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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 0.1 0.7 0.1 0.2 -0.1 -0.5 -0.2 0.9 0.1 -0.3 -0.4 -0.1 0.1 -0.2 -0.1 0.1 -0.2 -0.2 -0.1 0.4
0002 0.3 -0.1 0.9 2.9 2.3 -0.1 -0.5 -0.6 -0.5 0.1 -0.7 0.8 -0.5 -0.6 1.1 0.1 -0.8 -1 -0.9 -0.9
0003 0.6 0.1 0.4 0.1 0.2 -0.6 -0.8 0.4 -0.4 0 -0.1 0.3 -0.5 -0.1 -0.8 1.1 1.6 0.8 -0.8 -0.5
0004 -0.1 0.8 0.3 0.1 -0.5 -0.5 0.5 0.8 -0.4 -0.5 -0.2 0.4 -0.3 -0.4 -0.3 0.9 1.2 -0.7 -0.7 0.4
0005 -0.5 0.1 1.1 0.6 0.4 0.4 -0.4 -0.1 0.2 -0.2 0.5 0.4 -0.4 0.2 -0.2 -0.5 0.4 -0.6 0 -0.6
0006 -0.2 2.4 -0.2 0 -0.2 -0.2 -0.2 1.2 -0.2 -0.2 -0.2 -0.2 0.5 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0
0007 -0.8 -0.8 -0.6 0.9 0.3 -0.8 -0.5 0.3 -0.8 -0.2 -0.2 3.7 -0.2 -0.3 1.9 0.3 0.2 -0.8 -0.8 -0.1
0008 0.3 -0.4 1.8 1 1.4 0.1 -0.4 -0.2 0.1 -0.2 -0.4 -0.4 -0.4 -0.3 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4
0009 -0.8 -0.4 2.1 1.2 0.3 0.2 -0.5 0.3 -0.8 -1 1.5 1.3 -0.7 -0.1 0.1 -0.1 0.6 -1 -1 -0.2
0010 2.4 -0.4 0.2 0.8 2.6 -0.3 -0.6 -0.6 0 -0.6 -0.6 -0.5 -0.6 -0.3 -0.3 0.2 0.8 -0.5 -0.6 -0.4
0011 1.2 -0.6 -0.7 -0.3 0.1 -0.7 -0.6 -0.4 0.9 0.7 -0.2 0.4 -0.4 -0.2 -0.7 0.7 0.1 0.1 2.2 -0.9
0012 0.2 -0.6 -0.2 0.6 0.7 -0.7 -0.8 0.2 0.6 0.7 -0.1 0.1 0.3 0.6 0.5 -0.1 0.2 -0.5 -0.6 -0.3
0013 1.4 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 4.5 -0.3 -0.3
0014 0.3 -0.4 0.5 1.4 0.8 -0.3 -0.7 -0.4 0.7 0.5 -0.7 -0.7 0.1 0.2 1.1 -0.6 -0.3 -0.3 0.3 -0.7
0015 0 -0.6 -0.3 0.4 0.1 -0.2 -0.6 -0.6 -0.6 -0.6 -0.3 1.6 -0.6 -0.6 0.2 1.1 1.6 -0.3 -0.6 1.2
0016 0.2 -0.4 -0.7 0.1 -0.8 -0.5 -0.2 -0.4 0.3 0.3 0.7 1.4 0.1 0.2 -0.2 0.7 0.2 0.9 -0.8 -0.4
0017 -0.4 -0.1 0.8 0.9 0.1 0.1 -0.6 -0.3 -0.3 0.4 -0.3 1.4 0.4 -0.4 0.4 -0.4 -0.4 -0.5 0.2 -0.4
0018 -0.5 0.9 0.2 -0.1 -0.1 -0.5 -0.2 1.6 0.8 -0.5 -0.5 -0.5 0.6 0.8 -0.5 0.1 -0.5 -0.5 -0.1 -0.3
0019 2.8 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.5 -0.2 0.8 -0.2 -0.2
0020 -0.6 0.9 0.8 0.7 -0.5 -0.8 -0.2 1.3 -0.5 -0.3 -0.3 -0.2 0.3 -0.3 1 1 -0.1 -0.7 -0.8 0.1
0021 -0.5 0.3 0.4 1.1 -0.5 0.1 0.9 -0.1 -0.2 -0.5 0.3 1.3 -0.5 -0.3 -0.5 0.1 -0.5 -0.4 -0.5 0
0022 0.6 -0.1 0.5 1.6 1.5 0.2 -0.4 -0.4 0.1 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.1 -0.4 -0.4
0023 2.9 -0.5 -0.5 -0.5 0.1 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 0 -0.5 -0.5 -0.5 1.8 1 -0.1 -0.5 0.5
