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Instructions
  • Use the menu to the right to browse the coupling matrix, or select a position from the PSSM below to see what it is coupled with.
Conservation matrix (aka PSSM)
- A F I L V M W Y D E K R H N Q S T G P C
0002 0.2 -0.7 -0.1 -0.1 -0.1 -0.8 -0.8 -0.6 -0.3 -0.1 -0.1 0.5 -0.7 -0.6 -0.1 1.5 0.6 0.1 0.3 -0.4
0003 0.1 -0.7 -0.9 -0.4 -0.1 -0.5 -0.9 -0.9 1.7 0.5 -0.2 -0.1 0.1 1.2 0 0.7 0.1 -0.1 0.5 -0.6
0004 0.6 -0.5 0.8 0.6 1.4 0.3 -0.3 -0.5 -0.3 -0.5 -0.5 -0.1 -0.5 -0.5 -0.5 -0.2 0.2 -0.5 1.1 -0.3
0005 0.7 -0.5 -0.4 0.1 0.1 -0.3 -0.7 -0.4 -0.1 0 0.4 0.6 0 0 0 1 0.5 0.3 -0.4 -0.7
0006 0.1 -0.7 -0.3 0.1 -0.6 -0.3 -1.1 -0.3 0.2 0.8 1.1 0.2 0.5 0.8 0.5 0.7 0.8 -0.3 -1.1 -0.6
0007 -0.3 0.2 -0.3 0.6 -0.2 -0.3 2.6 0 -0.3 -0.3 -0.3 -0.3 -0.2 -0.3 -0.3 -0.3 0.1 -0.3 -0.3 -0.3
0008 0 -0.5 -0.5 -0.2 -0.4 -0.5 -0.2 -0.5 0.5 0.2 -0.3 -0.5 -0.5 0.8 -0.1 1.3 1.2 0.4 -0.2 -0.5
0009 0.6 -0.2 0.6 -0.3 0.7 -0.3 -0.6 -0.6 -0.1 -0.5 0.1 -0.5 -0.6 0 -0.1 0.5 1 -0.6 0.3 0.4
0010 0.6 -0.6 -0.6 -0.3 -0.3 -0.6 -0.2 -0.8 1.8 1.8 0.6 -0.5 -0.3 0.6 0.2 0.4 0.4 -0.2 -0.6 -1
0011 0 -0.7 -0.7 -0.5 -0.4 -0.1 -0.7 -0.7 2.7 2.5 0.3 0 -0.1 0 1.5 -0.7 -0.4 -0.7 -0.7 -0.5
0012 -0.3 -0.3 0.5 0.9 0.7 -0.3 0.2 -0.3 -0.3 -0.3 -0.3 -0.1 -0.3 -0.3 0 0 0.5 -0.3 -0.3 0
0013 1.9 0.1 0.3 0 0.9 0.1 -0.3 -0.1 -0.9 -0.4 -0.6 -0.1 -0.6 -0.7 -0.4 1.2 -0.5 0 -0.6 1
0014 0.4 -0.9 -0.8 0.1 -0.6 -0.1 -0.7 -0.5 0.3 0.7 1 0.3 -0.1 0.6 1.1 0.6 0.1 0.2 -0.7 -0.5
0015 0 1.4 -0.2 0 -0.3 -0.3 0.7 1.4 -0.5 0.1 -0.5 -0.1 0.5 -0.5 -0.5 -0.3 -0.5 -0.2 -0.2 -0.2
0016 -0.6 1.5 2.2 1.9 2.3 0.1 -0.6 -0.6 -0.6 -0.6 -0.6 -0.3 -0.6 -0.6 -0.4 -0.3 -0.6 -0.6 -0.6 -0.6
0017 0.6 -0.7 -0.2 0.1 -0.5 -0.6 -0.6 -0.7 -0.9 0.8 1.2 0.7 -0.1 0.1 0.4 0.8 0.5 0.2 -0.8 -0.2
0018 0.6 -0.7 -0.3 -0.2 -0.1 -0.6 -1.1 -0.8 0.2 0.9 0.8 0.7 0.3 0.3 0 1.6 0.8 -0.1 -1.1 -0.7
0019 0.7 -0.1 0.9 1.3 0.6 0.3 -0.8 -0.2 -0.8 -0.7 0.1 0.1 -0.1 -0.1 -0.2 -0.4 1.2 0 -0.8 -0.8
0020 -0.3 0.4 -0.5 0.8 -0.8 -0.8 -0.8 -0.1 1.8 0 -0.5 -0.5 -0.2 -0.3 -0.1 0.4 0.1 0.6 0.7 -0.3
