May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
rem Return to Main Page
Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0002 0 -0.7 -0.7 0 -0.4 1.1 -0.7 -0.7 -0.5 0.3 0.8 0.1 -0.7 0.1 -0.4 0.4 -0.2 -0.4 -0.1 -0.2
0003 0.4 0.1 0.5 -0.6 0.1 1.6 -0.9 -0.4 -0.3 -0.2 0 -0.4 -0.5 0 0.6 0.5 0.1 -0.5 -0.4 -0.6
0004 0.4 -0.6 -0.6 -0.4 0 0 -0.6 -0.6 -0.1 0.4 1.4 1.2 -0.2 0.1 0.3 0 -0.1 0.4 0 -0.6
0005 -0.3 1.2 0.4 0.3 0.6 0.5 -0.3 0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.1 0.2 -0.3 0.1 -0.2
0006 -0.1 0 1.4 1.4 1.7 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4
0007 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.6 -0.2 0.5 -0.1 0.9 1.8 0.1 1.3 -0.5 -0.2 -0.3 -0.5
0008 -0.2 -0.5 4.5 0.6 2.8 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5
0009 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.3 -0.2 0.4 0.3 1.9 -0.2 -0.2
0010 -0.3 0.6 -0.3 0.1 -0.3 -0.3 -0.3 0.7 0 0 0.6 0 0.3 0.4 -0.3 -0.1 -0.3 -0.1 -0.3 -0.3
0011 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 0.7 0.3 -0.1 -0.2 -0.5 1.2 -0.5 0.9 -0.5 2.3 -0.5 -0.5
0012 -0.2 0.1 -0.2 0.2 0.8 -0.2 -0.2 -0.2 0.3 -0.2 -0.2 -0.2 0 0 -0.2 0.8 -0.2 0.1 -0.2 -0.2
0013 0.4 1 1.3 1.1 1.6 1.3 -0.7 0.8 -0.7 -0.7 -0.7 -0.3 -0.7 -0.7 -0.7 0.3 0.5 -0.7 -0.7 -0.7
0014 0.1 -0.2 1.6 0.7 1.3 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0015 1 -0.2 0.1 0.3 0.8 0.4 -0.6 -0.6 -0.3 0 -0.3 -0.6 -0.6 1.4 -0.6 1.2 -0.5 -0.3 0.2 -0.3
0016 1.5 -0.4 0.1 0.1 0.8 0.3 -0.8 -0.8 -0.2 -0.1 0 0.6 -0.6 -0.8 -0.7 1.1 1.2 0.3 -0.2 -0.6
0017 0.3 -0.6 -0.6 -0.5 -0.6 -0.6 -0.6 -0.6 1.2 1.1 -0.1 -0.2 0.1 1.4 0.1 1.1 -0.1 1.1 -0.6 -0.6
0018 -0.2 -0.2 -0.2 0.1 -0.2 -0.2 -0.2 -0.2 0.1 0.1 2 0.6 0.4 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0019 -0.2 -0.3 2.2 1.1 1.7 0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0020 -0.4 -0.4 2.2 1.1 1.8 0.1 -0.4 -0.1 -0.4 -0.1 0 -0.4 0.1 -0.4 -0.4 -0.4 -0.2 -0.4 -0.4 -0.4
0021 3.4 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 2.2 1.4 0.5 -0.5 0.1
0022 0.4 -0.1 2.9 0.6 2.4 0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5
0023 0.5 -0.5 2.5 1.8 3 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.5 0 0 -0.5 -0.5 -0.5
0024 0.6 -0.7 -0.7 -0.3 -0.5 -0.7 -0.7 -0.7 -0.1 -0.7 -0.7 0.2 0.1 1.4 0.4 2.2 0.9 0.3 0.9 -0.5
0025 1.3 -0.4 0.7 -0.1 0.7 -0.4 -0.4 0 -0.1 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 0.5 -0.4 1.3 -0.4
0026 0.5 -0.5 -0.5 -0.5 -0.2 -0.5 -0.5 -0.5 1.2 0.8 0.1 -0.5 -0.5 0.8 -0.1 1.3 0.3 0.6 -0.5 -0.5
0027 1.1 0.2 -0.4 -0.1 -0.4 -0.4 -0.4 -0.4 -0.1 -0.1 -0.4 -0.4 -0.4 -0.1 -0.1 2.5 0.3 0.2 -0.1 -0.4
0028 1.9 -0.4 0.2 -0.2 0.2 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 0.2 0.3 1.6 0.5 -0.4 -0.4 -0.4
0029 0.3 -0.2 0.1 -0.2 0.7 0 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 0.3 0.4 0 0 0.6 -0.2
0030 1.5 0.2 0.7 0.1 0.8 0.4 -0.4 -0.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 0.5 0.1 -0.4 -0.4 -0.4
