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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0008 1 -0.7 -1 0 -0.4 -0.7 -1.1 -1 0.5 0.5 -0.5 -0.9 -0.4 0.3 -0.2 1.2 0.2 0.8 0.6 -1.1
0009 0.6 -0.2 -0.1 0.3 -0.1 -0.5 -1.1 -0.3 0.9 0.8 -0.5 -0.1 -0.5 0.2 0.2 0.9 0.3 0.3 0.4 -1.1
0010 0.9 -0.9 0.2 -0.3 -0.3 -0.4 -1.2 -0.5 0.2 0.6 0.1 -0.1 -0.9 0.1 0 1.2 0.6 1.1 0.9 -0.9
0011 0.8 -0.6 -0.6 -0.2 0.2 -0.4 -1.4 -0.9 0.6 0.8 0.6 -0.2 -1.2 -0.2 -0.3 0.7 0.5 0.8 2.1 -1.2
0012 0.8 -1 -0.4 1.1 0.7 0 -1.3 -0.8 -0.2 0.3 0.1 -0.5 -1.3 -0.1 0.3 0.6 0.2 0.4 0.8 -1.2
0013 1.1 -0.8 -0.3 -0.2 0.3 0.3 -1.2 -1.2 0.5 0.7 0.4 0.2 -0.6 0.2 0.1 0.9 -0.2 0.6 0.4 -0.9
0014 1.1 -1.1 -1.1 -0.1 0.1 -0.5 -1.4 -1.1 0.7 0.5 -0.1 -0.2 0 0 0.3 1.3 0.5 0.8 1.5 -0.7
0015 0.9 -0.3 0.2 0.4 0.8 -0.7 -1.4 -0.8 0.9 1.2 0 -0.3 -0.6 -0.1 0.1 -0.1 -0.1 1.2 0.5 -1.4
0016 -0.1 0.6 0.3 0.2 -0.2 -0.6 1.9 0.9 -0.5 -0.3 -0.3 -0.3 -0.6 -0.6 0.1 0.2 0 -0.3 -0.2 -0.3
0017 0.4 -0.9 0.3 -0.3 1.5 -0.3 -1.1 -0.8 -0.3 1.6 0.7 0.2 -0.7 -0.5 1.3 0.7 0.7 -0.2 -1.1 -0.4
0018 0.1 -0.8 0.1 0 1.4 0.7 -0.8 -0.7 -0.7 0.8 0.9 0.7 -0.7 -0.9 0.9 0.2 0.5 -0.4 -0.2 -0.5
0019 1.3 0.1 -0.2 0.1 0.3 -0.1 -1 0.8 -0.7 -0.6 0.4 0.9 0.6 -0.8 0.6 0.1 -0.1 0.2 -0.8 0
0020 -0.1 0.1 1 0.6 1.7 0 -1 -0.5 -0.6 -0.1 1.1 0.7 -0.4 -0.7 0.5 -0.1 1.4 -1.4 -0.6 -0.6
0021 0.6 -0.7 -0.8 -0.1 -0.7 -0.5 -0.9 -0.4 2.4 -0.2 -0.6 -0.1 -0.3 0.4 -0.1 1 1.7 -0.2 -0.4 -0.9
0022 1.6 -0.8 -1.3 -0.1 -0.7 -0.7 -1.3 -1.3 1.1 0.7 0.4 0 0.2 -0.2 0.2 1 0.4 0.1 2.3 -1.3
0023 0.4 -1.1 -1.2 0.4 -0.7 -0.7 -1.4 -0.4 2 1.2 0 0.4 -0.5 1.7 0.4 1.1 1.1 0.2 -1 -1
0024 0.1 -0.1 -0.2 0 -0.2 -0.6 -0.7 -0.7 0.5 0.2 0.2 0.4 -0.2 0.5 0.6 0 -0.2 1.3 -0.1 -0.6
0025 0.4 -0.2 0.1 0 0.5 -0.6 -0.4 -0.1 -0.2 -0.2 0.6 1.3 0.4 -0.4 0.9 0.1 -0.1 -0.7 0.1 -0.4
0026 0.4 -0.3 1.1 0.9 1.8 -0.6 -1.3 -1.1 -1.4 0 0.5 0.2 -1 -0.4 -0.2 -0.1 1.6 -1.2 1.4 -1.1
0027 -0.3 1 -0.2 0.7 -0.1 0.1 0.1 0.7 0 0.1 -0.5 -0.1 -0.2 0 0.3 -0.1 -0.1 -0.5 0 -0.1
