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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0002 -0.7 1 0.8 2.5 -0.1 1 0 -0.3 -0.9 -1 -0.9 -1 -1.1 -1.1 -1 0.3 -0.5 -1 1.6 -1.2
0003 0.2 -0.6 -0.4 0 -0.1 0 -1.1 -0.4 -0.4 -0.4 2 0.9 -0.3 0.3 -0.2 0.6 0.2 -0.1 1.2 -0.9
0004 0.7 -1 0.1 0.4 -0.2 -0.5 -1.3 -1.1 0.4 0.4 0 0.4 -0.5 1.2 0.3 0.8 0.4 0.3 1.2 -1
0005 0.1 0.5 2 1.2 1.8 0.5 -0.3 0.1 -1 -0.7 0.3 -0.3 -0.2 -1 -0.6 -0.6 0.8 -0.8 -0.8 -0.9
0006 -0.2 -1 -0.8 -0.6 -0.6 -0.8 -1.3 -0.4 0.6 -0.1 1.8 0.8 -0.4 1.1 -0.2 1.8 0.8 -0.8 1 -1.2
0007 0.7 0.8 -0.1 0.3 0.1 -0.9 0.1 1.6 -0.4 -0.4 -0.4 -1 -0.5 -0.8 -0.5 1 0.2 0.4 0 -0.3
0008 0.8 -1.2 -0.6 -0.2 -0.6 -1.5 -1.7 -1.3 0.5 1 2.3 2.6 -0.4 0.3 0.7 1 0.3 0 -0.5 -1.5
0009 0.4 -1.1 -0.2 0.1 -0.1 -0.8 -1.4 -0.7 1.9 1.9 1.8 1.2 -0.3 0.2 1.3 -0.2 0.3 -0.8 -1.5 -1.5
0010 0.7 1.9 1.3 2 1.4 0 -0.8 -0.5 -0.8 -0.5 -0.7 -0.7 -0.4 -0.6 -0.2 -0.3 0.1 -0.8 -0.6 -0.5
0011 0.4 -0.6 1.3 1.4 1.3 0.3 -1.2 0 -0.3 1.1 0.8 0.8 -0.2 -1.1 0 -0.3 -0.3 -0.9 -1.2 -0.3
0012 1.3 -1.2 -0.4 -0.6 -0.5 -1.2 -1.4 -0.4 0.2 0.3 3.1 2.4 -0.5 0.4 1.1 0.9 0.3 -0.4 -1.6 -1.1
0013 1 0.7 1.6 1.6 1.1 0.4 -0.7 0 -1 -0.3 0.7 0.9 -0.1 -0.9 0 -0.7 0 -1.2 -1.2 -1.1
0014 0.1 1.6 1.2 3.4 0.8 0.9 -0.8 -0.1 -0.5 -0.8 -0.8 -0.5 -0.6 -0.8 -0.8 -0.6 -0.8 -0.8 -0.2 0
0015 0.8 -0.6 0.5 0.9 0.2 -0.5 -1.3 -1 -0.7 1.5 2 1.7 -0.2 -0.2 0.4 0.3 0.3 -0.2 -1.6 -1
0016 1.3 -1.2 -1 0.2 -0.6 -1 -1.4 -0.4 0.5 0.8 2.1 1.8 -0.1 0.9 1 0.9 -0.1 0.3 -1.1 -1.4
0017 1.1 0.9 0.2 1.7 0.1 0.8 -0.9 0 -0.1 0.6 0 -0.3 0.1 -0.5 0.5 0.1 -0.3 -0.5 -1.2 -0.7
0018 0 -1.1 -0.7 -1.1 -0.9 -1.1 -0.1 -1.1 1.6 0.8 0.4 0.2 -0.9 1.1 -0.5 0.5 0.1 4.8 -0.2 -0.9
0019 -0.1 2.1 -0.3 0.7 0 -0.2 2 1.8 -0.6 -0.8 -0.8 0 -0.8 -0.8 -0.8 -0.8 -0.8 0.4 -0.3 0.6
0020 0.4 0.2 0.9 -0.2 1.8 -0.8 -1.2 0.2 -0.2 1.8 0.8 0.6 -0.3 -0.6 1 0.5 0.8 -0.9 -1.7 -1.1
0021 -0.2 0.9 1.3 1.4 0.9 -0.3 -0.2 0.2 -0.8 0.8 0.5 0.2 -0.5 -0.6 -0.2 -0.3 -0.7 -0.7 0.3 -0.5
0022 0 -0.7 0.9 0 1.4 -0.8 -1.6 -0.4 -0.2 0 1 1.3 -0.2 -0.2 -0.3 0.6 0.5 -1 -0.3 -0.8
