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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 1.4 -0.2 -0.1 0 0.5 -0.6 -0.6 -0.4 0.8 0.5 -0.5 0.1 -0.1 -0.5 -0.6 0.5 0.2 1 -0.2 -0.4
0002 0.1 0.8 1 1.5 2.4 -0.3 -0.7 -0.3 1 0.6 -0.7 -0.7 -0.2 -0.7 -0.7 -0.4 -0.4 -0.6 -0.7 -0.4
0003 0.2 -0.2 0.5 0 0 -0.2 -0.4 -0.5 -0.1 -0.2 0.3 1 -0.4 -0.2 -0.2 0.8 0.8 -0.2 -0.4 -0.1
0004 0.1 0.9 0.2 0 0.9 -0.5 -0.2 0.8 -0.5 -0.5 -0.5 0 0.2 -0.1 -0.1 0.5 -0.1 -0.5 -0.5 0.1
0005 -0.6 1.1 1.2 1.4 0.6 0.2 -0.1 0.1 -0.3 -0.4 -0.6 -0.2 -0.4 -0.5 -0.4 0 0.5 -0.6 -0.1 -0.4
0006 -0.1 1.5 -0.1 0.2 -0.1 -0.1 -0.1 0.4 -0.1 -0.1 -0.1 -0.1 0.3 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1
0007 0.7 -0.7 -0.7 0.5 0.9 -0.5 -0.7 -0.6 0.1 2.2 0 0.2 -0.2 -0.4 1.8 0.1 0.1 -0.7 -0.6 -0.7
0008 0.4 -0.2 0.9 0.4 1.4 0 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2
0009 0.1 -0.4 1 0.9 1.1 -0.2 -0.7 0 0.3 0.2 -0.2 1.1 0.5 -0.1 0.1 -0.7 -0.6 -0.6 -0.7 -0.5
0010 1.5 -0.2 0.4 1.6 3.4 0 -0.6 -0.6 0.2 0.3 -0.6 -0.6 -0.5 -0.3 -0.6 -0.6 -0.4 -0.6 -0.6 -0.6
0011 0.5 -0.8 -0.4 -0.1 0.2 -0.8 -1 -0.2 1.3 2.4 1.7 0.1 -0.2 -0.2 0.7 0.1 -0.2 -0.5 -0.4 -1
0012 -0.6 -0.4 -0.2 1.2 -0.1 -0.6 -0.3 -0.5 -0.4 0 0 1.6 0.3 0 0.1 0.4 0 0.4 0 -0.5
0013 1.7 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0 -0.2 2.8 -0.2 -0.2
0014 -0.5 0.4 0.7 5.2 0.1 0.8 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5
0015 0.1 -0.7 0.4 0.2 -0.5 -0.5 -0.7 -0.7 -0.7 -0.6 1.1 1.1 -0.7 0 0.5 1.1 3.1 -0.7 -0.7 -0.7
0016 -0.1 -0.4 -0.4 -0.2 -0.4 -0.4 -0.4 0 0.8 1.5 0.3 -0.1 0 0.3 0.8 0 -0.4 0.6 -0.4 -0.4
0017 -0.6 -0.6 0.2 -0.5 -0.7 -0.1 -0.9 0.7 0.2 0.9 1.9 -0.2 0.3 1.1 0.7 0.5 0.4 -0.9 -0.8 -0.7
0018 1.6 0.7 1.2 0.3 1.4 -0.4 -0.5 0.4 0.3 -0.3 -0.5 -0.5 -0.4 -0.3 -0.4 -0.3 -0.3 -0.5 -0.3 -0.5
0019 4 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.4 -0.3 0.4 -0.3 -0.3
0020 -0.3 -0.6 0.3 -0.3 -0.2 -0.2 -0.6 0.8 -0.3 0.3 1.2 0.5 -0.1 0.6 0.2 0 0.2 0 -0.6 -0.5
0021 -0.1 0.5 0.7 1 0.5 0.7 0.3 -0.2 -0.5 -0.5 0.1 -0.1 -0.5 -0.5 -0.3 0.1 0.3 -0.2 -0.5 -0.3
0022 0 0.4 0.1 0.7 1.1 0.2 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0023 0.5 -0.2 -0.2 -0.2 0 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.4 -0.2 0 -0.2 0.8 0.7 0.3 -0.2 0.2
0024 0.5 -0.4 0.1 0 -0.1 -0.5 0 -0.6 0.4 0.7 0.6 0.7 -0.4 -0.4 0.5 0.4 0.7 -0.2 -0.6 -0.6
