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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0001 -0.4 -0.6 1.6 -0.2 0.3 3.3 -0.6 -0.6 -0.1 -0.4 -0.1 -0.6 -0.6 -0.6 -0.6 -0.3 -0.4 -0.6 0.3 -0.6
0002 -0.2 -0.8 -0.3 -0.3 -0.4 -0.5 -0.5 -0.6 0.6 0.7 1.2 0.6 0.1 0.5 0.3 -0.2 0.3 -0.2 0 -0.8
0003 -0.5 0.6 0.1 1 0.1 1.5 0.6 -0.3 -0.5 -0.3 0 -0.7 0 -0.3 -0.2 0 0 -0.5 -0.2 -0.5
0004 -0.1 -0.8 0.9 0.8 0.9 -0.9 -1.2 -0.5 -0.2 0.4 0.5 0.3 0.9 -0.4 1.1 -0.6 0.9 -1.2 -0.5 -1
0005 0.6 -0.3 -0.5 -0.3 -0.8 -1.3 -1.5 0.1 0.3 0.2 -0.1 0.2 -0.1 0.1 0.1 0.9 0.4 -1.3 2.4 -1.5
0006 -0.2 1 1 0.6 1.2 0.8 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.2 0.5 -0.4 0.3 -0.6
0007 0.9 -1 0.1 -0.7 0.4 -0.8 -1 -1 0.9 1.2 0.1 0.2 -0.1 1 0.1 1.3 0.9 -0.6 -0.4 -1
0008 0.2 -0.3 -0.4 -0.5 -0.2 -0.6 -0.6 -0.6 -0.6 0.6 -0.3 0.4 -0.6 1.2 -0.5 2.3 1.1 -0.3 -0.6 -0.3
0009 0.7 -0.5 -0.5 -0.4 -0.3 -0.7 -0.7 -0.7 -0.2 -0.2 0.4 0.6 -0.4 0 -0.2 1.7 1.1 0.5 -0.1 -0.5
0010 0.5 -0.1 0.8 0.7 0.4 0.3 -0.8 -0.7 -0.3 0 0.2 0 -0.4 0.2 -0.6 0.1 0.2 0.5 -0.3 -0.6
0011 0.2 0.7 1.5 0.8 1.2 1.1 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.2 -0.4 -0.4 -0.4 -0.4
0012 1.2 -0.6 -0.2 0.2 0 -0.5 -1 -0.8 0.2 0.5 1.2 1.2 0.1 0 0.4 0.6 0.7 -0.8 -1.1 -0.9
0013 1.2 0 -0.7 -0.3 -0.7 -0.6 -0.8 -0.5 -0.1 0.2 0.3 1.1 0.1 0.1 0.3 1.7 0.4 0.3 -0.8 -0.6
0014 0.8 0.5 1 0.5 0.5 0.3 0.2 0.6 -0.3 -0.3 -0.5 -0.5 -0.3 -0.5 -0.5 -0.3 -0.1 0.1 -0.5 -0.5
0015 0.5 -0.3 -0.2 0.1 -0.3 -0.6 -0.4 0.1 0.8 0.6 0 0.3 0.3 -0.3 -0.2 0.3 -0.1 0.9 -0.7 0
0016 -0.5 1.4 -0.2 0.1 -0.5 -0.1 1.1 2 0.1 -0.5 -0.5 -0.5 1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.2
0017 0.2 -0.5 -0.5 -0.7 -0.5 -0.7 -0.7 -0.3 2.1 1.1 0.2 -0.2 0.2 1 0.2 1 0 -0.3 -0.7 -0.7
0018 1.1 -0.7 -0.6 -0.6 -0.6 -0.6 -0.9 -0.6 0.3 1.2 0.2 0.1 -0.1 -0.2 0.3 0.7 0.1 -0.2 1.3 -0.6
0019 0.9 -0.5 -0.4 0 -0.3 -1 -1.4 -0.9 1.1 1.6 -0.1 -0.1 -0.9 0.4 0.1 1.1 0.6 0.3 -0.2 -1.1
0020 0.5 -0.9 -0.7 0 -0.8 -1.1 -1.1 -0.9 0.7 1.2 0.2 0.4 -0.1 0.7 0.6 1 1.6 0.2 -0.8 -0.6
