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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 -0.3 -0.3 -0.3 -0.3 -0.3 1.7 -0.3 -0.3 -0.3 0 0.3 0 -0.3 -0.3 -0.3 0.2 -0.2 -0.3 0 -0.3
0002 0.5 -0.4 -0.4 -0.2 -0.4 -0.4 -0.4 -0.4 -0.3 0.3 0.6 -0.2 -0.4 -0.4 -0.1 0.8 0.2 -0.4 1.6 -0.4
0003 0.7 -0.5 -0.2 -0.4 -0.1 -0.2 -0.5 -0.5 -0.2 -0.5 0.5 -0.1 -0.2 0 0.5 1.2 0.7 0.1 0.1 -0.5
0004 -0.3 -0.3 -0.2 -0.3 0.3 -0.3 -0.3 -0.3 0.4 0.2 1.2 0.2 -0.3 0.2 -0.1 0.1 0.4 -0.3 0.4 -0.3
0005 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.6 0.5 -0.2 -0.2 -0.2 0.2 0.6 -0.1 -0.2 0.1 0.8 -0.2
0006 0.6 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.2 -0.2 2.4 -0.2
0007 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 4.5
0008 -0.2 -0.2 -0.2 0.4 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 1.4 -0.2 0.6 0.1 0.7 -0.2 -0.2 -0.2 -0.2 -0.2
0009 0.3 -0.4 -0.3 -0.4 0.4 -0.4 -0.4 -0.4 -0.1 -0.2 1.8 0.2 -0.4 -0.4 0.4 0.2 -0.1 -0.4 1.6 -0.4
0010 -0.2 0.5 -0.1 0 -0.4 -0.4 -0.4 0.4 -0.4 1.2 0.1 0.7 0.3 -0.1 1.1 -0.2 -0.4 -0.4 -0.4 -0.4
0011 4.5 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0012 -0.2 -0.2 -0.2 0.3 0.8 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.8
0013 0.5 -0.3 -0.1 -0.1 0 -0.3 -0.3 -0.3 0.7 0.7 0.7 0.2 -0.3 0 0.1 -0.3 -0.2 -0.1 -0.3 -0.2
0014 -0.1 -0.1 0.5 0.6 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 0 0 -0.1 -0.1 0.2 0.1 -0.1 0.2 -0.1
0015 -0.1 -0.1 -0.1 0 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 0.2 -0.1 -0.1 -0.1 1.6 -0.1 0.1 -0.1 0.3 -0.1
0016 0.7 -0.3 -0.3 -0.2 0.1 -0.3 -0.3 -0.3 0.9 -0.3 0.7 -0.3 0.2 0.5 -0.1 0.1 0.5 -0.1 -0.3 -0.3
0017 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 3.1
0018 -0.1 0.3 0.2 1.7 -0.1 0.2 -0.1 0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1 -0.1
0019 0.2 -0.3 0.1 -0.2 0.3 0.1 -0.3 -0.3 -0.3 0 0.5 -0.1 -0.3 0.1 0.9 0.2 0.2 -0.1 -0.3 -0.3
0020 0.9 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 0.5 0.7 1.5 0.7 -0.4 0.2 -0.2 0.2 -0.1 -0.1 -0.4 -0.4
0021 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 0.1 -0.2 0.8 1.5 -0.2 0.3 0.4 -0.2 -0.2 -0.2
0022 0 -0.3 0 -0.2 0.3 -0.1 -0.3 -0.3 0.2 -0.3 0.2 -0.1 0.3 0.6 -0.3 0.4 -0.3 1 -0.3 -0.3