0025 1.1 -0.4 0.5 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 0.2 -0.4 -0.4 -0.4 1.6 2.1 -0.4 -0.4 -0.2
0026 3.9 -0.3 -0.3 -0.3 0.5 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.6 0.5 -0.3 -0.3 -0.3
0027 1.4 -0.6 -0.4 0.4 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 0 0.6 -0.6 -0.6 -0.6 3.7 2 -0.6 -0.6 0.3
0028 -0.8 1.6 0.4 4.3 1.1 -0.4 0.1 -0.6 -0.8 -0.8 -0.8 0 -0.7 -0.7 -0.6 1.5 -0.3 -0.6 -0.8 -0.5
0029 -0.3 1.6 0 0.3 -0.3 -0.3 -0.3 2.5 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0030 -0.3 0.7 -0.9 0.6 -0.6 -0.9 0.3 0.5 -0.7 -0.5 -0.5 0.9 -0.6 0 -0.3 1.6 0.3 0.1 0 1.1
- A F I L V M W Y D E K R H N Q S T G P C
0031 1.1 -0.3 0.6 0.4 1.6 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 0 -0.1 -0.3 -0.3
0032 -0.2 -0.3 -0.1 1.1 0.3 -0.1 -0.5 -0.1 -0.1 0.6 0.3 0.2 0.1 -0.1 0.6 -0.3 -0.1 0 -0.3 -0.4
0033 -0.4 0.5 1.5 0.5 0.5 0.6 -0.4 0.6 -0.4 -0.4 -0.4 -0.4 0 0.3 -0.4 -0.4 0 -0.4 -0.4 -0.4
0034 0.3 0.4 0.1 1.4 2.1 0.9 -0.4 -0.6 -0.4 0.5 0 -0.2 -0.6 -0.6 -0.2 -0.6 -0.2 -0.6 -0.6 -0.6
0035 -0.3 0.1 1.7 3 0.6 0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0036 -0.1 -0.3 -0.1 0.4 -0.4 0.2 0.1 -0.2 -0.3 0.9 1.1 0.5 -0.4 0.3 0.2 -0.2 0.9 -0.6 -0.7 -0.6
0037 -0.3 1.4 0.6 0.4 0 -0.3 -0.3 1.9 -0.3 -0.3 -0.3 -0.3 -0.1 -0.1 -0.3 -0.3 -0.1 -0.3 -0.3 0.4
0038 0.6 0.4 -1 -0.4 -1 -1 -0.6 1.8 0.1 -0.5 0.1 0 0.1 0.7 -0.6 1.7 0.8 0.4 -0.6 0
0039 0.8 -0.6 -0.6 -0.3 0 -0.6 -0.6 -0.3 0.6 0.5 -0.6 0.5 -0.6 -0.6 -0.6 -0.3 -0.3 4.9 -0.6 -0.6
0040 -0.2 -0.1 0.7 1.3 -0.2 -0.3 -0.5 -0.3 -0.5 -0.3 0 0.9 0.1 -0.1 -0.3 0.9 0.1 -0.3 -0.1 -0.3
0041 -0.6 0.9 1 -0.1 0.2 -0.8 -0.5 2 -0.1 -0.3 0.1 -0.1 0.1 0 -0.7 0.8 -0.1 -0.6 -0.2 -0.1
0042 -0.3 2.1 0 0.8 0.6 -0.3 -0.3 1.4 -0.3 -0.3 -0.3 -0.2 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 -0.3 0
0043 -0.3 -0.3 -0.3 -0.3 -0.2 -0.3 -0.3 0.1 2.4 1.3 -0.3 -0.3 -0.2 0.8 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0044 -0.1 -0.1 0.8 0.9 0.2 0 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 0.2 -0.1 -0.1 -0.1
0045 -0.3 0.3 0.1 1.3 -0.2 -0.3 -0.2 -0.1 -0.3 -0.3 -0.3 0.7 0.9 -0.2 0.2 -0.3 -0.1 0 -0.3 -0.1
0046 -0.3 -0.2 0.1 -0.1 0.3 -0.3 -0.3 -0.1 1.2 0.9 0 -0.3 -0.2 1 -0.1 -0.3 -0.1 -0.1 -0.3 -0.3
0047 0.9 -0.3 -0.4 0.3 0.2 -0.8 -0.7 -0.7 -0.5 0.3 -0.6 1.8 0.2 -0.9 -0.1 0.7 -0.6 0.6 2 -0.4