0028 -0.1 0.9 -0.1 0.2 -0.3 -0.3 0.7 1.4 -0.6 -0.6 -0.1 -0.3 0.1 -0.1 -0.6 -0.3 0.2 0.1 -0.1 -0.3
0029 0.5 1 0 0.6 0.1 -0.5 -0.1 0.7 -0.4 -0.3 -0.4 0.2 0 -0.3 -0.3 0.1 0 -0.7 0.1 -0.1
0030 -0.2 -0.3 -0.5 -0.3 -0.4 -0.5 -0.7 -0.3 1.1 -0.3 0.2 0.3 0.9 1.9 -0.1 0.6 0 -0.7 -0.2 -0.3
0031 0.3 -0.5 0.2 0.1 0.1 -0.5 -0.8 -0.7 -0.2 -0.5 0.6 0.7 0.1 0.2 -0.4 0.8 0.8 -0.5 1 -0.7
0032 0.7 -0.4 0.6 0.5 0.6 -0.4 -1.3 -0.7 -0.1 0.8 0.6 0.7 -0.5 -0.1 0.3 0.2 0.4 -0.2 0 -1.3
0033 0.6 -0.7 -0.3 0.3 -0.9 -0.7 -0.9 -0.9 0.3 0.7 0.2 -0.2 0 0.7 -0.1 1.2 2.2 -0.4 -0.5 -0.9
0034 0.1 -0.6 -0.5 0 -0.7 -0.4 -0.9 -0.7 -0.5 0.2 1.2 0.8 -0.3 1 0.8 0.5 -0.3 1.9 -0.8 -0.6
0035 0.8 0.1 0.5 -0.1 0.6 -0.8 -0.8 -0.9 -0.2 0.4 0.3 0.8 -0.2 -0.3 0.3 0.8 0.2 -0.2 -0.4 -0.8
0036 0.7 -0.3 0 -0.2 0.7 -0.3 -0.5 -0.1 -0.1 -0.3 0 0.6 -0.5 0.3 -0.3 0.2 -0.1 0.1 0.2 0.3
0037 0.1 -0.5 -0.1 -0.1 0.6 -0.7 -0.5 -0.2 -0.5 -0.8 0.3 0.1 -0.4 0 0.6 1.5 1.7 -0.5 -0.1 -0.6
- A F I L V M W Y D E K R H N Q S T G P C
0038 -0.5 0.6 -0.3 0.4 -0.5 -0.2 1.6 0.5 0 -0.2 0 0 -0.5 -0.5 0.6 0.2 -0.5 -0.5 0.1 -0.4
0039 0.1 -0.8 0.2 0.3 0.9 -0.7 -1 -0.7 0.9 1.5 0.1 -0.4 0.2 0.1 -0.2 1.1 1.1 -0.3 -1 -0.9
0040 -0.1 0 -0.1 0.2 -0.2 -0.3 -0.5 -0.8 0.7 -0.1 1.3 1.6 0 0.1 -0.6 -0.2 -0.2 -0.5 0.6 -0.2
0041 -0.2 -0.2 0.1 -0.1 -0.2 -0.5 -0.5 -0.5 -0.5 0.1 -0.5 0.3 0.3 0.1 -0.2 0.8 0.5 0 1.2 -0.5
0042 0.7 -0.3 -0.3 0.2 0.3 -0.8 -1.4 -0.8 0 0.9 0.6 0.7 -0.6 -0.2 0.7 0.6 0.5 0.2 0.6 -0.9
0043 0.7 -0.3 -0.3 0.8 0.8 -0.9 -1.4 -1.2 0.5 0.6 -0.1 0.1 -0.6 0 -0.3 0.5 0.6 0.7 0.9 -0.7
0044 0.6 0.2 -0.3 0.2 0.2 -0.2 -0.9 -0.6 0.1 0.1 0 -0.1 -0.7 0.1 0.3 0.8 0.6 0.5 0.5 -1.2
0045 0.8 -0.2 -0.5 0.4 0.4 -0.2 -1.3 -0.6 0 0.1 0.6 0.6 -0.7 -0.2 0.2 1 0.5 -0.1 0.4 -0.9
0046 0.5 -0.4 -0.5 0.7 0.9 -0.5 -0.9 -0.9 0.5 0.6 -0.3 -0.1 -0.7 0 0.2 0.9 0.7 0.1 0.9 -1.6
0047 0.7 -1 -0.3 0.4 0.3 -0.5 -1.1 -1.2 0.1 0.6 0.5 0.2 -0.9 -0.1 0.4 0.9 0.5 0.2 1 -1.5
0048 0.8 -0.1 -0.1 0.4 0.2 -0.9 -1.5 -1 0.2 0.6 -0.2 0.2 -0.8 0 0.4 0.8 0.5 0.1 0.7 -1.2
