0 -0.8 0.7 0.8 1.6 0.5 2.1 0.1 -0.5
0011 -0.5 0.7 0.6 1 0.2 -0.4 -0.3 0.4 -0.2 0.4 0.3 0.8 -0.9 -0.7 0.3 0.5 -0.4 -0.5 0 -1.6
0012 0.2 1.5 2.1 3.2 1.2 0.7 0.1 0.1 0.1 -0.6 -1.3 -0.1 -1.4 -1.3 -0.8 0.2 0.1 -0.7 -1.5 -1.3
0013 -0.1 -0.8 -0.8 -0.8 -0.5 -0.8 -0.8 -0.8 -0.5 -0.5 -0.8 -0.8 -0.8 1.6 -0.8 -0.8 -0.8 7.4 -0.8 -0.8
0014 1.5 2.3 3.1 2.7 2.3 1.6 -1.1 -1 -1.2 -1.2 -1 -1.1 -1.2 -0.8 -1.2 -0.7 0.1 -0.6 -1.2 -0.7
0015 0.6 -1.2 -0.3 0 0.6 -0.5 -1.2 -0.6 -0.2 0.9 0.2 0.8 -0.9 0.7 1.3 2 1.9 0.5 -1.7 -1.9
0016 0.8 0.9 2.4 2.9 3.1 0.9 -1 0.2 -1.2 -1.4 -1.6 -1.6 -1.6 -1.3 -1.3 -0.1 0.3 0.1 0.7 -1.3
0017 1.3 -0.9 -0.6 -0.5 0.5 -0.7 -1.5 -0.9 0.6 1.1 0.7 1.1 -0.7 0.3 1.2 1.3 1 1.2 -1.6 -1.8
0018 0.8 -1.3 0.3 0.2 0.6 0.1 -1.7 -1 0.6 1.2 0.3 0.6 -1.2 -0.1 0.3 0.8 0.2 1 1.1 -1.9
0019 0.2 -0.2 0.3 -0.1 0.3 0.2 -1.2 -0.2 0.1 0.7 -0.9 -0.3 -0.5 0.5 -0.1 0.8 0.3 1.4 0.1 -1.3
0020 0.8 -1.1 -0.3 -0.7 0.1 -1.2 -1.7 -0.8 1.5 1 0.5 0.1 -1.1 1.2 0.8 1.6 1.1 0.4 0.8 -1.9
0021 1.6 -1.8 -0.4 -0.2 -0.2 -1.5 -1.4 -1.1 2.1 1.4 0.8 0.5 -1 0.8 0.8 1.1 0.2 0.5 1.4 -2.2
0022 0.9 -0.8 -0.8 -0.1 0.3 -1.2 -2 -1 1.7 1.4 1.1 0.1 -1 1.1 0.8 0.4 0.5 0.9 -0.1 -2.1
0023 0.6 -0.9 -0.6 -0.4 0 -0.4 -1.8 -1.1 0.8 0.7 -0.1 0.5 -0.8 0.3 0.6 1 -0.1 1.1 0.2 -1.9
0024 0.6 -1.1 0 -0.2 0.4 -1.4 -2.1 -1.3 1.1 1 0.9 0.5 -0.8 0.7 0.4 0.8 0.9 1.4 0.1 -2.2
0025 1.3 -1.6 0.2 0.1 0.8 -1 -2.3 -1.5 1.2 0.9 1 0.6 -1.1 0.6 0.7 0.7 1.3 0.6 1.2 -2.4
0026 0.7 -1.5 -0.9 -1.4 -0.4 -0.9 -2.3 -0.4 0.6 1.5 1.4 1.1 0.2 1.2 1.4 1.1 0.9 0.9 0.1 -2
0027 0.6 0 -0.6 0.1 0.1 -0.8 -1.1 0.8 -0.7 0.3 0.5 0.6 -0.2 0 0.7 0.2 0 2 0 -1.8
0028 -0.2 0.2 2.2 1.3 1.6 0.1 -1 -0.3 -1 -0.9 -0.5 -1 -0.9 -0.4 -0.6 -0.4 0.5 0.5 1.3 -0.3
0029 -0.1 0.2 1.6 0.3 1.9 0.1 -0.7 0.8 -1.3 0.3 0.6 0.5 -0.3 -0.7 0.1 0.1 0.9 -1 -1.2 -1.2
0030 0.5 -0.3 3.1 0.8 2.7 0 -0.7 -0.4 -0.7 -0.7 -0.4 -0.4 -0.5 -0.4 0.3 -0.6 -0.4 -0.4 -0.7 -0.7
0031 1.1 -1.1 0.8 0.2 1.5 0.2 -1.6 -0.9 0.5 0.6 -0.2 0.5 -0.9 0.1 0.5 0.9 0.8 1 -1.5 -1.7
0032 0.8 -1.1 -1.3 -1.1 -0.8 -0.7 -1.3 -1.1 1.6 2.1 0.9 1.4 -0.6 0.8 1.3 1.7 0.4 0.8 -1.6 -1.8
0033 1.1 0.2 1.9 1.6 2.4 0.1 -0.9 -0.6 -0.5 -0.6 -0.5 -0.4 -0.9 -0.7 -0.5 -0.3 0.9 -0.6 -1 -0.4