0023 -0.5 -0.4 -0.6 -0.8 -0.6 -0.8 -1 -0.1 -0.1 0 1.1 2.1 0.8 0.4 -0.3 0.5 0.2 0.9 -0.2 -1.2
0024 0.6 -1.1 -0.1 -1 -0.8 -0.8 -0.7 -0.7 -0.5 0.5 0.2 0.4 0.1 0 1 0.8 1.1 1.5 -0.2 -0.5
0025 0.4 -0.8 -0.7 -1.1 -0.1 -0.5 -0.6 -1.2 -0.5 0.5 1.3 0.8 -0.4 -0.1 -0.2 0.4 0.5 2.5 -0.3 -0.9
0026 0.5 -0.8 -0.5 -0.8 -0.2 -0.8 -0.4 -0.8 0 -0.2 0.7 1 -0.5 0.2 -0.8 0.8 0.6 2.4 -0.5 -0.1
0027 0.2 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 1.4 0.1 0.3 0.1 0.2 0.1 -0.3 1.5 -0.2 1 -0.2 -0.4
0028 -0.5 -0.2 0.2 -0.2 0 -0.5 -0.5 1.2 -0.5 -0.5 -0.5 -0.2 3.1 -0.3 -0.1 0.8 0.2 -0.5 0.1 -0.5
0029 0.3 0.3 0.2 1.1 0.7 0 -0.5 0 -0.5 -0.1 0 0.1 0.3 -0.6 0.3 -0.4 0.3 -0.8 0 -0.3
0030 -0.3 0.8 1.3 0.2 1.3 -0.2 -0.4 0.8 -1.4 -1 1.6 0.8 0.5 -0.8 0.7 -0.6 0.7 -0.9 -1.4 -1
0031 -0.2 1.4 0.9 0.9 0.8 0.6 0.6 1.3 -0.6 -0.7 -0.4 -0.2 -0.4 -0.7 -0.5 -0.7 -0.4 -0.5 -0.4 -0.5
- A F I L V M W Y D E K R H N Q S T G P C
0032 -0.1 0.3 0.7 0.1 0.9 -0.8 -0.6 0.8 -1.2 0.3 1.2 1.8 -0.3 -1.1 0.1 0.6 1.5 -0.5 -1.7 -0.5
0033 -0.6 -0.3 0.7 0.7 0 -0.4 -0.3 0 0 -0.4 0.9 0.6 -0.2 0.8 -0.5 0.2 -0.2 0.3 -0.3 -0.3
0034 0.3 -0.4 0 0.2 -0.3 -1.1 -1.6 -0.5 0.6 0.7 0.1 0.3 -0.6 -0.1 0.2 0.6 0.1 0.5 2 -1.8
0035 0.1 -0.6 0.1 0.1 0.1 -1.2 -1.4 -0.5 0.5 0.9 0.6 -0.1 -0.1 0.5 0 0.2 0.5 1.1 -0.8 -1.1
0036 0.2 -0.6 -0.4 -0.1 -0.2 -1 -0.9 -0.8 0.4 0.4 0.9 0.5 -0.5 0.4 0.4 0.3 0.4 2 -0.3 -1
0037 0.2 -0.7 -0.2 -0.1 0.1 -0.6 -1.1 -0.3 0.1 0.3 1 1.4 0.4 0.4 0.7 -0.1 -0.1 -0.4 0.3 -0.8
0038 -0.9 -0.5 0.8 0.2 1.1 0.1 -0.8 -0.8 -0.8 -0.6 1.9 1.4 0 -0.4 0.3 0.4 1.3 -1.2 0.2 -0.9
0039 0.3 0.9 1.6 1.1 1.5 -0.1 -0.9 0.1 -0.4 0.5 -0.5 -0.6 -0.6 -1 -0.1 -0.6 0.6 -0.6 -0.6 -0.4
0040 0.4 -0.6 1.3 -0.2 1.7 -0.6 -1.1 -0.9 -0.8 0 -0.8 0.1 -0.7 -0.5 0.2 0.9 2.2 -0.8 1.1 -0.7
0041 -0.4 1.3 2.5 1.8 2 0.6 -0.4 -0.5 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.8 -0.1 0.2 -0.8 -0.1 -0.6
0042 0.6 -0.8 -0.1 -0.1 0.2 -0.8 -0.6 -0.3 0.8 -0.2 0.3 0 0.1 0.2 -0.5 0.8 -0.1 0.1 0.8 -0.7
0043 0.1 0.1 0 -0.2 0.2 0 -1.2 0.5 0.2 -0.9 1.1 1.6 0.5 1.1 -0.4 -0.1 -0.1 0.3 -1.2 -0.5