0049 0.6 -0.8 -0.4 -0.2 0.5 -1.5 -1.3 -1.3 0.9 1.6 0.1 -0.5 -0.2 0.4 0.5 0.7 0.3 0.6 0.5 -1.1
0050 0.5 -0.4 -0.1 0.6 0.1 -0.9 -1.6 -0.8 0.5 0.8 0.7 0.7 -0.5 -0.1 0.8 1 0.1 -0.5 0.3 -1.3
0051 1.3 -0.8 0 0.5 0.4 -0.3 -1.5 -1.2 0.1 0.4 0.2 0.2 -1.2 -0.6 0.2 0.9 0.3 1 1.5 -1.7
0052 0.6 -0.7 0.7 1.6 0.3 -0.3 -1.6 -1.1 0.6 0.3 -0.2 -0.8 -0.6 -0.3 -0.4 0.7 0.4 0.3 0.9 -0.8
0053 1.3 -0.6 0 1.1 -0.1 -0.4 -0.9 -1.1 0.1 0.6 -0.1 -0.5 -0.3 0 -0.3 1.2 0.5 0 0.8 -1.1
0054 1 -0.7 -0.4 0.3 0.2 -0.3 -1 -0.7 0.4 0.7 0.5 0.1 -0.7 0.2 0.7 0.7 0.4 0.1 0 -0.9
0055 0.9 -0.4 -0.6 0.1 -0.4 -0.8 -1.4 -0.6 0.6 0.6 0 -0.3 -0.4 0 0.1 1.1 0.6 0.5 1.2 0
0056 0.4 -0.9 -0.4 0.2 -0.1 -1.1 -1.1 -0.8 0.4 0.9 0.7 0 -0.3 0.1 0.5 0.5 0.1 1.8 0.9 -0.9
0057 0 0.5 -0.6 0.2 0.5 -0.6 4.2 1.3 -0.6 -0.6 -0.4 -0.6 -0.6 -0.2 -0.2 -0.2 -0.6 -0.6 -0.6 -0.3
0058 0.1 -0.7 0.3 0.2 0.8 0.1 -0.6 -0.6 -0.2 0.9 0.8 0.9 -1.1 -0.4 0.7 0.8 0.5 -0.3 -1.1 -0.5
0059 0.2 -0.6 0.8 0.7 0.2 0.5 -0.9 -0.7 -0.3 0.2 1.2 0.9 -0.9 -0.6 0.2 0.5 0.2 -0.7 -0.1 -0.3
0060 0.8 0.5 0.3 0.5 1.6 -0.4 -1.2 1.3 -0.9 -0.5 0.1 -0.1 0.3 -0.7 0.3 0.1 -0.2 0.1 -1 0
0061 -0.3 0.6 0.5 0.7 0.9 -0.2 0.9 0.4 -0.4 -0.4 0.2 0.2 0 -0.8 0 -0.1 0.5 -1 -0.6 -0.9
0062 -0.1 -0.1 0 -0.4 0.3 -0.3 -0.7 -0.6 0.8 0.3 0 0.1 -0.8 0.2 -0.3 1.1 1.1 -0.1 -0.3 -0.4
0063 1 -1.4 -1.2 -0.5 0 -1.4 -1.4 -1.4 1.3 1.7 0.8 -0.5 -1 1 0.2 1.1 0.7 0.4 1.9 -1.6
0064 -0.4 -0.5 -1.2 -0.2 -0.4 -0.7 -1.2 -0.2 1.9 0 0.5 0.5 -0.3 1.5 0 1 1 1.1 -1.2 -1
0065 0.3 -0.1 -0.5 -0.1 -0.1 -0.7 -0.7 -0.4 0.5 0 0.2 0.4 0.1 0.6 0.6 0.3 -0.5 1.3 -0.3 -0.7
0066 0 -0.1 0.1 0.6 0.4 -0.3 -0.6 0.3 0 -0.1 0.4 -0.1 0.1 -0.6 0.7 0.3 0.5 -0.6 -0.1 -0.3
0067 0 -0.1 0.8 0.6 0.9 -0.1 -0.7 0.4 -0.9 -0.3 -0.1 0.2 -0.5 0 -0.1 0.4 0.4 -1 0.5 -0.7
- A F I L V M W Y D E K R H N Q S T G P C
0068 -0.1 0.8 0.4 0.7 0.2 -0.2 0 0 0.1 0.2 -0.1 -0.2 -0.2 0.1 -0.4 -0.2 0.1 -0.2 -0.4 -0.2
0069 0.3 1.6 -0.4 0.7 0.7 -0.3 0.5 2 -0.3 -0.3 -0.4 -0.6 0 -0.3 -0.3 -0.6 -0.1 -0.6 -0.6 -0.3
0070 0.1 0.9 0.4 0.5 1.1 -0.9 0.3 0.6 -0.7 -0.2 -0.5 -0.3 0.8 -0.4 -0.6 0.7 0.6 -0.2 -0.9 -0.4