0031 -0.3 -0.3 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 2.8 2.2 -0.3 -0.3 0.5 -0.1 -0.3 -0.1 -0.3 -0.3
- A F I L V M W Y D E K R H N Q S T G P C
0032 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 1.9 1.6 -0.2 0.1 0.1 -0.2 -0.2 -0.2 -0.2 -0.2
0033 0 -0.1 1.6 1.9 0.6 1.6 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.3 -0.3 -0.1 -0.3 0 -0.5 -0.5 -0.5
0034 -0.3 -0.3 1.3 0.3 0.5 0.1 -0.3 -0.1 -0.3 -0.3 0.7 1.2 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 -0.3
0035 0.3 -0.5 -0.5 -0.3 -0.5 -0.5 -0.5 -0.5 0.7 0.7 0.5 0.6 -0.1 0 1.1 0.2 0.4 0 -0.5 -0.5
0036 0.9 -0.5 -0.1 0 0.3 -0.1 -0.5 -0.5 0.2 0.1 0.6 0.1 -0.1 0.3 0.4 0.2 0.3 -0.3 -0.5 -0.5
0037 1.2 -0.2 0 0.2 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.2 0.1 0 -0.2 1 0.3 0.8 -0.4 -0.1
0038 0.2 -0.4 -0.4 -0.4 -0.1 -0.1 -0.4 -0.1 -0.1 0.3 1.9 1.6 -0.4 0.1 0.4 -0.1 -0.2 -0.4 -0.4 -0.4
0039 0.5 -0.3 -0.2 0 -0.3 -0.6 -0.6 -0.1 1 1.7 0.2 0 -0.6 0.5 0.3 0.1 -0.1 -0.1 -0.6 -0.6
0040 0.4 -0.6 -0.2 -0.4 -0.5 -0.4 -0.6 -0.6 0.2 0.9 1 0.8 0.3 0.3 0.3 0.7 0.3 -0.2 -0.6 -0.6
0041 -0.5 -0.1 -0.5 -0.5 -0.3 -0.5 -0.5 -0.5 0.3 0.5 0.3 0.3 -0.1 1.4 0 0.3 0 1.9 -0.5 -0.5
0042 0.1 -0.3 0.2 0.4 0 0.5 -0.6 -0.6 -0.2 0.1 0.9 0.9 -0.2 0.1 0.2 0.2 0.2 -0.3 -0.6 -0.4
0043 0.7 -0.2 1.1 2.1 0.9 0.3 -0.4 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 -0.4 -0.4 -0.2
0044 -0.2 -0.2 1.5 1 1.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2
0045 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 3.4 0.7 -0.3 -0.3 -0.3 2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0046 0.3 -0.3 0.6 1 1.1 0.6 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.3 0.3 -0.3 0.3
0047 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.3 1.9 2.7 -0.3 -0.3 -0.3
0048 0.3 0.5 -0.6 -0.2 -0.6 0 -0.6 1 -0.6 0.3 0 -0.6 0.4 0.1 0.9 0.3 -0.6 -0.3 -0.6 1.1
0049 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.5 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 3.2 -0.2 -0.2
0050 0.4 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 1.7 1.3 -0.2 -0.2 -0.2 -0.2 -0.2 0.1 -0.2 -0.2
0051 0 -0.3 -0.3 -0.1 -0.3 -0.3 -0.3 -0.3 -0.3 0.7 1.4 1.2 -0.3 -0.3 0.3 0.4 -0.1 0 -0.3 -0.1
0052 0.5 -0.4 -0.4 -0.1 0.9 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 3 -0.4 -0.4 0.9
0053 0.5 -0.3 -0.3 0.3 -0.3 0.1 -0.3 -0.3 -0.3 -0.3 1.5 0.8 -0.3 0 0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0054 1.2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 1.8 1.2 0.2 -0.3 0.7
0055 0.5 -0.3 2.1 0.5 1.9 0.3 -0.3 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0056 -0.3 0.6 2.1 1.9 0.8 -0.1 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0057 -0.3 1.3 1.4 0.9 1.2 -0.3 -0.3 0.2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.3 -0.3 -0.3
0058 0.1 -0.1 0.1 0.9 0 0.8 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0 0 1.1 -0.3 -0.3 0