0044 -0.2 -1 -1 -0.2 -0.7 -1 -0.7 -0.3 0.3 -0.7 0.3 -0.2 2.2 0.2 -0.3 0.8 0.3 0.9 1.1 -0.9
0045 0.4 -1.6 -1.5 -0.5 -0.6 -1.4 -1.4 -1.4 -0.6 0.1 2.3 0.6 0.2 1 0.2 1 -0.3 1.7 -0.8 -1
0046 -0.2 -1.5 -1.1 -1.5 -0.9 -1.7 -1.7 -1.3 1.4 1 2.8 1.8 -0.1 0.8 0.7 0.5 0.3 1 -0.1 -1.4
0047 -0.1 -1.1 0.8 -0.4 0.3 -0.5 -1.6 -1.2 1.7 2 1 -0.4 -1.4 0.2 0 0.8 1.3 -0.4 1 -1.5
0048 0.1 0.6 2.6 1.8 1.4 0.1 -0.9 0 -0.9 -0.5 0.3 -0.4 -0.8 -0.9 -0.3 -0.7 -0.2 -0.8 0.2 -0.5
0049 0.3 -0.8 -1.2 -0.6 -0.5 -0.9 -0.6 -1 0.9 -0.2 2.3 0 -0.3 0.6 -0.7 1.7 0.3 0.9 1.3 -1.2
0050 0.3 -0.7 0.2 0.5 0.2 -0.8 -1.1 -0.9 0 0.5 1.2 1.1 -0.3 0.1 -0.1 0.3 0.1 0.1 1.1 -1.2
0051 0.5 0.6 0.4 -0.1 0.1 -1 -0.5 0.6 -0.2 -0.4 0.8 0.4 0.1 0.1 -0.6 -0.1 0 0.9 0.2 -0.9
0052 -0.2 -0.1 1.5 2.6 0.9 0.5 -0.8 0.4 -0.6 -1 -1 -0.3 -0.6 -0.3 -0.5 -0.8 2.5 -1 -0.5 -0.8
0053 0.1 0.4 1.9 2 2.1 0.6 -0.4 -0.2 -1 0.5 -0.9 -0.2 -0.9 -1.1 0 -0.5 0.3 -0.9 -1 0.1
0054 0.5 -0.6 -0.3 0 -0.3 -0.1 -1.4 -0.3 -0.8 0.1 2.5 2.9 0.3 0.1 0.7 0.5 -0.1 0 -1.4 -1.1
0055 0.9 -1.1 -0.3 -0.6 -0.3 -0.2 -1.4 -1.2 0.5 0.6 1.3 1 0.1 0.8 1.1 1.8 0.3 0 -1.2 -1.1
0056 0.4 0.6 3.1 2.4 1.1 0.3 -0.9 -0.9 -0.6 -0.8 -0.9 -0.7 -0.7 0.1 0 -0.6 0.2 -0.6 -0.9 -0.3
0057 0.5 0.6 1.7 1.9 0.3 0.4 -0.8 0.3 -1 -0.6 0.4 0.2 -0.6 -0.3 -0.5 -0.2 -0.7 -0.6 -0.8 0.1
0058 0.2 -1.1 -0.8 -0.5 -0.3 -1 -1.6 -1.5 0.7 1.1 3.9 3 0.1 1 0.5 0.3 0.4 -0.7 -1.6 -1.6
0059 0.7 -0.8 0.7 0.8 0.5 -0.1 -1.3 -0.7 0.5 0.2 1 0.8 -0.4 -0.3 1.3 -0.4 0.1 -0.4 -0.8 -1.4
0060 0.5 0.8 1.2 2.1 0.4 0.5 -1 -0.6 -0.5 -0.6 -0.2 -0.6 -0.5 -0.4 -0.4 0 0.3 -0.2 -0.9 0.2
0061 0.2 -0.9 -1.1 0.1 -1.5 -1.4 -1.2 -1.2 0.8 2 1.3 0.4 -0.5 0.9 0.8 0.9 -0.4 2.7 -1.1 -1
- A F I L V M W Y D E K R H N Q S T G P C
0062 0.1 -0.5 1.8 1.6 1 0.2 -0.5 -0.7 -0.3 0 0.2 0 -0.8 -0.6 -0.2 -0.1 -0.3 0.2 -0.1 -0.6
0063 -0.1 -1 -0.5 0 -0.1 -1.6 -1.9 0 0.6 1.2 1.7 0.4 -1.1 0.3 -0.2 1.5 1.5 -0.7 -0.1 -1.2
0064 0 -0.7 0.8 0.2 0.8 -1 -0.8 -1.2 0.3 1 1.6 1.8 -0.8 -0.3 -0.2 -0.1 -0.2 -0.8 0.9 -1.6
0065 0.2 -0.7 -0.7 -0.6 -0.5 -1.2 -1.1 -0.7 2.4 2.7 1.2 -0.1 -0.9 0.5 0.6 0.8 -0.1 -0.2 -0.5 -1.4