0034 1.3 -0.2 0 0.3 0.7 0.1 -1.4 0.2 1.4 0.5 -0.5 -0.1 -0.6 0.3 0.3 0.9 0.2 -0.2 -1.1 -1.7
0035 1.2 -1.3 -0.8 -0.8 -0.5 -1.2 -1.5 -0.8 1.8 2 1 0.8 -0.9 0.3 0.6 0.9 -0.3 0.1 1.4 -1.3
0036 0.7 -0.8 -1.5 -1 -1.1 -1.2 -1.8 -0.8 2.8 1 0.5 0.2 -0.6 2.4 0.1 0.9 -0.2 3.4 -1.1 -1.9
- A F I L V M W Y D E K R H N Q S T G P C
0037 0.7 -0.2 -0.4 -0.1 -0.1 -0.2 -1 -0.5 -0.8 -0.4 0.1 -0.3 -0.7 -0.1 -0.2 2.7 0.3 2 0.3 -1
0038 2.8 0 -0.2 0.9 0.6 -0.3 -1.4 -0.8 -0.5 -0.2 0 -0.4 -1.3 -0.1 -0.7 1.1 0.1 0.1 2.2 -1.3
0039 3.2 0.1 -0.2 0 0.9 -0.2 -0.2 -0.4 0.3 0.2 -0.2 0.1 -1 -0.6 -0.5 1.1 -0.6 0.4 -0.8 -0.8
0040 1 0.1 -0.4 -0.3 -0.8 -0.4 -0.1 0.3 0.3 0.8 0.4 0.5 -0.4 -0.2 0.9 1.4 0.2 0.2 -1.2 -1.1
0041 1.2 -1 0 0.5 0.2 -0.3 -1.1 -0.5 0.5 0.6 0.7 1.7 -0.8 0.9 0.5 0.5 0.4 0.1 -1.3 -1.4
0042 0.6 -0.5 0.2 0.1 -0.1 -0.1 -0.9 -0.3 0 0.8 0.5 -0.4 -0.5 0 0.8 1.2 -0.2 1 -0.8 -0.9
0043 0.2 -0.8 -0.8 -0.5 -0.7 -0.8 -0.8 -0.8 -0.2 0.5 0.5 -0.1 -0.5 0.5 0.5 0.2 -0.2 1.8 0 -0.8
0044 0.1 0.8 2.3 1.6 1.3 1 -0.4 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.4 -0.4
0045 1.1 -0.5 -0.8 -0.2 -0.2 0.1 -1.1 -0.8 -0.7 1 1.8 1 0.3 0.3 1.6 0.2 0 -0.4 -0.6 -0.9
0046 1.9 -1.2 0.4 0.1 1.5 -0.9 -1.5 -1.4 -0.6 1.2 0.7 1.1 -0.9 -0.4 0.2 0.6 0.6 -0.9 2.6 -1.5
0047 0 -0.8 -1.3 -0.7 -1.4 -0.9 -0.4 0 1.6 1 0.9 0.5 -0.2 1.8 0.2 0.5 -0.9 4.4 -1.4 -1.4
0048 0.4 0.2 -0.6 0.2 -0.4 0.7 -0.6 -0.1 3.8 0.4 -0.8 -0.8 -0.2 -0.4 0 0.6 0.5 -0.5 -0.8 -0.8
0049 -0.2 0.4 2.5 1.6 2.1 -0.2 -0.8 0.2 -1.3 0.7 1.5 1.8 -1 -1.6 0.9 -1.2 0.3 -1.3 -1.6 -1.4
0050 -0.6 -0.3 5.4 3.5 3.6 0.4 -0.8 -0.8 -0.8 -0.8 -0.8 -0.6 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8
0051 -0.1 -0.5 2.5 2.9 2.5 0.8 -1.6 -0.1 -1.2 -0.1 0.1 0.4 -0.7 -1 0.4 -0.4 2.3 -1.5 -1.7 -1.5
0052 1.7 -1 -1.3 -0.5 -1.1 0.2 -1.6 -1.1 -0.9 1.8 2.1 1.4 -0.5 -0.1 1.8 1.9 0.2 1.2 -1.4 -1.4
0053 0.7 0.7 3 1.8 2.5 1 -0.2 0.4 -0.9 -0.9 -0.6 -0.7 -0.9 -0.9 -0.7 -0.9 -0.5 -0.9 -0.9 -0.6
0054 1.3 -1.1 -1.1 -0.8 -1.1 -1.1 -0.8 -1 2.9 1.4 -0.4 -0.3 -0.5 3.5 0.8 0.5 -1.1 2.4 -1.1 -1.1
0055 -0.3 -0.7 -1.3 -0.6 -1.3 -1.1 -1.1 -0.8 1.4 0.6 0.8 0.9 0.1 1.8 2.4 0.9 -0.2 2.7 -1.3 -1.4
0056 0.6 -1.5 0.8 -0.6 1.5 -1.2 -2.3 -0.9 0.2 1.9 2.6 1.7 0.2 0.5 2.4 0.4 1.6 -1.3 -2 -2.3