0059 -0.1 -0.3 -0.3 -0.3 0.1 -0.3 -0.3 -0.3 1.6 0.7 0.1 -0.1 -0.3 0.5 0.1 0.5 -0.1 -0.1 -0.3 -0.3
0060 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.9 0.1 -0.4 -0.2 -0.1 0.9 -0.1 0.8 1 0.7 -0.4 -0.3
0061 -0.4 -0.4 -0.4 -0.4 -0.2 -0.4 -0.4 -0.3 0.9 0.6 -0.1 0.2 -0.2 0.9 0.1 0.3 -0.4 2.1 -0.4 -0.4
- A F I L V M W Y D E K R H N Q S T G P C
0062 -0.1 0.4 -0.1 -0.2 -0.3 0 -0.3 0.2 -0.4 -0.2 0.3 -0.1 0.8 0.1 0.9 0 0.1 0 -0.4 -0.2
0063 -0.1 -0.3 1.2 1.3 1 0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.1 -0.2 -0.3 -0.3 0
0064 -0.3 0.8 1.5 0.8 1.4 0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3
0065 0.1 0.4 0.7 2.3 0.6 0.4 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 0.2 0 -0.3 -0.3
0066 1 -0.3 -0.3 1.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 1.9 0.6 -0.3 -0.3 -0.1
0067 2 0.1 -0.2 -0.5 -0.5 -0.5 -0.5 0.3 -0.5 -0.5 -0.5 -0.5 -0.3 -0.2 -0.5 1.7 -0.2 0.9 0.8 -0.3
0068 -0.6 -0.6 2.2 2.6 1.9 -0.3 -0.6 -0.4 -0.3 0.5 0 -0.6 -0.6 -0.1 -0.3 -0.2 -0.6 -0.6 -0.3 -0.6
0069 0.8 -0.5 -0.1 -0.2 -0.2 -0.3 -0.5 -0.5 0.2 -0.1 -0.1 0 -0.1 0.2 -0.1 0.7 0.8 0.2 0.8 -0.5
0070 1.5 -0.6 0 0.7 1 -0.6 -0.6 -0.2 -0.6 -0.6 -0.1 -0.6 -0.6 -0.6 -0.4 0.1 0.8 -0.6 2.5 -0.1
0071 -0.1 -0.6 -0.6 -0.3 -0.3 -0.6 -0.6 -0.6 2.2 3.5 0.5 -0.6 -0.6 0.1 0.7 0.1 -0.3 -0.4 -0.6 -0.6
0072 0.4 -0.3 0.2 -0.3 0 -0.3 -0.3 -0.3 -0.3 0.7 0.9 0.3 0 -0.3 0.1 0.4 -0.3 -0.3 -0.3 -0.3
0073 -0.4 0 2.4 2.2 1.6 0.5 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4
0074 1.2 -0.2 0.1 -0.1 0.3 0.1 -0.5 -0.2 -0.2 -0.2 -0.3 0.3 -0.4 -0.1 -0.1 1.1 0.7 0.2 -0.5 -0.3
0075 1 -1 -1 -0.5 -0.8 -0.6 -1 -1 -0.4 0.7 0.8 0.1 1 1.3 1.9 0.6 -0.5 1.7 -0.6 -1
0076 0.3 -0.4 0 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0 2.1 3.5 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4
0077 0.9 0.6 1.2 1.1 0.4 0.5 -0.2 0.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.2 0 -0.4 -0.4 0
0078 0.4 -0.3 -0.2 0.2 0 0 -0.7 -0.5 0.1 1.2 0.5 -0.4 -0.2 0.7 0 0.1 0.4 0.3 -0.7 -0.7
0079 0.5 -0.7 -0.1 -0.3 0.1 -0.4 -0.7 -0.7 0.4 0.7 0.2 -0.3 -0.4 0.5 0.3 0.5 0.5 0.9 -0.2 -0.5
0080 0.3 -0.4 0.2 0 -0.1 -0.1 -0.6 -0.5 0.2 0.7 0 0.3 -0.5 0.3 -0.1 0.3 0.1 0.2 0.2 -0.7
0081 -0.1 -0.1 0.2 -0.4 -0.2 -0.7 -0.7 -0.6 1.1 1.2 0.6 0.3 -0.7 0.2 -0.3 0.4 0.1 0.5 0 -1
0082 0.3 -0.4 -0.1 -0.2 -0.1 -0.2 -0.8 -0.4 0.7 1.3 0.2 -0.1 -0.6 0.6 0 0.2 -0.1 0.8 -0.3 -0.8
0083 -0.1 -0.6 0.2 -0.4 0 -0.8 -0.8 -0.5 0.6 1.1 0.2 -0.2 -0.4 0.3 0.4 0.7 -0.1 0.3 -0.1 -0.7
Select residue pair below:
i_j Score Prob
0018_0059 3.771 1.00
0069_0072 1.877 1.00
0025_0054 1.838 1.00
0026_0035 1.653 0.99
0018_0062 1.633 0.99
0023_0030 1.631 0.99
0030_0055 1.589 0.99
0035_0055 1.559 0.99
0019_0056 1.521 0.98
0019_0077 1.479 0.98
0061_0077 1.468 0.98
0072_0076 1.444 0.98
0031_0046 1.444 0.98
0018_0060 1.431 0.97
0010_0051 1.400 0.97
0018_0036 1.341 0.96
0037_0053 1.337 0.96
0034_0055 1.328 0.96
0053_0072 1.306 0.95