0021 0.2 -0.5 -0.1 -0.1 -0.3 -0.5 -0.8 -0.5 0.4 -0.1 -0.2 -0.4 -0.8 0.2 0.1 0.2 -0.1 0.8 2.2 -0.6
0022 0.3 -0.6 -0.4 -0.3 -0.2 -0.6 -0.6 -0.5 -0.3 -0.2 -0.4 -0.6 -0.4 -0.6 0.4 0.5 0.5 0.9 -0.3 0.8
0023 0.3 0.6 -0.1 1.1 -0.6 -0.1 -0.6 -0.2 -0.2 -0.2 -0.4 -0.2 -0.5 -0.2 0 0.7 0.3 -0.5 -0.6 1.1
0024 0.9 -1 -0.4 0.1 -0.4 -0.8 -1 -1 0.8 0.9 0.5 -0.4 -1 -0.5 0.4 1.1 0.2 0.7 0.2 -0.5
0025 0.5 -0.9 -0.5 -0.2 0.5 -0.4 -1.2 -1 1.5 1.9 0.5 -0.1 -0.4 -0.1 0.1 0.4 -0.1 0.1 0.7 -1
0026 -0.1 0.5 1.2 1.4 0.9 -0.5 -0.5 0.9 -0.9 0.7 -0.7 -0.9 0.6 -0.7 0.7 -0.3 -0.6 -0.9 -0.7 0
0027 2.7 -0.1 0.2 0.2 0.8 -0.7 -0.7 -0.5 -0.7 -0.7 -0.3 -0.5 -0.5 -0.7 -0.3 0.8 0.8 0.6 -0.2 0.6
0028 0.5 -0.8 -0.2 -0.3 -0.5 -0.8 -0.7 -0.1 0.9 1.3 0.7 -0.1 0.2 0.6 0.3 0.6 0.3 -0.2 -0.1 -0.7
0029 0.8 -0.7 0.8 1.2 1.1 -0.8 -1.1 -0.7 0.4 0.8 0.9 0 -0.3 0 0.3 -0.3 0.5 -0.8 -0.6 -0.4
0030 -0.4 1.8 1.1 1.1 0.1 0.3 -0.4 -0.4 -0.4 -0.4 -0.1 -0.4 -0.4 -0.1 -0.1 -0.1 -0.4 -0.1 -0.4 0
0031 0.1 -0.1 -0.1 0.9 0.1 -0.3 -0.8 -0.3 -0.8 0.8 0.8 1.8 -0.2 -0.4 0.7 0 0.2 -0.6 -0.5 -0.4
- A F I L V M W Y D E K R H N Q S T G P C
0032 0 -0.8 -0.1 -0.2 -0.4 -0.3 -0.7 -0.7 1.4 1.8 1.2 0.4 0 0.5 1.1 0.2 0.1 -1 -1 -0.8
0033 0.2 -0.1 -0.4 -0.4 -0.4 -0.3 -0.4 0.2 -0.1 1.4 0.2 -0.2 0.5 1.2 0.7 -0.2 -0.4 -0.4 -0.4 -0.4
0034 0.3 -0.6 -0.6 0 0.3 0.3 -0.6 -0.6 0.7 0.9 0 0.3 0 -0.1 0.6 0.8 -0.6 0 -0.6 -0.4
0035 0 0.1 0.6 0.3 0.9 0.1 -0.3 0 0 -0.3 -0.3 0.6 -0.3 -0.3 0 -0.3 -0.2 0 0 -0.3
0036 -0.2 -0.2 0.2 0.2 -0.2 -0.2 -0.2 -0.2 0.4 -0.2 0.3 -0.2 -0.2 0.7 0.1 0 0.5 -0.2 -0.2 0.2
0037 -0.1 -0.2 -0.2 -0.2 0.3 -0.2 -0.2 0.1 0.1 0.1 0.3 0.5 -0.2 -0.2 0.1 -0.2 -0.2 1.1 -0.2 -0.2
0038 0.8 -0.9 -0.5 -0.3 -0.8 -0.7 -0.9 -0.7 -0.4 1.6 1.7 1.2 -0.2 -0.6 1.7 0.2 0.2 -0.5 0.4 -0.5
0039 0.9 -0.4 0.7 -0.4 0.2 -0.1 -0.4 -0.4 -0.1 -0.4 -0.2 0.6 -0.1 -0.4 0 1.1 0.3 0.3 -0.4 0
0040 -0.3 0.9 0.4 0.8 0.3 0.5 0 -0.3 -0.3 -0.3 -0.3 0 -0.3 -0.3 0 -0.3 0.3 -0.3 -0.3 -0.1
0041 -0.1 0.1 0.2 0.8 0.5 0.5 -0.5 -0.5 -0.5 -0.5 -0.2 -0.5 0.3 -0.5 0.2 0.5 0.1 0.1 0.7 -0.5
0042 -0.1 0 -0.4 0.5 0.4 0.4 -0.4 -0.3 -0.1 0.5 -0.2 -0.4 0 -0.4 0.4 0.8 -0.2 -0.4 -0.4 -0.1
0043 0.3 0.2 0.6 0.9 0.5 0.9 -0.3 -0.3 -0.3 -0.3 -0.3 0 0 -0.3 0 -0.3 -0.3 0 -0.3 -0.3
