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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 0.7 -0.7 0.2 -0.5 0.5 1.3 -0.5 -0.8 -0.5 0.7 0.3 0.3 -0.5 -0.5 0.2 0 0.8 0 0.2 -0.6
0002 0.5 0.1 1.5 1.2 0.9 -0.4 -0.6 -0.1 -0.9 0.1 0.6 0.1 -0.4 -0.7 0.5 -0.6 0.5 -0.9 -0.2 -0.2
0003 -0.1 -1.1 -0.2 -0.6 0.5 -0.8 -1.1 -0.7 -0.5 2.1 1 1 -0.9 -0.1 1.4 1.9 1.5 -0.9 -0.9 -0.4
0004 0.6 0.8 0.3 0.2 0.2 -0.7 -1.1 -0.8 -0.2 0.4 1.3 1.2 -0.6 -0.4 1.1 -0.2 0.2 0.1 -1.1 -0.2
0005 0.4 -1.1 0 -0.3 0.3 -0.9 -1.1 -1.1 0.8 1.9 0.9 0.2 -0.2 -0.1 1.1 0.8 1.2 -1.1 0.1 -0.9
0006 0.7 1 1.3 1.2 1.1 0.1 0.6 1.1 -0.7 -0.6 -0.7 -0.7 0 -0.7 -0.7 -0.5 0.3 -0.7 -0.7 -0.5
0007 -0.1 -0.8 0.9 0.2 1.5 -0.4 -1.2 -1 -0.2 1.2 1 0.5 -0.5 -0.3 0.2 -0.5 2.5 -1.2 -0.1 -0.8
0008 -0.5 -0.1 3.3 1.8 2.6 0 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5
0009 0.6 -0.9 0.9 0 0.8 -0.3 -0.7 -0.9 -0.2 -0.2 0.8 0.3 -0.5 0.1 0.5 0.4 0.9 0.1 -0.4 -0.4
0010 0.9 -0.7 0.4 1.1 -0.2 -0.2 -0.5 0.3 0.2 -0.1 -0.5 -0.4 0.1 0.8 -0.4 0.8 -0.4 -0.3 -0.3 -0.2
0011 1 -1.2 -0.2 -0.8 -0.2 -0.7 -1.2 -1.2 0.3 1.5 2.3 1.5 -0.6 -0.5 0.4 1 -0.1 -0.9 2.1 -1.2
0012 0.3 -0.5 0.2 0.8 0 0 -0.3 -0.2 -0.3 0 0.1 0 0.3 0.4 0.4 0.5 -0.1 -0.1 -0.5 -0.4
0013 0.5 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 0.1 0.3 0 -0.2 -0.2 0 -0.2 0.4 0 1.3 -0.2 -0.2
0014 0.3 0.8 1.2 1 0.4 0.9 -0.2 -0.4 -0.4 -0.4 -0.2 -0.4 -0.4 -0.4 -0.4 -0.1 0.5 -0.4 -0.4 -0.4
0015 -0.1 0.2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 1.3 0.6 -0.3 -0.3 0.3 0.3 0.5 -0.3 0.2 -0.3 -0.3 -0.3
0016 0.9 -0.4 0.5 0.6 0.5 0.3 -0.4 -0.4 0.2 0.2 -0.4 -0.4 -0.4 -0.4 -0.2 0.1 0.3 0.3 -0.2 -0.2
0017 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 1 1.4 0.3 0 0.1 0.4 0 0 -0.3 -0.3
0018 1 0 -0.3 0 0.5 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 0 -0.1 -0.1 0 0.3 -0.3 1.7 -0.3
0019 2.1 -0.5 0.8 -0.5 1.4 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 2.1 0.6 -0.2 -0.5 -0.2
0020 2.5 -0.7 0 -0.4 0 -0.7 -0.7 -0.7 -0.5 -0.7 0.1 -0.5 -0.7 -0.2 -0.7 2.1 1.8 2.5 -0.7 -0.7
0021 0.7 -0.4 0.2 1 0.8 0.4 -0.8 -0.5 -0.4 0.4 1.4 1.2 -0.2 -0.5 0.5 -0.1 -0.4 -0.8 -0.8 -0.7
0022 0.5 -0.1 1.3 1.3 0.5 0 0.2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1
0023 2.6 -0.5 1 0 2.6 -0.2 -0.7 -0.7 -0.7 -0.7 -0.7 0 -0.7 -0.7 -0.5 0.7 0.8 -0.5 -0.7 0.4