0024 0.9 -0.6 -0.4 0.2 0.7 -0.3 -0.7 0.1 0.4 1.9 0.2 0 -0.1 -0.5 1.1 -0.4 0 -0.3 -0.7 -0.7
0025 0.9 -0.5 1.8 -0.1 1.4 0.5 -0.6 -0.6 -0.6 0.1 -0.2 -0.5 -0.5 -0.7 -0.7 0.5 1.7 -0.5 -0.7 -0.2
0026 4.6 -0.4 -0.4 -0.4 0.5 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 1 -0.4 -0.1 -0.4 -0.1
0027 2.1 -0.9 -0.4 0.4 -0.2 -0.7 -1 -0.2 -0.8 -0.8 -0.8 0.6 -0.6 0 -0.6 3.8 1.9 -0.4 -1 0.8
0028 -0.3 -0.6 -0.1 0.6 -0.5 0.1 -0.2 -0.5 -0.9 -0.5 0.8 2.2 -0.5 0.1 0.4 1.6 1.4 -0.4 -1.1 -0.7
0029 -0.7 1.6 2 0.4 1.2 -0.1 -0.4 1.4 -0.7 -0.7 0 -0.1 -0.7 0 -0.7 -0.5 0.4 -0.7 -0.7 -0.6
0030 0.3 -0.3 -0.4 0.1 -0.4 -0.1 -0.4 -0.3 -0.4 0.1 0 0.3 0 -0.3 0.2 0.8 0.9 -0.2 1.1 -0.4
- A F I L V M W Y D E K R H N Q S T G P C
0031 0.8 -0.4 1 0.7 3.3 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 1 -0.4 -0.4 -0.4
0032 0 -0.3 1.1 1.1 0.6 0 -0.5 -0.4 -0.1 0.6 0 0.5 -0.2 -0.1 0.2 -0.1 -0.3 -0.2 -0.6 -0.6
0033 -0.5 0.9 2.2 1.1 1.1 -0.4 -0.5 -0.3 -0.3 -0.5 -0.5 -0.5 -0.1 0.8 -0.5 -0.4 0.1 -0.5 -0.5 -0.3
0034 -0.6 -0.3 1.3 3.2 2.4 0.9 -0.5 -0.9 -0.4 0.5 -0.3 1.1 -0.7 -0.9 0.3 -0.9 -0.9 -0.9 -0.9 -0.7
0035 -0.5 0.3 1.3 1.8 1.8 0.4 -0.5 0.3 -0.5 -0.5 -0.5 -0.1 -0.5 -0.5 0.4 -0.5 -0.5 -0.5 -0.5 -0.5
0036 -0.8 1 -0.4 4.1 0.9 -0.1 0.5 -0.1 -0.6 -0.4 -0.8 0.1 -0.7 -0.8 0 0.1 -0.5 -0.6 -0.8 0.3
0037 -0.3 0.6 0.4 0.4 1.1 -0.1 -0.3 0 -0.1 -0.3 -0.3 -0.1 -0.1 -0.1 0 0 -0.1 -0.3 -0.3 -0.1
0038 -0.2 -0.3 -1 1.3 -0.5 -0.4 0.5 0 0.2 0.2 -0.2 1.4 0.1 0 0.4 0.4 -0.8 0.7 -1 0.3
0039 -0.1 -0.5 -0.3 -0.3 -0.5 -0.1 -0.5 0.2 0.8 -0.1 -0.1 0.1 0.2 0.8 0 0.6 -0.1 0.8 -0.5 -0.2
0040 -0.3 0.6 0.3 0.9 0.5 -0.8 -0.9 0.4 -0.6 -0.8 0 1.5 0.1 0.3 -0.5 1.2 1.1 -0.6 -0.7 -0.6
0041 -0.3 1.3 -0.1 0.3 0.3 -0.3 0 2 -0.3 -0.5 -0.5 -0.2 0.2 -0.3 -0.3 0.1 -0.5 -0.4 -0.3 0.4
0042 -0.5 2.7 -0.2 0.4 0.4 -0.5 -0.5 3.2 -0.5 -0.5 -0.5 -0.5 0.7 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5
0043 -0.4 -0.4 -0.1 -0.4 0.7 -0.4 -0.4 -0.4 1.8 0.7 0.1 -0.4 -0.4 1.5 -0.1 0 -0.4 -0.4 -0.1 -0.4
0044 -0.1 -0.5 0.7 1.9 1.1 2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.4 0.3 -0.3 0.2 -0.5 -0.5 -0.5
0045 -0.2 -0.5 -0.5 0.8 -0.5 -0.5 -0.1 -0.3 -0.5 -0.5 -0.5 2.8 2.4 0 0.1 0.6 -0.1 -0.5 -0.5 -0.5
0046 -0.6 0.3 0.5 0.5 -0.1 -0.5 -0.7 0.4 1.3 -0.1 -0.2 0.1 -0.1 0.9 0 0.4 0 -0.7 -0.7 -0.1