0057 1.6 -1.8 -0.9 -0.2 0.1 -1.4 -2 -1.8 1.6 1.8 1.7 1.3 -1.2 0.4 0.7 1.6 1.2 -0.8 2.6 -2.2
0058 1.6 0.1 2.7 2.1 2.9 0.8 -1 -0.7 -1 -1 -1 -1 -1 -1 -0.8 -0.1 1.2 -0.8 -0.5 -0.5
0059 1 -0.8 -0.3 -0.2 0.1 -0.7 -2 -1 1.1 1.2 0.9 1.1 -0.4 0.7 0.3 1.2 1.6 0.1 0.1 -2.1
0060 0.7 -1.5 -1.4 -1.1 -1.1 -1.3 -1.8 -0.9 2.8 1.2 0.4 0.2 -0.4 2.3 0.2 2.3 1.5 2.2 -0.7 -1.8
0061 0.6 0.5 0.2 0.8 0.3 1.2 0.7 -0.2 -0.3 0 -0.2 0.1 -0.3 -0.6 0.2 0.2 -0.1 -0.3 0.1 -1.6
0062 1.4 -1.3 -1 -0.9 -1 -1.3 -2.1 -1.3 1.3 1.2 0.5 1.1 -0.8 1 0.9 2 1.2 0.7 0.3 -2.2
0063 0.9 -0.5 -0.3 0.8 0.8 -0.5 -1.5 -0.5 2 1.4 -0.1 -0.5 -0.2 0 0.8 0.5 0.3 -0.1 -0.4 -1.7
0064 0.3 0.9 0.6 1.6 0.7 1 -0.7 -0.5 0.1 0.7 -0.3 -0.6 -0.8 -0.6 0.1 0.1 -0.1 -0.5 -0.6 -1.3
0065 0.6 -0.6 -0.2 -0.3 0.2 -0.8 -1.5 -0.5 0.9 1.2 1.1 1.1 -0.5 0.1 1.4 0.6 0.9 -0.5 -1.2 -1.6
0066 1.9 0.6 0.9 1 1.4 -0.6 -1.3 -0.4 -0.2 0 0.4 0.2 -1 0.6 0.3 0.1 -0.1 -0.1 -1.5 -1.4
- A F I L V M W Y D E K R H N Q S T G P C
0067 1.1 -0.1 1 1 1.3 0.4 -1.1 -0.5 -0.1 0.5 -0.1 1 -0.7 -0.8 1 0.3 0 -1 -1.1 -1.4
0068 1.1 -0.6 1.2 1.5 0.7 0.4 -1.1 -0.7 0 0.4 0.3 0.1 -0.7 -0.1 0.4 0.2 0.4 -0.6 -1.1 -1.3
0069 1.9 -0.3 -0.2 0.8 0.5 0.3 -1.7 -1 -0.4 0.6 0.9 0.9 -0.6 0 0.8 0.8 0.3 0.4 -1.6 -1.7
0070 0.7 -0.8 0.9 2.3 0.7 0.3 -1.6 -1 -0.3 0.1 0.5 0.8 -0.8 0.6 0.2 0.6 0.3 -0.2 -1.3 -1.4
0071 0.8 -0.6 -0.2 0.8 0.7 -0.1 -1.4 -0.3 -0.2 0.3 1.6 0.4 -0.3 -0.1 0.4 0.9 0.8 -0.4 -0.8 -1.4
0072 1.2 -1.2 -1.1 -0.5 -0.5 -0.3 -1.8 -1.3 0.6 1.1 1.5 0.7 -0.6 0.3 0.6 1.1 0.3 0.9 1.5 -1.8
0073 1.8 -1.3 0.1 -0.2 -0.1 -1.1 -1.8 -1.4 0.1 0.2 1.8 -0.1 -0.5 -0.2 0 1.5 0.9 0.5 1.9 -1.8
0074 0.9 -1.6 -1.3 -1.4 -0.4 -1.6 -1.7 -1.4 0.8 1 1.8 1 -0.8 1.2 0.5 1 0.2 2.6 0.3 -1.6
0075 0 -1.1 -1.4 -1.1 -1.1 -1.1 -1.4 -1.4 1.2 1.4 1.7 0.6 -0.8 1 1.1 1.3 0.5 1.7 -0.8 -1.4
0076 0.9 -1.8 -0.5 -0.7 1.3 -1 -2.2 -1.6 0.2 1.6 2.3 1 -1.1 0.4 0.9 1.6 2.1 -1.2 1 -2.5
0077 1.6 -0.3 2.8 2.4 3.4 0.7 -1 -0.9 -1.1 -0.7 -1.1 -1.1 -0.8 -1.1 -0.8 -0.4 0.3 -1.1 -1.1 -0.8
0078 1 -1.1 -0.7 0.4 -0.5 0 -1.5 -1 0 0.6 0.9 0.8 -0.1 0.2 0.7 0.9 1.3 -1 0.9 -1.4
0079 -0.7 1.3 1.7 2.9 2 2 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7
0080 -0.5 -0.9 -0.3 1.1 0.8 -0.9 -1.4 -0.9 0.1 1.2 1 0.4 -0.3 -0.3 0.7 0.1 1.9 0.6 -1.4 -1.5