0048 0.2 -0.1 -0.3 0.4 0 0.2 0.2 -0.2 -0.3 -0.4 -0.2 0.9 -0.4 -0.4 -0.1 0.5 0.6 0 -0.2 -0.1
0049 0.1 0.1 1.6 0.4 1.2 0.1 -0.9 -0.7 0.9 -0.4 -0.1 0.1 -0.4 0.4 -0.7 0.3 1.2 -0.7 -0.9 -0.7
0050 0 -0.2 0.7 2.1 1 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0 -0.2 -0.2 -0.2
0051 0.4 -0.1 0.9 0.6 0.3 -0.2 -0.5 0.1 -0.6 -0.2 0.1 0.5 -0.4 -0.4 -0.1 0.9 0.5 -0.6 -0.6 0
0052 1.3 -0.2 -0.3 0.9 -0.1 0.1 -0.5 -0.5 -0.5 -0.2 -0.1 0 -0.5 -0.5 -0.5 2.3 1.2 -0.5 -0.5 0
0053 2.6 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.3 -0.1 0 -0.2 -0.2
0054 0.3 0.2 -0.6 0.5 -0.6 -0.6 0 0.5 -0.6 -0.6 -0.6 0.2 -0.6 0.6 -0.6 1.5 0.7 0.4 0.5 0.2
0055 -0.4 0.4 1.3 2.2 1.1 0.2 -0.4 -0.1 -0.4 -0.4 -0.4 -0.4 0.3 -0.4 -0.4 -0.2 -0.4 -0.4 0 -0.4
0056 -0.5 0.2 0 -0.5 -0.4 -1 -1 1.7 1.3 0 0.3 0.3 2.3 1 0.7 0.3 -0.3 -1 -1.2 -0.8
0057 -0.2 1.4 1.4 2.5 0.5 -0.2 -0.8 0.2 -0.8 -0.3 0.2 -0.8 -0.6 -0.6 -0.5 1.1 -0.1 -0.8 -0.3 -0.5
0058 0.5 -0.3 -0.6 -0.4 -0.3 -0.6 -0.6 -0.6 0 -0.2 -0.6 1.4 -0.6 -0.1 -0.6 1 -0.3 4.8 -0.6 -0.6
0059 0.1 -0.5 -0.2 0.2 -0.5 -0.5 -0.5 -0.5 -0.1 -0.5 -0.5 0.4 -0.5 -0.5 -0.5 2 1.7 -0.3 -0.5 1.4
0060 -0.5 0.4 0.3 0.2 -0.1 0.3 -0.2 0.2 -0.4 -0.2 -0.1 0.8 0.2 -0.5 0.4 -0.1 0 -0.5 0.6 -0.5
- A F I L V M W Y D E K R H N Q S T G P C
0061 -0.2 2.3 0 -0.2 -0.2 -0.2 -0.2 1.6 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0062 -0.5 0.1 1.2 1.3 1.1 -0.3 -0.5 -0.4 -0.5 0.9 -0.3 0.6 0.1 -0.5 0.3 -0.5 -0.2 -0.5 -0.5 -0.5
0063 -0.3 -0.1 2.2 0.7 1 0.2 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 -0.3 -0.3 -0.3 0.3 -0.3 -0.3 -0.3
0064 -0.1 1.2 1.8 2.4 1.3 -0.6 -0.6 -0.4 -0.4 -0.3 -0.3 -0.6 0.2 -0.6 -0.2 -0.6 0.1 -0.4 -0.6 -0.6
0065 0.1 0 1.3 -0.1 4.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.1 -0.4 -0.4 -0.1
0066 0.3 -0.5 0.3 0.5 -0.1 -0.5 -0.2 -0.5 -0.5 -0.1 0.4 0.8 -0.6 0.5 0 0.6 1.1 -0.2 -0.6 -0.1
0067 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 3.8 -0.2 -0.2
0068 -0.1 -0.5 -0.2 -0.1 -0.2 -0.4 -0.5 -0.5 0.5 0.6 0.2 0.8 0.1 0 0.6 0.2 0.1 -0.1 0.2 -0.4
0069 -0.5 -0.5 -0.5 0.7 -0.2 -0.3 -0.5 0.2 0.6 0.8 -0.4 0 1.2 0.5 1.9 -0.5 -0.5 -0.5 -0.5 -0.5
0070 2.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 1.6 0.1 -0.4 -0.4 -0.4 0 -0.4 0.8 -0.1 0.7 -0.4 -0.4
0071 -0.9 -0.5 1 -0.2 0 -0.8 -0.8 -0.6 -0.7 -0.1 -0.1 2 -1 0.1 -0.5 2.3 1 0.5 -0.1 0.8