0024 0.7 -0.7 -0.7 -0.6 -0.1 -0.5 -0.8 -0.7 0.1 0.8 1.8 0.9 -0.6 0.4 1.1 0.6 0.4 0.4 -0.8 -0.8
0025 1.6 -0.4 0.6 1.2 1.1 -0.2 -1 -1 -1 1.6 0.7 -0.4 -0.5 -0.6 0 -0.5 1.1 -0.6 -1 0.1
0026 1.3 0.1 0.3 1 1.5 0.4 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.4 0.6 -0.5 -0.3 0.2
0027 1.4 -1 -0.4 0 -0.3 -0.3 -1 -1 0 -0.1 1.3 0.6 -1 0.7 0.8 1.7 0.4 0.9 -1 -0.7
0028 0.7 -1.2 -0.9 -1.1 -1.1 -1.1 -1.2 -1.2 -0.1 0.8 2.2 1.9 -0.5 0.5 1.5 1.2 0.5 1.5 0 -1.2
0029 0.6 1.7 -0.5 0.4 -0.1 -0.5 -0.6 1.3 -0.6 0 -0.6 -0.4 0.8 -0.6 -0.4 1.1 -0.6 -0.6 -0.6 0.6
0030 0 -0.9 -0.7 -0.7 -0.5 -0.8 -0.9 -0.9 1.8 1.2 0 -0.1 -0.6 0.6 0.7 0.9 0.3 1.2 1 -0.9
- A F I L V M W Y D E K R H N Q S T G P C
0031 1.3 -0.1 -0.1 -0.4 0.3 -0.4 -0.4 -0.4 -0.2 -0.2 -0.4 -0.4 0.1 -0.4 -0.4 0.7 0.2 0.8 -0.4 1.2
0032 0.2 -0.9 -0.9 -0.5 -0.5 -0.8 -0.9 -0.7 1.6 1.6 0.6 0.9 -0.1 0.5 1.2 1.1 0.9 -0.8 -0.8 -0.8
0033 0.9 0.2 1.3 0.5 2 0.1 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.1 0.4 -0.5 -0.5 -0.1
0034 -0.3 -0.2 0.3 0.3 -0.1 -0.1 0.3 -0.1 -0.5 1.1 0.1 0.5 0 -0.2 0.4 0.3 1.8 -0.8 -1.1 -0.8
0035 0.4 1.3 1.9 1.6 1.2 0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.5 -0.5 -0.1
0036 0.3 -0.1 0.3 0.2 0.6 -0.8 -0.8 -0.6 -0.5 1.1 0.5 0.4 0.3 -0.4 -0.2 0.8 0.6 0.4 -0.9 -0.3
0037 0.6 0.6 -0.3 -0.2 0.1 -0.3 -1 1.1 -0.7 -0.8 1.1 1 0.9 0.1 -0.4 0.1 0 -0.3 -1 0.1
0038 0.3 -0.9 -0.9 -0.5 -0.6 -0.9 -0.9 -0.9 1.3 0.9 1 0.5 -0.1 1.2 0.3 0.1 -0.6 2.5 -0.3 -0.5
0039 0.3 -0.9 -0.9 -0.9 -0.9 -0.9 -0.9 -0.6 2.3 1.5 -0.1 -0.3 -0.5 1.4 0 0.5 0.5 2.9 -0.6 -0.9
0040 -0.6 -0.8 -0.2 0.1 0.2 0.3 -0.9 -0.8 0.1 0.8 2.1 1.9 -0.1 0.1 1 -0.1 0.3 -0.2 -0.9 -1.1
0041 0.3 -0.7 -0.4 -0.6 0.4 -0.3 -0.8 -1.1 -0.4 1.6 1.3 1.2 -0.5 -0.1 0.8 1.2 1.4 -0.9 -1 -0.2
0042 2.2 -0.3 1.9 -0.7 1.9 -0.4 -0.7 0.7 -0.7 -0.7 -0.3 -0.7 -0.5 -0.7 -0.7 -0.2 0.5 0.6 -0.7 -0.1
0043 0.7 -0.8 -0.8 -0.5 0.2 -0.8 -0.8 -0.8 2.1 -0.2 0.1 -0.5 -0.8 1.8 -0.5 1.6 0 1.1 0.1 -0.6
0044 3.4 -0.8 0.4 1.5 0 0.4 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.3 -0.8 -0.2 -0.2 2.3 0.5 0.6
0045 0.5 -0.5 -0.4 -0.1 -0.4 -0.4 -0.5 -0.5 0.8 0.5 0.5 0.9 -0.3 0.1 0 0.4 0.9 0.1 -0.5 -0.4
0046 -0.5 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 0.3 -0.5 1.5 1.6 -0.8 1.7 -0.3 4.9 -0.5 0.3 -0.8 -0.8
0047 0 -0.6 2.1 1.9 2.3 0.8 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.4 -0.3 -0.6 0.8 -0.6