0081 -0.8 -0.8 3.6 2 3.7 -0.6 -0.8 0.3 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8
Select residue pair below:
i_j Score Prob
0052_0080 4.153 1.00
0015_0032 2.271 1.00
0027_0049 2.176 1.00
0018_0061 2.141 1.00
0017_0031 2.136 1.00
0020_0023 2.029 1.00
0017_0023 1.941 1.00
0035_0040 1.831 1.00
0064_0068 1.717 1.00
0053_0071 1.652 1.00
0072_0075 1.551 1.00
0052_0057 1.544 1.00
0026_0059 1.497 1.00
0071_0075 1.455 1.00
0028_0061 1.447 1.00
0044_0079 1.429 1.00
0065_0069 1.426 1.00
0059_0063 1.409 1.00
0052_0055 1.401 0.99
0016_0061 1.381 0.99
0066_0070 1.376 0.99
0054_0071 1.359 0.99
0037_0041 1.351 0.99
0033_0046 1.349 0.99
0026_0057 1.345 0.99
0011_0015 1.327 0.99
0063_0067 1.292 0.99
0030_0044 1.291 0.99
0032_0046 1.285 0.99
0055_0078 1.276 0.99
0019_0023 1.274 0.99
0038_0042 1.272 0.99
0011_0034 1.208 0.98
0036_0040 1.203 0.98
0018_0028 1.170 0.97
0029_0049 1.091 0.96
0028_0031 1.054 0.95
0028_0058 1.050 0.94
0061_0065 1.016 0.93
0011_0038 1.005 0.93
0051_0080 0.998 0.92
0015_0034 0.987 0.92
0044_0081 0.984 0.92
0068_0071 0.982 0.91
0056_0067 0.981 0.91
0053_0067 0.968 0.91
0039_0043 0.965 0.90
0067_0071 0.954 0.90
0019_0029 0.951 0.90
0037_0043 0.947 0.89
0045_0048 0.929 0.88
0062_0065 0.916 0.87
0054_0078 0.898 0.86
0039_0042 0.893 0.85
0053_0077 0.893 0.85
0037_0042 0.885 0.85
0067_0070 0.852 0.81
0044_0048 0.825 0.78
0063_0068 0.795 0.75
0023_0029 0.789 0.74
0040_0043 0.784 0.73
0063_0070 0.783 0.73
0060_0063 0.782 0.73
0053_0058 0.780 0.73
0018_0060 0.769 0.71
0024_0051 0.760 0.70
0033_0037 0.760 0.70
0034_0037 0.757 0.69
0053_0068 0.746 0.68
0015_0031 0.742 0.67
0010_0074 0.726 0.65
0016_0064 0.713 0.63
0040_0045 0.703 0.61
0039_0044 0.671 0.56
0028_0066 0.669 0.55
0017_0029 0.669 0.55
0035_0039 0.656 0.53
0061_0064 0.653 0.53
0056_0069 0.636 0.50
0050_0058 0.632 0.49
0011_0014 0.630 0.49
0030_0048 0.622 0.47
0065_0068 0.618 0.47
0028_0064 0.618 0.47
0052_0078 0.616 0.46
0010_0014 0.610 0.45
0050_0064 0.603 0.44
0053_0064 0.601 0.44
0033_0042 0.599 0.43
0062_0066 0.590 0.42
0017_0020 0.587 0.41
0071_0077 0.584 0.41
0033_0040 0.582 0.41
0019_0022 0.567 0.38
0061_0069 0.560 0.37