0047 1.1 -0.5 -0.4 -0.5 -0.3 -0.8 -0.5 0.1 0.1 0.2 -0.1 0 -0.5 0 -0.3 1.3 1 0.2 1.5 -0.8
0048 0.6 -0.4 -0.5 0.6 0.2 -0.4 0.1 -0.1 0 -0.4 -0.2 1.3 -0.3 -0.4 0.3 1.1 0.1 -0.6 0.5 -0.6
0049 0.3 -0.3 0.4 0.8 1.1 -0.2 -0.8 -0.7 0.7 0.2 -0.2 0.4 0 -0.3 1.1 0 0.3 -0.5 -0.8 -0.6
0050 -0.4 -0.4 1.9 2.2 1.2 0.9 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0 -0.1 -0.4 -0.4 -0.4
0051 -0.2 -0.4 -0.2 -0.3 -0.6 -0.6 -0.6 -0.1 1.5 1.9 -0.2 0 2 -0.4 1.1 -0.1 -0.6 -0.6 -0.6 -0.6
0052 1.2 -0.4 -0.4 0.1 -0.5 -0.7 -0.7 -0.1 -0.3 0 0.2 0.5 -0.4 0.4 -0.2 2.2 1.3 -0.2 -0.7 -0.5
0053 2 -0.3 -0.1 -0.3 -0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 1.4 0.9 0.1 -0.3 0.4
0054 -0.2 -0.6 0 1.7 -0.7 -0.4 -0.9 -1.1 -0.1 -0.5 0.3 1.5 0.2 0.8 0.3 1.2 -0.5 1.5 -0.7 -0.5
0055 0.4 0.3 1 1.2 -0.4 0.3 -0.8 -0.3 -0.5 -0.6 -0.8 -0.8 -0.8 0.4 -0.2 1.3 1.8 -0.8 0.8 -0.4
0056 0.3 0.5 -0.7 -0.4 -0.2 -0.8 0.1 0.2 0.1 0.1 -0.1 0.9 0.4 -0.4 -0.5 0.9 1.5 -0.4 -0.6 -0.2
0057 0 -0.4 -0.2 1.4 -0.3 -0.5 -0.7 -0.3 -0.7 0.1 1.5 0.5 -0.4 -0.2 1.5 0 0.1 -0.3 0.2 -0.6
0058 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 0.5 -0.2 0 0 1.8 -0.5 5.4 -0.5 -0.5
0059 0.8 -0.4 -0.6 -0.6 0 -0.4 -0.4 -0.3 -0.1 -0.3 -0.3 -0.1 -0.6 0.2 -0.6 2.1 2.3 -0.1 -0.6 0.3
0060 -0.2 1.8 0.4 1 1.4 -0.6 -0.3 1.1 -0.2 -0.2 -0.4 -0.2 -0.2 -0.5 -0.1 -0.1 -0.4 -0.6 -0.5 -0.2
- A F I L V M W Y D E K R H N Q S T G P C
0061 -0.7 4.8 0.5 0.6 0.5 -0.3 -0.7 3.5 -0.7 -0.7 -0.7 -0.7 -0.4 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7 -0.7
0062 -1 -0.7 0.6 1.7 0.6 -0.8 0.1 -0.3 -1 -0.2 -0.1 2.9 -0.4 -0.8 1.2 0.1 0.8 -0.8 -1 0.3
0063 -0.2 0.2 1.2 0.7 1.2 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0064 -0.2 1.4 0.8 1.9 0.8 -0.1 -0.4 0 -0.4 -0.3 -0.4 0.2 0.1 -0.6 0 -0.6 0 -0.6 -0.6 -0.6
0065 0.2 0.2 2.6 1 5.2 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6
0066 0.4 0.2 0 1.3 -0.5 -0.4 -0.3 0.8 -0.7 -0.5 -0.1 0.5 -0.3 -0.2 -0.1 1.9 0.2 -0.5 -0.9 0.1
0067 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 6.2 -0.3 -0.3
0068 1.6 -0.8 -0.5 -0.2 0.3 -0.9 -0.9 -0.8 0.8 0.2 -0.3 0 -0.5 -0.2 -0.2 1.4 0.1 0.5 1.8 -0.5
0069 -0.5 -0.3 -0.8 0.9 -0.4 -0.7 -0.5 0.2 0.1 1 -0.2 1.7 1.6 -0.1 0.8 0.3 -0.2 -0.8 -0.7 -0.7
0070 5.5 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.1 -0.1 -0.5 -0.5 -0.5 -0.5 -0.5 1.5 -0.5 0.5 -0.5 -0.5