0048 -0.1 0.7 1.2 1.3 0.8 1.2 -0.5 -0.4 -0.5 -0.5 -0.5 -0.2 -0.5 0.9 -0.5 -0.5 0.4 -0.5 -0.5 -0.5
0049 0.7 -0.7 -0.7 -0.4 -0.7 0 -0.7 -0.7 0.2 0.8 -0.1 -0.1 -0.7 0.9 0.5 1.9 0 0.9 -0.3 -0.1
0050 -0.2 -0.2 2 2.8 1.7 0.3 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4
0051 0.6 -0.4 1.2 1.1 0.1 1.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 0.1 -0.1 -0.4 -0.4 -0.4
0052 0.8 -0.6 -0.3 0.8 -0.2 -0.2 -0.6 -0.6 -0.6 -0.6 0.1 0.3 -0.6 -0.2 0.3 1.3 1.5 0.8 -0.6 -0.6
0053 1.1 0.1 0.2 1.6 -0.3 1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.3 0.4 -0.3 -0.1
0054 1.4 -0.7 -0.7 -0.7 -0.2 -0.4 -0.7 -0.7 0 0.3 -0.2 0.2 -0.5 0.3 0.6 0.6 -0.1 2 -0.7 1.1
0055 1.8 0 1.7 1.4 1.4 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 0.2 0.7 -0.2 -0.6 0.2
0056 1.4 -1.1 -0.9 -1 -0.1 -0.7 -1.3 -0.9 -0.3 0.4 1.8 0.8 -0.3 -0.3 -0.2 1.6 0.4 1.8 0.7 -0.5
0057 -0.1 -0.7 -0.1 -0.1 -0.8 -0.3 -1.2 -0.2 -1.2 0.4 1.9 0.4 0.2 0.1 1.6 0 0.1 -0.3 0.6 1
0058 -0.7 -0.7 -0.7 -0.4 -0.7 -0.7 -0.7 -0.7 1.9 -0.4 -0.7 -0.4 0.4 2 0.9 -0.4 -0.7 5 -0.7 -0.7
0059 1.3 -1.1 -0.9 -1.1 -0.3 -0.1 -1.1 -0.7 1.8 1.5 0.2 -0.4 -0.3 -0.3 0.7 1.4 1.9 -0.3 -1.1 0.1
0060 0.2 -0.6 -0.2 -0.3 0.4 -0.6 -1.2 -0.7 0.5 2 0.7 0.5 -0.7 -0.1 0.9 1.1 1.6 -1.2 -0.7 -0.6
- A F I L V M W Y D E K R H N Q S T G P C
0061 -0.4 0.2 2.1 1.8 1.9 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4
0062 0 -0.6 -0.1 0.3 0.6 -0.5 -1.1 -0.8 0.5 1.6 0.2 0.5 0 0 0.6 0.3 2 -0.6 -1.1 -0.9
0063 -0.5 1.2 1.9 2.3 2.2 -0.1 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.5 -0.5 -0.1
0064 0.3 -0.7 0.7 0.4 0.9 -0.7 -0.7 -0.6 -0.1 1.4 0.3 0.8 -0.2 -0.8 0.3 0.7 0.8 -0.8 -0.9 -0.2
0065 0.8 0.7 0.9 0.1 1.6 -0.4 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.1 0.6 0.2 -0.5 1.1
0066 0.2 -0.7 -0.2 -0.3 -0.1 -0.7 -0.8 -0.4 1.2 1.5 0.2 0.3 -0.4 0.5 0.4 1 0.5 -0.6 -0.8 -0.4
0067 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 0.1 -0.3 -0.3 -0.3 0.1 -0.3 0.6 -0.3 3.8 -0.3 -0.3
0068 1.5 -1 -0.7 -0.7 0.3 -0.9 -0.7 -0.6 1.3 2.6 0.1 -0.1 -0.6 -0.1 -0.2 0.6 0 -0.8 1.9 -1
0069 0.6 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.4 0.6 -0.1 0 0 0.6 0.3 0.6 -0.3 0.6 -0.3 -0.3
0070 2.6 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.5 0.5 -0.3 -0.3 -0.3 -0.3 0.1 0.6 -0.3 0.2 -0.3 -0.1