0013_0061 1.258 0.94
0053_0069 1.226 0.92
0039_0058 1.226 0.92
0038_0045 1.209 0.92
0016_0063 1.193 0.91
0003_0017 1.178 0.90
0027_0053 1.143 0.88
0005_0021 1.138 0.88
0037_0069 1.127 0.87
0017_0034 1.121 0.87
0020_0042 1.117 0.87
0036_0043 1.110 0.86
0057_0064 1.093 0.85
0053_0056 1.093 0.85
0012_0049 1.092 0.85
0058_0064 1.077 0.84
0020_0058 1.077 0.84
0058_0061 1.072 0.84
0014_0074 1.040 0.81
0050_0065 1.034 0.80
0058_0062 1.023 0.79
0042_0061 1.022 0.79
0017_0040 1.014 0.79
0018_0063 1.007 0.78
0024_0055 0.999 0.77
0015_0067 0.990 0.76
0021_0078 0.989 0.76
0019_0080 0.978 0.75
0009_0012 0.955 0.73
0036_0059 0.954 0.72
0064_0068 0.946 0.72
0022_0054 0.946 0.72
0017_0078 0.943 0.71
0033_0042 0.940 0.71
0010_0025 0.930 0.70
0014_0066 0.918 0.68
0005_0077 0.913 0.68
0032_0067 0.912 0.68
0006_0031 0.910 0.67
0074_0080 0.904 0.67
0033_0079 0.904 0.67
0053_0057 0.901 0.66
0007_0046 0.895 0.65
0043_0063 0.894 0.65
0020_0040 0.884 0.64
0019_0079 0.866 0.62
0041_0078 0.862 0.61
0027_0048 0.857 0.60
0005_0010 0.852 0.60
0019_0059 0.848 0.59
0044_0060 0.847 0.59
0029_0049 0.840 0.58
0033_0063 0.840 0.58
0014_0057 0.840 0.58
0037_0072 0.834 0.57
0029_0052 0.834 0.57
0014_0064 0.832 0.57
0005_0011 0.824 0.56
0033_0040 0.816 0.55
0026_0039 0.816 0.55
0026_0048 0.808 0.54
0004_0024 0.807 0.54
0002_0063 0.806 0.53
0026_0030 0.802 0.53
0006_0080 0.800 0.53
0009_0066 0.792 0.51
0028_0046 0.788 0.51
0030_0034 0.785 0.51
0007_0065 0.784 0.50
0006_0077 0.783 0.50
0041_0044 0.779 0.50
0048_0077 0.777 0.49
0044_0047 0.769 0.48
0028_0032 0.768 0.48
0038_0061 0.765 0.48
0069_0077 0.764 0.48
0023_0082 0.753 0.46
0039_0043 0.752 0.46
0035_0043 0.748 0.45
0037_0062 0.744 0.45
0006_0012 0.742 0.45
0034_0054 0.740 0.44
0004_0073 0.739 0.44
0012_0029 0.737 0.44
0061_0083 0.731 0.43
0037_0051 0.728 0.43
0011_0046 0.723 0.42
0013_0054 0.720 0.41
0056_0083 0.718 0.41
0034_0073 0.716 0.41
0036_0041 0.715 0.41
0022_0074 0.715 0.41
0032_0050 0.714 0.41
0016_0036 0.709 0.40
0026_0073 0.707 0.40
0005_0073 0.707 0.40
0071_0074 0.705 0.39
0015_0033 0.705 0.39
0015_0048 0.704 0.39
0075_0079 0.701 0.39
0050_0072 0.699 0.39
0014_0044 0.698 0.39
0047_0051 0.697 0.38
Local Interactions:
i_j Score Prob
0034_0035 2.992 1.00
0056_0058 2.548 1.00
0060_0062 2.545 1.00
0040_0042 2.120 1.00
0059_0060 1.819 1.00
0078_0080 1.150 0.89
0003_0004 1.108 0.86
0015_0017 1.088 0.85
0079_0081 1.078 0.84
0009_0010 1.000 0.77
0070_0072 1.000 0.77
0040_0041 0.981 0.75
0062_0063 0.941 0.71
0010_0012 0.933 0.70
0078_0079 0.931 0.70
0039_0041 0.926 0.69
0081_0082 0.919 0.68
0080_0082 0.864 0.61
0082_0083 0.849 0.59
0029_0030 0.849 0.59
0057_0058 0.801 0.53
0079_0080 0.799 0.52
0042_0044 0.740 0.44
0069_0070 0.732 0.43
0025_0027 0.724 0.42
0018_0020 0.705 0.39
0080_0081 0.705 0.39
0004_0005 0.703 0.39
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: M T I K L ...
Page generated in 0.4218 seconds.