0066 0.2 -0.9 -0.1 0.2 0 -0.6 -0.9 -0.2 1.7 2.7 0.6 0.4 -0.6 0.1 0.7 -0.3 0.1 0 -0.8 -0.9
0067 -0.1 2.5 0.6 1.9 -0.4 -0.7 0.9 1.2 -0.6 -0.9 -0.4 -0.9 -0.9 -0.3 -0.7 -0.4 -0.3 -0.7 -0.9 -0.9
0068 -0.1 0.1 0.9 1.8 0.3 0.1 -0.8 -0.6 0.1 0.7 0.6 0.9 -0.8 0.4 -0.2 -0.5 -0.1 -0.6 -1.3 -0.5
0069 0.4 -0.8 -0.6 -0.1 -0.4 -1.1 -1.1 -0.8 0.4 1.8 1.5 0.5 -0.6 0.8 0.7 0 0.4 0.6 -0.7 -1.1
0070 0.1 0.2 0.6 2.6 -0.1 -0.4 -0.9 0.1 -1 -0.1 0.7 -0.2 -0.3 0.2 -0.7 -0.3 -0.6 -0.7 -1.1 -0.6
Select residue pair below:
i_j Score Prob
0024_0029 3.364 1.00
0049_0052 2.780 1.00
0030_0040 2.740 1.00
0023_0030 2.639 1.00
0021_0024 2.333 1.00
0022_0032 2.239 1.00
0006_0009 2.147 1.00
0029_0043 2.057 1.00
0021_0031 1.863 1.00
0011_0031 1.670 1.00
0013_0017 1.593 1.00
0030_0038 1.587 1.00
0021_0029 1.559 1.00
0011_0015 1.547 1.00
0054_0064 1.516 1.00
0033_0037 1.408 1.00
0055_0059 1.384 0.99
0007_0043 1.357 0.99
0052_0055 1.303 0.99
0004_0047 1.293 0.99
0010_0067 1.288 0.99
0057_0062 1.282 0.99
0014_0041 1.262 0.99
0007_0011 1.242 0.98
0013_0057 1.217 0.98
0064_0068 1.213 0.98
0010_0053 1.190 0.98
0019_0033 1.189 0.98
0039_0060 1.178 0.98
0017_0070 1.162 0.97
0023_0038 1.142 0.97
0014_0060 1.136 0.97
0057_0060 1.133 0.97
0010_0057 1.063 0.95
0005_0010 1.062 0.95
0053_0057 1.061 0.95
0019_0039 1.032 0.94
0010_0048 1.007 0.93
0019_0060 1.004 0.93
0027_0042 0.999 0.92
0019_0037 0.998 0.92
0007_0044 0.996 0.92
0010_0056 0.969 0.91
0054_0063 0.967 0.91
0017_0062 0.959 0.90
0005_0009 0.951 0.90
0020_0032 0.936 0.89
0050_0053 0.932 0.88
0066_0069 0.893 0.85
0015_0031 0.827 0.79
0054_0058 0.821 0.78
0022_0030 0.813 0.77
0011_0029 0.796 0.75
0050_0054 0.788 0.74
0020_0034 0.784 0.73
0011_0041 0.783 0.73
0032_0038 0.751 0.69
0065_0069 0.747 0.68
0023_0040 0.742 0.67
0003_0050 0.737 0.67
0007_0048 0.731 0.66
0056_0059 0.731 0.66
0014_0056 0.725 0.65
0039_0059 0.723 0.64
0042_0048 0.718 0.64
0049_0055 0.697 0.60
0013_0062 0.673 0.56
0024_0027 0.664 0.55
0009_0012 0.647 0.52
0025_0030 0.647 0.52
0022_0038 0.636 0.50