0021 0.5 -0.8 -1.1 1 -1.1 0.4 -1.1 -1.1 -0.2 0.8 0.8 0.8 0.3 0.8 1.4 0.6 -0.4 1.1 -1.1 -0.9
0022 0.1 -0.7 1.4 0.6 1.4 -0.6 -0.8 -0.3 -0.1 1 0 1.1 -0.3 -0.5 0.2 0.1 1.5 -0.9 -1.1 -1.1
0023 -0.1 -0.4 0.5 3.2 1.1 1.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 0.1 -0.4 -0.4 -0.4
0024 -0.5 0.4 0 0 0.5 -0.8 -0.3 0.6 0.1 0.9 0.2 0.6 0.3 -0.5 0.1 0.2 0.7 -0.5 -0.8 -0.5
0025 0.1 -0.1 1.9 1 2.3 0.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4
0026 0.2 -0.7 -0.1 0.2 0.4 -0.5 0.3 -0.2 -0.2 0.6 0.3 1.3 -0.1 -0.1 1 0.1 0.6 -0.8 -0.9 -0.3
0027 -0.4 1.4 -0.1 0.9 0.1 -0.1 -0.2 1.3 -0.4 -0.4 -0.4 0 0.3 -0.4 -0.4 -0.3 0 -0.4 -0.4 0.3
0028 0.3 -0.9 -0.3 0.6 0.4 -0.7 -0.9 -0.5 0 -0.5 1 1 0.6 0.1 -0.2 0.2 0.7 -0.4 -0.8 -0.2
0029 0 -0.9 -0.7 -0.6 -0.7 -0.9 -0.9 -0.4 1.4 -0.1 0.2 0.5 0.1 1.5 0.5 1 0.8 0.5 -0.2 -0.6
0030 0.1 -0.4 -1 -0.9 -1 -0.9 -0.5 -0.8 0.5 -0.3 0.8 0.8 -0.1 0.1 0.1 1 0.4 3.1 -0.4 -0.8
- A F I L V M W Y D E K R H N Q S T G P C
0031 0.8 -1 -0.6 -0.2 -0.4 -0.7 -1 -0.6 0.2 0.3 0.9 1.1 -0.2 0.3 -0.3 1.2 0.6 1.4 -0.4 -0.9
0032 0.3 -0.3 0.9 0.1 1.4 -0.7 -0.8 -0.1 -0.7 0.2 -0.1 1 -0.2 -0.6 -0.2 0.2 1 -0.7 0 -0.1
0033 -0.5 0.3 0.1 0.9 0.3 -0.3 0.2 0.8 0.1 0 -0.2 0.5 -0.1 -0.3 0.3 -0.1 -0.5 -0.2 -0.5 -0.2
0034 0.5 -0.5 0 0.6 0.8 -0.7 -0.9 -0.5 0.7 1.2 -0.2 0.9 0.6 -0.8 0.6 0.3 0.3 -0.6 -0.7 -0.7
0035 -0.1 1.7 -0.4 -0.1 -0.1 -0.4 0.5 2.4 -0.1 -0.4 -0.4 -0.4 0.7 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.2
0036 0.3 1.6 0.1 1.1 -0.3 -0.8 -0.9 0.8 -0.2 0.5 -0.3 0 0.5 -0.6 -0.3 1.1 0.3 -0.8 -0.7 -0.2
0037 0.6 -0.8 -0.9 -0.1 -1 -1 -1 -1 2.1 0.9 0.7 0.5 -0.3 2.4 0 0.1 -0.6 2.4 -0.6 -1
0038 0 1.7 1.5 0 3.7 -0.3 -0.5 -0.3 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 0.2 -0.5 -0.5 -0.2
0039 0.6 -0.5 -0.5 -0.5 -0.3 -0.5 -0.5 -0.5 0.9 0.3 -0.3 -0.5 -0.4 0.3 -0.2 1.6 1.3 0.1 0.8 -0.5
0040 1.5 0.1 -0.2 0.4 0.1 -0.8 -0.9 -1 -0.2 1.8 0.5 0.2 -0.7 0 0.5 0.6 -0.6 -0.4 1.1 -1