0071 0.3 -0.4 -0.2 -0.6 -0.6 -0.6 -0.6 -0.3 0.7 0.1 0 0 1.2 1.6 0 0.4 0 -0.4 0.1 -0.6
0072 0.7 -0.7 0.7 -0.4 0.6 -0.2 -0.9 -0.9 -0.5 0 0.7 0.8 -0.5 -0.4 -0.1 0.9 0.7 -0.4 0.8 -0.9
0073 0.7 -0.8 0.7 0.1 1 -0.3 -1.1 -0.8 0.5 1 0.5 0 -0.7 -0.3 0.3 0.5 0.6 -0.1 -0.4 -1.1
0074 0.8 -0.7 -0.6 -0.1 -0.2 -0.6 -0.8 -0.7 -0.1 0.1 0.5 0.7 -0.1 1.1 0 0.8 1.4 0 -0.4 -0.8
0075 0.6 -0.7 -0.8 0.1 -0.6 -0.3 -0.8 -0.5 -0.4 0.5 1 0.7 0 0.6 0.5 0.5 -0.5 1.6 -0.5 -0.8
0076 0.6 -0.7 0.2 0.5 0.9 -0.7 -1 -1.1 -0.7 1.3 0.8 0.9 -0.4 -0.4 0.6 0.7 1 -0.7 -0.3 -0.8
0077 0 -0.2 -0.1 -0.4 0.5 -0.7 -0.5 -0.7 -0.4 -0.7 0.7 0.6 -0.4 0.3 -0.7 1.6 1.9 0.1 -0.3 -0.3
0078 0.1 -0.4 -0.3 0.1 0.5 -0.3 -0.7 -0.4 -0.3 0.1 0.4 1 -0.8 -0.4 0.7 1.1 1.4 -0.5 -0.8 -0.2
0079 -0.1 0.9 -0.6 0.3 -0.3 -0.6 1.1 1.1 -0.3 -0.6 -0.2 -0.3 0 0.1 0.3 -0.3 -0.3 0.3 -0.3 -0.3
0080 -0.2 -0.6 1 0.2 0.7 -0.9 -1.2 -0.7 1.3 1.7 0.7 0 -0.3 0.2 0.6 0.5 1.7 -0.9 -1.2 -1.2
0081 0.5 0.1 0.7 0.3 0 0.7 -1.1 -0.9 0 0 1 1 0 -0.7 -0.4 -0.4 0.4 -0.7 1 -0.3
0082 0.7 -0.1 0.1 -0.5 -0.2 -0.5 -0.5 -0.5 -0.4 0 -0.5 -0.2 -0.1 -0.2 -0.1 0.6 0.1 -0.1 2.9 -0.5
0083 1.1 -1 -0.4 -0.3 0 -0.5 -1.1 -1.1 1.1 1.3 0.5 -0.1 -0.5 0.2 0.2 0.4 0.4 0.3 1 -0.6
0084 0.9 0.3 -0.3 0.9 0.5 -0.9 -1.4 -1 0.9 1.4 -0.2 0.2 -0.9 -0.4 -0.1 0.6 0.3 0.7 -0.2 -1.1
0085 0.7 0.2 0 1 1.2 -0.4 -0.8 0.2 -0.4 0.1 -0.8 -0.5 -0.8 -0.3 -0.5 0.3 -0.2 0.4 0.5 -1.2
0086 0.7 -0.7 -0.1 0.2 0.5 -0.3 -1.4 -1 0.4 1.1 1.3 0.5 -1 -0.2 1.3 0.2 0.2 -0.1 -0.2 -1.1
0087 0.9 -0.9 -0.4 0.4 -0.3 -0.6 -1.3 -1.1 1.2 1.4 0.3 0 -0.7 0.1 0.6 0.6 0.2 0.1 0.2 -1.3
0088 1.1 -0.9 0.7 1.2 0.8 -0.6 -1 -0.5 -0.3 0.1 0.1 0.1 -0.7 -0.4 -0.1 -0.2 0.2 -0.2 0 -1.2
Select residue pair below:
i_j Score Prob
0020_0026 2.401 1.00
0015_0032 2.342 1.00
0056_0073 2.198 1.00
0061_0067 2.065 1.00
0012_0015 2.064 1.00
0071_0074 1.799 1.00
0061_0065 1.730 1.00
0059_0067 1.629 1.00
0083_0086 1.592 1.00
0019_0060 1.518 1.00
0029_0034 1.469 1.00
0069_0081 1.443 1.00
0042_0045 1.373 0.99