0027_0044 0.621 0.47
0004_0050 0.619 0.47
0010_0013 0.616 0.46
0007_0031 0.609 0.45
0033_0036 0.597 0.43
0014_0031 0.593 0.42
0015_0029 0.577 0.40
0033_0039 0.576 0.40
0054_0057 0.563 0.38
0019_0036 0.551 0.36
0051_0055 0.546 0.35
0046_0049 0.544 0.35
0048_0051 0.539 0.34
0015_0021 0.535 0.33
0012_0016 0.521 0.31
0011_0021 0.515 0.30
0057_0067 0.508 0.29
0043_0046 0.508 0.29
0037_0059 0.506 0.29
0013_0016 0.505 0.29
0007_0029 0.502 0.28
0039_0056 0.498 0.28
0028_0042 0.495 0.27
0018_0033 0.494 0.27
0019_0031 0.488 0.26
0003_0053 0.487 0.26
0031_0041 0.484 0.26
0008_0043 0.480 0.25
0037_0040 0.478 0.25
0020_0069 0.476 0.25
0003_0064 0.474 0.25
0050_0057 0.473 0.24
Local Interactions:
i_j Score Prob
0033_0035 1.947 1.00
0003_0004 1.794 1.00
0029_0031 1.690 1.00
0006_0007 1.664 1.00
0049_0051 1.653 1.00
0043_0044 1.577 1.00
0061_0062 1.307 0.99
0022_0023 1.284 0.99
0026_0027 1.260 0.99
0044_0045 1.252 0.99
0033_0034 1.230 0.98
0024_0025 0.985 0.92
0062_0063 0.981 0.91
0035_0036 0.925 0.88
0051_0052 0.899 0.86
0049_0050 0.871 0.83
0017_0019 0.869 0.83
0036_0037 0.836 0.80
0023_0024 0.825 0.78
0038_0040 0.817 0.77
0002_0003 0.814 0.77
0023_0025 0.813 0.77
0050_0051 0.804 0.76
0031_0033 0.796 0.75
0039_0040 0.780 0.73
0068_0069 0.758 0.70
0052_0053 0.739 0.67
0006_0008 0.737 0.67
0003_0005 0.735 0.66
0059_0060 0.733 0.66
0034_0035 0.708 0.62
0005_0006 0.688 0.59
0016_0017 0.657 0.53
0068_0070 0.646 0.52
0042_0044 0.628 0.48
0047_0048 0.620 0.47
0041_0042 0.619 0.47
0035_0037 0.618 0.47
0066_0068 0.605 0.45
0069_0070 0.590 0.42
0004_0005 0.588 0.42
0026_0028 0.588 0.42
0021_0022 0.583 0.41
0024_0026 0.570 0.39
0060_0061 0.562 0.37
0027_0029 0.558 0.37
0034_0036 0.554 0.36
0025_0026 0.550 0.35
0060_0062 0.549 0.35
0002_0004 0.543 0.34
0027_0028 0.539 0.34
0015_0016 0.526 0.32
0032_0033 0.519 0.31
0066_0067 0.511 0.30
0065_0066 0.489 0.27
0025_0027 0.477 0.25
0037_0038 0.474 0.25
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: M W M P P ...
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