0041 1 -0.4 -0.9 -0.8 -0.4 -0.9 -1.3 -0.4 0.7 1.8 0.5 0.9 0.6 0.6 0.4 1.4 0.3 0.2 -0.4 -1.5
0042 0.2 -0.6 0.4 1.4 0.3 -0.3 -0.6 -0.5 0.7 1.3 -0.2 -0.4 -0.2 0.1 0 -0.3 1 -0.6 -0.6 -0.3
0043 1.4 1.6 -0.3 -0.5 1.1 -0.5 0.9 2 -0.6 -0.3 -0.6 -0.4 0.3 -0.5 -0.5 -0.4 -0.6 -0.6 -0.4 -0.6
0044 0.5 -0.7 0 0.1 0.2 -1.1 -0.8 -0.3 1 2 0.2 0.8 -0.1 0.5 1.2 0.1 0.4 -0.5 -1.2 -1
0045 1.9 -0.7 -1 0 -0.3 -0.4 -1 -1 1.3 1.1 0.3 0.6 -0.8 0.4 0.9 0.5 0.1 1.1 -1 -1
0046 -0.4 1.5 0.4 1.6 0.5 1.5 0.2 -0.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.4 -0.2
0047 0 -0.5 1 1.3 0.7 0.6 -0.6 -0.5 -0.3 -0.1 0.6 0.5 -0.4 -0.6 0.1 -0.1 -0.1 -0.6 -0.4 0.1
0048 1.6 -0.7 -0.9 -0.7 -0.5 -0.4 -1.3 -0.7 0.4 0.5 0.5 0.5 -0.1 1.7 0.5 1.5 0.8 0.5 -1.3 -1
0049 3.1 -0.3 -0.7 -0.1 1 -0.7 -0.7 -0.4 -0.4 -0.3 -0.7 -0.3 -0.3 -0.7 -0.7 2.8 0.8 0.1 -0.7 -0.7
0050 0.7 -0.1 -0.8 -0.9 0.4 -1.2 -1 -1 1.6 1.6 0.1 0.3 -0.6 -0.4 -0.2 1.4 0.1 0.8 1.5 -1.2
0051 0.7 -0.3 -0.1 -0.1 0 -0.1 -0.3 -0.3 0.2 0.2 0.2 -0.2 0 0.8 -0.2 0.2 -0.1 -0.3 -0.3 -0.2
0052 0.9 -1 1.6 1.1 1.3 0.1 -1 -1 -1 -1 1.8 0.1 0.6 -1 0.5 -0.4 -0.4 -0.9 1.5 -1
0053 0.6 -0.2 -0.5 -0.5 -0.3 0 0.3 0 0.1 0.7 -0.3 0.2 0.1 0.6 -0.5 0.3 0.2 0 -0.1 -0.5
0054 0.4 -1 -0.3 -0.3 0 -1 -0.5 -0.7 -0.7 0.2 1.2 1.9 -0.4 -0.3 1.2 1.5 0.6 0.3 -0.5 -1
0055 0.7 2 -0.5 0.2 -0.5 -0.5 0.3 2.1 -0.5 -0.1 -0.3 -0.3 0.7 -0.2 -0.3 -0.5 -0.3 -0.5 -0.5 -0.1
0056 0.5 1.5 0.1 0.6 1 -0.1 0.4 1.1 -0.5 -0.5 -0.5 -0.5 0 -0.5 -0.5 -0.3 -0.4 -0.1 -0.5 -0.5
0057 0.5 -0.9 -0.3 -0.3 -0.6 -0.4 -0.4 -0.4 0 0.2 1 1.5 0.3 1.2 0.2 0.2 -0.2 0.2 -0.7 -0.9
0058 0.7 -0.9 -0.7 -0.4 -0.3 -0.7 -0.9 -0.2 0.9 0.7 0.7 1.4 -0.1 0.1 0.9 0.9 0.4 -0.1 -1.1 -0.7
0059 -0.3 0.3 -0.7 0 0.8 -0.3 -1 1.1 -0.6 0.2 -0.1 0.5 1.2 1.4 0.5 0.6 -0.5 -0.6 -1 -0.6
0060 -0.1 0.8 2.3 0.8 1.6 -0.5 -0.5 0.1 0.4 -0.5 -0.2 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5
- A F I L V M W Y D E K R H N Q S T G P C
0061 0.4 0.1 0 0.3 -0.2 0 -0.5 0.1 0.2 0.7 0.9 0.1 -0.2 -0.4 0 -0.4 -0.2 -0.5 -0.2 -0.3