0069_0073 0.559 0.37
0019_0049 0.556 0.36
0037_0040 0.552 0.36
0018_0065 0.545 0.35
0009_0012 0.543 0.34
0068_0073 0.542 0.34
0038_0041 0.540 0.34
0054_0067 0.537 0.33
0030_0033 0.535 0.33
0029_0047 0.531 0.33
0009_0015 0.526 0.32
0008_0072 0.522 0.31
0021_0025 0.521 0.31
0042_0055 0.520 0.31
0016_0019 0.513 0.30
0015_0046 0.507 0.29
0012_0019 0.504 0.29
Local Interactions:
i_j Score Prob
0024_0025 3.105 1.00
0019_0020 2.090 1.00
0073_0074 1.917 1.00
0012_0014 1.890 1.00
0063_0064 1.880 1.00
0024_0026 1.849 1.00
0037_0038 1.828 1.00
0068_0070 1.813 1.00
0020_0022 1.802 1.00
0051_0052 1.800 1.00
0034_0036 1.443 1.00
0007_0008 1.438 1.00
0065_0066 1.407 0.99
0027_0028 1.400 0.99
0057_0059 1.380 0.99
0011_0012 1.366 0.99
0009_0010 1.318 0.99
0014_0016 1.308 0.99
0054_0055 1.290 0.99
0042_0043 1.268 0.99
0020_0021 1.257 0.99
0041_0042 1.255 0.99
0080_0081 1.238 0.98
0031_0033 1.214 0.98
0059_0060 1.153 0.97
0025_0026 1.136 0.97
0031_0032 1.134 0.97
0041_0043 1.130 0.97
0073_0075 1.099 0.96
0021_0022 1.087 0.96
0032_0033 1.066 0.95
0040_0041 1.011 0.93
0032_0034 1.004 0.93
0049_0051 0.991 0.92
0027_0029 0.975 0.91
0065_0067 0.961 0.90
0058_0059 0.928 0.88
0066_0067 0.908 0.87
0033_0034 0.885 0.85
0009_0011 0.880 0.84
0074_0075 0.870 0.83
0078_0079 0.832 0.79
0075_0076 0.829 0.79
0072_0073 0.794 0.75
0022_0023 0.780 0.73
0046_0047 0.779 0.73
0076_0078 0.769 0.71
0072_0074 0.740 0.67
0035_0036 0.737 0.67
0017_0018 0.726 0.65
0066_0068 0.723 0.64
0069_0070 0.713 0.63
0070_0071 0.710 0.62
0008_0009 0.706 0.62
0019_0021 0.700 0.61
0060_0061 0.695 0.60
0045_0046 0.685 0.58
0040_0042 0.676 0.57
0071_0072 0.675 0.56
0067_0068 0.658 0.54
0079_0080 0.655 0.53
0062_0063 0.652 0.53
0077_0079 0.651 0.52
0028_0030 0.639 0.50
0033_0035 0.609 0.45
0064_0066 0.609 0.45
0060_0062 0.603 0.44
0018_0019 0.599 0.43
0070_0072 0.580 0.40
0029_0031 0.553 0.36
0078_0080 0.551 0.36
0045_0047 0.547 0.35
0079_0081 0.545 0.35
0053_0054 0.530 0.32
0015_0017 0.526 0.32
0043_0045 0.523 0.31
0034_0035 0.512 0.30
0068_0069 0.511 0.30
0075_0077 0.509 0.29
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: L V S I P ...
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