0025_0066 1.351 0.99
0016_0028 1.345 0.99
0038_0041 1.329 0.99
0018_0040 1.314 0.99
0018_0026 1.297 0.99
0053_0056 1.289 0.99
0055_0085 1.284 0.99
0081_0086 1.207 0.98
0027_0068 1.203 0.98
0068_0079 1.203 0.98
0039_0044 1.201 0.98
0019_0029 1.189 0.98
0054_0088 1.186 0.98
0029_0070 1.152 0.97
0072_0075 1.131 0.97
0080_0085 1.126 0.97
0030_0033 1.124 0.97
0024_0027 1.121 0.97
0027_0038 1.096 0.96
0025_0034 1.088 0.96
0055_0084 1.055 0.95
0036_0077 1.053 0.95
0072_0077 1.047 0.94
0028_0040 1.043 0.94
0058_0072 1.037 0.94
0021_0062 1.033 0.94
0030_0037 1.031 0.94
0023_0062 1.026 0.94
0046_0063 1.014 0.93
0036_0041 1.005 0.93
0059_0069 0.965 0.90
0074_0079 0.963 0.90
0031_0034 0.955 0.90
0029_0036 0.953 0.90
0078_0082 0.951 0.90
0025_0038 0.948 0.89
0059_0079 0.945 0.89
0066_0079 0.929 0.88
0065_0082 0.925 0.88
0008_0011 0.917 0.87
0054_0083 0.909 0.87
0071_0076 0.903 0.86
0062_0066 0.901 0.86
0062_0068 0.893 0.85
0019_0036 0.890 0.85
0030_0035 0.881 0.84
0016_0036 0.879 0.84
0016_0024 0.876 0.84
0081_0085 0.869 0.83
0067_0077 0.868 0.83
0028_0041 0.868 0.83
0083_0087 0.867 0.83
0015_0031 0.858 0.82
0031_0083 0.852 0.81
0017_0031 0.851 0.81
0056_0071 0.850 0.81
0053_0083 0.839 0.80
0068_0082 0.836 0.80
0060_0078 0.836 0.80
0059_0068 0.830 0.79
0069_0072 0.829 0.79
0045_0048 0.828 0.79
0017_0075 0.812 0.77
0009_0033 0.806 0.76
0062_0065 0.805 0.76
0035_0039 0.803 0.76
0009_0049 0.802 0.76
0040_0045 0.802 0.76
0027_0041 0.791 0.74
0010_0047 0.789 0.74
0062_0078 0.789 0.74
0008_0039 0.788 0.74
0059_0062 0.784 0.73
0014_0076 0.774 0.72
0042_0050 0.774 0.72
0072_0083 0.772 0.72
0066_0077 0.770 0.71
0043_0074 0.765 0.71
0017_0022 0.764 0.71
0054_0081 0.756 0.69
0014_0032 0.746 0.68
0031_0054 0.745 0.68
0013_0088 0.744 0.68
0044_0049 0.743 0.67
0057_0071 0.743 0.67
0030_0070 0.735 0.66
0034_0042 0.735 0.66
0055_0073 0.733 0.66
0022_0035 0.722 0.64
0060_0066 0.717 0.63
0058_0068 0.715 0.63
0062_0067 0.714 0.63
0066_0075 0.712 0.63
0040_0044 0.710 0.62
0057_0066 0.706 0.62