0071 0.7 0.2 0.1 0.4 0.2 -0.3 -0.1 -0.3 -0.4 -0.1 -0.1 0.6 -0.5 -0.5 -0.3 0.9 1 -0.2 -0.1 -0.6
0072 -0.2 -0.9 -0.2 -0.1 0.4 -1 -1 0.2 3 3 0.4 -0.6 0.5 -0.4 1 -0.5 -0.8 -0.1 -1 -1
0073 2.1 -0.3 -0.3 -0.3 0.2 -0.3 -0.3 -0.3 0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.6 1.8 -0.1 -0.3 0
0074 1.3 -0.7 0.4 1.7 1.3 0.4 -0.7 -0.8 -0.7 -0.5 0.2 0.3 -0.6 -0.5 0.1 0.2 1.9 -0.7 -0.9 -0.8
0075 -0.3 -0.3 0.2 1.3 -0.1 -0.2 -0.4 -0.3 -0.5 0.3 0.2 1.6 0.2 0.2 0.1 0.2 0.2 -0.1 -0.8 -0.5
0076 1.5 -0.4 -0.3 0.2 0.1 -0.7 -0.5 -0.7 0.1 0.5 0 0.3 -0.5 -0.1 -0.3 1.4 1.3 0.2 -0.7 -0.6
0077 -0.4 -0.4 1.6 3.3 0.8 0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.2 -0.4 0.6 -0.4 -0.4 -0.4 -0.4 -0.4
0078 -0.1 0.6 2 1 0.9 0.4 -0.6 -0.1 -0.6 -0.2 0.3 0.6 -0.8 -0.5 -0.8 0.2 0.6 -0.6 -0.8 -0.8
0079 0.7 -0.3 -0.1 1.3 0 -0.9 -0.1 -0.5 -0.1 -0.1 0.2 0.7 -0.5 0 0.3 1.5 1.4 -0.5 -1.3 -0.3
0080 -0.1 -0.7 0 2 0.4 -0.8 -0.3 -1 -0.4 -0.6 -0.7 2.5 0.1 -0.3 -0.3 1.5 0.4 0.6 -1 -0.1
0081 -0.7 1.5 3 2.4 0.8 1.1 -0.7 -0.1 -0.7 -0.7 -0.7 -0.7 -0.5 -0.7 -0.4 -0.7 0 -0.7 -0.7 -0.7
0082 0.6 0.5 0.9 0.9 0.2 -0.5 -0.8 0.4 -0.7 -0.3 0.7 0.5 -0.2 -0.1 -0.1 1.1 0.4 -0.5 -1 -0.8
0083 1.2 -0.3 0.2 0.4 0.5 -0.6 -0.6 -0.4 -0.1 0.2 0.2 0.6 -0.5 0.1 -0.4 0.8 0.7 -0.1 -0.6 -0.4
0084 -0.5 0.5 -0.5 3.2 -0.5 0.6 0 -0.5 -0.5 0 -0.5 0.5 0.3 -0.5 0.7 0.4 -0.5 -0.5 -0.5 -0.5
0085 -0.3 -0.5 -0.7 0.1 -0.9 -0.5 -0.2 -0.1 0.6 0.4 0.9 0.6 0.9 2.4 0.5 0 -0.1 -0.2 -0.9 -0.9
0086 -0.3 -0.4 3.5 2.7 2.4 0.5 -0.6 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6
0087 2.6 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 1.2 -0.2 -0.2
Select residue pair below:
i_j Score Prob
0004_0078 2.136 1.00
0032_0050 1.844 1.00
0025_0076 1.770 1.00
0056_0063 1.663 1.00
0035_0055 1.358 0.98
0005_0040 1.346 0.97
0015_0076 1.344 0.97
0049_0053 1.281 0.96
0037_0044 1.279 0.96
0034_0060 1.264 0.96
0014_0047 1.227 0.95
0016_0031 1.213 0.95
0021_0073 1.201 0.94
0011_0033 1.199 0.94
0012_0035 1.191 0.94
0025_0032 1.182 0.94
0041_0054 1.173 0.93
0008_0073 1.148 0.92
0043_0053 1.146 0.92
0068_0071 1.144 0.92
0006_0042 1.141 0.92
0010_0018 1.136 0.92
0029_0083 1.129 0.91
0006_0066 1.128 0.91
0001_0032 1.116 0.91
0024_0076 1.098 0.90
0036_0057 1.071 0.88
0005_0042 1.069 0.88
0066_0071 1.067 0.88
0021_0084 1.063 0.88
0022_0081 1.058 0.87
0017_0021 1.056 0.87
0037_0055 1.053 0.87