0044 0.2 -0.8 -0.8 -0.8 -0.7 -0.7 -0.8 -0.8 -0.2 -0.3 1.2 0.8 -0.5 1.1 1 1.5 2.1 0.1 -0.4 -0.7
0045 -0.2 -0.5 -0.5 1 0 -0.2 -0.8 -0.7 -0.4 0.7 0.8 0.8 -0.8 0.3 0.6 0.9 0.3 -0.1 -0.1 -0.8
0046 0.3 -1 -1 -1 -0.4 -0.5 -1 -0.6 1.5 1.6 0.1 -0.2 -0.1 1 0.5 1.3 0.6 -0.1 0.7 -0.7
0047 0 0.1 0 0.1 0.1 -0.4 -0.5 -0.5 0.7 0.3 -0.5 -0.5 0.6 0.3 0.6 0.2 0.6 -0.5 -0.1 -0.5
0048 -0.3 0.5 1.6 2.4 1.1 1 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.3 -0.3 -0.3 -0.3 -0.6 0.4
0049 -0.5 -0.5 1.4 1.5 1.8 1.2 -0.7 -0.5 -0.5 -0.2 -0.7 0.4 -0.5 -0.7 0.2 -0.1 0.7 -0.3 -0.7 -0.7
0050 -0.3 -0.5 -0.4 -0.9 -0.4 -0.3 -0.4 -0.9 0.8 1.1 1 0.1 -0.1 0.9 0.3 1 1.2 0 -0.7 -0.7
0051 0.4 -0.1 0.6 0.9 -0.1 -0.8 -1.1 0.9 -0.5 -0.8 -0.3 -0.1 0.6 0.3 -0.6 0.2 0.8 0.6 -0.1 0.1
0052 0.2 0.8 0.3 1 0.1 -0.1 -0.4 -0.2 0.1 -0.4 0.3 -0.4 -0.4 -0.4 -0.1 -0.1 0.4 0.1 -0.4 -0.4
0053 -0.7 -0.9 -0.9 -0.5 -0.9 -0.9 -0.9 -0.7 0.3 0.7 1 -0.1 0 1.7 0.4 1.7 -0.5 2.3 -0.2 -0.3
0054 -0.6 0.8 1.1 1.6 1 1.8 -0.6 -0.6 -0.6 -0.3 -0.3 -0.2 -0.3 -0.4 -0.6 -0.1 -0.6 -0.6 0 -0.3
0055 0.1 -0.4 -0.4 0.2 0.2 0 -0.4 -0.4 -0.4 0.3 1 0.7 -0.2 -0.1 0.4 -0.1 0.1 -0.1 0.1 -0.2
0056 -0.2 0.4 0.9 1.2 0.8 0.3 -0.2 -0.5 -0.5 -0.3 0.1 -0.2 -0.5 -0.4 -0.2 -0.2 -0.2 -0.2 -0.5 0.5
0057 0.5 -0.2 -0.2 -0.2 0.3 -0.2 -0.2 -0.2 -0.2 0.2 0.3 0 -0.2 -0.2 0.1 0.5 -0.2 -0.1 0.3 -0.1
0058 0.1 0 -0.3 0.2 0 -0.3 -0.3 -0.1 0 -0.3 0.1 0.2 0.4 -0.1 0.2 -0.1 0.6 -0.1 -0.1 -0.3
0059 1.7 -0.4 -0.2 -0.2 0.7 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 0 0.4 -0.4 -0.2 0.8 0.2 0 0.2 -0.4
0060 -0.1 -0.2 1.2 2.5 1.7 0.9 -0.6 -0.6 -0.6 -0.4 -0.6 -0.2 0 -0.6 -0.6 -0.6 -0.3 -0.6 -0.2 -0.6
0061 0.4 -0.3 -0.3 0.1 -0.1 -0.1 -0.3 -0.3 0.3 -0.1 0.1 0.9 0.1 -0.1 0.4 0.1 -0.1 -0.1 -0.3 0
- A F I L V M W Y D E K R H N Q S T G P C
0062 -0.6 0.5 2 2.6 1.3 0.7 -0.3 -0.6 -0.6 0.4 -0.6 -0.2 -0.6 -0.5 -0.6 -0.3 -0.6 -0.6 -0.6 -0.6
0063 0.2 0.6 0 0.1 0.5 -0.1 -0.8 0.7 -0.3 -0.2 -0.4 0.1 -0.1 0 -0.1 0.5 -0.1 -0.3 -0.6 0.6
0064 0.5 -0.6 -0.6 -0.3 -0.4 -0.7 -0.7 0.2 0.7 0.4 0.8 0.1 0.6 0.9 0.3 0.5 -0.2 -0.2 -0.7 -0.7