0062 -0.1 -0.8 -0.6 -0.8 -0.6 -0.7 -0.9 -0.2 0.9 0.7 0.5 -0.4 0.3 1.2 -0.6 -0.1 -0.3 1.9 0.5 -0.9
0063 0.3 -1.1 -0.6 -0.7 0.3 -1.2 -1.4 -0.4 -0.2 0.3 1.6 1.7 1.2 0.7 0.5 0.8 -0.5 -0.1 -0.7 -0.9
0064 -0.5 2.1 -0.5 -0.1 -0.3 -0.2 -0.3 1.7 -0.5 -0.1 -0.1 -0.5 0.3 -0.3 -0.5 -0.2 -0.2 -0.5 0.3 -0.3
0065 0.5 -0.8 -0.5 -0.3 -0.5 -1 -1.1 -0.3 0.3 0.6 0.6 0.9 -0.4 -0.4 0.2 0.9 0.6 -0.1 2.1 -1
0066 0.3 0.6 -0.5 -0.9 0.1 -0.9 -0.7 1.4 -0.7 1 -0.1 0.1 0 -0.5 -0.3 0 -0.1 -0.1 -0.5 0.5
0067 0.2 -0.9 0.2 -0.5 0.1 -0.5 -0.7 -0.3 -0.3 1.1 0.6 1.7 0 0.3 0.8 -0.1 0.8 -0.3 -0.5 -0.9
0068 -0.5 -1 -0.6 0.4 -0.2 -0.5 -0.8 -1.1 -1 0.5 2.5 2 -0.2 -0.3 0.7 -0.2 -0.3 -0.5 0.3 -0.5
0069 0.2 -0.5 2.1 1.8 2.1 -0.6 -1 -0.7 -0.7 -0.6 -0.2 -0.1 -0.6 -0.7 -0.5 -0.1 0 -0.3 -0.5 -1.1
0070 0.4 -0.9 -0.8 -0.5 -0.2 -1 -0.6 -0.8 0.4 1 0.4 0.6 -0.2 -0.1 -0.3 0.5 0.2 0.7 -0.3 -0.9
Select residue pair below:
i_j Score Prob
0003_0024 2.996 1.00
0024_0034 2.751 1.00
0045_0055 2.320 1.00
0040_0044 2.136 1.00
0042_0055 2.058 1.00
0006_0014 1.735 1.00
0056_0061 1.700 1.00
0003_0013 1.660 1.00
0008_0053 1.646 1.00
0043_0047 1.589 1.00
0039_0064 1.506 1.00
0053_0061 1.449 1.00
0046_0055 1.426 0.99
0003_0026 1.391 0.99
0018_0040 1.387 0.99
0011_0056 1.344 0.99
0023_0060 1.338 0.99
0047_0052 1.330 0.99
0036_0065 1.329 0.99
0036_0067 1.283 0.99
0026_0032 1.279 0.99
0016_0021 1.270 0.99
0022_0034 1.263 0.98
0054_0057 1.145 0.97
0057_0061 1.144 0.97
0014_0025 1.114 0.96
0037_0065 1.101 0.96
0053_0057 1.098 0.95
0008_0051 1.092 0.95
0039_0042 1.054 0.94
0010_0056 1.038 0.93
0040_0043 1.034 0.93
0042_0064 1.030 0.93
0035_0051 1.025 0.93
0014_0046 1.025 0.93
0027_0053 1.014 0.92
0004_0007 1.007 0.92
0017_0059 0.997 0.91
0011_0014 0.968 0.90
0009_0064 0.945 0.88
0067_0070 0.937 0.88
0015_0026 0.934 0.87
0011_0046 0.932 0.87
0026_0034 0.928 0.87
0012_0028 0.915 0.86
0027_0033 0.914 0.86
0016_0046 0.909 0.85
0036_0066 0.881 0.83
0025_0060 0.862 0.81