0072 0.3 -0.7 -0.1 0.2 0.1 -0.7 -0.5 -0.2 1.5 1.2 0.1 -0.2 -0.2 -0.1 1.1 -0.1 0.1 0.2 -0.7 -0.7
0073 4 -0.4 -0.4 -0.4 0.3 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0 1.9 0.5 -0.4 -0.3
0074 1.8 -0.6 0.5 1.8 1.2 1.5 -0.6 -0.5 -0.3 -0.1 -0.4 -0.6 -0.5 -0.4 -0.5 -0.4 0.1 -0.3 -0.6 -0.6
0075 0.1 -0.9 -0.6 1.7 0.1 0.4 0.8 -0.6 -0.7 -0.5 -0.6 3 -0.2 -0.9 0.3 0.4 0.1 0.2 -0.9 -0.4
0076 0.7 0.1 -0.2 -0.1 -0.4 -0.4 -0.4 0 -0.4 -0.4 -0.4 0 -0.4 -0.4 -0.4 2.3 1.7 -0.4 -0.4 0.6
0077 -0.2 -0.2 1 0.7 0.7 0.6 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0 -0.2 0 -0.2 -0.2 -0.2 -0.2 -0.2
0078 -0.1 -0.1 1.6 0.6 1.1 0.2 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 -0.3 -0.2 0.3 -0.3 -0.3 -0.3
0079 0.9 -0.9 -0.4 0.2 0.9 -0.9 -0.5 -0.8 1 2.4 0.6 0.7 0.2 -0.3 1 -0.2 -0.6 -0.5 -0.9 -0.9
0080 0.8 -0.4 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 1.9 3.6 -0.4 -0.4 -0.4
0081 -0.2 1 0.3 1.9 0 0 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0082 0.2 -0.5 -0.2 0.6 0.1 -0.3 0.8 -0.5 -0.5 -0.1 -0.5 1.4 0 -0.5 0.7 -0.2 -0.3 0.8 -0.5 -0.2
0083 2.2 -0.3 -0.7 -0.2 0.6 -0.7 -0.7 -0.4 0.5 -0.1 -0.5 -0.2 -0.4 0.3 -0.4 1.4 1.3 0.1 -0.7 -0.5
0084 -0.8 0.3 -0.8 1.4 -0.7 -0.8 -0.8 0.9 -0.3 0.8 -0.3 0.2 2 0.2 1.9 -0.5 0.2 -0.8 -0.8 -0.7
0085 -0.6 -0.2 -0.6 0.1 -0.7 -0.2 -0.7 0.1 1.6 -0.1 0.7 0.5 0.7 1.7 0.4 -0.1 -0.5 -0.3 -0.7 -0.6
0086 -0.3 -0.3 2 1.2 1.4 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 -0.3
0087 1.9 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.3 -0.2 0.9 -0.2 -0.2
Select residue pair below:
i_j Score Prob
0025_0076 2.367 1.00
0013_0022 2.004 1.00
0022_0061 1.924 1.00
0009_0050 1.888 1.00
0012_0016 1.623 0.99
0004_0082 1.583 0.99
0005_0062 1.502 0.99
0006_0079 1.493 0.99
0006_0087 1.470 0.99
0003_0064 1.430 0.98
0029_0077 1.411 0.98
0013_0032 1.409 0.98
0004_0074 1.397 0.98
0025_0051 1.383 0.98
0023_0087 1.366 0.98
0042_0048 1.365 0.97
0001_0064 1.345 0.97
0026_0077 1.344 0.97
0022_0081 1.300 0.96
0052_0077 1.285 0.96
0018_0035 1.273 0.96
0032_0086 1.263 0.96
0023_0029 1.210 0.94
0060_0070 1.174 0.93
0037_0054 1.173 0.93
0069_0086 1.166 0.92
0050_0086 1.161 0.92
0001_0015 1.151 0.92
0004_0064 1.139 0.91
0032_0052 1.128 0.91
0081_0087 1.111 0.90
0059_0068 1.096 0.89
0048_0078 1.086 0.88
0041_0072 1.067 0.87
0035_0055 1.061 0.87
0007_0017 1.054 0.86