0065 1.1 -0.1 0.4 1 -0.1 -0.9 -0.7 0.6 -0.6 -0.9 0.1 0.6 1.2 -0.8 0.7 0.6 -0.3 -0.7 -1.1 0.1
0066 -0.5 -0.5 2.1 1.8 2.6 -0.5 -0.5 -0.5 -0.5 -0.5 -0.3 -0.1 0.4 -0.5 -0.5 -0.4 -0.5 -0.2 -0.5 -0.5
0067 0.3 -0.7 -0.1 1.1 0.2 -0.2 -1.1 -1.1 0.9 0.7 0.8 0.7 -0.9 0.9 0.7 0.7 -0.5 -0.3 -1 -1.1
0068 0.5 -1 0.2 0.1 -0.3 0.5 -0.8 -1 -0.4 0.5 1.1 1.1 -0.5 -0.1 0.4 0.6 0.4 0 -0.9 -0.5
0069 0.3 0.8 0.6 2.1 0.7 0.8 -0.6 -0.4 -0.6 -0.6 -0.1 0.2 -0.3 -0.6 -0.6 -0.3 -0.4 -0.6 -0.4 -0.6
0070 0.2 -0.2 0.1 0.4 0.4 -0.5 -0.5 -0.5 -0.5 -0.3 1 0.8 -0.3 0.2 0.8 -0.2 -0.1 -0.3 -0.5 -0.5
0071 0.2 -0.5 -0.1 0 -0.1 -0.5 -0.4 -0.5 0.2 0.1 0 0.3 0.2 0.5 0.2 1 0.1 0.5 -0.5 -0.2
0072 1.4 -1.1 -0.6 -0.2 -0.1 -0.9 -1.1 -1.1 0.1 0.5 1.1 1.2 -0.4 0.2 0.3 0.7 0.3 0.5 -0.6 -1.1
0073 0.3 0.2 0.3 0.1 0.1 -0.7 -0.7 -0.3 0 0.1 -0.1 0.3 0 0 0.2 0.2 0.5 0 -0.7 -0.3
0074 -0.9 0 -0.9 0.2 -0.7 -0.3 -0.9 -0.1 1 1 0.3 0.1 -0.1 0.7 -0.2 0.4 0 -0.9 -0.2 -0.7
Select residue pair below:
i_j Score Prob
0010_0031 2.204 1.00
0013_0027 1.995 1.00
0057_0061 1.948 1.00
0066_0069 1.738 1.00
0007_0012 1.600 1.00
0033_0040 1.484 0.99
0012_0015 1.480 0.99
0037_0043 1.439 0.99
0020_0023 1.399 0.98
0016_0020 1.322 0.98
0046_0049 1.291 0.97
0047_0063 1.291 0.97
0041_0061 1.287 0.97
0058_0061 1.267 0.97
0008_0071 1.258 0.96
0045_0048 1.249 0.96
0034_0039 1.246 0.96
0035_0052 1.234 0.96
0040_0064 1.197 0.95
0049_0063 1.165 0.94
0009_0012 1.155 0.94
0063_0067 1.142 0.93
0035_0061 1.124 0.92
0052_0059 1.116 0.92
0052_0061 1.085 0.91
0014_0017 1.075 0.90
0017_0028 1.073 0.90
0048_0070 1.063 0.89
0017_0044 1.063 0.89
0037_0057 1.050 0.89
0004_0007 1.034 0.87
0005_0070 1.025 0.87
0028_0046 1.020 0.87
0068_0073 1.011 0.86
0047_0051 1.006 0.85
0039_0042 0.999 0.85
0025_0071 0.995 0.85
0012_0030 0.992 0.84
0004_0066 0.991 0.84
0061_0064 0.986 0.84
0029_0054 0.979 0.83
0036_0056 0.977 0.83
0055_0061 0.974 0.83
0019_0062 0.972 0.83
0036_0039 0.972 0.83
0036_0043 0.970 0.83
0037_0042 0.964 0.82
0030_0058 0.958 0.81
0037_0040 0.950 0.81
0023_0026 0.946 0.80
0055_0058 0.938 0.80
0045_0063 0.934 0.79
0010_0017 0.925 0.78
0035_0043 0.911 0.77
0052_0056 0.910 0.77
0033_0058 0.902 0.76