0013_0037 0.702 0.61
0075_0082 0.700 0.61
0024_0036 0.697 0.60
0021_0073 0.695 0.60
0056_0078 0.691 0.59
0025_0029 0.690 0.59
0024_0041 0.690 0.59
0017_0035 0.689 0.59
0018_0021 0.683 0.58
0012_0035 0.680 0.57
0065_0069 0.680 0.57
0009_0014 0.677 0.57
Local Interactions:
i_j Score Prob
0062_0064 4.802 1.00
0021_0023 4.717 1.00
0012_0013 3.150 1.00
0081_0083 2.923 1.00
0009_0010 2.817 1.00
0017_0019 2.729 1.00
0050_0051 2.648 1.00
0053_0054 2.553 1.00
0040_0042 2.518 1.00
0058_0060 2.182 1.00
0035_0037 2.175 1.00
0074_0076 1.917 1.00
0010_0011 1.847 1.00
0070_0072 1.789 1.00
0036_0038 1.751 1.00
0008_0009 1.727 1.00
0044_0045 1.722 1.00
0071_0073 1.713 1.00
0037_0038 1.689 1.00
0076_0078 1.666 1.00
0043_0044 1.648 1.00
0030_0032 1.596 1.00
0027_0029 1.526 1.00
0021_0022 1.509 1.00
0084_0085 1.474 1.00
0078_0080 1.396 0.99
0033_0035 1.390 0.99
0087_0088 1.357 0.99
0013_0015 1.280 0.99
0086_0087 1.237 0.98
0054_0055 1.228 0.98
0031_0032 1.199 0.98
0046_0047 1.199 0.98
0077_0079 1.189 0.98
0052_0054 1.145 0.97
0029_0031 1.142 0.97
0009_0011 1.126 0.97
0068_0070 1.126 0.97
0049_0050 1.115 0.96
0047_0048 1.097 0.96
0070_0071 1.049 0.94
0067_0069 1.046 0.94
0039_0041 1.025 0.93
0044_0046 0.997 0.92
0059_0061 0.993 0.92
0029_0030 0.966 0.91
0037_0039 0.964 0.90
0072_0073 0.963 0.90
0020_0021 0.954 0.90
0030_0031 0.944 0.89
0073_0074 0.925 0.88
0079_0080 0.924 0.88
0032_0034 0.915 0.87
0008_0010 0.913 0.87
0045_0046 0.876 0.84
0036_0037 0.864 0.83
0063_0064 0.857 0.82
0074_0075 0.854 0.82
0027_0028 0.827 0.79
0048_0049 0.821 0.78
0013_0014 0.813 0.77
0055_0056 0.807 0.76
0064_0065 0.802 0.76
0068_0069 0.788 0.74
0051_0052 0.778 0.72
0016_0018 0.764 0.71
0065_0067 0.763 0.70
0045_0047 0.746 0.68
0086_0088 0.734 0.66
0042_0043 0.724 0.64
0033_0034 0.706 0.62
0054_0056 0.686 0.58
0083_0084 0.684 0.58
0018_0020 0.683 0.58
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Sequence: G S D V A ...
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