0071 0.9 -0.9 -0.3 -0.5 0.5 -0.5 -0.9 -0.9 1.3 1.9 0.3 -0.1 -0.2 0.1 0.9 0.6 0.2 -0.1 -0.6 -0.8
0072 1.1 -0.6 -0.3 0.2 -0.3 -0.8 -0.8 -0.7 1.3 1.8 0.5 0.2 -0.3 0.1 0.8 0.1 0 -0.4 -0.2 -0.8
0073 0.2 0 0.6 0.6 1.2 0.2 -0.3 -0.3 0.3 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 0.3 -0.1 -0.3 0.3
0074 1.3 0.1 1 1.8 1 1 -0.5 0 -0.7 -0.5 -0.7 -0.2 -0.6 -0.3 -0.5 -0.1 -0.5 -0.1 -0.7 0.1
0075 1.4 -0.9 -0.7 -0.7 -0.2 -0.9 -0.9 -0.7 1.5 2.3 0.1 -0.2 -0.4 0.5 1.4 0.7 0.6 -0.7 -0.6 -0.9
0076 1.6 -0.7 -0.9 -0.6 -0.2 -0.7 -0.9 -0.6 0.3 1.2 0.9 0.6 0.1 0 0.5 0.5 0.5 0.6 -0.9 -0.3
0077 0.7 1 2.3 2.4 1.9 0.8 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6
0078 0.7 -0.7 0.2 0.8 0.5 -0.7 -0.9 -0.7 -0.4 0.7 0.9 0.3 -0.7 -0.4 0.6 0.8 0.5 0.3 -0.9 -0.1
0079 1.8 -0.9 -0.7 -0.3 -0.6 -1.1 -1.1 -0.9 1.4 1.7 1 0.5 -0.4 0.7 0.9 0.1 0.6 0.1 -0.8 -0.9
0080 0.6 2.1 0.8 1.5 0.8 -0.1 -0.8 1.6 -0.8 0.1 -0.4 -0.8 -0.8 -0.8 -0.3 -0.4 0.5 -0.8 -0.8 -0.8
0081 0.6 0.9 0.3 1.4 0.1 0.4 -0.3 -0.3 -0.3 -0.1 -0.2 -0.3 0 -0.3 -0.3 -0.3 -0.2 -0.3 -0.3 0.2
0082 1.7 -1.1 -0.3 -0.5 -0.3 -0.6 -1.1 -0.8 0.6 1.4 0.9 0.7 -0.2 1 0.6 0.9 0.7 -0.3 -1.1 -0.9
0083 1.2 -1.2 -1.2 -0.9 -0.6 -1.2 -1.2 -1.2 1.8 1.8 0.6 0.9 -0.6 1.9 0.6 1.9 0.8 0.5 -1.2 -1.1
0084 0.2 -0.9 -0.5 0.8 -0.2 -0.4 -0.9 -0.3 0.1 1.1 0.9 0.6 0.3 1.2 0.1 -0.3 -0.4 0.9 -0.5 -0.9
Select residue pair below:
i_j Score Prob
0005_0060 2.835 1.00
0031_0069 2.562 1.00
0065_0074 2.282 1.00
0022_0077 2.157 1.00
0030_0068 2.126 1.00
0001_0070 2.090 1.00
0004_0078 1.806 1.00
0030_0069 1.789 1.00
0026_0073 1.663 1.00
0034_0041 1.584 0.99
0006_0078 1.574 0.99
0022_0044 1.544 0.99
0003_0062 1.539 0.99
0032_0043 1.519 0.99
0029_0073 1.467 0.99
0079_0083 1.415 0.98
0071_0075 1.410 0.98
0012_0018 1.382 0.98
0041_0064 1.375 0.98
0002_0071 1.370 0.98
0036_0062 1.349 0.98
0004_0075 1.325 0.97
0007_0060 1.324 0.97
0078_0082 1.299 0.97
0022_0035 1.295 0.97
0036_0039 1.285 0.97
0042_0048 1.267 0.96
0010_0080 1.239 0.96
0048_0051 1.237 0.96
0032_0066 1.237 0.96
0023_0047 1.220 0.95
0075_0079 1.207 0.95
0025_0028 1.207 0.95
0037_0059 1.202 0.95
0036_0064 1.191 0.94
0042_0053 1.180 0.94
0014_0022 1.179 0.94
0005_0062 1.177 0.94
0031_0065 1.172 0.94
0008_0081 1.170 0.94
0029_0076 1.158 0.93
0066_0070 1.151 0.93
0009_0084 1.131 0.92
0025_0076 1.081 0.89