0023 -0.2 1.9 -0.2 -0.2 -0.2 -0.2 -0.2 1.7 -0.2 -0.2 -0.2 -0.2 0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0024 -0.4 -0.4 0.3 0.5 0.5 -0.1 -0.4 -0.4 0.6 -0.1 0.1 -0.2 -0.4 0.8 1.3 0.1 -0.3 -0.4 -0.4 -0.4
0025 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.1 0.9 -0.2 0.1 -0.2 -0.2 0.4 0.1 -0.2 -0.2 0.8 -0.2
0026 0.7 -0.3 -0.3 -0.3 -0.2 -0.3 -0.3 -0.3 0.7 0.8 -0.1 -0.3 0.2 -0.3 0.4 0.9 0.2 0.3 -0.3 -0.3
0027 0.6 -0.2 -0.2 -0.2 -0.2 0.3 -0.2 -0.2 -0.2 -0.2 1.1 1.4 0 -0.2 -0.2 0 -0.2 -0.2 -0.2 -0.2
0028 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 4.5
0029 0.5 -0.4 -0.3 0 0.8 -0.1 -0.4 -0.1 -0.1 0.7 0 0.5 -0.4 -0.4 0.8 0.2 0.2 -0.4 -0.4 -0.4
0030 0.5 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.1 0.3 0.2 1 0.1 0.5 0.2 -0.1 0.6 0 -0.1 -0.2 -0.4
- A F I L V M W Y D E K R H N Q S T G P C
0031 0.9 0.1 0.3 0.2 0.9 -0.3 0 0.2 -0.3 0 -0.3 -0.3 -0.1 -0.3 0.4 -0.3 -0.3 -0.3 -0.3 -0.2
0032 -0.3 0.1 1.8 1.3 0.8 0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0033 -0.5 -0.5 -0.1 0.3 -0.5 -0.5 -0.5 -0.5 1.2 1.4 0.5 1.1 -0.5 0.1 1 -0.1 -0.5 -0.2 -0.5 -0.5
0034 1.2 -0.4 -0.4 0.5 -0.4 -0.3 -0.4 -0.1 0.8 1.5 0 0.1 -0.4 0.3 0.1 -0.1 -0.4 -0.4 -0.4 -0.4
0035 -0.2 -0.2 0.3 1.7 -0.2 1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.1 -0.2
0036 -0.3 0 -0.3 0.3 -0.3 -0.3 -0.3 0.3 -0.2 0 0.6 0.9 0.4 -0.3 0.8 -0.3 -0.3 -0.3 0.1 -0.3
0037 0.1 -0.4 -0.2 0.2 -0.5 -0.3 -0.5 -0.5 0.3 1.4 1.5 0.8 -0.3 0 0.7 -0.1 -0.1 -0.5 -0.5 -0.5
0038 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 4.5
0039 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 4.5
0040 0.9 -0.4 -0.2 0.4 0.2 -0.3 -0.4 -0.4 0.2 0.7 0.4 0.5 -0.4 0.5 0.3 -0.3 -0.1 -0.4 -0.4 -0.4
0041 0.8 -0.5 0.3 -0.1 0 -0.4 -0.5 -0.5 -0.5 0.6 1.3 0.6 -0.4 -0.1 0.8 0.2 0.2 -0.5 -0.5 -0.5
0042 -0.3 2 -0.6 0.2 -0.6 -0.6 1.2 1 -0.3 -0.6 -0.6 -0.3 1.2 -0.6 -0.6 -0.6 -0.6 -0.6 0.2 1
0043 0 -0.3 -0.4 -0.1 -0.4 -0.4 -0.1 0.5 -0.1 0.1 0.4 0.1 0.1 0.5 -0.4 0.3 0.5 0.3 0.4 -0.4
0044 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.3 0.2 0.5 1 0.1 -0.4 -0.1 0.4 -0.4 0.2 0.4 -0.4 -0.4
0045 0 -0.1 -0.5 -0.2 0 -0.5 -0.5 -0.5 0.2 0.8 1 0.6 -0.5 0 0.3 0.1 0.5 0.5 -0.5 -0.5
0046 -0.5 -0.2 -0.4 -0.5 0.3 -0.2 -0.5 0.2 0 0.4 0.8 0.8 -0.2 1 0.3 0.6 -0.4 -0.2 -0.5 -0.5
0047 0.3 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 0.8 0.8 0.1 0.4 -0.1