0008_0012 0.901 0.76
0033_0049 0.897 0.75
0036_0057 0.895 0.75
0009_0015 0.890 0.74
0034_0055 0.888 0.74
0034_0060 0.879 0.73
0039_0061 0.878 0.73
0066_0070 0.876 0.73
0047_0064 0.873 0.72
0015_0022 0.869 0.72
0002_0031 0.865 0.71
0018_0044 0.864 0.71
0058_0062 0.863 0.71
0006_0017 0.860 0.71
0013_0031 0.860 0.71
0029_0050 0.846 0.69
0028_0031 0.846 0.69
0030_0043 0.844 0.69
0014_0044 0.843 0.69
0002_0028 0.840 0.68
0014_0034 0.833 0.67
0009_0044 0.830 0.67
0063_0071 0.827 0.66
0034_0065 0.824 0.66
0028_0032 0.822 0.66
0037_0041 0.822 0.66
0002_0005 0.817 0.65
0069_0073 0.817 0.65
0006_0014 0.811 0.64
0036_0042 0.806 0.63
0005_0008 0.805 0.63
0047_0052 0.802 0.63
0040_0057 0.801 0.63
0054_0068 0.800 0.63
0043_0055 0.796 0.62
0042_0052 0.794 0.62
0011_0070 0.787 0.61
0017_0025 0.787 0.61
0006_0031 0.785 0.60
0026_0048 0.781 0.60
0057_0060 0.778 0.59
0009_0033 0.777 0.59
0026_0047 0.775 0.59
0027_0059 0.774 0.59
0041_0058 0.772 0.59
0036_0040 0.768 0.58
0009_0024 0.765 0.57
0042_0054 0.762 0.57
0033_0056 0.760 0.57
0005_0011 0.754 0.56
0071_0074 0.754 0.56
0035_0040 0.753 0.56
Local Interactions:
i_j Score Prob
0045_0047 2.384 1.00
0020_0021 2.085 1.00
0022_0023 1.793 1.00
0019_0021 1.711 1.00
0053_0054 1.561 0.99
0035_0036 1.559 0.99
0072_0073 1.537 0.99
0073_0074 1.523 0.99
0057_0058 1.490 0.99
0036_0037 1.413 0.99
0003_0004 1.400 0.98
0047_0048 1.360 0.98
0035_0037 1.223 0.96
0069_0070 1.220 0.96
0049_0050 1.202 0.95
0039_0041 1.163 0.94
0056_0057 1.131 0.93
0022_0024 1.125 0.92
0003_0005 1.118 0.92
0050_0051 1.114 0.92
0067_0068 1.114 0.92
0055_0057 1.112 0.92
0015_0016 1.078 0.90
0070_0071 1.050 0.89
0002_0003 1.047 0.88
0007_0008 0.977 0.83
0004_0005 0.929 0.79
0071_0072 0.917 0.77
0058_0059 0.903 0.76
0018_0019 0.899 0.75
0064_0065 0.897 0.75
0057_0059 0.890 0.74
0071_0073 0.870 0.72
0032_0033 0.858 0.70
0021_0022 0.846 0.69
0014_0016 0.815 0.65
0038_0040 0.790 0.61
0011_0013 0.768 0.58
See all coupling residues
Download raw data
Renumber residues to start with:
Position: 1 2 3 4 5 ...
Sequence: D S M P I ...
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