0031_0068 0.852 0.80
0054_0058 0.847 0.79
0017_0020 0.839 0.79
0009_0051 0.832 0.78
0013_0024 0.817 0.76
0008_0061 0.815 0.76
0015_0043 0.809 0.75
0011_0035 0.802 0.74
0015_0032 0.801 0.74
0006_0015 0.800 0.74
0027_0056 0.778 0.71
0003_0032 0.776 0.70
0018_0069 0.773 0.70
0027_0064 0.771 0.70
0033_0066 0.770 0.70
0018_0030 0.764 0.69
0043_0070 0.762 0.68
0014_0047 0.761 0.68
0062_0068 0.755 0.67
0052_0055 0.751 0.67
0011_0025 0.750 0.67
0029_0054 0.748 0.66
0034_0067 0.748 0.66
0025_0056 0.747 0.66
0031_0070 0.747 0.66
0058_0067 0.745 0.66
0041_0048 0.743 0.66
0007_0047 0.735 0.64
0038_0042 0.727 0.63
0010_0061 0.727 0.63
0028_0054 0.726 0.63
0056_0066 0.725 0.63
0002_0037 0.722 0.62
0027_0051 0.702 0.59
0007_0028 0.687 0.57
0019_0040 0.682 0.56
0009_0012 0.677 0.55
0045_0059 0.664 0.53
0033_0053 0.664 0.53
0002_0025 0.663 0.53
0010_0027 0.659 0.52
0044_0047 0.658 0.52
0010_0033 0.658 0.52
0006_0023 0.656 0.51
0015_0024 0.648 0.50
0021_0065 0.645 0.50
0012_0050 0.641 0.49
0017_0036 0.638 0.48
0013_0043 0.633 0.48
0014_0043 0.630 0.47
0028_0050 0.626 0.46
0058_0061 0.620 0.45
0013_0034 0.620 0.45
0016_0039 0.617 0.45
0012_0029 0.615 0.45
Local Interactions:
i_j Score Prob
0051_0053 1.941 1.00
0024_0026 1.607 1.00
0049_0051 1.509 1.00
0029_0031 1.255 0.98
0020_0022 1.152 0.97
0006_0007 1.137 0.96
0013_0015 1.039 0.93
0022_0024 1.028 0.93
0001_0002 0.996 0.91
0038_0039 0.956 0.89
0067_0069 0.954 0.89
0062_0063 0.939 0.88
0016_0017 0.882 0.83
0003_0004 0.865 0.81
0058_0059 0.828 0.77
0048_0050 0.752 0.67
0065_0067 0.743 0.66
0046_0047 0.737 0.65
0057_0059 0.733 0.64
0002_0003 0.728 0.63
0019_0020 0.712 0.61
0014_0015 0.703 0.59
0009_0010 0.699 0.59
0031_0032 0.698 0.59
0033_0035 0.694 0.58
0017_0018 0.687 0.57
0029_0030 0.675 0.55
0028_0029 0.664 0.53
0061_0062 0.642 0.49
0001_0003 0.634 0.48
0044_0045 0.629 0.47
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: M Q R Q P ...
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