0048 0.5 0.1 0.7 0.7 1 -0.4 -0.4 -0.4 0.2 -0.4 -0.2 -0.3 -0.4 -0.4 -0.4 0 0.3 0.3 0.5 -0.4
0049 0.3 -0.2 -0.1 -0.2 0.8 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1 -0.2 -0.2 0.1 0.8
0050 -0.2 -0.1 -0.2 0.6 0.7 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.9
0051 0.3 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 0.8 0.2 -0.2 -0.2 -0.2 0.1 -0.2 0.7 -0.1 -0.2 0.7 -0.2
0052 0.2 -0.2 0.1 0.1 -0.2 -0.1 -0.2 -0.2 -0.1 -0.2 0.6 -0.2 -0.1 0.4 -0.2 -0.2 -0.2 1.2 -0.2 -0.2
0053 0.5 0.6 0.7 0.6 -0.3 0.1 0 -0.1 -0.3 -0.3 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.6 -0.3
0054 -0.2 -0.3 0.1 0.8 -0.4 -0.4 -0.4 -0.4 0.6 0.5 0.7 0.5 -0.4 0.3 -0.3 0.3 -0.1 -0.4 -0.4 -0.4
0055 -0.1 -0.4 0.6 0.5 -0.1 -0.4 -0.4 -0.1 -0.1 -0.4 1.4 0.2 -0.4 -0.4 -0.1 0.1 0.2 0 0.1 -0.4
0056 0.2 -0.4 -0.4 -0.4 0.2 -0.4 -0.4 -0.4 0.3 1.4 -0.1 -0.4 -0.4 -0.2 0.7 0.3 0.5 -0.2 -0.1 -0.4
0057 -0.2 -0.2 0.1 0 0 -0.2 -0.2 0 -0.2 0.3 0.4 0.1 0.2 0.4 0.1 -0.2 -0.2 0 0 -0.2
0058 0.2 -0.2 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 0.2 0.3 0.5 0.5 -0.2 0 -0.2 0.2 -0.2 0 -0.1 -0.2
0059 0 0.1 -0.2 -0.2 -0.2 0 -0.2 -0.2 -0.1 0.4 0.1 -0.2 0.1 -0.2 -0.2 0.5 0 -0.2 0.5 -0.2
0060 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.4 0.5 -0.2 0.1 -0.1 -0.1 0.3 -0.2 -0.2 -0.2
- A F I L V M W Y D E K R H N Q S T G P C
0061 -0.2 -0.2 -0.2 0.2 -0.2 -0.2 -0.2 -0.2 0 0.5 0.4 -0.2 -0.2 0.2 0.4 0.2 0 0 -0.2 -0.2
0062 0 -0.2 -0.2 0 0 -0.2 -0.2 -0.2 0 0.4 0.4 -0.1 -0.2 -0.2 0.2 -0.2 0.3 -0.2 0.2 -0.2
0063 -0.2 -0.2 -0.2 0.1 -0.2 0 0 -0.2 0 -0.2 0.6 -0.2 -0.1 0.2 0.2 0.2 -0.2 -0.2 0.1 -0.2
Select residue pair below:
i_j Score Prob
0012_0015 3.244 1.00
0031_0040 2.058 0.99
0029_0049 1.789 0.97
0005_0008 1.633 0.94
0010_0037 1.598 0.94
0059_0062 1.581 0.93
0035_0049 1.579 0.93
0058_0061 1.498 0.90
0005_0053 1.425 0.87
0016_0052 1.386 0.85
0003_0026 1.385 0.85
0030_0046 1.371 0.84
0059_0063 1.350 0.83
0008_0047 1.315 0.81
0054_0057 1.279 0.78
0046_0053 1.260 0.77
0058_0062 1.244 0.75
0008_0019 1.229 0.74
0006_0034 1.227 0.74
0058_0063 1.222 0.74
0036_0051 1.132 0.65
0005_0019 1.127 0.65
0024_0033 1.098 0.62
0060_0063 1.089 0.61
0005_0052 1.066 0.58
0032_0040 1.062 0.58
0014_0022 1.061 0.58
0045_0057 1.058 0.57
0029_0058 1.053 0.57
0008_0041 1.046 0.56
0004_0022 1.013 0.53
0047_0050 0.994 0.50