0059_0083 1.053 0.86
0021_0083 1.052 0.86
0062_0077 1.051 0.86
0008_0040 1.049 0.86
0016_0082 1.046 0.86
0061_0078 1.038 0.85
0011_0018 1.036 0.85
0021_0043 1.029 0.84
0002_0062 1.016 0.83
0013_0023 1.007 0.83
0023_0055 1.005 0.82
0031_0078 0.999 0.82
0044_0066 0.995 0.82
0057_0072 0.993 0.81
0016_0051 0.982 0.80
0023_0037 0.980 0.80
0006_0053 0.978 0.80
0003_0061 0.977 0.80
0074_0078 0.938 0.76
0032_0070 0.936 0.76
0024_0069 0.927 0.75
0054_0075 0.925 0.74
0002_0015 0.923 0.74
0018_0027 0.921 0.74
0009_0013 0.920 0.74
0049_0078 0.907 0.72
0050_0060 0.907 0.72
0004_0087 0.898 0.71
0006_0025 0.897 0.71
0008_0042 0.896 0.71
0005_0008 0.891 0.70
0048_0053 0.889 0.70
0046_0065 0.885 0.70
0045_0082 0.883 0.69
0021_0074 0.877 0.69
0046_0076 0.876 0.69
0034_0042 0.874 0.68
0016_0030 0.874 0.68
0044_0050 0.864 0.67
0008_0033 0.863 0.67
0010_0069 0.861 0.67
0008_0024 0.860 0.67
0022_0043 0.857 0.66
0066_0083 0.854 0.66
0048_0060 0.853 0.66
0040_0085 0.850 0.65
0021_0047 0.848 0.65
0021_0066 0.846 0.65
0017_0048 0.843 0.64
0033_0046 0.843 0.64
0063_0086 0.842 0.64
0036_0072 0.826 0.62
0037_0066 0.826 0.62
0036_0082 0.820 0.61
0016_0029 0.811 0.60
0010_0078 0.809 0.60
0031_0069 0.809 0.60
0022_0032 0.805 0.59
0051_0070 0.803 0.59
0033_0080 0.802 0.59
0025_0068 0.801 0.58
0008_0041 0.798 0.58
0003_0073 0.798 0.58
0005_0044 0.797 0.58
0006_0084 0.792 0.57
0020_0073 0.786 0.56
0005_0020 0.783 0.56
0024_0059 0.782 0.56
0020_0085 0.780 0.55
0044_0067 0.777 0.55
0009_0084 0.777 0.55
0001_0051 0.776 0.55
0012_0050 0.774 0.55
0037_0070 0.773 0.54
0006_0040 0.772 0.54
0040_0087 0.769 0.54
0001_0059 0.768 0.54
0063_0081 0.767 0.54
0023_0059 0.767 0.54
0012_0076 0.763 0.53
0021_0060 0.758 0.52
0049_0072 0.758 0.52
0046_0063 0.757 0.52
0024_0057 0.757 0.52
0019_0031 0.757 0.52
0034_0048 0.753 0.51
0044_0085 0.745 0.50
0045_0053 0.744 0.50
0006_0036 0.743 0.50
0006_0030 0.743 0.50
0020_0029 0.742 0.50
0068_0077 0.740 0.50
0031_0068 0.738 0.49
0003_0047 0.737 0.49
Local Interactions:
i_j Score Prob
0043_0045 1.833 1.00
0060_0061 1.280 0.96
0037_0038 1.142 0.91
0052_0054 1.105 0.89
0068_0070 0.987 0.81
0007_0008 0.916 0.73
0034_0036 0.908 0.73
0061_0062 0.752 0.51
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Sequence: V I T Y F ...
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