0036_0041 1.081 0.89
0061_0081 1.073 0.89
0033_0073 1.052 0.88
0002_0074 1.045 0.87
0010_0084 1.030 0.86
0003_0064 1.025 0.86
0035_0050 1.022 0.86
0022_0050 0.988 0.83
0010_0015 0.920 0.76
0048_0052 0.911 0.75
0072_0075 0.902 0.74
0022_0081 0.878 0.71
0063_0081 0.875 0.71
0015_0018 0.874 0.71
0018_0021 0.867 0.70
0045_0050 0.866 0.70
0011_0057 0.859 0.69
0069_0073 0.855 0.69
0021_0024 0.854 0.68
0001_0066 0.848 0.68
0022_0063 0.847 0.67
0018_0052 0.838 0.66
0006_0081 0.837 0.66
0012_0021 0.832 0.65
0023_0049 0.800 0.61
0006_0063 0.797 0.61
0015_0080 0.794 0.60
0013_0019 0.793 0.60
0067_0073 0.780 0.58
0016_0054 0.774 0.57
0049_0052 0.772 0.57
0033_0065 0.761 0.55
0009_0082 0.757 0.55
0002_0070 0.736 0.51
0026_0077 0.729 0.50
0034_0043 0.723 0.50
0010_0081 0.712 0.48
0026_0033 0.695 0.45
0026_0081 0.691 0.45
0009_0070 0.687 0.44
0012_0052 0.687 0.44
0051_0061 0.687 0.44
0029_0069 0.685 0.44
0013_0017 0.680 0.43
0031_0045 0.678 0.43
0012_0054 0.678 0.43
0031_0070 0.676 0.43
0012_0033 0.675 0.42
0021_0025 0.672 0.42
0027_0050 0.659 0.40
0035_0061 0.657 0.40
0024_0051 0.656 0.40
0055_0061 0.647 0.38
0001_0045 0.645 0.38
0024_0047 0.644 0.38
0061_0074 0.635 0.37
0035_0054 0.632 0.36
0072_0076 0.632 0.36
0006_0082 0.625 0.35
0034_0064 0.621 0.35
0031_0066 0.619 0.34
0053_0065 0.616 0.34
0081_0084 0.614 0.34
0033_0063 0.612 0.33
0056_0059 0.609 0.33
0016_0051 0.605 0.33
0052_0055 0.605 0.33
0012_0081 0.600 0.32
0016_0053 0.597 0.31
0008_0055 0.595 0.31
0020_0053 0.592 0.31
0005_0032 0.591 0.31
0019_0040 0.590 0.31
0006_0074 0.584 0.30
0009_0078 0.581 0.29
0078_0084 0.581 0.29
0008_0037 0.575 0.29
0014_0017 0.575 0.29
0027_0049 0.572 0.28
0045_0069 0.571 0.28
Local Interactions:
i_j Score Prob
0038_0039 3.130 1.00
0030_0031 1.764 1.00
0037_0038 1.388 0.98
0071_0072 1.295 0.97
0043_0045 1.228 0.95
0015_0017 1.101 0.91
0013_0014 1.007 0.84
0049_0051 0.996 0.84
0047_0048 0.977 0.82
0070_0071 0.774 0.57
0013_0015 0.761 0.55
0007_0009 0.751 0.54
0032_0034 0.749 0.53
0036_0038 0.708 0.47
0067_0069 0.685 0.44
0064_0065 0.674 0.42
0070_0072 0.671 0.42
0017_0018 0.662 0.40
0068_0069 0.657 0.40
0002_0004 0.616 0.34
0015_0016 0.589 0.30
0078_0079 0.585 0.30
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: A K S V S ...
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