0002_0062 0.993 0.50
0047_0052 0.993 0.50
0008_0026 0.978 0.49
0027_0062 0.969 0.48
0027_0045 0.967 0.47
0014_0035 0.964 0.47
0001_0016 0.963 0.47
0006_0022 0.939 0.44
0025_0049 0.937 0.44
0021_0026 0.936 0.44
0014_0051 0.924 0.43
0004_0030 0.921 0.42
0036_0043 0.917 0.42
0010_0026 0.891 0.39
0014_0027 0.886 0.39
0010_0031 0.882 0.38
0033_0057 0.881 0.38
0006_0031 0.872 0.37
0023_0047 0.871 0.37
0010_0024 0.865 0.37
0013_0025 0.864 0.36
0015_0044 0.863 0.36
0005_0020 0.859 0.36
0035_0048 0.857 0.36
0027_0060 0.855 0.36
0035_0051 0.853 0.35
0004_0051 0.851 0.35
0043_0051 0.844 0.34
0027_0061 0.826 0.33
0018_0044 0.825 0.33
0057_0062 0.821 0.32
0003_0041 0.811 0.31
0049_0053 0.810 0.31
0030_0040 0.805 0.31
0004_0031 0.797 0.30
0019_0047 0.797 0.30
0030_0045 0.784 0.29
0029_0040 0.776 0.28
0045_0054 0.775 0.28
0032_0035 0.775 0.28
0034_0059 0.768 0.27
0054_0058 0.766 0.27
0050_0053 0.754 0.26
0043_0059 0.751 0.26
0031_0048 0.738 0.25
0021_0052 0.727 0.24
0032_0044 0.726 0.24
0030_0057 0.716 0.23
0022_0025 0.708 0.22
0036_0050 0.707 0.22
0025_0053 0.707 0.22
0027_0058 0.706 0.22
0025_0050 0.705 0.22
0043_0057 0.703 0.22
0014_0049 0.697 0.21
0026_0029 0.676 0.20
0032_0063 0.673 0.20
0009_0019 0.664 0.19
0036_0059 0.663 0.19
0036_0061 0.663 0.19
0024_0063 0.661 0.19
0048_0055 0.660 0.19
Local Interactions:
i_j Score Prob
0012_0014 2.189 1.00
0013_0014 2.007 0.99
0014_0015 1.940 0.99
0060_0061 1.808 0.97
0012_0013 1.796 0.97
0013_0015 1.587 0.93
0060_0062 1.559 0.93
0062_0063 1.529 0.92
0019_0021 1.453 0.89
0061_0063 1.451 0.88
0058_0059 1.387 0.85
0058_0060 1.363 0.84
0023_0025 1.316 0.81
0061_0062 1.223 0.74
0005_0006 1.201 0.72
0056_0057 1.098 0.62
0021_0023 1.054 0.57
0051_0052 1.038 0.55
0004_0005 1.032 0.55
0001_0002 0.976 0.48
0059_0060 0.962 0.47
0059_0061 0.920 0.42
0020_0021 0.889 0.39
0017_0018 0.870 0.37
0057_0059 0.855 0.36
0029_0031 0.848 0.35
0046_0048 0.848 0.35
0055_0057 0.845 0.34
0030_0031 0.822 0.32
0008_0009 0.815 0.32
0055_0056 0.777 0.28
0047_0049 0.775 0.28
0057_0058 0.772 0.28
0016_0018 0.757 0.26
0022_0024 0.737 0.25
0003_0004 0.684 0.21
0054_0055 0.678 0.20
0056_0058 0.673 0.20
0018_0019 0.666 0.19
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: M P Q K D ...
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