0028_0085 1.044 0.86
0019_0030 1.040 0.86
0046_0072 1.037 0.86
0020_0025 1.037 0.86
0004_0034 1.036 0.86
0008_0019 1.033 0.86
0063_0073 1.032 0.86
0018_0047 1.031 0.86
0023_0049 1.026 0.85
0013_0030 1.026 0.85
0017_0063 1.023 0.85
0001_0053 1.018 0.85
0022_0031 1.015 0.84
0003_0047 1.013 0.84
0016_0029 1.012 0.84
0071_0085 1.011 0.84
0009_0048 1.006 0.84
0001_0006 1.003 0.83
0006_0035 1.002 0.83
0069_0087 0.991 0.82
0031_0056 0.989 0.82
0008_0057 0.986 0.82
0005_0063 0.984 0.82
0018_0087 0.979 0.81
0046_0081 0.977 0.81
0012_0078 0.974 0.81
0020_0043 0.966 0.80
0023_0032 0.964 0.80
0017_0074 0.962 0.80
0075_0083 0.961 0.80
0012_0062 0.958 0.79
0023_0068 0.954 0.79
0037_0082 0.952 0.79
0009_0037 0.952 0.79
0004_0008 0.947 0.78
0037_0079 0.945 0.78
0003_0020 0.943 0.78
0051_0075 0.933 0.77
0049_0083 0.932 0.77
0039_0048 0.928 0.76
0060_0074 0.922 0.76
0023_0080 0.920 0.75
0017_0056 0.914 0.75
0063_0071 0.909 0.74
0003_0017 0.908 0.74
0007_0037 0.908 0.74
0037_0074 0.907 0.74
0014_0023 0.904 0.74
0017_0040 0.899 0.73
0032_0046 0.897 0.73
0025_0071 0.896 0.73
0001_0021 0.895 0.72
0055_0083 0.894 0.72
0037_0050 0.894 0.72
0044_0053 0.890 0.72
0083_0086 0.890 0.72
0057_0078 0.889 0.72
0063_0082 0.886 0.71
0001_0044 0.879 0.71
0035_0041 0.879 0.71
0029_0048 0.876 0.70
0014_0022 0.876 0.70
0053_0078 0.876 0.70
0038_0068 0.873 0.70
0029_0086 0.873 0.70
0015_0040 0.872 0.70
0046_0051 0.867 0.69
0039_0051 0.865 0.69
0024_0041 0.860 0.68
0005_0062 0.857 0.68
0015_0059 0.855 0.67
0050_0075 0.852 0.67
0033_0077 0.852 0.67
0002_0071 0.851 0.67
0011_0038 0.846 0.66
0026_0059 0.846 0.66
0018_0060 0.842 0.66
0006_0083 0.836 0.65
0019_0039 0.832 0.64
0010_0049 0.827 0.64
0063_0087 0.826 0.64
0015_0037 0.821 0.63
0041_0064 0.819 0.63
0016_0066 0.819 0.63
0004_0075 0.817 0.62
0064_0084 0.817 0.62
0010_0085 0.816 0.62
0033_0039 0.815 0.62
0001_0024 0.814 0.62
0014_0076 0.805 0.61
0022_0077 0.804 0.60
0039_0044 0.802 0.60
0004_0057 0.801 0.60
0024_0028 0.801 0.60
0003_0064 0.800 0.60
0011_0015 0.800 0.60
Local Interactions:
i_j Score Prob
0043_0045 2.976 1.00
0046_0048 1.849 1.00
0037_0038 1.317 0.97
0051_0052 1.223 0.95
0047_0048 0.988 0.82
0050_0052 0.847 0.66
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Sequence: Y F A C M ...
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